Background: Early detection of Alzheimer disease (AD) is essential for timely intervention; yet, diagnostic performance varies widely across modalities and datasets. Recent multimodal artificial intelligence (AI) models have made significant progress, but the evidence base remains fragmented due to heterogeneous datasets, modeling frameworks, and reporting quality. Objective: This systematic review aimed to analyze studies on multimodal AI models for AD diagnosis, prognosis, and risk prediction over 5 years. We evaluated dataset characteristics, modality combinations, modeling strategies, performance metrics, and methodological limitations. We further discuss real-world implications and translational pathways. Methods: Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines, we systematically searched PubMed, IEEE Xplore, Scopus, ACM Digital Library, Cochrane, and arXiv, with the final datasets last searched on November 15, 2025. Studies applying multimodal machine learning or deep learning to AD, mild cognitive impairment, and dementia outcomes were included, whereas studies using a single modality or lacking sufficient methodological detail were excluded. QUADAS-2 (Revised Quality Assessment of Diagnostic Accuracy Studies tool) assessed risk of bias. Extracted performance results were synthesized across 4 major multimodal dataset families. Results: A total of 66 studies met the inclusion criteria. Across datasets, multimodal models consistently outperformed single-modal baselines. Alzheimer’s Disease Neuroimaging Initiative–based diagnosis achieved an average accuracy of 92.5% (SD 3.8%), while mild cognitive impairment–conversion models achieved an average area under the curve (AUC) of 0.922 (SD 0.045), and several fusion architectures reported AUCs above 0.95. In contrast, UK Biobank risk-prediction studies reported an average AUC of 0.84 (SD 0.056), and this reflects performance in large, population-based datasets. DementiaBank speech-language studies achieved an average AUC of 0.813 (SD 0.042), and cross-lingual AD detection achieved an accuracy of 77% (SD 6.5%). Self-collected multimodal datasets demonstrated average accuracies around 96% (SD 2.4%), but their generalizability is limited due to small sample sizes and single-center designs. Conclusions: This systematic review demonstrates that multimodal AI models consistently outperform single-modal models for AD diagnosis, prognosis, and risk prediction by integrating complementary biological, clinical, and behavioral information. Unlike prior reviews, this review provides a unified synthesis across heterogeneous clinical, imaging, genetic, and linguistic datasets, enabling cross-domain comparison of modeling strategies and performance. However, the generalizability of reported performance was limited due to substantial heterogeneity in dataset composition, outcome definitions, and validation, and prevalent risks of bias. By evaluating these factors, this review clarifies where current evidence is robust and where caution is warranted. The findings highlight the need for standardized multimodal benchmarks, transparent evaluation protocols, and clinically grounded model design to enable reliable real-world deployment. Overall, this work advances the field by framing multimodal AI not only as a performance-driven tool but also as a translational framework for equitable, interpretable, and scalable AD diagnosis. Trial Registration: PROSPERO CRD420251241895;

arXiv:2603.22869v1 Announce Type: new Abstract: Large Language Models (LLMs) have become core cognitive components in modern artificial intelligence (AI) systems, combining internal knowledge with external context to perform complex tasks. However, LLMs typically treat all accessible data indiscriminately, lacking inherent awareness of knowledge ownership and access boundaries. This deficiency heightens risks of sensitive data leakage and adversarial manipulation, potentially enabling unauthorized system access and severe security crises. Existing protection strategies rely on rigid, uniform defense that prevent dynamic authorization. Structural isolation methods faces scalability bottlenecks, while prompt guidance methods struggle with fine-grained permissions distinctions. Here, we propose the Chain-of-Authorization (CoA) framework, a secure training and reasoning paradigm that internalizes authorization logic into LLMs' core capabilities. Unlike passive external defneses, CoA restructures the model's information flow: it embeds permission context at input and requires generating explicit authorization reasoning trajectory that includes resource review, identity resolution, and decision-making stages before final response. Through supervised fine-tuning on data covering various authorization status, CoA integrates policy execution with task responses, making authorization a causal prerequisite for substantive responses. Extensive evaluations show that CoA not only maintains comparable utility in authorized scenarios but also overcomes the cognitive confusion when permissions mismatches. It exhibits high rejection rates against various unauthorized and adversarial access. This mechanism leverages LLMs' reasoning capability to perform dynamic authorization, using natural language understanding as a proactive security mechanism for deploying reliable LLMs in modern AI systems.

