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cs.AI, q-bio.NC updates on arXiv.org
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VideoTemp-o3: Harmonizing Temporal Grounding and Video Understanding in Agentic Thinking-with-Videos
arXiv:2602.07801v3 Announce Type: replace-cross Abstract: In long-video understanding, conventional uniform frame sampling often fails to capture key visual evidence, leading to degraded performance and increased hallucinations. To address this, recent agentic thinking-with-videos paradigms have emerged, adopting a localize-clip-answer pipeline in which the model actively identifies relevant video segments, performs dense sampling within those clips, and then produces answers. However, existing
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cs.AI, q-bio.NC updates on arXiv.org
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Automatic In-Domain Exemplar Construction and LLM-Based Refinement of Multi-LLM Expansions for Query Expansion
arXiv:2602.08917v2 Announce Type: replace-cross Abstract: Query expansion with large language models is promising but often relies on hand-crafted prompts, manually chosen exemplars, or a single LLM, making it non-scalable and sensitive to domain shift. We present an automated, domain-adaptive QE framework that builds in-domain exemplar pools by harvesting pseudo-relevant passages using a BM25-MonoT5 pipeline. A training-free cluster-based strategy selects diverse demonstrations, yielding stron
Automatic In-Domain Exemplar Construction and LLM-Based Refinement of Multi-LLM Expansions for Query Expansion
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Functional-based multi-omics early prediction of radiation pneumonitis in NSCLC using AI-generated perfusion and ventilation from planning CT
Phys Med Biol. 2026 Mar 13. doi: 10.1088/1361-6560/ae5209. Online ahead of print.ABSTRACTObjectiveThis study aims to develop a functional-based multi-omics model for early prediction of radiation pneumonitis (RP) by extracting radiomic and dosiomic features from functionally defined lung regions, using generated perfusion (Q) and ventilation (V) from pre-radiotherapy planning computed tomography (CT).
ApproachWe retrospectively analyzed data from 121 patients with locally advanced non-sm
Functional-based multi-omics early prediction of radiation pneumonitis in NSCLC using AI-generated perfusion and ventilation from planning CT
Phys Med Biol. 2026 Mar 13. doi: 10.1088/1361-6560/ae5209. Online ahead of print.
ABSTRACT
ObjectiveThis study aims to develop a functional-based multi-omics model for early prediction of radiation pneumonitis (RP) by extracting radiomic and dosiomic features from functionally defined lung regions, using generated perfusion (Q) and ventilation (V) from pre-radiotherapy planning computed tomography (CT).
ApproachWe retrospectively analyzed data from 121 patients with locally advanced non-small cell lung cancer (NSCLC) treated with curative-intent IMRT between 2015 and 2019, including pre-treatment CT and dose maps. Q and V maps were generated from CT with deep learning-based and supervoxel-based approaches, respectively. Regions of interest (ROIs) combined the planning target volume (PTV) with each of three functional lung regions-high functional lung (HFL), low functional lung (LFL), and whole lung (WL)-defined by thresholds on Q and V maps. Radiomic and dosiomic features were extracted from CT and dose distributions within each ROI. For each ROI, For each ROI, three methods-radiomics (R), dosiomics (D), and dual-omics (RD)-were constructed. 13 machine learning algorithms were trained and evaluated using 10-fold cross-validation, and model performance was assessed by the average area under the receiver operating characteristic curve (AUC), accuracy, precision, recall, and F1 score. RP was defined as CTCAE grade ≥ 2.
Main resultsOf the 35 selected features, 20 were from HFL. In dual-omics models, using HFL features improved predictive performance for RP (AUC 0.879±0.105) compared to WL (AUC 0.778 ± 0.100). In HFL, the RD method outperformed both R (AUC 0.786± 0.076) and D (AUC 0.791 ± 0.107) methods. Decision curve analysis showed the dual-omics model based on HFL provided the highest net benefit across threshold probabilities.
SignificanceThis study is the first to systematically demonstrate that features extracted from CT-derived HFL capture important functional differences and provide strong predictive value for RP. Compared to conventional methods, integrating radiomics, dosiomics, and CT-based functional information further improves predictive performance.
