Oncogene, Published online: 25 September 2026; doi:10.1038/s41388-026-03992-6

A positive feedback loop between YTHDC1 and EP300 drives multiple myeloma tumorigenesis

arXiv:2609.08435v2 Announce Type: replace Abstract: In persistent interactions, long contexts may encode an evolving process rather than a fixed record: later events can revise or revoke earlier information, changing what remains valid and what conclusions follow. We call this setting information evolution (IE). Solving IE requires identifying valid records, applying updates in order, and reconstructing the query-relevant state from the event history. Existing text-first synthesis pipelines make such data difficult to verify because state transitions and answer logic remain implicit. We introduce EvolveScaler, a code-driven framework that defines information evolution before rendering it as natural language. Human-authored operational specifications define state transitions, record validity, difficulty controls, and executable answer logic; a strong LLM then synthesizes a self-contained simulator from each specification. Executing validated simulators produces natural-language multi-turn event histories, while deterministic replay computes reference answers and atomic checklists. We instantiate EvolveScaler with 117 task prototypes and 159 final-question operators across five difficulty levels spanning approximately 7 to 1,200 events per instance, yielding about 35,100 training examples and 585 validated evaluation instances. On the very_long tier, the strongest model reaches 59.3% avg@5, while six models score below 10%. Training an internal A3B model on 6,000 EvolveScaler examples improves performance over its base checkpoint on all eight independently constructed out-of-distribution benchmarks, with a 5.25-point average gain. These results show that code-driven IE synthesis provides both challenging evaluation and transferable training supervision.

arXiv:2605.24410v1 Announce Type: new Abstract: Graph few-shot learning, which aims to classify nodes from novel classes with only a few labeled examples, is a widely studied problem in graph learning. However, existing methods often face two key limitations. First, the predominant graph few-shot learning paradigm relies on supervised tasks, failing to leverage the vast number of unlabeled nodes in the graph. Second, many approaches require complex task adaptation or fine-tuning during inference, limiting their efficiency and applicability. Inspired by the powerful in-context learning capabilities of large language models, we propose a novel model named VISION for adVancIng graph few-Shot learning via In-cOntext LearNing to address these challenges. Our model reframes graph few-shot learning as a fine-tuning-free sequence reasoning problem. At its core is a context-aware network that initializes nodes with role embeddings and employs a dual-context fusion module to synergistically integrate local topological structures and global task-level dependencies. This allows our model to dynamically generate class-aware representations for the query set conditioned on the support set context in a single forward pass. To effectively train our model, we introduce an unsupervised task generator that creates structure-adaptive features and constructs diverse pseudo-tasks from abundant unlabeled data. Our method unifies unsupervised meta-learning with graph in-context learning, achieving efficient inference. Extensive experiments on multiple benchmark datasets demonstrate the superiority of our model. Our public code can be found