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cs.AI, q-bio.NC updates on arXiv.org
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Active Adaptation, Not Static Defense: Temporal Dynamics of Preventative Steering in Adversarial Fine-Tuning
arXiv:2609.10142v1 Announce Type: cross Abstract: Large language models remain fragile against malicious fine-tuning, motivating training-time defenses against harmful persona drift. Preventative Steering injects undesirable-trait persona vectors during fine-tuning and removes them at evaluation time, yet the mechanism behind its lasting protection remains unclear. Analyzing its temporal optimization dynamics, we find that the defense emerges from an early compensatory adaptation phase followed
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cs.AI, q-bio.NC updates on arXiv.org
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JT-SAFE-V2: Safety-by-Design Foundation Model with World-Context Data
arXiv:2605.24414v1 Announce Type: new Abstract: We introduce JT-Safe-V2, a large language model designed to advance the safety and trustworthiness of foundation models, extending our previous JT-Safe model toward a more comprehensive safety-by-design paradigm. JT-Safe-V2 emphasizes the joint optimization of general intelligence and safety-by-design through several key innovations: enriching pre-training data with contextual world knowledge, high-certainty pre-training procedures, and safety str
JT-SAFE-V2: Safety-by-Design Foundation Model with World-Context Data
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(Multiomics OR Omics) AND (Pancreatic)
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Gut-Brain Axis Dysregulation in Inflammatory Bowel Disease: Implications for Coagulation Abnormalities and Extraintestinal Manifestations
Int J Gen Med. 2026 Mar 24;19:590621. doi: 10.2147/IJGM.S590621. eCollection 2026.ABSTRACTInflammatory bowel disease (IBD) involves chronic intestinal inflammation driven by gut-brain axis imbalance, fostering complications through an "inflammation-neuro-coagulation" triad. Current staging systems inadequately capture the dynamics of this multidimensional network. Therefore, integrated multi-omics analyses-including metagenomics, metabolomics, and single-cell transcriptomics-are essential to con
Gut-Brain Axis Dysregulation in Inflammatory Bowel Disease: Implications for Coagulation Abnormalities and Extraintestinal Manifestations
Int J Gen Med. 2026 Mar 24;19:590621. doi: 10.2147/IJGM.S590621. eCollection 2026.
ABSTRACT
Inflammatory bowel disease (IBD) involves chronic intestinal inflammation driven by gut-brain axis imbalance, fostering complications through an "inflammation-neuro-coagulation" triad. Current staging systems inadequately capture the dynamics of this multidimensional network. Therefore, integrated multi-omics analyses-including metagenomics, metabolomics, and single-cell transcriptomics-are essential to construct dynamic models that monitor coagulation, microbiome, and metabolism for precise assessment of disease activity and thrombotic or bleeding risks. Interventions targeting gut-brain axis nodes, such as eliminating tissue factor-positive (TF⁺) T cells or modulating vagal activity, show potential to disrupt the inflammation-coagulation cycle, although rigorous randomized trials are still needed. Artificial intelligence (AI)-assisted systems that integrate real-time biomarker monitoring with multi-omics predictions represent a novel paradigm for managing IBD-related coagulation dysfunction. Key challenges include elucidating gut-brain-liver axis regulation of coagulation and characterizing platelet functional heterogeneity. Future efforts must prioritize ethically compliant multi-omics platforms and racially stratified risk models to advance personalized coagulation management in IBD.
PMID:41913906 | PMC:PMC13033200 | DOI:10.2147/IJGM.S590621
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cs.AI, q-bio.NC updates on arXiv.org
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Unveiling the Mechanism of Continuous Representation Full-Waveform Inversion: A Wave Based Neural Tangent Kernel Framework
arXiv:2603.22362v1 Announce Type: cross Abstract: Full-waveform inversion (FWI) estimates physical parameters in the wave equation from limited measurements and has been widely applied in geophysical exploration, medical imaging, and non-destructive testing. Conventional FWI methods are limited by their notorious sensitivity to the accuracy of the initial models. Recent progress in continuous representation FWI (CR-FWI) demonstrates that representing parameter models with a coordinate-based neu
Unveiling the Mechanism of Continuous Representation Full-Waveform Inversion: A Wave Based Neural Tangent Kernel Framework
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cs.AI, q-bio.NC updates on arXiv.org
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CCR-Bench: A Comprehensive Benchmark for Evaluating LLMs on Complex Constraints, Control Flows, and Real-World Cases
arXiv:2603.07886v1 Announce Type: cross Abstract: Enhancing the ability of large language models (LLMs) to follow complex instructions is critical for their deployment in real-world applications. However, existing evaluation methods often oversimplify instruction complexity as a mere additive combination of atomic constraints, failing to adequately capture the high-dimensional complexity arising from the intricate interplay of content and format, logical workflow control, and real-world applica
CCR-Bench: A Comprehensive Benchmark for Evaluating LLMs on Complex Constraints, Control Flows, and Real-World Cases
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cs.AI, q-bio.NC updates on arXiv.org
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Beyond One-Size-Fits-All: Adaptive Subgraph Denoising for Zero-Shot Graph Learning with Large Language Models
arXiv:2603.02938v1 Announce Type: cross Abstract: Graph-based tasks in the zero-shot setting remain a significant challenge due to data scarcity and the inability of traditional Graph Neural Networks (GNNs) to generalize to unseen domains or label spaces. While recent advancements have transitioned toward leveraging Large Language Models (LLMs) as predictors to enhance GNNs, these methods often suffer from cross-modal alignment issues. A recent paradigm (i.e., Graph-R1) overcomes the aforementi