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Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model

arXiv:2603.29176v1 Announce Type: new Abstract: Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing non-negligible surgical risk and cost. Previous explorations either resort to limited statistical biomarkers that are insufficient to characterize variability, or employ AI-driven methods which is prone to overfitting and opacity. We bridge this gap with a pretraining-finetuning framework to predict outcomes directly from resting-state fMRI. Critically, a generative virtual brain foundation model, pretrained on a collective dataset (2707 subjects, 5621 sessions) to capture universal disorder patterns, was finetuned on PD cohorts receiving TI (n=51) or DBS (n=55) to yield individualized virtual brains with high fidelity to empirical functional connectivity (r=0.935). By constructing counterfactual estimations between pathological and healthy neural states within these personalized models, we predicted clinical responses (TI: AUPR=0.853; DBS: AUPR=0.915), substantially outperforming baselines. External and prospective validations (n=14, n=11) highlight the feasibility of clinical translation. Moreover, our framework provides state-dependent regional patterns linked to response, offering hypothesis-generating mechanistic insights.

Smartphone-Based Identification of Unknown Liquids via Active Vibration Sensing

arXiv:2603.28787v1 Announce Type: cross Abstract: Traditional liquid identification instruments are often unavailable to the general public. This paper shows the feasibility of identifying unknown liquids with commercial lightweight devices, such as a smartphone. The key insight is that different liquid molecules have different viscosity coefficients and therefore must overcome different energy barriers during relative motion. With this intuition in mind, we introduce a novel model that measures liquids' viscosity based on active vibration. However, building a robust system using built-in smartphone accelerometers is challenging. Practical issues include under-sampling, self-interference, and the impact of liquid-volume changes. Instead of machine learning, we tackle these issues through multiple signal processing stages to reconstruct the original signals and cancel out the interference. Our approach estimates liquid viscosity with a mean relative error of 2.9% and distinguishes 30 types of liquids with an average accuracy of 95.47%.

OneComp: One-Line Revolution for Generative AI Model Compression

arXiv:2603.28845v1 Announce Type: cross Abstract: Deploying foundation models is increasingly constrained by memory footprint, latency, and hardware costs. Post-training compression can mitigate these bottlenecks by reducing the precision of model parameters without significantly degrading performance; however, its practical implementation remains challenging as practitioners navigate a fragmented landscape of quantization algorithms, precision budgets, data-driven calibration strategies, and hardware-dependent execution regimes. We present OneComp, an open-source compression framework that transforms this expert workflow into a reproducible, resource-adaptive pipeline. Given a model identifier and available hardware, OneComp automatically inspects the model, plans mixed-precision assignments, and executes progressive quantization stages, ranging from layer-wise compression to block-wise refinement and global refinement. A key architectural choice is treating the first quantized checkpoint as a deployable pivot, ensuring that each subsequent stage improves the same model and that quality increases as more compute is invested. By converting state-of-the-art compression research into an extensible, open-source, hardware-aware pipeline, OneComp bridges the gap between algorithmic innovation and production-grade model deployment.
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  • Wildfire Suppression: Complexity, Models, and Instances Gustavo Delazeri · Marcus Ritt
    arXiv:2603.29865v1 Announce Type: cross Abstract: Wildfires cause major losses worldwide, and the frequency of fire-weather conditions is likely to increase in many regions. We study the allocation of suppression resources over time on a graph-based representation of a landscape to slow down fire propagation. Our contributions are theoretical and methodological. First, we prove that this problem and related variants in the literature are NP-complete, including cases without resource-timing cons
     

Wildfire Suppression: Complexity, Models, and Instances

arXiv:2603.29865v1 Announce Type: cross Abstract: Wildfires cause major losses worldwide, and the frequency of fire-weather conditions is likely to increase in many regions. We study the allocation of suppression resources over time on a graph-based representation of a landscape to slow down fire propagation. Our contributions are theoretical and methodological. First, we prove that this problem and related variants in the literature are NP-complete, including cases without resource-timing constraints. Second, we propose a new mixed-integer programming (MIP) formulation that obtains state-of-the-art results, showing that MIP is a competitive approach contrary to earlier findings. Third, showing that existing benchmarks lack realism and difficulty, we introduce a physics-grounded instance generator based on Rothermel's surface fire spread model. We use these diverse instances to benchmark the literature, identifying the specific conditions where each algorithm succeeds or fails.

