Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04621-1

The International Consortium of Digital Twins in Healthcare and Medicine was established to advance medical digital twin technology as a new infrastructure for precision health.

Background: New HIV cases among Malaysian men who have sex with men continue to rise, with young men who have sex with men (YMSM) accounting for 44% of new infections and experiencing high rates of comorbidities. Mobile health (mHealth) apps offer a promising approach to addressing these challenges by providing discreet access to health information, screening tools, and linkage to services. Given the near-universal smartphone ownership among Malaysian YMSM and high levels of mobile gaming engagement, gamified mHealth apps may be particularly effective in sustaining engagement and promoting HIV prevention behaviors and comorbidity management. However, realizing their full potential requires identifying the features and design principles that are most important to Malaysian YMSM and that can support sustained engagement and improve health outcomes in this vulnerable population. Objective: This study used an interdisciplinary expert panel approach to identify the key features, design principles, and gamification elements to be incorporated into MY-Hero, a gamified mHealth app designed to support HIV prevention, comorbidity management, and overall well-being among Malaysian YMSM. Methods: Guided by the integrated behavioral model (IBM), we conducted an interdisciplinary expert panel comprising experts in health, technology, and design sciences, as well as health care professionals with expertise in the Malaysian YMSM population, along with local lesbian, gay, bisexual, transgender, queer, and others (LGBTQ+) community leaders. Through a structured series of discussions and thematic analysis, we identified culturally appropriate design principles and key features for MY-Hero that align with the health needs and sociocultural context of Malaysian YMSM. Results: Three expert panel sessions were conducted with 9 experts. Several key themes emerged: (1) the importance of establishing clinical affiliation and facilitating linkage to HIV testing, pre-exposure prophylaxis (PrEP), and related services, including harm reduction services; (2) the need to enhance user interface (UI) and user experience (UX) by optimizing usability, interactivity, and engagement to maintain user interest; (3) the incorporation of customizable health content to tailor interventions based on individual characteristics and preferences; (4) the use of gamification mechanisms, such as reward systems and progression tracking to promote adoption and sustained engagement with health services; and (5) the importance of privacy and data security as critical design considerations for ensuring user safety, confidentiality, and trust. Conclusions: The findings highlight the importance of user-centered design, contextualized health content, and gamification mechanisms in mHealth tools for Malaysian YMSM. These insights provide practical guidance for developing culturally appropriate gamified mHealth interventions for vulnerable populations by informing strategies to enhance user engagement, reduce HIV prevention fatigue, and support the well-being of YMSM in stigmatized contexts.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10565-w

By using singularity physics to enable cubic-root scaling of frequency and phase modulations induced by the Coriolis effect to enhance the performance of chip-scale Coriolis vibratory gyroscopes, substantial improvements in signal-to-noise ratio and precision are demonstrated.

arXiv:2509.22097v2 Announce Type: replace-cross Abstract: Large language model-powered code agents are rapidly transforming software engineering, yet the security risks of their generated code have become a critical concern. Existing benchmarks have provided valuable insights, but they fail to capture scenarios in which vulnerabilities are actually introduced by human developers, making fair comparisons between humans and agents infeasible. We therefore introduce SecureVibeBench, a benchmark of 105 C/C++ secure coding tasks sourced from 41 projects in OSS-Fuzz for code agents. SecureVibeBench has the following features: (i) realistic task settings that require multi-file edits in large repositories, (ii)~aligned contexts based on real-world open-source vulnerabilities with precisely identified vulnerability introduction points, and (iii) comprehensive evaluation that combines functionality testing and security checking with both static and dynamic oracles. We evaluate 5 popular code agents like OpenHands, supported by 5 LLMs (e.g., Claude sonnet 4.5) on SecureVibeBench. Results show that current agents struggle to produce both correct and secure code, as even the best-performing one, produces merely 23.8\% correct and secure solutions on SecureVibeBench.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10303-2

A fully automated methodology based on rubrics capturing a broad range of cognitive and intellectual demands is illustrated using LLMs and tasks, demonstrating a new way to evaluate the capabilities of AI systems and anticipate their performance.

Oncogene, Published online: 23 March 2026; doi:10.1038/s41388-026-03734-8

PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment