arXiv:2604.01670v1 Announce Type: new Abstract: While long-term memory is essential for intelligent agents to maintain consistent historical awareness, the accumulation of extensive interaction data often leads to performance bottlenecks. Naive storage expansion increases retrieval noise and computational latency, overwhelming the reasoning capacity of models deployed on constrained personal devices. To address this, we propose Hierarchical Memory Orchestration (HMO), a framework that organizes interaction history into a three-tiered directory driven by user-centric contextual relevance. Our system maintains a compact primary cache, coupling recent and pivotal memories with an evolving user profile to ensure agent reasoning remains aligned with individual behavioral traits. This primary cache is complemented by a high-priority secondary layer, both of which are managed within a global archive of the full interaction history. Crucially, the user persona dictates memory redistribution across this hierarchy, promoting records mapped to long-term patterns toward more active tiers while relegating less relevant information. This targeted orchestration surfaces historical knowledge precisely when needed while maintaining a lean and efficient active search space. Evaluations on multiple benchmarks achieve state-of-the-art performance. Real-world deployments in ecosystems like OpenClaw demonstrate that HMO significantly enhances agent fluidity and personalization.

arXiv:2604.01236v1 Announce Type: cross Abstract: Traditional network architectures suffer from severe protocol ossification and structural fragility due to their reliance on static, human-defined rules that fail to adapt to the emergent edge cases and probabilistic reasoning of modern autonomous agents. To address these limitations, this paper proposes DarwinNet, a bio-inspired, self-evolving network architecture that transitions communication protocols from a \textit{design-time} static paradigm to a \textit{runtime} growth paradigm. DarwinNet utilizes a tri-layered framework-comprising an immutable physical anchor (L0), a WebAssembly-based fluid cortex (L1), and an LLM-driven Darwin cortex (L2)-to synthesize high-level business intents into executable bytecode through a dual-loop \textit{Intent-to-Bytecode} (I2B) mechanism. We introduce the Protocol Solidification Index (PSI) to quantify the evolutionary maturity of the system as it collapses from high-latency intelligent reasoning (Slow Thinking) toward near-native execution (Fast Thinking). Validated through a reliability growth framework based on the Crow-AMSAA model, experimental results demonstrate that DarwinNet achieves anti-fragility by treating environmental anomalies as catalysts for autonomous evolution. Our findings confirm that DarwinNet can effectively converge toward physical performance limits while ensuring endogenous security through zero-trust sandboxing, providing a viable path for the next generation of intelligent, self-optimizing networks.

arXiv:2604.01007v2 Announce Type: replace Abstract: AI agents increasingly operate over extended time horizons, yet their ability to retain, organize, and recall multimodal experiences remains a critical bottleneck. Building effective lifelong memory requires navigating a vast design space spanning architecture, retrieval strategies, prompt engineering, and data pipelines; this space is too large and interconnected for manual exploration or traditional AutoML to explore effectively. We deploy an autonomous research pipeline to discover Omni-SimpleMem, a unified multimodal memory framework for lifelong AI agents. Starting from a na\"ive baseline (F1=0.117 on LoCoMo), the pipeline autonomously executes ${\sim}50$ experiments across two benchmarks, diagnosing failure modes, proposing architectural modifications, and repairing data pipeline bugs, all without human intervention in the inner loop. The resulting system achieves state-of-the-art on both benchmarks, improving F1 by +411% on LoCoMo (0.117$\to$0.598) and +214% on Mem-Gallery (0.254$\to$0.797) relative to the initial configurations. Critically, the most impactful discoveries are not hyperparameter adjustments: bug fixes (+175%), architectural changes (+44%), and prompt engineering (+188% on specific categories) each individually exceed the cumulative contribution of all hyperparameter tuning, demonstrating capabilities fundamentally beyond the reach of traditional AutoML. We provide a taxonomy of six discovery types and identify four properties that make multimodal memory particularly suited for autoresearch, offering guidance for applying autonomous research pipelines to other AI system domains. Code is available at this https://github.com/aiming-lab/SimpleMem.

