Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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LC-QAT: Data-Efficient 2-Bit QAT for LLMs via Linear-Constrained Vector Quantization
arXiv:2606.10531v3 Announce Type: replace-cross Abstract: Quantization-aware training (QAT) is essential for extremely low-bit large language models (LLMs). Current QAT methods are mainly based on scalar quantization (SQ), which enables efficient optimization but suffers from severe performance degradation at 2-bit precision. On the other hand, vector quantization (VQ) provides substantially higher representational capacity, but its discrete codebook lookup prevents end-to-end training. We prop
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Molecular Therapy
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A complement C5-targeted GalNAc-conjugated siRNA with sustained efficacy in a non-human primate model of IgA nephropathy
This study characterizes a GalNAc-C5 small interfering RNA with potent in vitro and in vivo activity. Single subcutaneous dosing sustains long-term C5 suppression in cynomolgus monkeys with IgA nephropathy, outperforming Nefecon in blocking glomerular complement deposition, supporting its standalone or combinational clinical application.
A complement C5-targeted GalNAc-conjugated siRNA with sustained efficacy in a non-human primate model of IgA nephropathy
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Molecular Therapy
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A helicase-fused Cas9 improves large-size fragment knockin
By fusing MCM5, a subunit of the eukaryotic MCM2–7 helicase complex, to the N terminus of spCas9 (MCCas), the MCCas fusion protein enhances large-size fragment knockin via homologous recombination, reduces insertions and deletions (indels), and enables efficient large-size fragment insertions in human cells and rabbit embryos.
A helicase-fused Cas9 improves large-size fragment knockin
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cs.AI, q-bio.NC updates on arXiv.org
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Efficient Diversity-based Experience Replay for Deep Reinforcement Learning
arXiv:2410.20487v5 Announce Type: replace-cross Abstract: Experience replay is widely used to improve learning efficiency in reinforcement learning by leveraging past experiences. However, existing experience replay methods, whether based on uniform or prioritized sampling, often suffer from low efficiency, particularly in real-world scenarios with high-dimensional state spaces. To address this limitation, we propose a novel approach, Efficient Diversity-based Experience Replay (EDER). EDER emp
Efficient Diversity-based Experience Replay for Deep Reinforcement Learning
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Cell Death Discovery nature.com science feeds
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G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease
Cell Death Discovery, Published online: 07 September 2026; doi:10.1038/s41420-026-03299-1G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease
G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease
Cell Death Discovery, Published online: 07 September 2026; doi:10.1038/s41420-026-03299-1
G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease-
Omics in Hepatocellular
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Integrative Pan-Cancer Characterization of lncRNA UPK1A-AS1 and Its Role in Hypoxia-Associated Sorafenib Resistance in Hepatocellular Carcinoma
Anal Cell Pathol (Amst). 2026;2026(1):e1554526. doi: 10.1155/ancp/1554526.ABSTRACTLong noncoding RNAs (lncRNAs) are emerging as critical regulators of tumor initiation and progression through transcriptional and posttranscriptional mechanisms. UPK1A antisense RNA 1 (UPK1A-AS1), a cancer-associated lncRNA, has been reported to participate in oncogenic processes; however, its overall landscape across human malignancies and its biological role in therapy resistance remain poorly understood. Given t
Integrative Pan-Cancer Characterization of lncRNA UPK1A-AS1 and Its Role in Hypoxia-Associated Sorafenib Resistance in Hepatocellular Carcinoma
Anal Cell Pathol (Amst). 2026;2026(1):e1554526. doi: 10.1155/ancp/1554526.
