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Received — 10 September 2026 ⏭
Received — 27 May 2026 ⏭

Investigation Into the Association Between Neurotransmitters, Immune Features, and Lung Adenocarcinoma: Identifying GABA-Related Features Using Machine Learning Methods

✇(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
By: Jiangtao You · Tianren Wang · Qingshi Wang · Yong Zhang · Rui Zhao · Wei Cui · Huan Chen
25 May 2026 at 18:00

Stem Cells Int. 2026 May 21;2026:3060138. doi: 10.1155/sci/3060138. eCollection 2026.

ABSTRACT

BACKGROUND: Lung adenocarcinoma (LUAD), a predominant subtype of non-small cell lung cancer (NSCLC), is associated with a high mortality rate. Currently, there are no reliable or sensitive biomarkers or prognostic methodologies available for its early detection or diagnosis. Gamma-aminobutyric acid (GABA), a pivotal inhibitory neurotransmitter within the central nervous system (CNS), primarily exerts its effects through interactions with GABA receptors (GABARs). Recent studies have increasingly highlighted GABA's significant role in mediating the initiation and progression of various tumors beyond the CNS. Nonetheless, research investigating the role of GABA in LUAD is limited, and the specific molecular and cellular mechanisms underlying its interactions remain to be fully elucidated.

METHODS: We developed an innovative machine learning framework designed to screen GABA-related genes (GABARgenes) at both single-cell and large transcriptomic levels. This framework encompasses 10 algorithms and 101 combinatorial pairing patterns, which facilitate the construction of consistent GABA-related features (GABARFs). The framework's performance was assessed using both a training set and an external validation set. To provide a quantitative prognostic tool for clinical application, we established a nomogram that incorporates GABARF. Additionally, we conducted multiomics analyses, including genomics, single-cell transcriptomics, and comprehensive transcriptomics, to derive and consolidate more extensive prognostic features. We also evaluated the response of GABARF-defined risk subgroups to immunotherapy and identified potential personalized therapeutic agents for specific risk categories.

RESULTS: Among the 124 GABARgenes analyzed, 38 demonstrated a significant correlation with overall survival (OS) in patients. Our machine learning-derived GABARF exhibited exceptional performance in predicting prognosis and clinical outcomes, showing promise in forecasting the onset and progression of LUAD. Multivariate analysis confirmed that GABARF serves as an independent prognostic factor for OS in LUAD. Furthermore, distinct GABARF risk subgroups exhibited significant differences in biological function, mutation status, and tumor immune infiltration. Notably, there were significant variations in the immunophenoscore (IPS) across the risk subgroups. GABARF risk stratification aligns with stemness properties of tumor cells, indicating that high-risk patients may harbor tumors with enhanced stemness features that contribute to their poor prognosis and reduced immunotherapy response. Sensitivity analyses of conventional LUAD therapies indicated that patients in the low-risk group may derive greater benefit from immune checkpoint inhibitors (ICIs), while those in the high-risk group may exhibit heightened sensitivity to first-line chemotherapy agents. Furthermore, LDHA overexpression was found to promote proliferation and migration, while inhibiting apoptosis. In addition, overexpression of LDHA can upregulate the expression of stemness markers CD133, SOX2, and OCT4 in LUAD cells, enhancing the malignant phenotype of tumor cells.

CONCLUSION: This study presents a novel machine learning-based model for GABARF, which shows promise as a potential tool to aid in prognostic prediction, targeted prevention, and individualized treatment planning in LUAD. Initial investigations into the interaction mechanisms of GABARF at the molecular, cellular, and tumor immune microenvironment (TIME) levels in LUAD have commenced. The GABARF model not only serves as a prognostic indicator but may also reflect the stemness status of LUAD tumors, offering insights into personalized treatment strategies that account for both neural-immune-stemness interactions.

PMID:42181964 | PMC:PMC13191820 | DOI:10.1155/sci/3060138

Investigation Into the Association Between Neurotransmitters, Immune Features, and Lung Adenocarcinoma: Identifying GABA-Related Features Using Machine Learning Methods

✇Omics In Lung
By: Jiangtao You · Tianren Wang · Qingshi Wang · Yong Zhang · Rui Zhao · Wei Cui · Huan Chen
25 May 2026 at 18:00

Stem Cells Int. 2026 May 21;2026:3060138. doi: 10.1155/sci/3060138. eCollection 2026.

ABSTRACT

BACKGROUND: Lung adenocarcinoma (LUAD), a predominant subtype of non-small cell lung cancer (NSCLC), is associated with a high mortality rate. Currently, there are no reliable or sensitive biomarkers or prognostic methodologies available for its early detection or diagnosis. Gamma-aminobutyric acid (GABA), a pivotal inhibitory neurotransmitter within the central nervous system (CNS), primarily exerts its effects through interactions with GABA receptors (GABARs). Recent studies have increasingly highlighted GABA's significant role in mediating the initiation and progression of various tumors beyond the CNS. Nonetheless, research investigating the role of GABA in LUAD is limited, and the specific molecular and cellular mechanisms underlying its interactions remain to be fully elucidated.