Background: High stress levels are common among health care workers (HCWs), threatening their health and workforce stability. Internet-based mobile stress management (MSM) is a promising intervention for reducing work-related stress; however, poor adherence limits effectiveness. Exploring factors influencing HCWs’ adherence may thus aid in developing optimal interventions. Objective: The research aimed to investigate (1) how HCWs’ well-being and cognitive factors influenced MSM treatment adherence and (2) what HCWs’ specific needs for MSM were. Methods: This study was a convergent mixed methods secondary analysis of a nonrandomized controlled trial. HCWs who were currently employed, had internet access, had no serious medical problems, and were willing to participate were recruited by convenience sampling through an MSM project in a large Chinese general hospital from August 11, 2021, to January 31, 2022. Those intending to leave the hospital or with insufficient medical condition for follow-up were excluded. Quantitative data were collected from 157 HCWs (n=135, 86% female participants; mean age of 33.7, SD 4.9 y) electronically via Research Electronic Data Capture (REDCap). Measures included sociodemographic characteristics, the Fatigue Assessment Scale, the 14-item Perceived Stress Scale, a user experience questionnaire, an attitudes scale (perceived usefulness, feasibility, and enjoyment), and self-reported practice frequency. Qualitative data were collected via an open-ended question answered by 96 participants. Quantitative data were analyzed using hierarchical regression and structural equation modeling. Qualitative data were analyzed using reflexive-thematic analysis in NVivo (QSR International). Results: In the quantitative study (n=157), hierarchical regression analyses showed that fatigue was a significant negative predictor of adherence (b=−0.050, 95% CI −0.086 to −0.015; =−2.859; 2-tailed =.005), while user experience (b=0.074, 95% CI 0.042-0.106; =4.569; 2-tailed

SPYTAC is a synthetic peptide-programmed targeted protein degradation platform harnessing LRP1 to drive lysosomal degradation of extracellular amyloid-β in the brain and periphery. In 5×FAD mice, SPYTAC treatment efficiently degrades amyloid-β, preserves neurons, and improves cognition with reduced neuroinflammation and microhemorrhage when compared with antibody therapy.

Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3′-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.

arXiv:2512.02902v2 Announce Type: replace-cross Abstract: Vision-language-action (VLA) models achieve strong in-distribution performance but degrade sharply under novel camera viewpoints and visual perturbations. We show that this brittleness primarily arises from misalignment in Spatial Modeling, rather than Physical Modeling. To address this, we propose a one-shot adaptation framework that recalibrates visual representations through lightweight, learnable updates. Our first method, Feature Token Modulation (FTM), applies a global affine transformation to visual tokens and improves Libero viewpoint accuracy from 48.5% to 87.1% with only 4K parameters. Building on this, Feature Linear Adaptation (FLA) introduces low-rank updates to the ViT encoder, achieving 90.8% success with 4.7M parameters -- matching LoRA-scale finetuning at far lower cost. Together, these results reveal substantial untapped robustness in pretrained VLA models and demonstrate that targeted, minimal visual adaptation is sufficient to restore viewpoint generalization.

arXiv:2603.22869v1 Announce Type: new Abstract: Large Language Models (LLMs) have become core cognitive components in modern artificial intelligence (AI) systems, combining internal knowledge with external context to perform complex tasks. However, LLMs typically treat all accessible data indiscriminately, lacking inherent awareness of knowledge ownership and access boundaries. This deficiency heightens risks of sensitive data leakage and adversarial manipulation, potentially enabling unauthorized system access and severe security crises. Existing protection strategies rely on rigid, uniform defense that prevent dynamic authorization. Structural isolation methods faces scalability bottlenecks, while prompt guidance methods struggle with fine-grained permissions distinctions. Here, we propose the Chain-of-Authorization (CoA) framework, a secure training and reasoning paradigm that internalizes authorization logic into LLMs' core capabilities. Unlike passive external defneses, CoA restructures the model's information flow: it embeds permission context at input and requires generating explicit authorization reasoning trajectory that includes resource review, identity resolution, and decision-making stages before final response. Through supervised fine-tuning on data covering various authorization status, CoA integrates policy execution with task responses, making authorization a causal prerequisite for substantive responses. Extensive evaluations show that CoA not only maintains comparable utility in authorized scenarios but also overcomes the cognitive confusion when permissions mismatches. It exhibits high rejection rates against various unauthorized and adversarial access. This mechanism leverages LLMs' reasoning capability to perform dynamic authorization, using natural language understanding as a proactive security mechanism for deploying reliable LLMs in modern AI systems.

npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02424-9

Evaluating eRAMP telecare for diabetes in outpatient clinics: a hybrid effectiveness-implementation study

Oncogene, Published online: 24 March 2026; doi:10.1038/s41388-026-03730-y

Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A

arXiv:2603.12719v1 Announce Type: cross Abstract: Point cloud registration (PCR) is a fundamental task in 3D vision and provides essential support for applications such as autonomous driving, robotics, and environmental modeling. Despite its widespread use, existing methods often fail when facing real-world challenges like heavy noise, significant occlusions, and large-scale transformations. These limitations frequently result in compromised registration accuracy and insufficient robustness in complex environments. In this paper, we propose IGASA as a novel registration framework constructed upon a Hierarchical Pyramid Architecture (HPA) designed for robust multi-scale feature extraction and fusion. The framework integrates two pivotal components consisting of the Hierarchical Cross-Layer Attention (HCLA) module and the Iterative Geometry-Aware Refinement (IGAR) module. The HCLA module utilizes skip attention mechanisms to align multi-resolution features and enhance local geometric consistency. Simultaneously, the IGAR module is designed for the fine matching phase by leveraging reliable correspondences established during coarse matching. This synergistic integration within the architecture allows IGASA to adapt effectively to diverse point cloud structures and intricate transformations. We evaluate the performance of IGASA on four widely recognized benchmark datasets including 3D(Lo)Match, KITTI, and nuScenes. Our extensive experiments consistently demonstrate that IGASA significantly surpasses state-of-the-art methods and achieves notable improvements in registration accuracy. This work provides a robust foundation for advancing point cloud registration techniques while offering valuable insights for practical 3D vision applications. The code for IGASA is available in \href{https://github.com/DongXu-Zhang/IGASA}{https://github.com/DongXu-Zhang/IGASA}.

arXiv:2603.13028v1 Announce Type: cross Abstract: Diffusion models enable high-fidelity image editing but can also be misused for unauthorized style imitation and harmful content generation. To mitigate these risks, proactive image protection methods embed small, often imperceptible adversarial perturbations into images before sharing to disrupt downstream editing or fine-tuning. However, in realistic post-release scenarios, content owners cannot control downstream processing pipelines, and protections optimized for a surrogate model may fail when attackers use mismatched diffusion pipelines. Existing purification methods can weaken protections but often sacrifice image quality and rarely examine architectural mismatch. We introduce a unified post-release purification framework to evaluate protection survivability under model mismatch. We propose two practical purifiers: VAE-Trans, which corrects protected images via latent-space projection, and EditorClean, which performs instruction-guided reconstruction with a Diffusion Transformer to exploit architectural heterogeneity. Both operate without access to protected images or defense internals. Across 2,100 editing tasks and six representative protection methods, EditorClean consistently restores editability. Compared to protected inputs, it improves PSNR by 3-6 dB and reduces FID by 50-70 percent on downstream edits, while outperforming prior purification baselines by about 2 dB PSNR and 30 percent lower FID. Our results reveal a purify-once, edit-freely failure mode: once purification succeeds, the protective signal is largely removed, enabling unrestricted editing. This highlights the need to evaluate protections under model mismatch and design defenses robust to heterogeneous attackers.

