Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Hyperbolic Geometry for Open-World Object Detection in Remote Sensing Imagery
arXiv:2609.09626v1 Announce Type: cross Abstract: Open-world object detection (OWOD) extends closed-set detection by requiring models to identify unknown objects and incrementally learn them once annotations become available. In remote sensing imagery, object categories often exhibit latent hierarchical relationships that may be inadequately represented in the Euclidean spaces commonly adopted by existing methods, limiting unknown-object recall and incremental-learning performance. To address t
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(Multiomics OR Omics) AND (Pancreatic)
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Agrimol B induces autophagic death in TP53-mutant pancreatic cancer by targeting the S100A6-HDAC2-mutant p53 acetylation axis
Phytomedicine. 2026 Aug 26;161:158760. doi: 10.1016/j.phymed.2026.158760. Online ahead of print.ABSTRACTBACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) harbors TP53 mutations at high frequency, yet therapeutic strategies that specifically target mutant p53 remain limited.PURPOSE: This study aimed to identify S100A6, a calcium-binding protein frequently upregulated in TP53-mutant PDAC, as a critical regulator of mutant p53 stability and tumor progression, and to explore potential S100A6-targe
Agrimol B induces autophagic death in TP53-mutant pancreatic cancer by targeting the S100A6-HDAC2-mutant p53 acetylation axis
Phytomedicine. 2026 Aug 26;161:158760. doi: 10.1016/j.phymed.2026.158760. Online ahead of print.
ABSTRACT
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) harbors TP53 mutations at high frequency, yet therapeutic strategies that specifically target mutant p53 remain limited.
PURPOSE: This study aimed to identify S100A6, a calcium-binding protein frequently upregulated in TP53-mutant PDAC, as a critical regulator of mutant p53 stability and tumor progression, and to explore potential S100A6-targeting agents for therapeutic intervention.
METHODS: We integrated computer-assisted drug screening with transcriptomics, acetylation omics, and molecular biology techniques to identify Agrimol B (AgrB), a bioactive compound derived from the traditional Chinese herb Agrimonia pilosa Ledeb., as a potential S100A6-targeting agent.
RESULTS: High S100A6 expression was closely associated with poor prognosis in patients with TP53-mutant PDAC, whereas S100A6 depletion markedly suppressed PDAC cell growth and metastatic potential. Mechanistically, AgrB enhanced the interaction between S100A6 and the deacetylase HDAC2, leading to reduced acetylation of mutant p53 at lysine 382. This disruption activated autophagy-dependent cell death and thereby inhibited PDAC progression.
CONCLUSION: Our findings reveal an S100A6-HDAC2-mutant p53 acetylation axis that regulates TP53-mutant pancreatic tumorigenesis, providing mechanistic evidence supporting S100A6 as a therapeutic vulnerability and highlighting AgrB as a promising natural-product-derived candidate for further development against this aggressive malignancy.
PMID:42700714 | DOI:10.1016/j.phymed.2026.158760
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Pulmonary nodule
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Multiomic characterization of malignant pulmonary nodules and development of a methylation-based diagnostic Model
J Transl Med. 2026 Jun 8;24(1):776. doi: 10.1186/s12967-026-08382-w.ABSTRACTBACKGROUND: The molecular distinction between benign and malignant pulmonary nodules remains a significant diagnostic challenge. While genomic drivers are well studied, multiomic integration of the epigenetic-transcriptional landscape and its translation into noninvasive tools are lacking.METHODS: We performed a multiomic characterization (genomic, epigenomic, and transcriptomic) of 158 pulmonary nodules. Unsupervised fa
Multiomic characterization of malignant pulmonary nodules and development of a methylation-based diagnostic Model
J Transl Med. 2026 Jun 8;24(1):776. doi: 10.1186/s12967-026-08382-w.
ABSTRACT
BACKGROUND: The molecular distinction between benign and malignant pulmonary nodules remains a significant diagnostic challenge. While genomic drivers are well studied, multiomic integration of the epigenetic-transcriptional landscape and its translation into noninvasive tools are lacking.
METHODS: We performed a multiomic characterization (genomic, epigenomic, and transcriptomic) of 158 pulmonary nodules. Unsupervised factor analysis integrated these layers to identify core regulatory axes. A 9-gene cell-free DNA (cfDNA) methylation classifier was developed and validated in blood and tissue cohorts.