Building evidence-based knowledge graphs from full-text literature for disease-specific biomedical reasoning

arXiv:2603.28325v2 Announce Type: replace-cross Abstract: Biomedical knowledge resources often either preserve evidence as unstructured text or compress it into flat triples that omit study design, provenance, and quantitative support. Here we present EvidenceNet, a framework and dataset for building disease-specific knowledge graphs from full-text biomedical literature. EvidenceNet uses a large language model (LLM)-assisted pipeline to extract experimentally grounded findings as structured evidence nodes, normalize biomedical entities, score evidence quality, and connect evidence records through typed semantic relations. We release two resources: EvidenceNet-HCC with 7,872 evidence records, 10,328 graph nodes, and 49,756 edges, and EvidenceNet-CRC with 6,622 records, 8,795 nodes, and 39,361 edges. Technical validation shows high component fidelity, including 98.3% field-level extraction accuracy, 100.0% high-confidence entity-link accuracy, 87.5% fusion integrity, and 90.0% semantic relation-type accuracy. In downstream evaluation, EvidenceNet improves internal and external retrieval-augmented question answering and retains structural signal for future link prediction and target prioritization. These results establish EvidenceNet as a disease-specific resource for evidence-aware biomedical reasoning and hypothesis generation.

A Convex Route to Thermomechanics: Learning Internal Energy and Dissipation

arXiv:2603.28707v2 Announce Type: replace-cross Abstract: We present a physics-based neural network framework for the discovery of constitutive models in fully coupled thermomechanics. In contrast to classical formulations based on the Helmholtz energy, we adopt the internal energy and a dissipation potential as primary constitutive functions, expressed in terms of deformation and entropy. This choice avoids the need to enforce mixed convexity--concavity conditions and facilitates a consistent incorporation of thermodynamic principles. In this contribution, we focus on materials without preferred directions or internal variables. While the formulation is posed in terms of entropy, the temperature is treated as the independent observable, and the entropy is inferred internally through the constitutive relation, enabling thermodynamically consistent modeling without requiring entropy data. Thermodynamic admissibility of the networks is guaranteed by construction. The internal energy and dissipation potential are represented by input convex neural networks, ensuring convexity and compliance with the second law. Objectivity, material symmetry, and normalization are embedded directly into the architecture through invariant-based representations and zero-anchored formulations. We demonstrate the performance of the proposed framework on synthetic and experimental datasets, including purely thermal problems and fully coupled thermomechanical responses of soft tissues and filled rubbers. The results show that the learned models accurately capture the underlying constitutive behavior. All code, data, and trained models are made publicly available via https://doi.org/10.5281/zenodo.19248596.

Parametric Knowledge and Retrieval Behavior in RAG Fine-Tuning for Electronic Design Automation

arXiv:2603.23047v1 Announce Type: cross Abstract: Retrieval-Augmented Generation (RAG) fine-tuning has shown substantial improvements over vanilla RAG, yet most studies target document question answering and often rely on standard NLP metrics that can obscure factual differences. We evaluate RAG fine-tuning for long-form text generation in electronic design automation, adapting a 7B model under five context augmentation strategies with varying retrieval conditions. We introduce TriFEX, a human-validated, triple-based evaluation pipeline that attributes generated claims to their origin-user query, context and reference-and propose Parametric Knowledge Precision (PKP), which isolates internalized knowledge by filtering out claims leaked in the prompt. We show that ROUGE and BERTScore fail to detect factual differences that our triple-based evaluation reveals. Additionally, we demonstrate that an existing metric for knowledge internalization is retrieva-sensitive, with about 75% of its cross-condition variance driven by changes in the rate at which internal knowledge is expressed (PR), rather than by changes in its actual correctness (PKP). The fine-tuned 7B variants outperform a 72B baseline on most metrics, further showing generalization across conditions and on a related benchmark. These results underscore the limitations of available metrics in RAG evaluation and show that smaller models could be reasonably well adapted to specialized tasks for cost-efficient, on-premises deployment.

