Nature, Published online: 13 March 2026; doi:10.1038/s41586-026-10376-z

Author Correction: SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10240-0

Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements, enabling more efficient viral entry.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-w

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

arXiv:2509.24230v2 Announce Type: replace Abstract: Large Language Models (LLMs) enable intelligent multi-robot collaboration but face fundamental trade-offs: open-loop methods that compile tasks into formal representations for external executors produce sound plans but lack adaptability in partially observable environments, while iterative methods incur prohibitive computational costs that scale poorly with team size and task complexity. In this paper, we propose Efficient Long-Horizon Planning (ELHPlan), a novel framework that introduces Action Chains, sequences of actions explicitly bound to sub-goal intentions, as the fundamental planning primitive. ELHPlan operates via a cyclical process: 1) constructing intention-bound action sequences, 2) proactively validating for conflicts and feasibility, 3) refining issues through targeted mechanisms, and 4) executing validated actions. This design balances adaptability and efficiency by providing intention-bound action sequences with longer lookahead while avoiding expensive full re-planning. We further advocate comprehensive efficiency metrics, including token consumption and planning time, to more holistically evaluate multi-agent collaboration. Our experiments on benchmarks TDW-MAT and C-WAH demonstrate that ELHPlan achieves comparable task success rates while consuming only 30-40% of the tokens required by state-of-the-art methods. Our research establishes a new efficiency-effectiveness frontier for LLM-based multi-agent planning systems.

arXiv:2506.18485v3 Announce Type: replace-cross Abstract: Reinforcement Learning with Verifiable Rewards~(RLVR) has emerged as a powerful learn-to-reason paradigm for large reasoning models to tackle complex tasks. However, the current RLVR paradigm is still not efficient enough, as it works in a trial-and-error manner. To perform better, the model needs to explore the reward space by numerously generating responses and learn from fragmented reward signals, blind to the overall reward patterns. Fortunately, verifiable rewards make the natural language description of the reward function possible, and meanwhile, LLMs have demonstrated strong in-context learning ability. This motivates us to explore if large reasoning models can benefit from a \textbf{motivation} of the task, \textit{i.e.}, awareness of the reward function, during the reinforcement finetuning process, as we humans sometimes do when learning. In this paper, we introduce \textit{\textbf{M}otivation-\textbf{e}nhanced \textbf{R}einforcement \textbf{F}inetuning}~(\textbf{MeRF}), an intuitive yet effective method enhancing reinforcement finetuning of LLMs by involving \emph{``telling LLMs rules of the game''}. Specifically, \textbf{MeRF} directly injects the reward specification into the prompt, which serves as an in-context motivation for the model to be aware of the optimization objective. This simple modification leverages the in-context learning ability of LLMs, aligning generation with optimization, thereby incentivizing the model to generate desired outputs from both inner motivation and external reward. Empirical evaluations demonstrate that \textbf{MeRF} achieves substantial performance gains over the RLVR baseline. Moreover, ablation studies show that MeRF performs better with greater consistency between the in-context motivation and the external reward function, while the model also demonstrates an ability to adapt to misleading motivations through reinforcement finetuning.

arXiv:2603.03099v2 Announce Type: replace-cross Abstract: Despite Adam demonstrating faster empirical convergence than SGD in many applications, much of the existing theory yields guarantees essentially comparable to those of SGD, leaving the empirical performance gap insufficiently explained. In this paper, we uncover a key second-moment normalization in Adam and develop a stopping-time/martingale analysis that provably distinguishes Adam from SGD under the classical bounded variance model (a second moment assumption). In particular, we establish the first theoretical separation between the high-probability convergence behaviors of the two methods: Adam achieves a $\delta^{-1/2}$ dependence on the confidence parameter $\delta$, whereas corresponding high-probability guarantee for SGD necessarily incurs at least a $\delta^{-1}$ dependence.

arXiv:2603.03099v1 Announce Type: cross Abstract: Despite Adam demonstrating faster empirical convergence than SGD in many applications, much of the existing theory yields guarantees essentially comparable to those of SGD, leaving the empirical performance gap insufficiently explained. In this paper, we uncover a key second-moment normalization in Adam and develop a stopping-time/martingale analysis that provably distinguishes Adam from SGD under the classical bounded variance model (a second moment assumption). In particular, we establish the first theoretical separation between the high-probability convergence behaviors of the two methods: Adam achieves a $\delta^{-1/2}$ dependence on the confidence parameter $\delta$, whereas corresponding high-probability guarantee for SGD necessarily incurs at least a $\delta^{-1}$ dependence.

arXiv:2505.02156v5 Announce Type: replace-cross Abstract: Effective social intelligence simulation requires language agents to dynamically adjust reasoning depth, a capability notably absent in current studies. Existing methods either lack explicit reasoning or employ lengthy Chain-of-Thought reasoning uniformly across all scenarios, resulting in excessive token usage and inflexible social behaviors in tasks such as negotiation or collaboration. To address this, we propose an $\textbf{A}$daptive $\textbf{S}$ocial $\textbf{L}$earning ($\textbf{ASL}$) framework in this paper, aiming to improve the adaptive reasoning ability of language agents in dynamic social interactions. To this end, we first identify the hierarchical reasoning modes under such context, ranging from intuitive response to deep deliberation based on the cognitive control theory. We then develop the $\textbf{A}$daptive $\textbf{M}$ode $\textbf{P}$olicy $\textbf{O}$ptimization ($\textbf{AMPO}$) algorithm to learn the context-aware mode adaptation and reasoning. Our framework advances existing research in three key aspects: (1) Multi-granular reasoning mode design, (2) Context-aware mode switching in rich social interaction, and (3) Token-efficient reasoning with depth adaptation. Extensive experiments on the benchmark social intelligence environment verify that ASL achieves 15.6% higher task performance than GPT-4o. Notably, our AMPO outperforms GRPO by 7.0% with 32.8% shorter thinking chains, demonstrating the advantages of our AMPO and the learned adaptive reasoning ability over GRPO's solution.