arXiv:2601.18113v3 Announce Type: replace-cross Abstract: LLM-based web agents have become increasingly popular for their utility in daily life and work. However, they exhibit critical vulnerabilities when processing malicious URLs: accepting a disguised malicious URL enables subsequent access to unsafe webpages, which can cause severe damage to service providers and users. Despite this risk, no benchmark currently targets this emerging threat. To address this gap, we propose MalURLBench, the first benchmark for evaluating LLMs' vulnerabilities to malicious URLs. MalURLBench contains 61,845 attack instances spanning 10 real-world scenarios and 7 categories of real malicious websites. Experiments with 12 popular LLMs reveal that existing models struggle to detect elaborately disguised malicious URLs. We further identify and analyze key factors that impact attack success rates and propose URLGuard, a lightweight defense module. We believe this work will provide a foundational resource for advancing the security of web agents. Our code is available at https://github.com/JiangYingEr/MalURLBench.

arXiv:2602.07801v3 Announce Type: replace-cross Abstract: In long-video understanding, conventional uniform frame sampling often fails to capture key visual evidence, leading to degraded performance and increased hallucinations. To address this, recent agentic thinking-with-videos paradigms have emerged, adopting a localize-clip-answer pipeline in which the model actively identifies relevant video segments, performs dense sampling within those clips, and then produces answers. However, existing methods remain inefficient, suffer from weak localization, and adhere to rigid workflows. To solve these issues, we propose VideoTemp-o3, a unified agentic thinking-with-videos framework that jointly models video grounding and question answering. VideoTemp-o3 exhibits strong localization capability, supports on-demand clipping, and can refine inaccurate localizations. Specifically, in the supervised fine-tuning stage, we design a unified masking mechanism that encourages exploration while preventing noise. For reinforcement learning, we introduce dedicated rewards to mitigate reward hacking. Besides, from the data perspective, we develop an effective pipeline to construct high-quality long video grounded QA data, along with a corresponding benchmark for systematic evaluation across various video durations. Experimental results demonstrate that our method achieves remarkable performance on both long video understanding and grounding.

Nature, Published online: 16 March 2026; doi:10.1038/s41586-026-10372-3

Direct conversion from alkenes to alkynes

arXiv:2603.06748v1 Announce Type: cross Abstract: Protein sequence design must balance designability, defined as the ability to recover a target backbone, with multiple, often competing, developability properties such as solubility, thermostability, and expression. Existing approaches address these properties through post hoc mutation, inference-time biasing, or retraining on property-specific subsets, yet they are target dependent and demand substantial domain expertise or careful hyperparameter tuning. In this paper, we introduce ProtAlign, a multi-objective preference alignment framework that fine-tunes pretrained inverse folding models to satisfy diverse developability objectives while preserving structural fidelity. ProtAlign employs a semi-online Direct Preference Optimization strategy with a flexible preference margin to mitigate conflicts among competing objectives and constructs preference pairs using in silico property predictors. Applied to the widely used ProteinMPNN backbone, the resulting model MoMPNN enhances developability without compromising designability across tasks including sequence design for CATH 4.3 crystal structures, de novo generated backbones, and real-world binder design scenarios, making it an appealing framework for practical protein sequence design.

arXiv:2603.07023v1 Announce Type: cross Abstract: Despite the promise of Retrieval-Augmented Generation in grounding Multimodal Large Language Models with external knowledge, the transition to extensive contexts often leads to significant attention dilution and reasoning hallucinations. The surge in information density causes critical evidence to be submerged by voluminous noise, which complicates the discernment of relevant fragments within a dense input. In this paper, we propose \textbf{Hit-RAG}, a multi-stage preference alignment framework designed to resolve these cognitive bottlenecks through a progressive optimization pipeline. Our approach systematically refines the utilization of external evidence via three distinct stages. First, Supervised Fine-tuning establishes baseline context awareness to minimize information neglect. Next, Discriminative Preference Alignment enhances robustness against misleading distractors. Finally, Group-Relative Policy Optimization stabilizes logical synthesis to prevent reasoning collapse. Extensive evaluations on eight benchmarks demonstrate that Hit-RAG consistently yields substantial performance gains, enabling models to bridge the gap between context acquisition and accurate reasoning while surpassing much larger counterparts in long-context scenarios.

