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Detecting Structural Heart Disease from Electrocardiograms via a Generalized Additive Model of Interpretable Foundation-Model Predictors

arXiv:2603.02616v1 Announce Type: cross Abstract: Structural heart disease (SHD) is a prevalent condition with many undiagnosed cases, and early detection is often limited by the high cost and accessibility constraints of echocardiography (ECHO). Recent studies show that artificial intelligence (AI)-based analysis of electrocardiograms (ECGs) can detect SHD, offering a scalable alternative. However, existing methods are fully black-box models, limiting interpretability and clinical adoption. To address these challenges, we propose an interpretable and effective framework that integrates clinically meaningful ECG foundation-model predictors within a generalized additive model, enabling transparent risk attribution while maintaining strong predictive performance. Using the EchoNext benchmark of over 80,000 ECG-ECHO pairs, the method demonstrates relative improvements of +0.98% in AUROC, +1.01% in AUPRC, and +1.41% in F1 score over the latest state-of-the-art deep-learning baseline, while achieving slightly better performance even with only 30% of the training data. Subgroup analyses confirm robust performance across heterogeneous populations, and the estimated entry-wise functions provide interpretable insights into the relationships between risks of traditional ECG diagnoses and SHD. This work illustrates a complementary paradigm between classical statistical modeling and modern AI, offering a pathway to interpretable, high-performing, and clinically actionable ECG-based SHD screening.
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  • On the Granularity of Causal Effect Identifiability Yizuo Chen Β· Adnan Darwiche
    arXiv:2510.16703v2 Announce Type: replace-cross Abstract: The classical notion of causal effect identifiability is defined in terms of treatment and outcome variables. In this paper, we consider the identifiability of state-based causal effects: how an intervention on a particular state of treatment variables affects a particular state of outcome variables. We demonstrate that state-based causal effects may be identifiable even when variable-based causal effects may not. Moreover, we show that
     

On the Granularity of Causal Effect Identifiability

arXiv:2510.16703v2 Announce Type: replace-cross Abstract: The classical notion of causal effect identifiability is defined in terms of treatment and outcome variables. In this paper, we consider the identifiability of state-based causal effects: how an intervention on a particular state of treatment variables affects a particular state of outcome variables. We demonstrate that state-based causal effects may be identifiable even when variable-based causal effects may not. Moreover, we show that this separation occurs only when additional knowledge -- such as context-specific independencies -- is available. We further examine knowledge that constrains the states of variables, and show that such knowledge can improve both variable-based and state-based identifiability when combined with other knowledge such as context-specific independencies. We finally propose an approach for identifying causal effects under these additional constraints, and conduct empirical studies to further illustrate the separations between the two levels of identifiability.

Information-Theoretic Causal Bounds under Unmeasured Confounding

arXiv:2601.17160v3 Announce Type: replace-cross Abstract: We develop a data-driven information-theoretic framework for sharp partial identification of causal effects under unmeasured confounding. Existing approaches often rely on restrictive assumptions, such as bounded or discrete outcomes; require external inputs (for example, instrumental variables, proxies, or user-specified sensitivity parameters); necessitate full structural causal model specifications; or focus solely on population-level averages while neglecting covariate-conditional effects. We overcome all four limitations simultaneously by establishing novel information-theoretic, data-driven divergence bounds. Our key theoretical contribution shows that the f-divergence between the observational distribution P(Y | A = a, X = x) and the interventional distribution P(Y | do(A = a), X = x) is upper bounded by a function of the propensity score alone. This result enables sharp partial identification of conditional causal effects directly from observational data, without requiring external sensitivity parameters, auxiliary variables, full structural specifications, or outcome boundedness assumptions. For practical implementation, we develop a semiparametric estimator satisfying Neyman orthogonality (Chernozhukov et al., 2018), which ensures root-n consistent inference even when nuisance functions are estimated via flexible machine learning methods. Simulation studies and real-world data applications, implemented in the GitHub repository (https://github.com/yonghanjung/Information-Theretic-Bounds), demonstrate that our framework provides tight and valid causal bounds across a wide range of data-generating processes.

The Well-Tempered Classifier: Some Elementary Properties of Temperature Scaling

arXiv:2602.14862v1 Announce Type: cross Abstract: Temperature scaling is a simple method that allows to control the uncertainty of probabilistic models. It is mostly used in two contexts: improving the calibration of classifiers and tuning the stochasticity of large language models (LLMs). In both cases, temperature scaling is the most popular method for the job. Despite its popularity, a rigorous theoretical analysis of the properties of temperature scaling has remained elusive. We investigate here some of these properties. For classification, we show that increasing the temperature increases the uncertainty in the model in a very general sense (and in particular increases its entropy). However, for LLMs, we challenge the common claim that increasing temperature increases diversity. Furthermore, we introduce two new characterisations of temperature scaling. The first one is geometric: the tempered model is shown to be the information projection of the original model onto the set of models with a given entropy. The second characterisation clarifies the role of temperature scaling as a submodel of more general linear scalers such as matrix scaling and Dirichlet calibration: we show that temperature scaling is the only linear scaler that does not change the hard predictions of the model.
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