arXiv:2603.22352v1 Announce Type: cross Abstract: Recent progress in reinforcement learning with verifiable rewards (RLVR) offers a practical path to self-improvement of language models, but existing methods face a key trade-off: endogenous self-play can drift over iterations, while corpus-grounded approaches rely on curated data environments. We present \textbf{WIST}, a \textbf{W}eb-grounded \textbf{I}terative \textbf{S}elf-play \textbf{T}ree framework for domain-targeted reasoning improvement that learns directly from the open web without requiring any pre-arranged domain corpus. WIST incrementally expands a domain tree for exploration, and retrieves and cleans path-consistent web corpus to construct a controllable training environment. It then performs Challenger--Solver self-play with verifiable rewards, and feeds learnability signals back to update node posteriors and guide subsequent exploration through an adaptive curriculum. Across four backbones, WIST consistently improves over the base models and typically outperforms both purely endogenous self-evolution and corpus-grounded self-play baselines, with the Overall gains reaching \textbf{+9.8} (\textit{Qwen3-4B-Base}) and \textbf{+9.7} (\textit{OctoThinker-8B}). WIST is also domain-steerable, improving \textit{Qwen3-8B-Base} by \textbf{+14.79} in medicine and \textit{Qwen3-4B-Base} by \textbf{+5.28} on PhyBench. Ablations further confirm the importance of WIST's key components for stable open-web learning. Our Code is available at https://github.com/lfy-123/WIST.

arXiv:2603.22364v1 Announce Type: cross Abstract: Diffusion models have achieved state-of-the-art performance in generative modeling, but their success often relies heavily on classifier-free guidance (CFG), an inference-time heuristic that modifies the sampling trajectory. From a theoretical perspective, diffusion models trained with standard denoising score matching (DSM) are expected to recover the target data distribution, raising the question of why inference-time guidance is necessary in practice. In this work, we ask whether the DSM training objective can be modified in a principled manner such that standard reverse-time sampling, without inference-time guidance, yields effects comparable to CFG. We identify insufficient inter-class separation as a key limitation of standard diffusion models. To address this, we propose MCLR, a principled alignment objective that explicitly maximizes inter-class likelihood-ratios during training. Models fine-tuned with MCLR exhibit CFG-like improvements under standard sampling, achieving comparable qualitative and quantitative gains without requiring inference-time guidance. Beyond empirical benefits, we provide a theoretical result showing that the CFG-guided score is exactly the optimal solution to a weighted MCLR objective. This establishes a formal equivalence between classifier-free guidance and alignment-based objectives, offering a mechanistic interpretation of CFG.

arXiv:2603.22876v1 Announce Type: cross Abstract: Learning a generalist control policy for dexterous manipulation typically relies on large-scale datasets. Given the high cost of real-world data collection, a practical alternative is to generate synthetic data through simulation. However, the resulting synthetic data often exhibits a significant gap from real-world distributions. While many prior studies have proposed algorithms to bridge the Sim-to-Real discrepancy, there remains a lack of principled research that grounds these methods in real-world manipulation tasks, particularly their performance on generalist policies such as Vision-Language-Action (VLA) models. In this study, we empirically examine the primary determinants of Sim-to-Real generalization across four dimensions: multi-level domain randomization, photorealistic rendering, physics-realistic modeling, and reinforcement learning updates. To support this study, we design a comprehensive evaluation protocol to quantify the real-world performance of manipulation tasks. The protocol accounts for key variations in background, lighting, distractors, object types, and spatial features. Through experiments involving over 10k real-world trials, we derive critical insights into Sim-to-Real transfer. To inform and advance future studies, we release both the robotic platforms and the evaluation protocol for public access to facilitate independent verification, thereby establishing a realistic and standardized benchmark for dexterous manipulation policies.

arXiv:2603.23405v1 Announce Type: cross Abstract: Modern Multi-Agent Path Finding (MAPF) algorithms must plan for hundreds to thousands of agents in congested environments within a second, requiring highly efficient algorithms. Priority Inheritance with Backtracking (PIBT) is a popular algorithm capable of effectively planning in such situations. However, PIBT is constrained by its rule-based planning procedure and lacks generality because it restricts its search to paths that conflict with at most one other agent. This limitation also applies to Enhanced PIBT (EPIBT), a recent extension of PIBT. In this paper, we describe a new perspective on solving MAPF by planning over agent dependencies. Taking inspiration from PIBT's priority inheritance logic, we define the concept of agent dependencies and propose Multi-Dependency PIBT (MD-PIBT) that searches over agent dependencies. MD-PIBT is a general framework where specific parameterizations can reproduce PIBT and EPIBT. At the same time, alternative configurations yield novel planning strategies that are not expressible by PIBT or EPIBT. Our experiments demonstrate that MD-PIBT effectively plans for as many as 10,000 homogeneous agents under various kinodynamic constraints, including pebble motion, rotation motion, and differential drive robots with speed and acceleration limits. We perform thorough evaluations on different variants of MAPF and find that MD-PIBT is particularly effective in MAPF with large agents.