arXiv:2603.07131v1 Announce Type: cross Abstract: Large Vision Language Models (LVLMs) show immense potential for automated ophthalmic diagnosis. However, their clinical deployment is severely hindered by lacking domain-specific knowledge. In this work, we identify two structural deficiencies hindering reliable medical reasoning: 1) the Perception Gap, where general-purpose visual encoders fail to resolve fine-grained pathological cues (e.g., microaneurysms); and 2) the Reasoning Gap, where sparse visual evidence is progressively overridden by massive language priors in deeper transformer layers, leading to ungrounded hallucinations. To bridge these gaps, we propose EyExIn, a data-efficient framework designed to anchor retinal VLMs with expert knowledge via a Deep Expert Injection mechanism. Our architecture employs an Expert-Aware Dual-Stream encoding strategy that decouples visual representation into a general stream for anatomical context and a specialized expert stream for pathological semantics. To ensure high-fidelity integration, we design a Semantic-Adaptive Gated Fusion module, which dynamically amplifies subtle lesion signals while filtering irrelevant background noise. Furthermore, we introduce Adaptive Deep Expert Injection to embed persistent "Vision Anchors" by integrating fused visual features as residual biases directly into intermediate LLM layers. This mechanism creates a visual shortcut that forces the reasoning stack to remain strictly grounded in visual evidence. Extensive experiments across four benchmarks demonstrate that our model consistently outperforms massive proprietary systems. EyExIn significantly enhances domain-specific knowledge embedding and achieves state-of-the-art precision in ophthalmic visual question answering, advancing the development of trustworthy ophthalmic AI.

arXiv:2603.07264v1 Announce Type: cross Abstract: Data-efficient learning remains a central challenge in autonomous driving due to the high cost and safety risks of large-scale real-world interaction. Although world-model-based reinforcement learning enables policy optimization through latent imagination, existing approaches often lack explicit mechanisms to encode spatial and kinematic structure essential for driving tasks. In this work, we build upon the Recurrent State-Space Model (RSSM) and propose a kinematics-aware latent world model framework for autonomous driving. Vehicle kinematic information is incorporated into the observation encoder to ground latent transitions in physically meaningful motion dynamics, while geometry-aware supervision regularizes the RSSM latent state to capture task-relevant spatial structure beyond pixel reconstruction. The resulting structured latent dynamics improve long-horizon imagination fidelity and stabilize policy optimization. Experiments in a driving simulation benchmark demonstrate consistent gains over both model-free and pixel-based world-model baselines in terms of sample efficiency and driving performance. Ablation studies further verify that the proposed design enhances spatial representation quality within the latent space. These results suggest that integrating kinematic grounding into RSSM-based world models provides a scalable and physically grounded paradigm for autonomous driving policy learning.

arXiv:2603.07980v1 Announce Type: cross Abstract: As language models (LMs) evolve from chat assistants to long-horizon agents capable of multi-step reasoning and tool use, existing benchmarks remain largely confined to structured or exam-style tasks that fall short of real-world professional demands. To this end, we introduce \$OneMillion-Bench \$OneMillion-Bench, a benchmark of 400 expert-curated tasks spanning Law, Finance, Industry, Healthcare, and Natural Science, built to evaluate agents across economically consequential scenarios. Unlike prior work, the benchmark requires retrieving authoritative sources, resolving conflicting evidence, applying domain-specific rules, and making constraint decisions, where correctness depends as much on the reasoning process as the final answer. We adopt a rubric-based evaluation protocol scoring factual accuracy, logical coherence, practical feasibility, and professional compliance, focused on expert-level problems to ensure meaningful differentiation across agents. Together, \$OneMillion-Bench provides a unified testbed for assessing agentic reliability, professional depth, and practical readiness in domain-intensive scenarios.