Oncogene, Published online: 24 March 2026; doi:10.1038/s41388-026-03728-6

TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation

arXiv:2602.18532v1 Announce Type: cross Abstract: Following the rise of large foundation models, Vision-Language-Action models (VLAs) emerged, leveraging strong visual and language understanding for general-purpose policy learning. Yet, the current VLA landscape remains fragmented and exploratory. Although many groups have proposed their own VLA models, inconsistencies in training protocols and evaluation settings make it difficult to identify which design choices truly matter. To bring structure to this evolving space, we reexamine the VLA design space under a unified framework and evaluation setup. Starting from a simple VLA baseline similar to RT-2 and OpenVLA, we systematically dissect design choices along three dimensions: foundational components, perception essentials, and action modelling perspectives. From this study, we distill 12 key findings that together form a practical recipe for building strong VLA models. The outcome of this exploration is a simple yet effective model, VLANeXt. VLANeXt outperforms prior state-of-the-art methods on the LIBERO and LIBERO-plus benchmarks and demonstrates strong generalization in real-world experiments. We will release a unified, easy-to-use codebase that serves as a common platform for the community to reproduce our findings, explore the design space, and build new VLA variants on top of a shared foundation.

arXiv:2602.13718v1 Announce Type: cross Abstract: Limited by inference latency, existing robot manipulation policies lack sufficient real-time interaction capability with the environment. Although faster generation methods such as flow matching are gradually replacing diffusion methods, researchers are pursuing even faster generation suitable for interactive robot control. MeanFlow, as a one-step variant of flow matching, has shown strong potential in image generation, but its precision in action generation does not meet the stringent requirements of robotic manipulation. We therefore propose \textbf{HybridFlow}, a \textbf{3-stage method} with \textbf{2-NFE}: Global Jump in MeanFlow mode, ReNoise for distribution alignment, and Local Refine in ReFlow mode. This method balances inference speed and generation quality by leveraging the rapid advantage of MeanFlow one-step generation while ensuring action precision with minimal generation steps. Through real-world experiments, HybridFlow outperforms the 16-step Diffusion Policy by \textbf{15--25\%} in success rate while reducing inference time from 152ms to 19ms (\textbf{8$\times$ speedup}, \textbf{$\sim$52Hz}); it also achieves 70.0\% success on unseen-color OOD grasping and 66.3\% on deformable object folding. We envision HybridFlow as a practical low-latency method to enhance real-world interaction capabilities of robotic manipulation policies.

arXiv:2602.07506v2 Announce Type: replace-cross Abstract: Humanoid facial expression shadowing enables robots to realistically imitate human facial expressions in real time, which is critical for lifelike, facially expressive humanoid robots and affective human-robot interaction. Existing progress in humanoid facial expression imitation remains limited, often failing to achieve either real-time performance or realistic expressiveness due to offline video-based inference designs and insufficient ability to capture and transfer subtle expression details. To address these limitations, we present VividFace, a real-time and realistic facial expression shadowing system for humanoid robots. An optimized imitation framework X2CNet++ enhances expressiveness by fine-tuning the human-to-humanoid facial motion transfer module and introducing a feature-adaptation training strategy for better alignment across different image sources. Real-time shadowing is further enabled by a video-stream-compatible inference pipeline and a streamlined workflow based on asynchronous I/O for efficient communication across devices. VividFace produces vivid humanoid faces by mimicking human facial expressions within 0.05 seconds, while generalizing across diverse facial configurations. Extensive real-world demonstrations validate its practical utility. Videos are available at: https://lipzh5.github.io/VividFace/.