arXiv:2608.21099v2 Announce Type: replace-cross Abstract: Multi-modal object detection is essential for robust scene understanding in challenging conditions, including low-light and adverse environments. Recent vision foundation models (e.g., DINOv3) have exhibited strong representation capabilities, yet adapting them to multi-modal scenarios remains challenging. Existing dense cross-modal fusion strategies often force heterogeneous modalities to interact indiscriminately, which may introduce redundant information and disrupt the valuable pre-trained representations. To address this issue, we revisit multi-modal fusion from the perspective of socialized learning and propose adapter to DINOv3 (A2DINOv3), a multi-expert collaboration framework with a Socialized Collaboration Protocol (SCP). Specifically, RGB and infrared branches are modeled as heterogeneous experts that independently preserve their specialized knowledge while exchanging complementary information through selective and constrained interactions. This design mitigates harmful cross-modal interference and prevents degradation of pre-trained priors during adaptation. Furthermore, a zero-initialization strategy is introduced to gradually activate cross-modal collaboration, enabling a smooth transition from modality-specific learning to cooperative representation learning. Extensive experiments on four multi-modal benchmarks, including aerial detection (GAIIC), autonomous driving (FLIR), low-light surveillance (LLVIP), and diverse real-world scenarios (M3FD), demonstrate that A2DINOv3 consistently achieves state-of-the-art performance in multi-modal object detection.

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01787-4

Applying extensive chemical modifications to RNA motifs substantially enhances prime editing efficiency in vivo and can be applied for improved efficiencies across RNA-based editing systems.

Nature Cancer, Published online: 25 August 2026; doi:10.1038/s43018-026-01241-z

Author Correction: Low-protein diet enhances antitumor immunity in pancreatic cancer through microbiota-derived UDP-galactose

arXiv:2605.24326v1 Announce Type: cross Abstract: The rapid scaling of large language model training requires distributing GPU resources across multiple data center buildings and regions. We refer to such paradigm as "scale-across" training. As infrastructure expands, the system design space becomes increasingly intricate, encompassing new model architectures, hardware heterogeneity, and evolving communication patterns. Drawing from Meta's production experience, we highlight the complexities of deploying training jobs across a few data centers housing hundreds of thousands of GPUs. To accelerate exploration of the large design space and to enable efficient training for frontier model development, we conduct in-depth characterization of three key design dimensions: parallelism placement, parallelism scheduling, and network layer technologies. We then propose ScaleAcross Explorer, an optimizer that considers the interplay of design dimensions and holistically optimizes scale-across training. Testbed experiments and simulations demonstrate up to 64.62% training speedups over production configuration and up to 37.59% training speedups over the state-of-the-art baseline across a wide range of design points.

arXiv:2509.02113v2 Announce Type: replace-cross Abstract: The advancement of graph-based malware analysis is critically limited by the absence of large-scale datasets that capture the inherent hierarchical structure of software. Existing methods often oversimplify programs into single level graphs, failing to model the crucial semantic relationship between high-level functional interactions and low-level instruction logic. To bridge this gap, we introduce \dataset, the largest public hierarchical graph dataset for malware analysis, comprising over \textbf{200M} Control Flow Graphs (CFGs) nested within \textbf{595K} Function Call Graphs (FCGs). This two-level representation preserves structural semantics essential for building robust detectors resilient to code obfuscation and malware evolution. We demonstrate HiGraph's utility through a large-scale analysis that reveals distinct structural properties of benign and malicious software, establishing it as a foundational benchmark for the community. The dataset and tools are publicly available at https://higraph.org.

Oncogene, Published online: 16 April 2026; doi:10.1038/s41388-026-03794-w

XPO1 inhibitor KPT-330 disrupts the core transcriptional regulatory circuitry of dedifferentiated liposarcoma by modulating the translation process

npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02516-6

Application of machine learning in osteoporosis screening: a narrative review

The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.

arXiv:2603.08561v1 Announce Type: new Abstract: Large language model (LLM)-based agents trained with reinforcement learning (RL) have shown strong potential on complex interactive tasks. However, standard RL paradigms favor static problem-solving over continuous adaptation: agents often converge to suboptimal strategies due to insufficient exploration, while learned knowledge remains implicit within parameters rather than explicitly retrievable, limiting effective experiential learning. To address these limitations, we introduce RetroAgent, an online RL framework that empowers agents to master complex interactive environments not just by solving, but by evolving. Concretely, RetroAgent features a hindsight self-reflection mechanism that produces dual intrinsic feedback: (1) intrinsic numerical feedback that that tracks incremental subtask completion relative to prior attempts, rewarding promising explorations, and (2) intrinsic language feedback that distills reusable lessons into a memory buffer, retrieved via our proposed Similarity & Utility-Aware Upper Confidence Bound (SimUtil-UCB) strategy balancing relevance, utility, and exploration to effectively leverage past experiences. Extensive experiments on two model families across four challenging agentic tasks demonstrate that RetroAgent significantly outperforms existing methods, achieving state-of-the-art results -- e.g., surpassing Group Relative Policy Optimization (GRPO)-trained agents by +18.3% on ALFWorld, +15.4% on WebShop, +27.1% on Sokoban, and +8.9% on MineSweeper -- while exhibiting strong test-time adaptation and generalization to out-of-distribution scenarios.

Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-03005-1

Targeting cell death in Crohn’s disease: from mechanisms to medicines