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PMID:41825133 | DOI:10.1088/1361-6560/ae5209
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Omics in Gastric
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Targeting the OXNAD1-PTGS2 axis with resveratrol overcomes ferroptosis Inhibition and reverses 5-FU resistance in gastric cancer
Gastric Cancer. 2026 Mar 13. doi: 10.1007/s10120-026-01718-x. Online ahead of print.ABSTRACTBACKGROUND: 5-Fluorouracil (5-FU) remains a cornerstone of first-line chemotherapy for gastric cancer, yet the emergence of resistance severely compromises its clinical efficacy. Although ferroptosis suppression has been recognized as a pivotal mechanism of chemoresistance, the mitochondrial regulatory processes involved remain poorly understood.METHODS: We integrated clinical specimen analysis, in vitro
Targeting the OXNAD1-PTGS2 axis with resveratrol overcomes ferroptosis Inhibition and reverses 5-FU resistance in gastric cancer
Gastric Cancer. 2026 Mar 13. doi: 10.1007/s10120-026-01718-x. Online ahead of print.
ABSTRACT
BACKGROUND: 5-Fluorouracil (5-FU) remains a cornerstone of first-line chemotherapy for gastric cancer, yet the emergence of resistance severely compromises its clinical efficacy. Although ferroptosis suppression has been recognized as a pivotal mechanism of chemoresistance, the mitochondrial regulatory processes involved remain poorly understood.
METHODS: We integrated clinical specimen analysis, in vitro and in vivo functional assays, multi-omics profiling, and molecular docking to delineate the role of the mitochondrial oxidoreductase OXNAD1 in mediating 5-FU resistance in gastric cancer, and to assess the therapeutic potential of the natural polyphenol resveratrol as a chemosensitizing agent.
RESULTS: OXNAD1 was found to be significantly overexpressed in gastric cancer tissues and cell lines, correlating with unfavorable prognosis and enhanced 5-FU resistance. Mechanistically, OXNAD1 directly bound to and suppressed the ferroptosis driver PTGS2, thereby attenuating lipid peroxidation and mitochondrial damage, ultimately restraining ferroptosis and promoting drug resistance. Notably, resveratrol disrupted the OXNAD1-PTGS2 interaction by directly binding OXNAD1, reinstating ferroptotic activity, markedly enhancing the cytotoxic effect of 5-FU in resistant cells, and potentiating the antitumor efficacy of 5-FU in xenograft models.
CONCLUSION: The OXNAD1-PTGS2 axis constitutes a critical metabolic-cell death cross-regulatory pathway underlying 5-FU resistance in gastric cancer. Targeting this axis with resveratrol provides a promising combinatorial strategy to overcome chemoresistance.
PMID:41824193 | DOI:10.1007/s10120-026-01718-x
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Omics In Lung
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Functional-based multi-omics early prediction of radiation pneumonitis in NSCLC using AI-generated perfusion and ventilation from planning CT
Phys Med Biol. 2026 Mar 13. doi: 10.1088/1361-6560/ae5209. Online ahead of print.ABSTRACTObjectiveThis study aims to develop a functional-based multi-omics model for early prediction of radiation pneumonitis (RP) by extracting radiomic and dosiomic features from functionally defined lung regions, using generated perfusion (Q) and ventilation (V) from pre-radiotherapy planning computed tomography (CT).
ApproachWe retrospectively analyzed data from 121 patients with locally advanced non-sm
Functional-based multi-omics early prediction of radiation pneumonitis in NSCLC using AI-generated perfusion and ventilation from planning CT
Phys Med Biol. 2026 Mar 13. doi: 10.1088/1361-6560/ae5209. Online ahead of print.
ABSTRACT
ObjectiveThis study aims to develop a functional-based multi-omics model for early prediction of radiation pneumonitis (RP) by extracting radiomic and dosiomic features from functionally defined lung regions, using generated perfusion (Q) and ventilation (V) from pre-radiotherapy planning computed tomography (CT).
