Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
CogBias: Measuring and Mitigating Cognitive Bias in Large Language Models
arXiv:2604.01366v1 Announce Type: new Abstract: Large Language Models (LLMs) are increasingly deployed in high-stakes decision-making contexts. While prior work has shown that LLMs exhibit cognitive biases behaviorally, whether these biases correspond to identifiable internal representations and can be mitigated through targeted intervention remains an open question. We define LLM cognitive bias as systematic, reproducible deviations from correct answers in tasks with computable ground-truth ba
-
cs.AI, q-bio.NC updates on arXiv.org
-
Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model
arXiv:2603.29176v1 Announce Type: new Abstract: Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing non-negligible surgical risk and cost. Previous explorations either resort to limited statistical biomarkers that are insufficient to characterize variability, or employ AI-driven methods which is prone to overf
Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model
-
cs.AI, q-bio.NC updates on arXiv.org
-
AGFT: Alignment-Guided Fine-Tuning for Zero-Shot Adversarial Robustness of Vision-Language Models
arXiv:2603.29410v1 Announce Type: cross Abstract: Pre-trained vision-language models (VLMs) exhibit strong zero-shot generalization but remain vulnerable to adversarial perturbations. Existing classification-guided adversarial fine-tuning methods often disrupt pre-trained cross-modal alignment, weakening visual-textual correspondence and degrading zero-shot performance. In this paper, we propose an Alignment-Guided Fine-Tuning (AGFT) framework that enhances zero-shot adversarial robustness whil
AGFT: Alignment-Guided Fine-Tuning for Zero-Shot Adversarial Robustness of Vision-Language Models
-
cs.AI, q-bio.NC updates on arXiv.org
-
LaSM: Layer-wise Scaling Mechanism for Defending Pop-up Attack on GUI Agents
arXiv:2507.10610v2 Announce Type: replace-cross Abstract: Graphical user interface (GUI) agents built on multimodal large language models (MLLMs) have recently demonstrated strong decision-making abilities in screen-based interaction tasks. However, they remain highly vulnerable to pop-up-based environmental injection attacks, where malicious visual elements divert model attention and lead to unsafe or incorrect actions. Existing defense methods either require costly retraining or perform poorl
LaSM: Layer-wise Scaling Mechanism for Defending Pop-up Attack on GUI Agents
-
(Multiomics OR Omics) AND (Pancreatic)
-
Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma
Cell Rep Med. 2026 Mar 30:102708. doi: 10.1016/j.xcrm.2026.102708. Online ahead of print.ABSTRACTIntratumor heterogeneity (ITH) undermines transcriptome-based stratification in intrahepatic cholangiocarcinoma (iCCA). Here, we integrate multi-omics data from multi-region, single-region, and single-cell RNA sequencing cohorts to systematically characterize gene expression ITH. We uncover that immune and stromal heterogeneity are primary drivers of ITH, leading to misclassification of a median 27.8
Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma
Cell Rep Med. 2026 Mar 30:102708. doi: 10.1016/j.xcrm.2026.102708. Online ahead of print.
ABSTRACT
Intratumor heterogeneity (ITH) undermines transcriptome-based stratification in intrahepatic cholangiocarcinoma (iCCA). Here, we integrate multi-omics data from multi-region, single-region, and single-cell RNA sequencing cohorts to systematically characterize gene expression ITH. We uncover that immune and stromal heterogeneity are primary drivers of ITH, leading to misclassification of a median 27.8% of tumors by existing subtyping systems. To overcome this, we identify a low-intratumor-heterogeneity/high-intertumor-variability (LIHV) gene set and develop an ITH-insensitive classification system defining five subgroups: inflammatory (SI), metabolic (SII), atypical (SIII-1), immune-silent (SIII-2), and neurodegenerative (SIII-3). These subgroups exhibit distinct clinical outcomes, molecular features, immune landscapes, and therapeutic vulnerabilities. GPRC5A and VTCN1 serve as robust immunohistochemical biomarkers for SI and SIII tumors, while serum CEA and CA19-9 identify inflammatory iCCA. Therapeutically, HSP90 inhibition synergizes with anti-PD1 in inflammatory iCCA, whereas combined anti-PD1 and anti-TIM3 suppresses neurodegenerative iCCA. Collectively, our study provides a robust molecular framework and actionable therapeutic strategies for iCCA.
