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cs.AI, q-bio.NC updates on arXiv.org
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MovieTeller: Tool-augmented Movie Synopsis with ID Consistent Progressive Abstraction
arXiv:2602.23228v2 Announce Type: replace-cross Abstract: With the explosive growth of digital entertainment, automated video summarization has become indispensable for applications such as content indexing, personalized recommendation, and efficient media archiving. Automatic synopsis generation for long-form videos, such as movies and TV series, presents a significant challenge for existing Vision-Language Models (VLMs). While proficient at single-image captioning, these general-purpose model
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cs.AI, q-bio.NC updates on arXiv.org
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Narrative Weaver: Towards Controllable Long-Range Visual Consistency with Multi-Modal Conditioning
arXiv:2603.06688v2 Announce Type: replace-cross Abstract: We present "Narrative Weaver", a novel framework that addresses a fundamental challenge in generative AI: achieving multi-modal controllable, long-range, and consistent visual content generation. While existing models excel at generating high-fidelity short-form visual content, they struggle to maintain narrative coherence and visual consistency across extended sequences - a critical limitation for real-world applications such as filmmak
Narrative Weaver: Towards Controllable Long-Range Visual Consistency with Multi-Modal Conditioning
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization
CPT Pharmacometrics Syst Pharmacol. 2026 Mar;15(3):e70178. doi: 10.1002/psp4.70178.ABSTRACTAzathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy-combining network toxicology, machine learning, Mendelian randomization (MR), and molecular docking-to elucidate the biological basis of AZA-induced AP. AZA-associated genes were first identified through bioin
Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization
CPT Pharmacometrics Syst Pharmacol. 2026 Mar;15(3):e70178. doi: 10.1002/psp4.70178.
ABSTRACT
Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy-combining network toxicology, machine learning, Mendelian randomization (MR), and molecular docking-to elucidate the biological basis of AZA-induced AP. AZA-associated genes were first identified through bioinformatics databases and analyzed using protein-protein interaction networks and GO/KEGG functional enrichment. Least absolute shrinkage and selection operator (LASSO) regression and support vector machine recursive feature elimination (SVM-RFE) were applied to prioritize key differentially expressed genes for diagnostic modeling. MR was then used to examine potential causal links between gene expression and AP risk, followed by molecular docking to assess AZA-protein interactions. Sixty-eight candidate genes related to AZA-induced AP were identified. Enrichment analyses indicated involvement in lipid metabolic regulation, inflammatory pathways, and energy homeostasis. Machine learning highlighted seven key genes-CES1, CTSK, JAK1, NR3C2, PLIN5, WEE1, and RORA-as central to AP development. MR analysis further demonstrated that decreased expression of CES1 and CTSK may mediate AZA-related AP susceptibility. Docking simulations revealed strong, specific binding between AZA and both CES1 and CTSK. Overall, this study identifies CES1 and CTSK as genetically protective factors and mechanistic mediators in AZA-triggered AP. These findings offer new molecular insights into the genomic and biochemical pathways underlying this adverse drug reaction.
PMID:41832938 | DOI:10.1002/psp4.70178
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Nature - Issue - nature.com science feeds
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Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-wA clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.
Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-w
A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.-
cs.AI, q-bio.NC updates on arXiv.org
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The Struggle Between Continuation and Refusal: A Mechanistic Analysis of the Continuation-Triggered Jailbreak in LLMs
arXiv:2603.08234v1 Announce Type: new Abstract: With the rapid advancement of large language models (LLMs), the safety of LLMs has become a critical concern. Despite significant efforts in safety alignment, current LLMs remain vulnerable to jailbreaking attacks. However, the root causes of such vulnerabilities are still poorly understood, necessitating a rigorous investigation into jailbreak mechanisms across both academic and industrial communities. In this work, we focus on a continuation-tri
The Struggle Between Continuation and Refusal: A Mechanistic Analysis of the Continuation-Triggered Jailbreak in LLMs
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cs.AI, q-bio.NC updates on arXiv.org
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Narrative Weaver: Towards Controllable Long-Range Visual Consistency with Multi-Modal Conditioning
arXiv:2603.06688v1 Announce Type: cross Abstract: We present "Narrative Weaver", a novel framework that addresses a fundamental challenge in generative AI: achieving multi-modal controllable, long-range, and consistent visual content generation. While existing models excel at generating high-fidelity short-form visual content, they struggle to maintain narrative coherence and visual consistency across extended sequences - a critical limitation for real-world applications such as filmmaking and
Narrative Weaver: Towards Controllable Long-Range Visual Consistency with Multi-Modal Conditioning
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cs.AI, q-bio.NC updates on arXiv.org
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GIPO: Gaussian Importance Sampling Policy Optimization
arXiv:2603.03955v1 Announce Type: cross Abstract: Post-training with reinforcement learning (RL) has recently shown strong promise for advancing multimodal agents beyond supervised imitation. However, RL remains limited by poor data efficiency, particularly in settings where interaction data are scarce and quickly become outdated. To address this challenge, GIPO (Gaussian Importance sampling Policy Optimization) is proposed as a policy optimization objective based on truncated importance sampli
GIPO: Gaussian Importance Sampling Policy Optimization
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cs.AI, q-bio.NC updates on arXiv.org
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CMI-RewardBench: Evaluating Music Reward Models with Compositional Multimodal Instruction
arXiv:2603.00610v2 Announce Type: replace-cross Abstract: While music generation models have evolved to handle complex multimodal inputs mixing text, lyrics, and reference audio, evaluation mechanisms have lagged behind. In this paper, we bridge this critical gap by establishing a comprehensive ecosystem for music reward modeling under Compositional Multimodal Instruction (CMI), where the generated music may be conditioned on text descriptions, lyrics, and audio prompts. We first introduce CMI-
CMI-RewardBench: Evaluating Music Reward Models with Compositional Multimodal Instruction
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cs.AI, q-bio.NC updates on arXiv.org
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Beyond One-Size-Fits-All: Adaptive Subgraph Denoising for Zero-Shot Graph Learning with Large Language Models
arXiv:2603.02938v1 Announce Type: cross Abstract: Graph-based tasks in the zero-shot setting remain a significant challenge due to data scarcity and the inability of traditional Graph Neural Networks (GNNs) to generalize to unseen domains or label spaces. While recent advancements have transitioned toward leveraging Large Language Models (LLMs) as predictors to enhance GNNs, these methods often suffer from cross-modal alignment issues. A recent paradigm (i.e., Graph-R1) overcomes the aforementi
Beyond One-Size-Fits-All: Adaptive Subgraph Denoising for Zero-Shot Graph Learning with Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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PoTable: Towards Systematic Thinking via Plan-then-Execute Stage Reasoning on Tables
arXiv:2412.04272v4 Announce Type: replace-cross Abstract: In recent years, table reasoning has garnered substantial research interest, particularly regarding its integration with Large Language Models (LLMs), which have revolutionized natural language applications. Existing LLM-based studies typically achieve step-by-step thinking for table reasoning guided by task semantics. While these approaches emphasize autonomous exploration and enhance fine-grained table understanding, they often overloo
PoTable: Towards Systematic Thinking via Plan-then-Execute Stage Reasoning on Tables
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cs.AI, q-bio.NC updates on arXiv.org
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OmniVideoBench: Towards Audio-Visual Understanding Evaluation for Omni MLLMs
arXiv:2510.10689v2 Announce Type: replace Abstract: Recent advances in multimodal large language models (MLLMs) have demonstrated substantial potential in video understanding. However, existing benchmarks fail to comprehensively evaluate synergistic reasoning capabilities across audio and visual modalities, often neglecting either one of the modalities or integrating them in a logically inconsistent manner. To bridge this gap, we introduce OmniVideoBench, a large-scale and rigorously designed b