ApproachWe retrospectively analyzed data from 121 patients with locally advanced non-small cell lung cancer (NSCLC) treated with curative-intent IMRT between 2015 and 2019, including pre-treatment CT and dose maps. Q and V maps were generated from CT with deep learning-based and supervoxel-based approaches, respectively. Regions of interest (ROIs) combined the planning target volume (PTV) with each of three functional lung regions-high functional lung (HFL), low functional lung (LFL), and whole lung (WL)-defined by thresholds on Q and V maps. Radiomic and dosiomic features were extracted from CT and dose distributions within each ROI. For each ROI, For each ROI, three methods-radiomics (R), dosiomics (D), and dual-omics (RD)-were constructed. 13 machine learning algorithms were trained and evaluated using 10-fold cross-validation, and model performance was assessed by the average area under the receiver operating characteristic curve (AUC), accuracy, precision, recall, and F1 score. RP was defined as CTCAE grade ≥ 2.
Main resultsOf the 35 selected features, 20 were from HFL. In dual-omics models, using HFL features improved predictive performance for RP (AUC 0.879±0.105) compared to WL (AUC 0.778 ± 0.100). In HFL, the RD method outperformed both R (AUC 0.786± 0.076) and D (AUC 0.791 ± 0.107) methods. Decision curve analysis showed the dual-omics model based on HFL provided the highest net benefit across threshold probabilities.
SignificanceThis study is the first to systematically demonstrate that features extracted from CT-derived HFL capture important functional differences and provide strong predictive value for RP. Compared to conventional methods, integrating radiomics, dosiomics, and CT-based functional information further improves predictive performance.
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PMID:41825133 | DOI:10.1088/1361-6560/ae5209
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cs.AI, q-bio.NC updates on arXiv.org
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Grouter: Decoupling Routing from Representation for Accelerated MoE Training
arXiv:2603.06626v1 Announce Type: cross Abstract: Traditional Mixture-of-Experts (MoE) training typically proceeds without any structural priors, effectively requiring the model to simultaneously train expert weights while searching for an optimal routing policy within a vast combinatorial space. This entanglement often leads to sluggish convergence and training instabilities. This paper introduces Grouter, a preemptive routing method that by distilling high-quality structures from fully-traine
Grouter: Decoupling Routing from Representation for Accelerated MoE Training
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cs.AI, q-bio.NC updates on arXiv.org
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Hide and Find: A Distributed Adversarial Attack on Federated Graph Learning
arXiv:2603.07743v1 Announce Type: cross Abstract: Federated Graph Learning (FedGL) is vulnerable to malicious attacks, yet developing a truly effective and stealthy attack method remains a significant challenge. Existing attack methods suffer from low attack success rates, high computational costs, and are easily identified and smoothed by defense algorithms. To address these challenges, we propose \textbf{FedShift}, a novel two-stage "Hide and Find" distributed adversarial attack. In the first
Hide and Find: A Distributed Adversarial Attack on Federated Graph Learning
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Oncogene - Issue - nature.com science feeds
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Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor
Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03708-wDexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor
Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor
Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03708-w
Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor-
cs.AI, q-bio.NC updates on arXiv.org
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Phys4D: Fine-Grained Physics-Consistent 4D Modeling from Video Diffusion
arXiv:2603.03485v1 Announce Type: cross Abstract: Recent video diffusion models have achieved impressive capabilities as large-scale generative world models. However, these models often struggle with fine-grained physical consistency, exhibiting physically implausible dynamics over time. In this work, we present \textbf{Phys4D}, a pipeline for learning physics-consistent 4D world representations from video diffusion models. Phys4D adopts \textbf{a three-stage training paradigm} that progressive
Phys4D: Fine-Grained Physics-Consistent 4D Modeling from Video Diffusion
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cs.AI, q-bio.NC updates on arXiv.org
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PhyPrompt: RL-based Prompt Refinement for Physically Plausible Text-to-Video Generation