ABSTRACT
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of tumor initiation and progression through transcriptional and posttranscriptional mechanisms. UPK1A antisense RNA 1 (UPK1A-AS1), a cancer-associated lncRNA, has been reported to participate in oncogenic processes; however, its overall landscape across human malignancies and its biological role in therapy resistance remain poorly understood. Given the increasing importance of identifying functional lncRNAs with prognostic and therapeutic potential, this study presents a comprehensive multiomics characterization of UPK1A-AS1 and its experimental validation in hepatocellular carcinoma (HCC). We integrated datasets from The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression Project (GTEx), the cancer immunology data engine (CIDE), and the cBioPortal for cancer genomics (cBioPortal) to systematically assess its expression pattern, genomic alterations, clinical significance, and immunological associations. Our analyses revealed that UPK1A-AS1 is significantly upregulated in multiple tumor types, with copy-number amplification as the predominant genomic alteration driving its overexpression. Elevated UPK1A-AS1 expression was correlated with advanced disease stage, poor differentiation, immune exclusion, and unfavorable prognosis, supporting its potential as a cancer type-dependent biomarker. In parallel, functional studies demonstrated that hypoxia transcriptionally induces UPK1A-AS1 in HCC, where it promotes sorafenib resistance by suppressing apoptosis. Silencing UPK1A-AS1 restored apoptotic and enhanced sorafenib efficacy both in vitro and in vivo. Collectively, our findings suggest that UPK1A-AS1 is a hypoxia-inducible oncogenic lncRNA that plays dual roles in cancer, with cancer type-dependent associations with progression and immune modulation across malignancies and mechanistically mediating hypoxia-associated drug resistance in HCC.
PMID:42678131 | PMC:PMC13532061 | DOI:10.1155/ancp/1554526
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cs.AI, q-bio.NC updates on arXiv.org
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NeoAMT: Neologism-Aware Agentic Machine Translation with Reinforcement Learning
arXiv:2601.03790v4 Announce Type: replace-cross Abstract: Neologism-aware machine translation aims to translate source sentences containing neologisms into target languages. This field remains underexplored compared with general machine translation (MT). In this paper, we propose an agentic framework, NeoAMT, for neologism-aware machine translation equipped with a Wiktionary-based search toolkit. Specifically, we first construct a dedicated dataset for neologism-aware machine translation and bu
NeoAMT: Neologism-Aware Agentic Machine Translation with Reinforcement Learning
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(Multiomics OR Omics) AND (Pancreatic)
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Kaempferol functionally reprograms CD47 signaling to promote cytoprotection and attenuate oxeiptosis in severe acute pancreatitis
Phytomedicine. 2026 May 15;157:158305. doi: 10.1016/j.phymed.2026.158305. Online ahead of print.ABSTRACTBACKGROUND: Severe acute pancreatitis (SAP) lacks targeted therapies, and massive loss of functional pancreatic acinar cells (PAC) drives mortality. Kaempferol (KA) possesses well-established anti-inflammatory and cytoprotective activities and is derived from herbal medicinal plants, but its direct molecular targets and mechanism of action in SAP remain undefined.PURPOSE: To evaluate the prote
Kaempferol functionally reprograms CD47 signaling to promote cytoprotection and attenuate oxeiptosis in severe acute pancreatitis
Phytomedicine. 2026 May 15;157:158305. doi: 10.1016/j.phymed.2026.158305. Online ahead of print.
ABSTRACT
BACKGROUND: Severe acute pancreatitis (SAP) lacks targeted therapies, and massive loss of functional pancreatic acinar cells (PAC) drives mortality. Kaempferol (KA) possesses well-established anti-inflammatory and cytoprotective activities and is derived from herbal medicinal plants, but its direct molecular targets and mechanism of action in SAP remain undefined.
PURPOSE: To evaluate the protective effects of KA against SAP and to elucidate its molecular mechanism of specific action, with a focus on identifying the direct cellular target through which KA exerts its cytoprotective effects.
STUDY DESIGN: Gain‑/loss‑of‑function in vitro and PAC‑specific CD47 SAP mouse models, combined with multi‑omics screening and biophysical assays.