arXiv:2510.05318v3 Announce Type: replace Abstract: Large language models (LLMs) have demonstrated remarkable performance on single-turn text-to-SQL tasks, but real-world database applications predominantly require multi-turn interactions to handle ambiguous queries, execution errors, and evolving user requirements. Existing multi-turn benchmarks fall short by treating conversation histories as static context or limiting evaluation to read-only operations, failing to reflect production-grade database assistant challenges. We introduce BIRD-INTERACT, a benchmark that restores this realism through: (1) a comprehensive interaction environment coupling each database with a hierarchical knowledge base, metadata files, and a function-driven user simulator, enabling models to solicit clarifications, retrieve knowledge, and recover from errors without human supervision; (2) two evaluation settings consisting of a pre-defined conversational protocol (c-Interact) and an open-ended agentic setting (a-Interact) where models autonomously decide when to query the user simulator or explore the environment; (3) a challenging task suite covering the full CRUD spectrum for business-intelligence and operational use cases, guarded by executable test cases. Each task features ambiguous and follow-up sub-tasks requiring dynamic interaction. The suite comprises BIRD-INTERACT-FULL (600 tasks, up to 11,796 interactions) for comprehensive performance assessment, and BIRD-INTERACT-LITE (300 tasks with simplified databases) for detailed behavioral analysis and rapid method development. Our empirical results highlight BIRD-INTERACT's difficulty: GPT-5 completes only 8.67% of tasks in c-Interact and 17.00% in a-Interact. Analysis via memory grafting and Interaction Test-time Scaling validates the importance of effective interaction for complex, dynamic text-to-SQL tasks.

arXiv:2602.22983v3 Announce Type: replace Abstract: As Large Language Models (LLMs) are increasingly used, their security risks have drawn increasing attention. Existing research reveals that LLMs are highly susceptible to jailbreak attacks, with effectiveness varying across language contexts. This paper investigates the role of classical Chinese in jailbreak attacks. Owing to its conciseness and obscurity, classical Chinese can partially bypass existing safety constraints, exposing notable vulnerabilities in LLMs. Based on this observation, this paper proposes a framework, CC-BOS, for the automatic generation of classical Chinese adversarial prompts based on multi-dimensional fruit fly optimization, facilitating efficient and automated jailbreak attacks in black-box settings. Prompts are encoded into eight policy dimensions-covering role, behavior, mechanism, metaphor, expression, knowledge, trigger pattern and context; and iteratively refined via smell search, visual search, and cauchy mutation. This design enables efficient exploration of the search space, thereby enhancing the effectiveness of black-box jailbreak attacks. To enhance readability and evaluation accuracy, we further design a classical Chinese to English translation module. Extensive experiments demonstrate that effectiveness of the proposed CC-BOS, consistently outperforming state-of-the-art jailbreak attack methods.

arXiv:2603.20670v2 Announce Type: replace Abstract: The rapid growth in the volume, variety, and velocity of geospatial data has created data ecosystems that are highly distributed, heterogeneous, and semantically inconsistent. Existing data catalogs, portals, and infrastructures still rely largely on keyword-based search with limited semantic support, which often fails to capture user intent and leads to weak retrieval performance. To address these challenges, this study proposes a knowledge graph-driven multi-agent framework for intelligent geospatial data discovery, powered by large language models. The framework introduces a unified geospatial metadata ontology as a semantic mediation layer to align heterogeneous metadata standards across platforms and constructs a geospatial metadata knowledge graph to explicitly model datasets and their multidimensional relationships. Building on the structured representation, the framework adopts a multi-agent collaborative architecture to perform intent parsing, knowledge graph retrieval, and answer synthesis, forming an interpretable and closed-loop discovery process from user queries to results. Results from representative use cases and performance evaluation show that the framework substantially improves intent matching accuracy, ranking quality, recall, and discovery transparency compared with traditional systems. This study advances geospatial data discovery toward a more semantic, intent-aware, and intelligent paradigm, providing a practical foundation for next-generation intelligent and autonomous spatial data infrastructures and contributing to the broader vision of Autonomous GIS.

