arXiv:2509.12783v2 Announce Type: replace Abstract: Inferring the biophysical parameters of conductance-based models (CBMs) from experimentally accessible recordings remains a central challenge in computational neuroscience. Spike times are the most widely available data, yet they reveal little about which combinations of ion channel conductances generate the observed activity. This inverse problem is further complicated by neuronal degeneracy, where multiple distinct conductance sets yield similar spiking patterns. We introduce a method that addresses this challenge by combining deep learning with Dynamic Input Conductances (DICs), a theoretical framework that reduces complex CBMs to three interpretable feedback components governing excitability and firing patterns. Our approach first maps spike times to DIC densities at threshold using a neural network that learns a low-dimensional representation of neuronal activity. The predicted DIC values are then used to generate degenerate CBM populations via an iterative compensation algorithm, ensuring compatibility with the intermediate target DICs, and thereby reproducing the corresponding firing patterns, even in high-dimensional models. Applied to two models, this algorithmic pipeline reconstructs spiking and bursting regimes with high accuracy and robustness to variability, including spike trains generated under noisy current injection mimicking physiological stochasticity. It produces diverse degenerate populations within milliseconds on standard hardware, enabling scalable and efficient inference from spike recordings alone. Together, this work positions DICs as a practical and interpretable link between experimentally observed activity and mechanistic models. By enabling fast and scalable reconstruction of degenerate populations directly from spike times, our approach provides a powerful way to investigate how neurons exploit conductance variability to achieve reliable computation.

arXiv:2603.03201v1 Announce Type: cross Abstract: Reasoning is the ability to integrate internal states and external inputs in a meaningful and semantically consistent flow. Contemporary machine learning (ML) systems increasingly rely on such sequential reasoning, from language understanding to multi-modal generation, often operating over dictionaries of prototypical patterns reminiscent of associative memory models. Understanding retrieval and sequentiality in associative memory models provides a powerful bridge to gain insight into ML reasoning. While the static retrieval properties of associative memory models are well understood, the theoretical foundations of sequential retrieval and multi-memory integration remain limited, with existing studies largely relying on numerical evidence. This work develops a dynamical theory of sequential reasoning in Hopfield networks. We consider the recently proposed input-driven plasticity (IDP) Hopfield network and analyze a two-timescale architecture coupling fast associative retrieval with slow reasoning dynamics. We derive explicit conditions for self-sustained memory transitions, including gain thresholds, escape times, and collapse regimes. Together, these results provide a principled mathematical account of sequentiality in associative memory models, bridging classical Hopfield dynamics and modern reasoning architectures.

arXiv:2012.15834v3 Announce Type: replace-cross Abstract: Neural network training is commonly based on SGD. However, the understanding of SGD's ability to converge to good local minima, given the non-convex nature of loss functions and the intricate geometric characteristics of loss landscapes, remains limited. In this paper, we apply topological data analysis methods to loss landscapes to gain insights into the learning process and generalization properties of deep neural networks. We use the loss function topology to relate the local behavior of gradient descent trajectories with the global properties of the loss surface. For this purpose, we define the neural network's Topological Obstructions score ("TO-score") with the help of robust topological invariants, barcodes of the loss function, which quantify the escapability of local minima for gradient-based optimization. Our two principal observations are: 1) the loss barcode of the neural network decreases with increasing depth and width, therefore the topological obstructions to learning diminish; 2) in certain situations there is a connection between the length of minima segments in the loss barcode and the minima's generalization errors. Our statements are based on extensive experiments with fully connected, convolutional, and transformer architectures and several datasets including MNIST, FMNIST, CIFAR10, CIFAR100, SVHN, and multilingual OSCAR text dataset.