TRACE: Temporal Rule-Anchored Chain-of-Evidence on Knowledge Graphs for Interpretable Stock Movement Prediction

arXiv:2603.12500v1 Announce Type: cross Abstract: We present a Temporal Rule-Anchored Chain-of-Evidence (TRACE) on knowledge graphs for interpretable stock movement prediction that unifies symbolic relational priors, dynamic graph exploration, and LLM-guided decision making in a single end-to-end pipeline. The approach performs rule-guided multi-hop exploration restricted to admissible relation sequences, grounds candidate reasoning chains in contemporaneous news, and aggregates fully grounded evidence into auditable \texttt{UP}/\texttt{DOWN} verdicts with human-readable paths connecting text and structure. On an S\&P~500 benchmark, the method achieves 55.1\% accuracy, 55.7\% precision, 71.5\% recall, and 60.8\% F1, surpassing strong baselines and improving recall and F1 over the best graph baseline under identical evaluation. The gains stem from (i) rule-guided exploration that focuses search on economically meaningful motifs rather than arbitrary walks, and (ii) text-grounded consolidation that selectively aggregates high-confidence, fully grounded hypotheses instead of uniformly pooling weak signals. Together, these choices yield higher sensitivity without sacrificing selectivity, delivering predictive lift with faithful, auditably interpretable explanations.

AutoClimDS: Climate Data Science Agentic AI -- A Knowledge Graph is All You Need

arXiv:2509.21553v2 Announce Type: replace Abstract: Climate data science remains constrained by fragmented data sources, heterogeneous formats, and steep technical expertise requirements. These barriers slow discovery, limit participation, and undermine reproducibility. We present AutoClimDS, a Minimum Viable Product (MVP) Agentic AI system that addresses these challenges by integrating a curated climate knowledge graph (KG) with a set of Agentic AI workflows designed for cloud-native scientific analysis. The KG unifies datasets, metadata, tools, and workflows into a machine-interpretable structure, while AI agents, powered by generative models, enable natural-language query interpretation, automated data discovery, programmatic data acquisition, and end-to-end climate analysis. A key result is that AutoClimDS can reproduce published scientific figures and analyses from natural-language instructions alone, completing the entire workflow from dataset selection to preprocessing to modeling. When given the same tasks, state-of-the-art general-purpose LLMs (e.g., ChatGPT GPT-5.1) cannot independently identify authoritative datasets or construct valid retrieval workflows using standard web access. This highlights the necessity of structured scientific memory for agentic scientific reasoning. By encoding procedural workflow knowledge into a KG and integrating it with existing technologies (cloud APIs, LLMs, sandboxed execution), AutoClimDS demonstrates that the KG serves as the essential enabling component, the irreplaceable structural foundation, for autonomous climate data science. This approach provides a pathway toward democratizing climate research through human-AI collaboration.

Latent diffusion models for parameterization and data assimilation of facies-based geomodels

arXiv:2406.14815v5 Announce Type: replace-cross Abstract: Geological parameterization entails the representation of a geomodel using a small set of latent variables and a mapping from these variables to grid-block properties such as porosity and permeability. Parameterization is useful for data assimilation (history matching), as it maintains geological realism while reducing the number of variables to be determined. Diffusion models are a new class of generative deep-learning procedures that have been shown to outperform previous methods, such as generative adversarial networks, for image generation tasks. Diffusion models are trained to "denoise", which enables them to generate new geological realizations from input fields characterized by random noise. Latent diffusion models, which are the specific variant considered in this study, provide dimension reduction through use of a low-dimensional latent variable. The model developed in this work includes a variational autoencoder for dimension reduction and a U-net for the denoising process. Our application involves conditional 2D three-facies (channel-levee-mud) systems. The latent diffusion model is shown to provide realizations that are visually consistent with samples from geomodeling software. Quantitative metrics involving spatial and flow-response statistics are evaluated, and general agreement between the diffusion-generated models and reference realizations is observed. Stability tests are performed to assess the smoothness of the parameterization method. The latent diffusion model is then used for ensemble-based data assimilation. Two synthetic "true" models are considered. Significant uncertainty reduction, posterior P$_{10}$-P$_{90}$ forecasts that generally bracket observed data, and consistent posterior geomodels, are achieved in both cases. PLEASE CITE AS: 10.1016/j.cageo.2024.105755 https://www.sciencedirect.com/science/article/pii/S0098300424002383 NOT WITH THE ARXIV VERSION