arXiv:2512.16167v2 Announce Type: replace-cross Abstract: Autonomous LLM-based agents are increasingly engaging in decentralized service interactions to collaboratively execute complex tasks. However, the intrinsic instability and low-cost generativity of LLMs introduce a systemic vulnerability, where self-interested agents are incentivized to pursue short-term gains through deceptive behaviors. Such strategies can rapidly proliferate within the population and precipitate a systemic trust collapse. To address this, we propose Ev-Trust, a strategy-equilibrium trust mechanism grounded in evolutionary game theory. Ev-Trust constructs a dynamic feedback loop that couples trust evaluation with evolutionary incentives, embedding interaction history and reputation directly into the agent's expected revenue function. This mechanism fundamentally reshapes the revenue structure, converting trustworthiness into a decisive survival advantage that suppresses short-sightedness. We provide a rigorous theoretical foundation based on the Replicator Dynamics, proving the asymptotic stability of Evolutionary Stable Strategies (ESS) that favor cooperation. Experimental results indicate that Ev-Trust effectively eliminates malicious strategies and enhances collective revenue, exhibiting resilience against the invasion of mutant behaviors.

arXiv:2602.14872v1 Announce Type: cross Abstract: Reinforcement learning with verifiable rewards (RLVR) has been a main driver of recent breakthroughs in large reasoning models. Yet it remains a mystery how rewards based solely on final outcomes can help overcome the long-horizon barrier to extended reasoning. To understand this, we develop a theory of the training dynamics of RL for transformers on compositional reasoning tasks. Our theory characterizes how the effectiveness of RLVR is governed by the smoothness of the difficulty spectrum. When data contains abrupt discontinuities in difficulty, learning undergoes grokking-type phase transitions, producing prolonged plateaus before progress recurs. In contrast, a smooth difficulty spectrum leads to a relay effect: persistent gradient signals on easier problems elevate the model's capabilities to the point where harder ones become tractable, resulting in steady and continuous improvement. Our theory explains how RLVR can improve performance at the edge of competence, and suggests that appropriately designed data mixtures can yield scalable gains. As a technical contribution, our analysis develops and adapts tools from Fourier analysis on finite groups to our setting. We validate the predicted mechanisms empirically via synthetic experiments.

arXiv:2510.22876v3 Announce Type: replace-cross Abstract: Speculative decoding must produce outputs distribution identical to standard autoregressive generation-this output equivalence is not an optimization target but the defining criterion of valid speculative decoding. We demonstrate that all existing batch speculative decoding implementations violate this fundamental requirement, producing corrupted outputs ranging from repetitive tokens to gibberish. These failures stem from the ragged tensor problem: sequences in the same batch accept different numbers of draft tokens, desynchronizing position IDs, attention masks, and KV-cache state. We present the first authentic batch speculative decoding framework. We (1) formalize the synchronization invariants that valid batch speculative decoding must satisfy, (2) present EQSPEC, the first algorithm that guarantees output equivalence, and analyze its cost structure to show that alignment overhead grows superlinearly and consumes up to 40\% of computation, and (3) introduce EXSPEC, which reduces this overhead through cross-batch scheduling that dynamically groups same-length sequences. On SpecBench across Vicuna-7B/68M, Qwen3-8B/0.6B, and GLM-4-9B/0.6B pairs, our methods achieve up to 3x throughput improvement at batch size 8 while maintaining algorithmic correctness. Our methods achieve 95\% decoding-equivalence, with residual divergence attributable to floating-point non-determinism in GPU inference, not the synchronization failures that cause near-zero equivalence of prior methods. Our code is available at https://github.com/eBay/spec_dec.

arXiv:2602.03195v2 Announce Type: replace-cross Abstract: Reinforcement learning (RL) has emerged as a key paradigm for aligning and optimizing large language models (LLMs). Standard approaches treat the LLM as the policy and apply RL directly over the full vocabulary space. However, this formulation includes the massive tail of contextually irrelevant tokens in the action space, which could distract the policy from focusing on decision-making among the truly reasonable tokens. In this work, we verify that valid reasoning paths could inherently concentrate within a low-rank subspace. Based on this insight, we introduce Reinforcement Learning with Promising Tokens (RLPT), a framework that mitigates the action space issue by decoupling strategic decision-making from token generation. Specifically, RLPT leverages the semantic priors of the base model to identify a dynamic set of promising tokens and constrains policy optimization exclusively to this refined subset via masking. Theoretical analysis and empirical results demonstrate that RLPT effectively reduces gradient variance, stabilizes the training process, and improves sample efficiency. Experiment results on math, coding, and telecom reasoning show that RLPT outperforms standard RL baselines and integrates effectively across various model sizes (4B and 8B) and RL algorithms (GRPO and DAPO).