Oncogene, Published online: 13 March 2026; doi:10.1038/s41388-026-03706-y

METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation

arXiv:2501.17860v2 Announce Type: replace-cross Abstract: Current medical AI systems often fail to replicate real-world clinical reasoning, as they are predominantly trained and evaluated on static text and question-answer tasks. These tuning methods and benchmarks overlook critical aspects like evidence-based reasoning and handling distracting information. To bridge this gap, we introduce a novel benchmark that simulates real-world diagnostic scenarios, integrating noise and difficulty levels aligned with USMLE standards. Moreover, we explore dialogue-based fine-tuning, which transforms static datasets into conversational formats to better capture iterative reasoning processes. Experiments show that dialogue-tuned models outperform traditional methods, with improvements of $9.64\%$ in multi-round reasoning scenarios and $6.18\%$ in accuracy in a noisy environment. Our findings highlight dialogue tuning as a promising approach for advancing clinically aligned and robust medical AI systems.

arXiv:2602.14169v1 Announce Type: cross Abstract: Effective exploration is a key challenge in reinforcement learning for large language models: discovering high-quality trajectories within a limited sampling budget from the vast natural language sequence space. Existing methods face notable limitations: GRPO samples exclusively from the root, saturating high-probability trajectories while leaving deep, error-prone states under-explored. Tree-based methods blindly disperse budgets across trivial or unrecoverable states, causing sampling dilution that fails to uncover rare correct suffixes and destabilizes local baselines. To address this, we propose Deep Dense Exploration (DDE), a strategy that focuses exploration on $\textit{pivots}$-deep, recoverable states within unsuccessful trajectories. We instantiate DDE with DEEP-GRPO, which introduces three key innovations: (1) a lightweight data-driven utility function that automatically balances recoverability and depth bias to identify pivot states; (2) local dense resampling at each pivot to increase the probability of discovering correct subsequent trajectories; and (3) a dual-stream optimization objective that decouples global policy learning from local corrective updates. Experiments on mathematical reasoning benchmarks demonstrate that our method consistently outperforms GRPO, tree-based methods, and other strong baselines.

arXiv:2602.14408v1 Announce Type: cross Abstract: Multimodal methods are widely used in rice deterioration detection, which exhibit limited capability in representing and extracting fine-grained abnormal features. Moreover, these methods rely on devices, such as hyperspectral cameras and mass spectrometers, increasing detection costs and prolonging data acquisition time. To address these issues, we propose a feature recalibration based olfactory-visual multimodal model for fine-grained rice deterioration detection. The fine-grained deterioration embedding constructor (FDEC) is proposed to reconstruct the labeled multimodal embedded-feature dataset, enhancing sample representation. The fine-grained deterioration recalibration attention network (FDRA-Net) is proposed to emphasize signal variations and increase sensitivity to fine-grained deterioration on the rice surface. Experiments show that the proposed method achieves a classification accuracy of 99.89%. Compared with state-of-the-art methods, the detection accuracy is improved and the procedure is simplified. Furthermore, field detection demonstrates the advantages of accuracy and operational simplicity. The proposed method can also be extended to other agrifood in agriculture and food industry.

arXiv:2509.18776v3 Announce Type: replace-cross Abstract: Large language models (LLMs), as a novel information technology, are seeing increasing adoption in the Architecture, Engineering, and Construction (AEC) field. They have shown their potential to streamline processes throughout the building lifecycle. However, the robustness and reliability of LLMs in such a specialized and safety-critical domain remain to be evaluated. To address this challenge, this paper establishes AECBench, a comprehensive benchmark designed to quantify the strengths and limitations of current LLMs in the AEC domain. The benchmark features a five-level, cognition-oriented evaluation framework (i.e., Knowledge Memorization, Understanding, Reasoning, Calculation, and Application). Based on the framework, 23 representative evaluation tasks were defined. These tasks were derived from authentic AEC practice, with scope ranging from codes retrieval to specialized documents generation. Subsequently, a 4,800-question dataset encompassing diverse formats, including open-ended questions, was crafted primarily by engineers and validated through a two-round expert review. Furthermore, an "LLM-as-a-Judge" approach was introduced to provide a scalable and consistent methodology for evaluating complex, long-form responses leveraging expert-derived rubrics. Through the evaluation of nine LLMs, a clear performance decline across five cognitive levels was revealed. Despite demonstrating proficiency in foundational tasks at the Knowledge Memorization and Understanding levels, the models showed significant performance deficits, particularly in interpreting knowledge from tables in building codes, executing complex reasoning and calculation, and generating domain-specific documents. Consequently, this study lays the groundwork for future research and development aimed at the robust and reliable integration of LLMs into safety-critical engineering practices.

arXiv:2602.13021v2 Announce Type: replace-cross Abstract: Symbolic Regression (SR) aims to discover interpretable equations from observational data, with the potential to reveal underlying principles behind natural phenomena. However, existing approaches often fall into the Pseudo-Equation Trap: producing equations that fit observations well but remain inconsistent with fundamental scientific principles. A key reason is that these approaches are dominated by empirical risk minimization, lacking explicit constraints to ensure scientific consistency. To bridge this gap, we propose PG-SR, a prior-guided SR framework built upon a three-stage pipeline consisting of warm-up, evolution, and refinement. Throughout the pipeline, PG-SR introduces a prior constraint checker that explicitly encodes domain priors as executable constraint programs, and employs a Prior Annealing Constrained Evaluation (PACE) mechanism during the evolution stage to progressively steer discovery toward scientifically consistent regions. Theoretically, we prove that PG-SR reduces the Rademacher complexity of the hypothesis space, yielding tighter generalization bounds and establishing a guarantee against pseudo-equations. Experimentally, PG-SR outperforms state-of-the-art baselines across diverse domains, maintaining robustness to varying prior quality, noisy data, and data scarcity.