METHODS: CD47 manipulation (siRNA/overexpression) was performed in primary PACs and cell lines, combined with WT/CD47-/-/Mist1‑CD47‑iOE (PAC‑specific) mouse models. Network pharmacology, transcriptomics and proteomics were integrated to screen and validate KA's protective effects. Computational‑experimental approaches (molecular docking/dynamics, CETSA, SPR, co‑IP, pharmacological epistasis) characterized KA's allosteric modulation of CD47 signaling.
RESULTS: CD47 was upregulated in SAP; its knockout reduced PAC death via KEAP1/PGAM5/AIFM1-driven oxeiptosis. KA reduced PAC death across genotypes, afforded no extra benefit in CD47-KO, and was not overridden by CD47‑OE. Mechanistically, KA allosterically binds CD47 ectodomain, stabilizes the CD47‑ UBQLN1 complex, and redirects signaling from Gαi‑mediated death to Gβγ/ ERK/NRF2‑mediated survival. ERK inhibition attenuated KA's protection. KA's action was CD47‑dependent.
CONCLUSION: This study identifies anti-oxeiptosis as a novel pharmacological activity of KA in SAP. This is achieved through allosteric modulation of CD47, redirecting its signaling from death‑promoting to a protective axis via activating Gβγ/ERK/NRF2 to suppress oxeiptosis. These findings reveal the CD47‑oxeiptosis axis as a therapeutic target and position KA as a promising candidate for SAP therapy, adding a new mechanistic dimension to KA's known pharmacological profile.
PMID:42184499 | DOI:10.1016/j.phymed.2026.158305
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Nature Cancer
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CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8<sup>+</sup> T cells
Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8<sup>+</sup> T cells
Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4
Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.-
AAAS: Table of Contents
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Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design
Science, Ahead of Print.
Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design
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Oncogene - Issue - nature.com science feeds
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Methodological considerations for centromere copy number analyses in HER2-positive metastatic breast cancer
Oncogene, Published online: 16 April 2026; doi:10.1038/s41388-026-03793-xMethodological considerations for centromere copy number analyses in HER2-positive metastatic breast cancer
Methodological considerations for centromere copy number analyses in HER2-positive metastatic breast cancer
Oncogene, Published online: 16 April 2026; doi:10.1038/s41388-026-03793-x
Methodological considerations for centromere copy number analyses in HER2-positive metastatic breast cancer-
cs.AI, q-bio.NC updates on arXiv.org
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ActionNex: A Virtual Outage Manager for Cloud
arXiv:2604.03512v1 Announce Type: new Abstract: Outage management in large-scale cloud operations remains heavily manual, requiring rapid triage, cross-team coordination, and experience-driven decisions under partial observability. We present \textbf{ActionNex}, a production-grade agentic system that supports end-to-end outage assistance, including real-time updates, knowledge distillation, and role- and stage-conditioned next-best action recommendations. ActionNex ingests multimodal operationa
ActionNex: A Virtual Outage Manager for Cloud
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cs.AI, q-bio.NC updates on arXiv.org
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Scale over Preference: The Impact of AI-Generated Content on Online Content Ecology
arXiv:2604.01690v1 Announce Type: new Abstract: The rapid proliferation of Artificial Intelligence-Generated Content (AIGC) is fundamentally restructuring online content ecologies, necessitating a rigorous examination of its behavioral and distributional implications. Leveraging a comprehensive longitudinal dataset comprising tens of millions of users from a leading Chinese video-sharing platform, this study elucidated the distinct creation and consumption behaviors characterizing AIGC versus H
Scale over Preference: The Impact of AI-Generated Content on Online Content Ecology
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Oncogene - Issue - nature.com science feeds
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Correction: The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03756-2Correction: The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization
Correction: The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03756-2
Correction: The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization-
cs.AI, q-bio.NC updates on arXiv.org