METHODS: We developed an innovative machine learning framework designed to screen GABA-related genes (GABARgenes) at both single-cell and large transcriptomic levels. This framework encompasses 10 algorithms and 101 combinatorial pairing patterns, which facilitate the construction of consistent GABA-related features (GABARFs). The framework's performance was assessed using both a training set and an external validation set. To provide a quantitative prognostic tool for clinical application, we established a nomogram that incorporates GABARF. Additionally, we conducted multiomics analyses, including genomics, single-cell transcriptomics, and comprehensive transcriptomics, to derive and consolidate more extensive prognostic features. We also evaluated the response of GABARF-defined risk subgroups to immunotherapy and identified potential personalized therapeutic agents for specific risk categories.

RESULTS: Among the 124 GABARgenes analyzed, 38 demonstrated a significant correlation with overall survival (OS) in patients. Our machine learning-derived GABARF exhibited exceptional performance in predicting prognosis and clinical outcomes, showing promise in forecasting the onset and progression of LUAD. Multivariate analysis confirmed that GABARF serves as an independent prognostic factor for OS in LUAD. Furthermore, distinct GABARF risk subgroups exhibited significant differences in biological function, mutation status, and tumor immune infiltration. Notably, there were significant variations in the immunophenoscore (IPS) across the risk subgroups. GABARF risk stratification aligns with stemness properties of tumor cells, indicating that high-risk patients may harbor tumors with enhanced stemness features that contribute to their poor prognosis and reduced immunotherapy response. Sensitivity analyses of conventional LUAD therapies indicated that patients in the low-risk group may derive greater benefit from immune checkpoint inhibitors (ICIs), while those in the high-risk group may exhibit heightened sensitivity to first-line chemotherapy agents. Furthermore, LDHA overexpression was found to promote proliferation and migration, while inhibiting apoptosis. In addition, overexpression of LDHA can upregulate the expression of stemness markers CD133, SOX2, and OCT4 in LUAD cells, enhancing the malignant phenotype of tumor cells.

CONCLUSION: This study presents a novel machine learning-based model for GABARF, which shows promise as a potential tool to aid in prognostic prediction, targeted prevention, and individualized treatment planning in LUAD. Initial investigations into the interaction mechanisms of GABARF at the molecular, cellular, and tumor immune microenvironment (TIME) levels in LUAD have commenced. The GABARF model not only serves as a prognostic indicator but may also reflect the stemness status of LUAD tumors, offering insights into personalized treatment strategies that account for both neural-immune-stemness interactions.

PMID:42181964 | PMC:PMC13191820 | DOI:10.1155/sci/3060138

Received — 8 April 2026 ⏭

GA-GS: Generation-Assisted Gaussian Splatting for Static Scene Reconstruction

✇cs.AI, q-bio.NC updates on arXiv.org
By: Yedong Shen · Shiqi Zhang · Sha Zhang · Yifan Duan · Xinran Zhang · Wenhao Yu · Lu Zhang · Jiajun Deng · Yanyong Zhang
7 April 2026 at 12:00
arXiv:2604.04331v1 Announce Type: cross Abstract: Reconstructing static 3D scene from monocular video with dynamic objects is important for numerous applications such as virtual reality and autonomous driving. Current approaches typically rely on background for static scene reconstruction, limiting the ability to recover regions occluded by dynamic objects. In this paper, we propose GA-GS, a Generation-Assisted Gaussian Splatting method for Static Scene Reconstruction. The key innovation of our work lies in leveraging generation to assist in reconstructing occluded regions. We employ a motion-aware module to segment and remove dynamic regions, and thenuse a diffusion model to inpaint the occluded areas, providing pseudo-ground-truth supervision. To balance contributions from real background and generated region, we introduce a learnable authenticity scalar for each Gaussian primitive, which dynamically modulates opacity during splatting for authenticity-aware rendering and supervision. Since no existing dataset provides ground-truth static scene of video with dynamic objects, we construct a dataset named Trajectory-Match, using a fixed-path robot to record each scene with/without dynamic objects, enabling quantitative evaluation in reconstruction of occluded regions. Extensive experiments on both the DAVIS and our dataset show that GA-GS achieves state-of-the-art performance in static scene reconstruction, especially in challenging scenarios with large-scale, persistent occlusions.