PMID:41916296 | DOI:10.1016/j.xcrm.2026.102708
-
MRD
-
Dynamic Targetable Extracellular Vesicle Surface Proteins Monitor Depth of Response to CAR T Therapy
Res Sq [Preprint]. 2026 Mar 18:rs.3.rs-8913641. doi: 10.21203/rs.3.rs-8913641/v1.ABSTRACTExtracellular vesicles (EVs) represent a promising liquid biopsy platform in multiple myeloma (MM). We developed an MM EV Surface Protein Assay to quantify and dynamically monitor four MM EV subpopulations defined by targetable MM surface proteins (BCMA, CD38, GPRC5D, and CD319) across 336 serial blood samples from 45 relapsed/refractory MM (RRMM) patients treated with anti-BCMA chimeric antigen receptor (CA
Dynamic Targetable Extracellular Vesicle Surface Proteins Monitor Depth of Response to CAR T Therapy
Res Sq [Preprint]. 2026 Mar 18:rs.3.rs-8913641. doi: 10.21203/rs.3.rs-8913641/v1.
ABSTRACT
Extracellular vesicles (EVs) represent a promising liquid biopsy platform in multiple myeloma (MM). We developed an MM EV Surface Protein Assay to quantify and dynamically monitor four MM EV subpopulations defined by targetable MM surface proteins (BCMA, CD38, GPRC5D, and CD319) across 336 serial blood samples from 45 relapsed/refractory MM (RRMM) patients treated with anti-BCMA chimeric antigen receptor (CAR) T-cell therapy. All four MM EV subpopulations significantly decreased in 43 patients with initial response, while BCMA+, GPRC5D+, and CD319+ MM EVs increased in 19 patients with progression, and antigen escape was detected by BCMA+ MM EVs. MM EV subpopulations differentiated minimal residual disease (MRD) status and complemented MRD for detecting early relapse before clinical progression. Notably, CD319+ MM EVs were early predictors of progression-free and overall survival in MRD-negative patients. This assay enables noninvasive monitoring of deep response, progression, and antigen escape, and stratifies survival in MRD-negative patients with RRMM.
PMID:41890853 | PMC:PMC13015583 | DOI:10.21203/rs.3.rs-8913641/v1
-
cs.AI, q-bio.NC updates on arXiv.org
-
OmniDiT: Extending Diffusion Transformer to Omni-VTON Framework
arXiv:2603.19643v2 Announce Type: replace-cross Abstract: Despite the rapid advancement of Virtual Try-On (VTON) and Try-Off (VTOFF) technologies, existing VTON methods face challenges with fine-grained detail preservation, generalization to complex scenes, complicated pipeline, and efficient inference. To tackle these problems, we propose OmniDiT, an omni Virtual Try-On framework based on the Diffusion Transformer, which combines try-on and try-off tasks into one unified model. Specifically, w
OmniDiT: Extending Diffusion Transformer to Omni-VTON Framework
-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
-
Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization
CPT Pharmacometrics Syst Pharmacol. 2026 Mar;15(3):e70178. doi: 10.1002/psp4.70178.ABSTRACTAzathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy-combining network toxicology, machine learning, Mendelian randomization (MR), and molecular docking-to elucidate the biological basis of AZA-induced AP. AZA-associated genes were first identified through bioin
Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization
CPT Pharmacometrics Syst Pharmacol. 2026 Mar;15(3):e70178. doi: 10.1002/psp4.70178.