arXiv:2603.03505v1 Announce Type: cross Abstract: State-of-the-art text-to-video (T2V) generators frequently violate physical laws despite high visual quality. We show this stems from insufficient physical constraints in prompts rather than model limitations: manually adding physics details reliably produces physically plausible videos, but requires expertise and does not scale. We present PhyPrompt, a two-stage reinforcement learning framework that automatically refines prompts for physically
PhyPrompt: RL-based Prompt Refinement for Physically Plausible Text-to-Video Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Pretrained Vision-Language-Action Models are Surprisingly Resistant to Forgetting in Continual Learning
arXiv:2603.03818v1 Announce Type: cross Abstract: Continual learning is a long-standing challenge in robot policy learning, where a policy must acquire new skills over time without catastrophically forgetting previously learned ones. While prior work has extensively studied continual learning in relatively small behavior cloning (BC) policy models trained from scratch, its behavior in modern large-scale pretrained Vision-Language-Action (VLA) models remains underexplored. In this work, we found
Pretrained Vision-Language-Action Models are Surprisingly Resistant to Forgetting in Continual Learning
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cs.AI, q-bio.NC updates on arXiv.org
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CoDAR: Continuous Diffusion Language Models are More Powerful Than You Think
arXiv:2603.02547v1 Announce Type: cross Abstract: We study why continuous diffusion language models (DLMs) have lagged behind discrete diffusion approaches despite their appealing continuous generative dynamics. Under a controlled token--recovery study, we identify token rounding, the final projection from denoised embeddings to tokens, as a primary bottleneck. Building on these insights, we propose CoDAR (Continuous Diffusion with Contextual AutoRegressive Decoder), a two--stage framework that
CoDAR: Continuous Diffusion Language Models are More Powerful Than You Think
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cs.AI, q-bio.NC updates on arXiv.org
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xLLM Technical Report
arXiv:2510.14686v2 Announce Type: replace-cross Abstract: We introduce xLLM, an intelligent and efficient Large Language Model (LLM) inference framework designed for high-performance, large-scale enterprise-grade serving, with deep optimizations for diverse AI accelerators. To address these challenges, xLLM builds a novel decoupled service-engine architecture. At the service layer, xLLM-Service features an intelligent scheduling module that efficiently processes multimodal requests and co-locat
xLLM Technical Report
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cs.AI, q-bio.NC updates on arXiv.org
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VideoTemp-o3: Harmonizing Temporal Grounding and Video Understanding in Agentic Thinking-with-Videos
arXiv:2602.07801v2 Announce Type: replace-cross Abstract: In long-video understanding, conventional uniform frame sampling often fails to capture key visual evidence, leading to degraded performance and increased hallucinations. To address this, recent agentic thinking-with-videos paradigms have emerged, adopting a localize-clip-answer pipeline in which the model actively identifies relevant video segments, performs dense sampling within those clips, and then produces answers. However, existing
VideoTemp-o3: Harmonizing Temporal Grounding and Video Understanding in Agentic Thinking-with-Videos
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cs.AI, q-bio.NC updates on arXiv.org
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JAEGER: Joint 3D Audio-Visual Grounding and Reasoning in Simulated Physical Environments
arXiv:2602.18527v1 Announce Type: cross Abstract: Current audio-visual large language models (AV-LLMs) are predominantly restricted to 2D perception, relying on RGB video and monaural audio. This design choice introduces a fundamental dimensionality mismatch that precludes reliable source localization and spatial reasoning in complex 3D environments. We address this limitation by presenting JAEGER, a framework that extends AV-LLMs to 3D space, to enable joint spatial grounding and reasoning thr
JAEGER: Joint 3D Audio-Visual Grounding and Reasoning in Simulated Physical Environments
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cs.AI, q-bio.NC updates on arXiv.org
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AnchorWeave: World-Consistent Video Generation with Retrieved Local Spatial Memories
arXiv:2602.14941v1 Announce Type: cross Abstract: Maintaining spatial world consistency over long horizons remains a central challenge for camera-controllable video generation. Existing memory-based approaches often condition generation on globally reconstructed 3D scenes by rendering anchor videos from the reconstructed geometry in the history. However, reconstructing a global 3D scene from multiple views inevitably introduces cross-view misalignment, as pose and depth estimation errors cause