FCMBench: The First Large-scale Financial Credit Multimodal Benchmark for Real-world Applications

arXiv:2601.00150v3 Announce Type: replace-cross Abstract: FCMBench is the first large-scale and privacy-compliant multimodal benchmark for real-world financial credit applications, covering tasks and robustness challenges from domain specific workflows and constraints. The current version of FCMBench covers 26 certificate types, with 5198 privacy-compliant images and 13806 paired VQA samples. It evaluates models on Perception and Reasoning tasks under real-world Robustness interferences, including 3 foundational perception tasks, 4 credit-specific reasoning tasks demanding decision-oriented visual evidence interpretation, and 10 real-world challenges for rigorous robustness stress testing. Moreover, FCMBench offers privacy-compliant realism with minimal leakage risk through in-house scenario-aware captures of manually synthesized templates, without any publicly released images. We conduct extensive evaluations of 28 state-of-the-art vision-language models spanning 14 AI companies and research institutes. Among them, Gemini 3 Pro achieves the best F1 score as a commercial model (65.16), Kimi-K2.5 achieves the best score as an open-source baseline (60.58). The mean and the std. of all tested models is 44.8 and 10.3 respectively, indicating that FCMBench is non-trivial and provides strong resolution for separating modern vision-language model capabilities. Robustness evaluations reveal that even top-performing models experience notable performance degradation under the designed challenges. We have open-sourced this benchmark to advance AI research in the credit domain and provide a domain-specific task for real-world AI applications.

Towards a more efficient bias detection in financial language models

arXiv:2603.08267v1 Announce Type: new Abstract: Bias in financial language models constitutes a major obstacle to their adoption in real-world applications. Detecting such bias is challenging, as it requires identifying inputs whose predictions change when varying properties unrelated to the decision, such as demographic attributes. Existing approaches typically rely on exhaustive mutation and pairwise prediction analysis over large corpora, which is effective but computationally expensive-particularly for large language models and can become impractical in continuous retraining and releasing processes. Aiming at reducing this cost, we conduct a large-scale study of bias in five financial language models, examining similarities in their bias tendencies across protected attributes and exploring cross-model-guided bias detection to identify bias-revealing inputs earlier. Our study uses approximately 17k real financial news sentences, mutated to construct over 125k original-mutant pairs. Results show that all models exhibit bias under both atomic (0.58\%-6.05\%) and intersectional (0.75\%-5.97\%) settings. Moreover, we observe consistent patterns in bias-revealing inputs across models, enabling substantial reuse and cost reduction in bias detection. For example, up to 73\% of FinMA's biased behaviours can be uncovered using only 20\% of the input pairs when guided by properties derived from DistilRoBERTa outputs.

Agora: Teaching the Skill of Consensus-Finding with AI Personas Grounded in Human Voice

arXiv:2603.07339v1 Announce Type: cross Abstract: Deliberative democratic theory suggests that civic competence: the capacity to navigate disagreement, weigh competing values, and arrive at collective decisions is not innate but developed through practice. Yet opportunities to cultivate these skills remain limited, as traditional deliberative processes like citizens' assemblies reach only a small fraction of the population. We present Agora, an early-stage AI-powered platform that uses LLMs to organize authentic human voices on policy issues, helping users build consensus-finding skills by proposing and revising policy recommendations, hearing supporting and opposing perspectives, and receiving feedback on how policy changes affect predicted support. In a preliminary study with 44 university students, participants using the full interface (with access to voice explanations) reported higher levels of problem-solving skills, internal deliberation, and produced higher quality consensus statements compared to a control condition showing only aggregate support distributions. These initial findings point toward a promising direction for scaling civic education.