ABSTRACT
Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy-combining network toxicology, machine learning, Mendelian randomization (MR), and molecular docking-to elucidate the biological basis of AZA-induced AP. AZA-associated genes were first identified through bioinformatics databases and analyzed using protein-protein interaction networks and GO/KEGG functional enrichment. Least absolute shrinkage and selection operator (LASSO) regression and support vector machine recursive feature elimination (SVM-RFE) were applied to prioritize key differentially expressed genes for diagnostic modeling. MR was then used to examine potential causal links between gene expression and AP risk, followed by molecular docking to assess AZA-protein interactions. Sixty-eight candidate genes related to AZA-induced AP were identified. Enrichment analyses indicated involvement in lipid metabolic regulation, inflammatory pathways, and energy homeostasis. Machine learning highlighted seven key genes-CES1, CTSK, JAK1, NR3C2, PLIN5, WEE1, and RORA-as central to AP development. MR analysis further demonstrated that decreased expression of CES1 and CTSK may mediate AZA-related AP susceptibility. Docking simulations revealed strong, specific binding between AZA and both CES1 and CTSK. Overall, this study identifies CES1 and CTSK as genetically protective factors and mechanistic mediators in AZA-triggered AP. These findings offer new molecular insights into the genomic and biochemical pathways underlying this adverse drug reaction.
PMID:41832938 | DOI:10.1002/psp4.70178
-
Oncogene - Issue - nature.com science feeds
-
LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma
Oncogene, Published online: 14 March 2026; doi:10.1038/s41388-026-03714-yLINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma
LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma
Oncogene, Published online: 14 March 2026; doi:10.1038/s41388-026-03714-y
LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma-
cs.AI, q-bio.NC updates on arXiv.org
-
RECAP: Local Hebbian Prototype Learning as a Self-Organizing Readout for Reservoir Dynamics
arXiv:2603.06639v1 Announce Type: cross Abstract: Robust perception in brains is often attributed to high-dimensional population activity together with local plasticity mechanisms that reinforce recurring structure. In contrast, most modern image recognition systems are trained by error backpropagation and end-to-end gradient optimization, which are not naturally aligned with local computation and local plasticity. We introduce RECAP (Reservoir Computing with Hebbian Co-Activation Prototypes),
RECAP: Local Hebbian Prototype Learning as a Self-Organizing Readout for Reservoir Dynamics
-
cs.AI, q-bio.NC updates on arXiv.org
-
Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
arXiv:2512.16301v3 Announce Type: replace Abstract: Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool use, and OpenClaw highlights a newer direction in which agents accumulate persistent memory and reusable skills. Yet the research landscape remains fragmented across post-training, retrieval, memory, and skill
Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
-
cs.AI, q-bio.NC updates on arXiv.org
-
CaMeLs Can Use Computers Too: System-level Security for Computer Use Agents
arXiv:2601.09923v2 Announce Type: replace Abstract: AI agents are vulnerable to prompt injection attacks, where malicious content hijacks agent behavior to steal credentials or cause financial loss. The only known robust defense is architectural isolation that strictly separates trusted task planning from untrusted environment observations. However, applying this design to Computer Use Agents (CUAs) -- systems that automate tasks by viewing screens and executing actions -- presents a fundamenta
CaMeLs Can Use Computers Too: System-level Security for Computer Use Agents
-
cs.AI, q-bio.NC updates on arXiv.org
-
Unified Medical Image Segmentation with State Space Modeling Snake
arXiv:2507.12760v2 Announce Type: replace-cross Abstract: Unified Medical Image Segmentation (UMIS) is critical for comprehensive anatomical assessment but faces challenges due to multi-scale structural heterogeneity. Conventional pixel-based approaches, lacking object-level anatomical insight and inter-organ relational modeling, struggle with morphological complexity and feature conflicts, limiting their efficacy in UMIS. We propose Mamba Snake, a novel deep snake framework enhanced by state s
Unified Medical Image Segmentation with State Space Modeling Snake
-
cs.AI, q-bio.NC updates on arXiv.org
-
MemSifter: Offloading LLM Memory Retrieval via Outcome-Driven Proxy Reasoning