RESULTS: Genomic profiling revealed EGFR mutations (exclusive to malignant nodules) and MYC amplification as fundamental initiators of malignancy. Multiomic factor analysis (Factor 1) revealed profound genetic‒epigenetic synergy, in which these alterations dictate a permissive methylome, leading to aberrant epigenetic programming of chromatin accessibility, as well as epigenetic-transcriptional effects: hypomethylation at the promoters of cell cycle genes that augments their expression, and hypermethylation at immune related pathways gene loci that silences their transcription. This effect orchestrates formation of proproliferative (E2F target/G2M checkpoint) and "immune-cold" malignant phenotype, characterized by elevated Treg/CD8+ ratios and fibroblast recruitment. Notably, we observed a gradual accumulation of methylation aberrations along the premalignant-to-invasive continuum (adenocarcinoma in situ [AIS]→minimally invasive adenocarcinoma [MIA]→adenocarcinoma [ADC]), identifying progressive epigenetic dysregulation as a hallmark of tumor aggressiveness. Global methylome remodeling drives ADC progression through hypermethylation-mediated silencing of tumor suppressors (RASA3 and PPARG) and hypomethylation-activated oncogenic axes, specifically the GDF15 axis, which independently predict poor survival in patients with lung ADC in the TCGA cohort. We translated these tissue-derived insights into a 9-gene cfDNA methylation classifier, which achieved exceptional diagnostic accuracy across independent cohorts (training AUC = 1.00; test AUC = 0.93; tissue AUC = 0.96). Rooted in the biological "ground truth" of tissue dysregulation, this classifier functions specifically as a functional readout of the core cell cycle and proliferative pathways, offering a robust, noninvasive tool for the biology-informed risk assessment of pulmonary nodules.
CONCLUSIONS: This study delineates an epigenetic-transcriptional regulatory network that drives nodule malignancy. Our findings provide a robust theoretical foundation and a high-performance liquid biopsy tool for the precise, noninvasive diagnosis of pulmonary nodules.
PMID:42260586 | PMC:PMC13274191 | DOI:10.1186/s12967-026-08382-w
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cs.AI, q-bio.NC updates on arXiv.org
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AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
arXiv:2605.20025v2 Announce Type: replace Abstract: Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across cycles. Existing autonomous research systems often model this process as a linear pipeline: they rely on single-agent reasoning, stop when execution fails, and do not carry experience across runs. We present
AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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SkillOpt: Executive Strategy for Self-Evolving Agent Skills
arXiv:2605.23904v2 Announce Type: replace Abstract: Agent skills today are hand-crafted, generated one-shot, or evolved through loosely controlled self-revision, none of which behaves like a deep-learning optimizer for the skill, and none of which reliably improves over its starting point under feedback. We argue the skill should instead be trained as the external state of a frozen agent, with the same discipline that makes weight-space optimization reproducible. SkillOpt is, to our knowledge,
SkillOpt: Executive Strategy for Self-Evolving Agent Skills
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Nature - Issue - nature.com science feeds
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Mapping convergent regulators of melanoma drug resistance by PerturbFate
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.
Mapping convergent regulators of melanoma drug resistance by PerturbFate
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0
PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.-
Oncogene - Issue - nature.com science feeds
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Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03754-4Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis
Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03754-4
Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis-
cs.AI, q-bio.NC updates on arXiv.org
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Diagnosing Retrieval Bias Under Multiple In-Context Knowledge Updates in Large Language Models
arXiv:2603.12271v1 Announce Type: cross Abstract: LLMs are widely used in knowledge-intensive tasks where the same fact may be revised multiple times within context. Unlike prior work focusing on one-shot updates or single conflicts, multi-update scenarios contain multiple historically valid versions that compete at retrieval, yet remain underexplored. This challenge resembles the AB-AC interference paradigm in cognitive psychology: when the same cue A is successively associated with B and C, t
Diagnosing Retrieval Bias Under Multiple In-Context Knowledge Updates in Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Dial: A Knowledge-Grounded Dialect-Specific NL2SQL System
arXiv:2603.07449v1 Announce Type: cross Abstract: Enterprises commonly deploy heterogeneous database systems, each of which owns a distinct SQL dialect with different syntax rules, built-in functions, and execution constraints. However, most existing NL2SQL methods assume a single dialect (e.g., SQLite) and struggle to produce queries that are both semantically correct and executable on target engines. Prompt-based approaches tightly couple intent reasoning with dialect syntax, rule-based trans
Dial: A Knowledge-Grounded Dialect-Specific NL2SQL System
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cs.AI, q-bio.NC updates on arXiv.org