HarmonyCell: Automating Single-Cell Perturbation Modeling under Semantic and Distribution Shifts

arXiv:2603.01396v2 Announce Type: replace Abstract: Single-cell perturbation studies face dual heterogeneity bottlenecks: (i) semantic heterogeneity--identical biological concepts encoded under incompatible metadata schemas across datasets; and (ii) statistical heterogeneity--distribution shifts from biological variation demanding dataset-specific inductive biases. We propose HarmonyCell, an end-to-end agent framework resolving each challenge through a dedicated mechanism: an LLM-driven Semantic Unifier autonomously maps disparate metadata into a canonical interface without manual intervention; and an adaptive Monte Carlo Tree Search engine operates over a hierarchical action space to synthesize architectures with optimal statistical inductive biases for distribution shifts. Evaluated across diverse perturbation tasks under both semantic and distribution shifts, HarmonyCell achieves a 95% valid execution rate on heterogeneous input datasets (versus 0% for general agents) while matching or even exceeding expert-designed baselines in rigorous out-of-distribution evaluations. This dual-track orchestration enables scalable automatic virtual cell modeling without dataset-specific engineering.

Online Dispatching and Routing for Automated Guided Vehicles in Pickup and Delivery Systems on Loop-Based Graphs

arXiv:2310.02195v4 Announce Type: replace-cross Abstract: Automated guided vehicles (AGVs) are widely used in various industries, and scheduling and routing them in a conflict-free manner is crucial to their efficient operation. We propose a loop-based algorithm that solves the online, conflict-free scheduling and routing problem for AGVs with any capacity and ordered jobs in loop-based graphs. The proposed algorithm is compared against an exact method, a greedy heuristic and a metaheuristic. We experimentally show, using theoretical and real instances on a model representing a real manufacturing plant, that this algorithm either outperforms the other algorithms or gets an equally good solution in less computing time.

Explainable Heterogeneous Anomaly Detection in Financial Networks via Adaptive Expert Routing

arXiv:2510.17088v2 Announce Type: replace-cross Abstract: Financial anomalies arise from heterogeneous mechanisms -- price shocks, liquidity freezes, contagion cascades, and momentum reversals -- yet existing detectors produce uniform scores without revealing which mechanism is failing. This hinders targeted responses: liquidity freezes call for market-making support, whereas price shocks call for circuit breakers. Three key challenges remain: (1) static graphs cannot adapt when correlations shift across regimes; (2) uniform detectors overlook heterogeneous anomaly signatures; and (3) black-box scores provide no actionable guidance on driving mechanisms. We address these challenges with an adaptive graph learning framework that embeds interpretability architecturally rather than post hoc. The framework constructs stress-modulated graphs that adaptively interpolate between known sector and geographic relationships and data-driven correlations as market conditions evolve. Anomalies are decomposed via four mechanism-specific experts -- Price-Shock, Liquidity, Systemic-Contagion, and Momentum-Reversal -- each capturing a distinct anomaly channel documented in the financial economics literature. The resulting routing weights serve as interpretable proxies for mechanism attribution, with their relative values indicating each anomaly's primary driving mechanism. A hierarchical Market Pressure Index aggregates entity-level anomaly scores into graduated market-wide alerts. On 100 U.S. equities (2017-2024), the framework detects all six major stress events with a 3.7-day mean lead time, outperforming baselines by +33 percentage points, with AUC 0.888 and AP 0.626. Case studies on SVB (March 2023) and Japan carry-trade unwind (August 2024) demonstrate that routing weights automatically distinguish localized from systemic crises without labeled supervision.

Bitcoin Price Prediction using Machine Learning and Combinatorial Fusion Analysis

arXiv:2602.00037v2 Announce Type: replace-cross Abstract: In this work, we propose to apply a new model fusion and learning paradigm, known as Combinatorial Fusion Analysis (CFA), to the field of Bitcoin price prediction. Price prediction of financial product has always been a big topic in finance, as the successful prediction of the price can yield significant profit. Every machine learning model has its own strength and weakness, which hinders progress toward robustness. CFA has been used to enhance models by leveraging rank-score characteristic (RSC) function and cognitive diversity in the combination of a moderate set of diverse and relatively well-performed models. Our method utilizes both score and rank combinations as well as other weighted combination techniques. Key metrics such as RMSE and MAPE are used to evaluate our methodology performance. Our proposal presents a notable MAPE performance of 0.19\%. The proposed method greatly improves upon individual model performance, as well as outperforms other Bitcoin price prediction models.