arXiv:2603.03379v1 Announce Type: cross Abstract: As Large Language Models (LLMs) are increasingly used for long-duration tasks, maintaining effective long-term memory has become a critical challenge. Current methods often face a trade-off between cost and accuracy. Simple storage methods often fail to retrieve relevant information, while complex indexing methods (such as memory graphs) require heavy computation and can cause information loss. Furthermore, relying on the working LLM to process
MemSifter: Offloading LLM Memory Retrieval via Outcome-Driven Proxy Reasoning
-
cs.AI, q-bio.NC updates on arXiv.org
-
See, Think, Act: Teaching Multimodal Agents to Effectively Interact with GUI by Identifying Toggles
arXiv:2509.13615v4 Announce Type: replace Abstract: The advent of multimodal agents facilitates effective interaction within graphical user interface (GUI), especially in ubiquitous GUI control. However, their inability to reliably execute toggle control instructions remains a key bottleneck. To investigate this, we construct a state control benchmark with binary toggle instructions derived from public datasets. Evaluation results of existing agents demonstrate their notable unreliability, part
See, Think, Act: Teaching Multimodal Agents to Effectively Interact with GUI by Identifying Toggles
-
cs.AI, q-bio.NC updates on arXiv.org
-
Training High-Level Schedulers with Execution-Feedback Reinforcement Learning for Long-Horizon GUI Automation
arXiv:2511.22235v2 Announce Type: replace Abstract: The rapid development of large vision-language model (VLM) has greatly promoted the research of GUI agent. However, GUI agents still face significant challenges in handling long-horizon tasks. First, single-agent models struggle to balance high-level capabilities and low-level execution capability, facing prevalent issues of responsibility coupling and capability conflicts. Second, agents lack awareness of the task state, leading to progress l
Training High-Level Schedulers with Execution-Feedback Reinforcement Learning for Long-Horizon GUI Automation
-
cs.AI, q-bio.NC updates on arXiv.org
-
Dynamic Adversarial Reinforcement Learning for Robust Multimodal Large Language Models
arXiv:2602.22227v3 Announce Type: replace-cross Abstract: Despite their impressive capabilities, Multimodal Large Language Models (MLLMs) exhibit perceptual fragility when confronted with visually complex scenes. This weakness stems from a reliance on finite training datasets, which are prohibitively expensive to scale and impose a ceiling on model robustness. We introduce \textbf{AOT-SFT}, a large-scale adversarial dataset for bootstrapping MLLM robustness. Building on this, we propose \textbf
Dynamic Adversarial Reinforcement Learning for Robust Multimodal Large Language Models
-
cs.AI, q-bio.NC updates on arXiv.org
-
MedFeat: Model-Aware and Explainability-Driven Feature Engineering with LLMs for Clinical Tabular Prediction
arXiv:2603.02221v1 Announce Type: cross Abstract: In healthcare tabular predictions, classical models with feature engineering often outperform neural approaches. Recent advances in Large Language Models enable the integration of domain knowledge into feature engineering, offering a promising direction. However, existing approaches typically rely on a broad search over predefined transformations, overlooking downstream model characteristics and feature importance signals. We present MedFeat, a
MedFeat: Model-Aware and Explainability-Driven Feature Engineering with LLMs for Clinical Tabular Prediction
-
cs.AI, q-bio.NC updates on arXiv.org
-
Efficient Self-Evaluation for Diffusion Language Models via Sequence Regeneration
arXiv:2603.02760v1 Announce Type: cross Abstract: Diffusion large language models (dLLMs) have recently attracted significant attention for their ability to enhance diversity, controllability, and parallelism. However, their non-sequential, bidirectionally masked generation makes quality assessment difficult, underscoring the need for effective self-evaluation. In this work, we propose DiSE, a simple yet effective self-evaluation confidence quantification method for dLLMs. DiSE quantifies confi
Efficient Self-Evaluation for Diffusion Language Models via Sequence Regeneration
-
cs.AI, q-bio.NC updates on arXiv.org
-
Chain of World: World Model Thinking in Latent Motion
arXiv:2603.03195v1 Announce Type: cross Abstract: Vision-Language-Action (VLA) models are a promising path toward embodied intelligence, yet they often overlook the predictive and temporal-causal structure underlying visual dynamics. World-model VLAs address this by predicting future frames, but waste capacity reconstructing redundant backgrounds. Latent-action VLAs encode frame-to-frame transitions compactly, but lack temporally continuous dynamic modeling and world knowledge. To overcome thes