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Towards Efficient Federated Learning of Networked Mixture-of-Experts for Mobile Edge Computing
arXiv:2511.01743v2 Announce Type: replace-cross Abstract: Recent advancements in large artificial intelligence models (LAMs) are driving significant innovations in mobile edge computing within next-generation wireless networks. However, the substantial demands for computational resources and larges-cale training data required to train LAMs conflict with the limited storage and computational capacity of edge devices, posing significant challenges to training and deploying LAMs at the edge. In th
Towards Efficient Federated Learning of Networked Mixture-of-Experts for Mobile Edge Computing
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cs.AI, q-bio.NC updates on arXiv.org
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Attn-QAT: 4-Bit Attention With Quantization-Aware Training
arXiv:2603.00040v2 Announce Type: replace-cross Abstract: Achieving reliable 4-bit attention is a prerequisite for end-to-end FP4 computation on emerging FP4-capable GPUs, yet attention remains the main obstacle due to FP4's tiny dynamic range and attention's heavy-tailed activations. This paper presents the first systematic study of 4-bit quantization-aware training (QAT) for attention. We find that "drop-in" QAT, which naively combines an FP4 forward pass with a high-precision Flash Attention
Attn-QAT: 4-Bit Attention With Quantization-Aware Training
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cs.AI, q-bio.NC updates on arXiv.org
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R1-Code-Interpreter: LLMs Reason with Code via Supervised and Multi-stage Reinforcement Learning
arXiv:2505.21668v3 Announce Type: replace Abstract: Practical guidance on training Large Language Models (LLMs) to leverage Code Interpreter across diverse tasks remains lacking. We present R1-Code-Interpreter, an extension of a text-only LLM trained via multi-turn supervised fine-tuning (SFT) and reinforcement learning (RL) to autonomously generate multiple code queries during step-by-step reasoning. Unlike prior RL + tool-use efforts focused on narrow domains such as math or retrieval, we cur
R1-Code-Interpreter: LLMs Reason with Code via Supervised and Multi-stage Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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Finding the Signal in the Noise: An Exploratory Study on Assessing the Effectiveness of AI and Accessibility Forums for Blind Users' Support Needs
arXiv:2602.18623v1 Announce Type: cross Abstract: Accessibility forums and, more recently, generative AI tools have become vital resources for blind users seeking solutions to computer-interaction issues and learning about new assistive technologies, screen reader features, tutorials, and software updates. Understanding user experiences with these resources is essential for identifying and addressing persistent support gaps. Towards this, we interviewed 14 blind users who regularly engage with
Finding the Signal in the Noise: An Exploratory Study on Assessing the Effectiveness of AI and Accessibility Forums for Blind Users' Support Needs
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cs.AI, q-bio.NC updates on arXiv.org
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Lost in Instructions: Study of Blind Users' Experiences with DIY Manuals and AI-Rewritten Instructions for Assembly, Operation, and Troubleshooting of Tangible Products
arXiv:2602.18630v1 Announce Type: cross Abstract: AI tools like ChatGPT and Be-My-AI are increasingly being used by blind individuals. Although prior work has explored their use in some Do-It-Yourself (DIY) tasks by blind individuals, little is known about how they use these tools and the available product-manual resources to assemble, operate, and troubleshoot physical or tangible products - tasks requiring spatial reasoning, structural understanding, and precise execution. We address this kno
Lost in Instructions: Study of Blind Users' Experiences with DIY Manuals and AI-Rewritten Instructions for Assembly, Operation, and Troubleshooting of Tangible Products
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cs.AI, q-bio.NC updates on arXiv.org
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Think with Grounding: Curriculum Reinforced Reasoning with Video Grounding for Long Video Understanding
arXiv:2602.18702v1 Announce Type: cross Abstract: Long video understanding is challenging due to rich and complicated multimodal clues in long temporal range.Current methods adopt reasoning to improve the model's ability to analyze complex video clues in long videos via text-form reasoning.However,the existing literature suffers from the fact that the text-only reasoning under fixed video context may exacerbate hallucinations since detailed crucial clues are often ignored under limited video co
Think with Grounding: Curriculum Reinforced Reasoning with Video Grounding for Long Video Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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Qute: Towards Quantum-Native Database
arXiv:2602.14699v1 Announce Type: cross Abstract: This paper envisions a quantum database (Qute) that treats quantum computation as a first-class execution option. Unlike prior simulation-based methods that either run quantum algorithms on classical machines or adapt existing databases for quantum simulation, Qute instead (i) compiles an extended form of SQL into gate-efficient quantum circuits, (ii) employs a hybrid optimizer to dynamically select between quantum and classical execution plans,