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Cheers: Decoupling Patch Details from Semantic Representations Enables Unified Multimodal Comprehension and Generation
arXiv:2603.12793v1 Announce Type: cross Abstract: A recent cutting-edge topic in multimodal modeling is to unify visual comprehension and generation within a single model. However, the two tasks demand mismatched decoding regimes and visual representations, making it non-trivial to jointly optimize within a shared feature space. In this work, we present Cheers, a unified multimodal model that decouples patch-level details from semantic representations, thereby stabilizing semantics for multimod
Cheers: Decoupling Patch Details from Semantic Representations Enables Unified Multimodal Comprehension and Generation
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Journal of Medical Internet Research
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Investigating the Effect of Hospital Infection Control Informatization on Optimizing Microbiological Specimen Submission Before Antibiotic Therapy: Failure Mode and Effects Analysis
Background: Antimicrobial resistance (AMR) poses a critical global health threat, with inappropriate antibiotic use being a major driver. Timely microbiological specimen submission before initiating antibiotic therapy is a cornerstone of antimicrobial stewardship (AMS), enabling pathogen-directed therapy and reducing unnecessary broad-spectrum exposure. However, suboptimal compliance remains common due to workflow interruptions, technological barriers, and behavioral factors. Failure Mode and Ef
Investigating the Effect of Hospital Infection Control Informatization on Optimizing Microbiological Specimen Submission Before Antibiotic Therapy: Failure Mode and Effects Analysis
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Nature - Issue - nature.com science feeds
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Maximizing carrier extraction in hybrid back-contact silicon solar cells
Nature, Published online: 10 March 2026; doi:10.1038/s41586-026-10351-8Maximizing carrier extraction in hybrid back-contact silicon solar cells
Maximizing carrier extraction in hybrid back-contact silicon solar cells
Nature, Published online: 10 March 2026; doi:10.1038/s41586-026-10351-8
Maximizing carrier extraction in hybrid back-contact silicon solar cells-
cs.AI, q-bio.NC updates on arXiv.org
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GeoSeg: Training-Free Reasoning-Driven Segmentation in Remote Sensing Imagery
arXiv:2603.03983v1 Announce Type: cross Abstract: Recent advances in MLLMs are reframing segmentation from fixed-category prediction to instruction-grounded localization. While reasoning based segmentation has progressed rapidly in natural scenes, remote sensing lacks a generalizable solution due to the prohibitive cost of reasoning-oriented data and domain-specific challenges like overhead viewpoints. We present GeoSeg, a zero-shot, training-free framework that bypasses the supervision bottlen
GeoSeg: Training-Free Reasoning-Driven Segmentation in Remote Sensing Imagery
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cs.AI, q-bio.NC updates on arXiv.org
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HONEST-CAV: Hierarchical Optimization of Network Signals and Trajectories for Connected and Automated Vehicles with Multi-Agent Reinforcement Learning
arXiv:2602.18740v1 Announce Type: cross Abstract: This study presents a hierarchical, network-level traffic flow control framework for mixed traffic consisting of Human-driven Vehicles (HVs), Connected and Automated Vehicles (CAVs). The framework jointly optimizes vehicle-level eco-driving behaviors and intersection-level traffic signal control to enhance overall network efficiency and decrease energy consumption. A decentralized Multi-Agent Reinforcement Learning (MARL) approach by Value Decom
HONEST-CAV: Hierarchical Optimization of Network Signals and Trajectories for Connected and Automated Vehicles with Multi-Agent Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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AI-driven Large-scale Electron Microscopy enables Whole-tissue Subcellular Digitization
arXiv:2511.02860v2 Announce Type: replace-cross Abstract: The distribution and interactions of cellular organelles play a critical role in mediating cellular physiology and pathology. Large-scale electron microscopy enables visualization of organelle distribution and interactions at the tissue level with nanometer resolution, but robust and efficient computational analysis tools are lacking. Here, we present a deep learning tool for universal large-scale 2D/3D electron microscopy analysis, Deep