arXiv:2508.09537v2 Announce Type: replace-cross Abstract: The growing capabilities of Large Language Models (LLMs) have led to their widespread adoption for function completion within code repositories. Recent studies on such tasks show promising results when explicit instructions, often in the form of docstrings, are available to guide the completion. However, in real-world scenarios, clear docstrings are frequently absent. Under such conditions, LLMs typically fail to produce accurate completions. To enable more automated and accurate function completion in such settings, we aim to enable LLMs to accurately infer the developer's intent prior to code completion. Our key insight is that the preceding code, namely the code context before the function to be completed, often contains valuable cues that help the model understand the intended functionality. However, inferring intent from such implicit context is non-trivial and constitutes a core challenge in function-level code completion. To tackle this challenge, inspired by how humans interpret context, we propose a reasoning-based prompting framework that guides LLMs to utilize these contextual cues to infer intent step by step. To incentivize LLMs to reason through the preceding code and infer intent, we further curate a dataset of 40k examples, each annotated with intermediate reasoning traces and corresponding docstrings. Extensive experiments on DevEval and ComplexCodeEval demonstrate consistent performance improvements across multiple models, achieving over 25% relative gains in pass@1 for both DeepSeekCoder and CodeLLaMA families. Building upon our framework, we further develop an intent-interactive platform that supports lightweight human feedback. This platform allows developers to select from a set of candidate intentions or edit the intent to better guide the model. Our experiments show that this interactive approach leads to further performance improvements.

arXiv:2509.04338v2 Announce Type: replace-cross Abstract: Leveraging visual priors from pre-trained text-to-image (T2I) generative models has shown success in dense prediction. However, dense prediction is inherently an image-to-image task, suggesting that image editing models, rather than T2I generative models, may be a more suitable foundation for fine-tuning. Motivated by this, we conduct a systematic analysis of the fine-tuning behaviors of both editors and generators for dense geometry estimation. Our findings show that editing models possess inherent structural priors, which enable them to converge more stably by ``refining" their innate features, and ultimately achieve higher performance than their generative counterparts. Based on these findings, we introduce \textbf{FE2E}, a framework that pioneeringly adapts an advanced editing model based on Diffusion Transformer (DiT) architecture for dense geometry prediction. Specifically, to tailor the editor for this deterministic task, we reformulate the editor's original flow matching loss into the ``consistent velocity" training objective. And we use logarithmic quantization to resolve the precision conflict between the editor's native BFloat16 format and the high precision demand of our tasks. Additionally, we leverage the DiT's global attention for a cost-free joint estimation of depth and normals in a single forward pass, enabling their supervisory signals to mutually enhance each other. Without scaling up the training data, FE2E achieves impressive performance improvements in zero-shot monocular depth and normal estimation across multiple datasets. Notably, it achieves over 35\% performance gains on the ETH3D dataset and outperforms the DepthAnything series, which is trained on 100$\times$ data. The project page can be accessed \href{https://amap-ml.github.io/FE2E/}{here}.

arXiv:2510.26865v2 Announce Type: replace-cross Abstract: Reading measurement instruments is effortless for humans and requires relatively little domain expertise, yet it remains surprisingly challenging for current vision-language models (VLMs) as we find in preliminary evaluation. In this work, we introduce MeasureBench, a benchmark on visual measurement reading covering both real-world and synthesized images of various types of measurements, along with an extensible pipeline for data synthesis. Our pipeline procedurally generates a specified type of gauge with controllable visual appearance, enabling scalable variation in key details such as pointers, scales, fonts, lighting, and clutter. Evaluation on popular proprietary and open-weight VLMs shows that even the strongest frontier VLMs struggle with measurement reading in general. We have also conducted preliminary experiments with reinforcement finetuning (RFT) over synthetic data, and find a significant improvement on both in-domain synthetic subset and real-world images. Our analysis highlights a fundamental limitation of current VLMs in fine-grained spatial grounding. We hope this resource and our code releases can help future advances on visually grounded numeracy and precise spatial perception of VLMs, bridging the gap between recognizing numbers and measuring the world.