SETDB2 induces abnormal SHP-1 splicing and promotes immunosuppression in hepatocellular carcinoma

✇Oncogene - Issue - nature.com science feeds
By: Qinlian Jiao · Yidan Ren · Xin Su · Zigan Li · Yuxuan Cai · Tangbin Hu · Yunshan Wang · Guangyong Zhang · Miaoqing Zhao · Maoxiao Feng
7 April 2026 at 08:00

Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03759-z

SETDB2 induces abnormal SHP-1 splicing and promotes immunosuppression in hepatocellular carcinoma
Received — 4 April 2026 ⏭

OpenGo: An OpenClaw-Based Robotic Dog with Real-Time Skill Switching

✇cs.AI, q-bio.NC updates on arXiv.org
By: Hanbing Li · Xuewei Cao · Zhiwen Zeng · Yuhan Wu · Yanyong Zhang · Yan Xia
3 April 2026 at 12:00
arXiv:2604.01708v1 Announce Type: cross Abstract: Adaptation to complex tasks and multiple scenarios remains a significant challenge for a single robot agent. The ability to acquire organize, and switch between a wide range of skills in real time, particularly in dynamic environments, has become a fundamental requirement for embodied intelligence. We introduce OpenGo, an OpenClaw-powered embodied robotic dog capable of switching skills in real time according to the scene and task instructions. Specifically, the agent is equipped with (1) a customizable skill library with easy skill import and autonomous skill validation, (2) a dispatcher that selects and invokes different skills according to task prompts or language instructions, and (3) a self-learning framework that fine-tunes skills based on task completion and human feedback. We deploy the agent in Unitree's Go2 robotic dog and validate its capabilities in self-checking and switching of skills autonomously. In addition, by integrating Feishu-platform communication, we enable natural-language guidance and human feedback, allowing inexperienced users to control the robotic dog through simple instructions.

TRACE: Transparent Web Reliability Assessment with Contextual Explanations

✇cs.AI, q-bio.NC updates on arXiv.org
By: Joydeep Chandra · Aleksandr Algazinov · Satyam Kumar Navneet · Rim El Filali · Matt Laing · Andrew Hanna · Yong Zhang
3 April 2026 at 12:00
arXiv:2506.12072v4 Announce Type: replace-cross Abstract: In an era of AI-generated misinformation flooding the web, existing tools struggle to empower users with nuanced, transparent assessments of content credibility. They often default to binary (true/false) classifications without contextual justifications, leaving users vulnerable to disinformation. We address this gap by introducing TRACE: Transparent Reliability Assessment with Contextual Explanations, a unified framework that performs two key tasks: (1) it assigns a fine-grained, continuous reliability score (from 0.1 to 1.0) to web content, and (2) it generates a contextual explanation for its assessment. The core of TRACE is the TrueGL-1B model, fine-tuned on a novel, large-scale dataset of over 140,000 articles. This dataset's primary contribution is its annotation with 35 distinct continuous reliability scores, created using a Human-LLM co-creation and data poisoning paradigm. This method overcomes the limitations of binary-labeled datasets by populating the mid-ranges of reliability. In our evaluation, TrueGL-1B consistently outperforms other small-scale LLM baselines and rule-based approaches on key regression metrics, including MAE, RMSE, and R2. The model's high accuracy and interpretable justifications make trustworthy information more accessible. To foster future research, our code and model are made publicly available here: github.com/zade90/TrueGL.
Received — 11 March 2026 ⏭

PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression

✇Oncogene - Issue - nature.com science feeds
By: Zheng Peng · Bing Ma · Zhou Song · Yunshan Zhao · Yang Yang · Yong Liu · Chenggang Li · Yong Zhang
6 March 2026 at 08:00

Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03707-x

PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression
Received — 17 February 2026 ⏭

C^2ROPE: Causal Continuous Rotary Positional Encoding for 3D Large Multimodal-Models Reasoning

✇cs.AI, q-bio.NC updates on arXiv.org
By: Guanting Ye · Qiyan Zhao · Wenhao Yu · Xiaofeng Zhang · Jianmin Ji · Yanyong Zhang · Ka-Veng Yuen
17 February 2026 at 13:00
arXiv:2602.10551v2 Announce Type: replace-cross Abstract: Recent advances in 3D Large Multimodal Models (LMMs) built on Large Language Models (LLMs) have established the alignment of 3D visual features with LLM representations as the dominant paradigm. However, the inherited Rotary Position Embedding (RoPE) introduces limitations for multimodal processing. Specifically, applying 1D temporal positional indices disrupts the continuity of visual features along the column dimension, resulting in spatial locality loss. Moreover, RoPE follows the prior that temporally closer image tokens are more causally related, leading to long-term decay in attention allocation and causing the model to progressively neglect earlier visual tokens as the sequence length increases. To address these issues, we propose C^2RoPE, an improved RoPE that explicitly models local spatial Continuity and spatial Causal relationships for visual processing. C^2RoPE introduces a spatio-temporal continuous positional embedding mechanism for visual tokens. It first integrates 1D temporal positions with Cartesian-based spatial coordinates to construct a triplet hybrid positional index, and then employs a frequency allocation strategy to encode spatio-temporal positional information across the three index components. Additionally, we introduce Chebyshev Causal Masking, which determines causal dependencies by computing the Chebyshev distance of image tokens in 2D space. Evaluation results across various benchmarks, including 3D scene reasoning and 3D visual question answering, demonstrate C^2RoPE's effectiveness. The code is be available at https://github.com/ErikZ719/C2RoPE.
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