Impact of LLMs news Sentiment Analysis on Stock Price Movement Prediction

arXiv:2602.00086v3 Announce Type: replace-cross Abstract: This paper addresses stock price movement prediction by leveraging LLM-based news sentiment analysis. Earlier works have largely focused on proposing and assessing sentiment analysis models and stock movement prediction methods, however, separately. Although promising results have been achieved, a clear and in-depth understanding of the benefit of the news sentiment to this task, as well as a comprehensive assessment of different architecture types in this context, is still lacking. Herein, we conduct an evaluation study that compares 3 different LLMs, namely, DeBERTa, RoBERTa and FinBERT, for sentiment-driven stock prediction. Our results suggest that DeBERTa outperforms the other two models with an accuracy of 75% and that an ensemble model that combines the three models can increase the accuracy to about 80%. Also, we see that sentiment news features can benefit (slightly) some stock market prediction models, i.e., LSTM-, PatchTST- and tPatchGNN-based classifiers and PatchTST- and TimesNet-based regression tasks models.

Neuro-Symbolic Financial Reasoning via Deterministic Fact Ledgers and Adversarial Low-Latency Hallucination Detector

arXiv:2603.04663v2 Announce Type: replace-cross Abstract: Standard Retrieval-Augmented Generation (RAG) architectures fail in high-stakes financial domains due to two fundamental limitations: the inherent arithmetic incompetence of Large Language Models (LLMs) and the distributional semantic conflation of dense vector retrieval (e.g., mapping "Net Income" to "Net Sales" due to contextual proximity). In deterministic domains, a 99% accuracy rate yields 0% operational trust. To achieve zero-hallucination financial reasoning, we introduce the Verifiable Numerical Reasoning Agent (VeNRA). VeNRA shifts the RAG paradigm from retrieving probabilistic text to retrieving deterministic variables via a strictly typed Universal Fact Ledger (UFL). We mathematically bound this ledger using a novel Double-Lock Grounding algorithm. Coupled with deterministic Python execution, this neuro-symbolic routing compresses systemic hallucination rates to a near-zero 1.2%. Recognising that upstream parsing anomalies inevitably occur, we introduce the VeNRA Sentinel: a 3-billion parameter SLM trained to forensically audit candidate using a single-token inference budget with optional post-hoc reasoning. To train the Sentinel, we steer away from traditional hallucination datasets in favour of Adversarial Simulation, programmatically sabotaging financial records to simulate Ecological Errors. The compact Sentinel consequently outperforms 70B+ frontier models in error detection. Through Loss Dilution phenomenon in Reverse-CoT training, we present a novel Micro-Chunking loss algorithm to stabilise gradients under extreme verdict penalisation, yielding a 28x latency speedup without sacrificing forensic rigor.

Zero-Knowledge Proof (ZKP) Authentication for Offline CBDC Payment System Using IoT Devices

arXiv:2603.03804v1 Announce Type: cross Abstract: Central Bank Digital Currency (CBDCs) are becoming a new digital financial tool aimed at financial inclusion, increased monetary stability, and improved efficiency of payment systems, as they are issued by central banks. One of the most important aspects is that the CBDC must offer secure offline payment methods to users, allowing them to retain cash-like access without violating Anti-Money Laundering and Counter-terrorism Financing (AML/CFT) rules. The offline CBDC ecosystems will provide financial inclusion, empower underserved communities, and ensure equitable access to digital payments, even in connectivity-poor remote locations. With the rapid growth of Internet of Things (IoT) devices in our everyday lives, they are capable of performing secure digital transactions. Integrating offline CBDC payment with IoT devices enables seamless, automated payment without internet connectivity. However, IoT devices face special challenges due to their resource-constrained nature. This makes it difficult to include features such as double-spending prevention, privacy preservation, low-computation operation, and digital identity management. The work proposes a privacy-preserving offline CBDC model with integrated secure elements (SEs), zero-knowledge proofs (ZKPs), and intermittent synchronisation to conduct offline payments on IoT hardware. The proposed model is based on recent improvements in offline CBDC prototypes, regulations and cryptographic design choices such as hybrid architecture that involves using combination of online and offline payment in IoT devices using secure hardware with lightweight zero-knowledge proof cryptographic algorithm.
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