arXiv:2512.03454v3 Announce Type: replace-cross Abstract: Interpreting natural-language commands to localize target objects is critical for autonomous driving (AD). Existing visual grounding (VG) methods for autonomous vehicles (AVs) typically struggle with ambiguous, context-dependent instructions, as they lack reasoning over 3D spatial relations and anticipated scene evolution. Grounded in the principles of world models, we propose ThinkDeeper, a framework that reasons about future spatial states before making grounding decisions. At its core is a Spatial-Aware World Model (SA-WM) that learns to reason ahead by distilling the current scene into a command-aware latent state and rolling out a sequence of future latent states, providing forward-looking cues for disambiguation. Complementing this, a hypergraph-guided decoder then hierarchically fuses these states with the multimodal input, capturing higher-order spatial dependencies for robust localization. In addition, we present DrivePilot, a multi-source VG dataset in AD, featuring semantic annotations generated by a Retrieval-Augmented Generation (RAG) and Chain-of-Thought (CoT)-prompted LLM pipeline. Extensive evaluations on six benchmarks, ThinkDeeper ranks #1 on the Talk2Car leaderboard and surpasses state-of-the-art baselines on DrivePilot, MoCAD, and RefCOCO/+/g benchmarks. Notably, it shows strong robustness and efficiency in challenging scenes (long-text, multi-agent, ambiguity) and retains superior performance even when trained on 50% of the data.

arXiv:2512.21201v2 Announce Type: replace-cross Abstract: Zero-shot object navigation (ZSON) requires robots to locate target objects in unseen environments without task-specific fine-tuning or pre-built maps, a capability crucial for service and household robotics. Existing methods perform well in simulation but struggle in realistic, cluttered environments where heavy occlusions and latent hazards make large portions of the scene unobserved. These approaches typically act on a single inferred scene, making them prone to overcommitment and unsafe behavior under uncertainty. To address these challenges, we propose Schr\"odinger's Navigator, a belief-aware framework that explicitly reasons over multiple trajectory-conditioned imagined 3D futures at inference time. A trajectory-conditioned 3D world model generates hypothetical observations along candidate paths, maintaining a superposition of plausible scene realizations. An adaptive, occluder-aware trajectory sampling strategy focuses imagination on uncertain regions, while a Future-Aware Value Map (FAVM) aggregates imagined futures to guide robust, proactive action selection. Evaluations in simulation and on a physical Go2 quadruped robot demonstrate that Schr\"odinger's Navigator outperforms strong ZSON baselines, achieving more robust self-localization, object localization, and safe navigation under severe occlusions and latent hazards. These results highlight the effectiveness of reasoning over imagined 3D futures as a scalable and generalizable strategy for zero-shot navigation in uncertain real-world environments.

arXiv:2603.17808v2 Announce Type: replace-cross Abstract: Video generative models are increasingly used as world models for robotics, where a model generates a future visual rollout conditioned on the current observation and task instruction, and an inverse dynamics model (IDM) converts the generated frames into executable robot actions. However, current video world models lack explicit executability constraints. As a result, visually coherent rollouts may still violate rigid-body and kinematic consistency, producing unstable or infeasible control commands when decoded by an IDM. We refer to this mismatch between visual generation and physically executable control as the executability gap. While this gap can be mitigated at inference time using techniques such as rejection sampling, such approaches are inefficient due to the high cost of video generation. In this paper, we leverage the executability gap as a training signal and introduce Executable Video Alignment (EVA), a reinforcement-learning post-training framework for aligning video world models. EVA trains an inverse dynamics model on real robot trajectories and repurposes it as a reward model that evaluates generated videos through the action sequences they induce, encouraging smooth motions measured by velocity, acceleration, and jerk while penalizing actions that violate embodiment constraints. Importantly, the reward remains informative even when generated videos contain severe visual artifacts, since such artifacts typically translate into unstable or out-of-bound actions. Experiments on the RoboTwin benchmark and a real bimanual robot show that EVA reduces embodiment-specific artifacts in generated rollouts and improves downstream task execution success.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10273-5

SnRK1β1A in rice promotes susceptibility to multiple fungal diseases, and disrupting this infection-inducible gene confers broad-spectrum resistance without compromising growth or yield under normal field conditions.

npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02515-7

Effects of multisensory stimulation based on immersive virtual reality in postoperative neuropsychiatric recovery after gynecological laparoscopy

Oncogene, Published online: 23 March 2026; doi:10.1038/s41388-026-03734-8

PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment