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  • Circulating tumor DNA in neoadjuvant therapy for solid tumors Xueqin Huang Β· Yu Deng Β· Yi Shen
    Front Oncol. 2026 Aug 26;16:1909934. doi: 10.3389/fonc.2026.1909934. eCollection 2026.ABSTRACTCirculating tumor DNA (ctDNA), a core component of liquid biopsy, demonstrates significant potential in the field of neoadjuvant therapy for solid tumors. This review systematically examines the role of ctDNA across the pre-, intra-, and post-neoadjuvant treatment phases, with a focus on its value in predicting therapeutic efficacy, assessing early treatment response, detecting minimal residual disease
     

Circulating tumor DNA in neoadjuvant therapy for solid tumors

10 September 2026 at 18:00

Front Oncol. 2026 Aug 26;16:1909934. doi: 10.3389/fonc.2026.1909934. eCollection 2026.

ABSTRACT

Circulating tumor DNA (ctDNA), a core component of liquid biopsy, demonstrates significant potential in the field of neoadjuvant therapy for solid tumors. This review systematically examines the role of ctDNA across the pre-, intra-, and post-neoadjuvant treatment phases, with a focus on its value in predicting therapeutic efficacy, assessing early treatment response, detecting minimal residual disease (MRD), and monitoring for recurrence. By synthesizing the latest clinical research data and advancements in molecular detection technologies, this article aims to elucidate how ctDNA is facilitating a shift towards more precise, dynamic, and individualized paradigms in neoadjuvant therapy for solid tumors. Furthermore, it analyzes the current challenges and future directions for integrating ctDNA analysis into clinical practice to optimize patient management and outcomes. Throughout, clinically validated applications are explicitly distinguished from those that remain investigational, and key unresolved questions are highlighted.

PMID:42719676 | PMC:PMC13555526 | DOI:10.3389/fonc.2026.1909934

Parallel Differentiable Reachability for Learning and Planning with Certified Neural Dynamics and Controllers

arXiv:2605.25346v1 Announce Type: cross Abstract: Neural network (NN) dynamics models and control policies achieve strong performance in robotics, but providing sound guarantees under uncertainty remains difficult, especially for closed-loop NN systems. Existing reachability tools provide formal over-approximations, yet are often non-differentiable, overly conservative, or too slow for modern learning and online planning pipelines. To address this, we present a parallelizable, differentiable reachability framework in JAX for continuous- and discrete-time systems with analytical and NN-based dynamics and controllers. Our framework combines Taylor-model flowpipe construction with CROWN-style linear bound propagation through a unified representation that preserves affine dependencies while supporting GPU-batched computation and automatic differentiation. Building on this reachability primitive, we develop (i) a certified training method that encourages reachability-friendly dynamics models and controllers, and (ii) a reachability-aware sampling-based MPC scheme with gradient-based refinement. Experiments on non-prehensile manipulation and quadrotor tasks, including hardware and higher-dimensional evaluations (up to 72D), demonstrate practical online planning while maintaining certified reachable-set over-approximations under bounded uncertainty.

Deciphering functional intra-tumoral heterogeneity in BRAF<sup>V600E</sup>-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03742-8

Deciphering functional intra-tumoral heterogeneity in BRAFV600E-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling
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