Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Can Heterogeneous Language Models Be Fused?
arXiv:2604.01674v1 Announce Type: new Abstract: Model merging aims to integrate multiple expert models into a single model that inherits their complementary strengths without incurring the inference-time cost of ensembling. Recent progress has shown that merging can be highly effective when all source models are \emph{homogeneous}, i.e., derived from the same pretrained backbone and therefore share aligned parameter coordinates or compatible task vectors. Yet this assumption is increasingly unr
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cs.AI, q-bio.NC updates on arXiv.org
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AssetOpsBench: Benchmarking AI Agents for Task Automation in Industrial Asset Operations and Maintenance
arXiv:2506.03828v3 Announce Type: replace Abstract: AI for Industrial Asset Lifecycle Management aims to automate complex operational workflows, such as condition monitoring and maintenance scheduling, to minimize system downtime. While traditional AI/ML approaches solve narrow tasks in isolation, Large Language Model (LLM) agents offer a next-generation opportunity for end-to-end automation. In this paper, we introduce AssetOpsBench, a unified framework for orchestrating and evaluating domain-
AssetOpsBench: Benchmarking AI Agents for Task Automation in Industrial Asset Operations and Maintenance
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cs.AI, q-bio.NC updates on arXiv.org
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PsychAgent: An Experience-Driven Lifelong Learning Agent for Self-Evolving Psychological Counselor
arXiv:2604.00931v2 Announce Type: replace Abstract: Existing methods for AI psychological counselors predominantly rely on supervised fine-tuning using static dialogue datasets. However, this contrasts with human experts, who continuously refine their proficiency through clinical practice and accumulated experience. To bridge this gap, we propose an Experience-Driven Lifelong Learning Agent (\texttt{PsychAgent}) for psychological counseling. First, we establish a Memory-Augmented Planning Engin
PsychAgent: An Experience-Driven Lifelong Learning Agent for Self-Evolving Psychological Counselor
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cs.AI, q-bio.NC updates on arXiv.org
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Automating Android Build Repair: Bridging the Reasoning-Execution Gap in LLM Agents with Domain-Specific Tools
arXiv:2510.08640v3 Announce Type: replace-cross Abstract: Android is the largest mobile platform, yet automatically building applications remains a practical challenge. While Large Language Models (LLMs) show promise for code repair, their use for fixing Android build errors remains underexplored. To address this gap, we first introduce AndroidBuildBench, a benchmark of 1,019 build failures curated from the commit histories of 43 open-source Android projects. Each problem is paired with a verif
Automating Android Build Repair: Bridging the Reasoning-Execution Gap in LLM Agents with Domain-Specific Tools
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cs.AI, q-bio.NC updates on arXiv.org
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Do Phone-Use Agents Respect Your Privacy?
arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile a
Do Phone-Use Agents Respect Your Privacy?
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Nature Cancer
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Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling
Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-yHuang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.
Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling
Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-y
Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.-
npj Digital Medicine
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Multidimensional evaluation of large language models in radiology report readability
npj Digital Medicine, Published online: 01 April 2026; doi:10.1038/s41746-026-02589-3Multidimensional evaluation of large language models in radiology report readability
Multidimensional evaluation of large language models in radiology report readability
npj Digital Medicine, Published online: 01 April 2026; doi:10.1038/s41746-026-02589-3
Multidimensional evaluation of large language models in radiology report readability-
cs.AI, q-bio.NC updates on arXiv.org
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A Rational Account of Categorization Based on Information Theory
arXiv:2603.29895v1 Announce Type: new Abstract: We present a new theory of categorization based on an information-theoretic rational analysis. To evaluate this theory, we investigate how well it can account for key findings from classic categorization experiments conducted by Hayes-Roth and Hayes-Roth (1977), Medin and Schaffer (1978), and Smith and Minda (1998). We find that it explains the human categorization behavior at least as well (or better) than the independent cue and context models (
A Rational Account of Categorization Based on Information Theory
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Nature Biotechnology - Issue - nature.com science feeds
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Mirror-enhanced 4Pi-SMLM with one objective enables isotropic nanoscale imaging
Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.
Mirror-enhanced 4Pi-SMLM with one objective enables isotropic nanoscale imaging
Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7
Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.-
Omics In Lung
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A monocyte-centered framework for predicting immunochemotherapy efficacy in lung squamous cell carcinoma patients
EMBO Mol Med. 2026 Mar 30. doi: 10.1038/s44321-026-00410-y. Online ahead of print.ABSTRACTLung cancer is the leading cause of cancer-related mortality worldwide, with lung squamous cell carcinoma (LUSC) comprising 20-30% of cases. Immunochemotherapy (IC) is the standard first-line treatment for advanced LUSC, yet reliable predictors of therapeutic response remain unavailable. Using single-cell multi-omics profiling of paired pre- and post-treatment tumor and blood samples, we observed that patie
A monocyte-centered framework for predicting immunochemotherapy efficacy in lung squamous cell carcinoma patients
EMBO Mol Med. 2026 Mar 30. doi: 10.1038/s44321-026-00410-y. Online ahead of print.
ABSTRACT
Lung cancer is the leading cause of cancer-related mortality worldwide, with lung squamous cell carcinoma (LUSC) comprising 20-30% of cases. Immunochemotherapy (IC) is the standard first-line treatment for advanced LUSC, yet reliable predictors of therapeutic response remain unavailable. Using single-cell multi-omics profiling of paired pre- and post-treatment tumor and blood samples, we observed that patients responding to IC exhibited significantly higher baseline levels of peripheral blood monocytes, tumor-infiltrating classical monocytes, and APOBEC3A+ monocytes across both compartments compared with non-responders. These associations were independently validated in additional cohorts using routine complete blood count testing and multiplex immunofluorescence analysis of native tumor tissues. Our findings reveal monocyte-related parameters as clinically accessible indicators that link systemic immunity with the tumor microenvironment and hold promise for predicting IC responsiveness in patients with LUSC.
PMID:41912871 | DOI:10.1038/s44321-026-00410-y
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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A monocyte-centered framework for predicting immunochemotherapy efficacy in lung squamous cell carcinoma patients
EMBO Mol Med. 2026 Mar 30. doi: 10.1038/s44321-026-00410-y. Online ahead of print.ABSTRACTLung cancer is the leading cause of cancer-related mortality worldwide, with lung squamous cell carcinoma (LUSC) comprising 20-30% of cases. Immunochemotherapy (IC) is the standard first-line treatment for advanced LUSC, yet reliable predictors of therapeutic response remain unavailable. Using single-cell multi-omics profiling of paired pre- and post-treatment tumor and blood samples, we observed that patie
A monocyte-centered framework for predicting immunochemotherapy efficacy in lung squamous cell carcinoma patients
EMBO Mol Med. 2026 Mar 30. doi: 10.1038/s44321-026-00410-y. Online ahead of print.
ABSTRACT
Lung cancer is the leading cause of cancer-related mortality worldwide, with lung squamous cell carcinoma (LUSC) comprising 20-30% of cases. Immunochemotherapy (IC) is the standard first-line treatment for advanced LUSC, yet reliable predictors of therapeutic response remain unavailable. Using single-cell multi-omics profiling of paired pre- and post-treatment tumor and blood samples, we observed that patients responding to IC exhibited significantly higher baseline levels of peripheral blood monocytes, tumor-infiltrating classical monocytes, and APOBEC3A+ monocytes across both compartments compared with non-responders. These associations were independently validated in additional cohorts using routine complete blood count testing and multiplex immunofluorescence analysis of native tumor tissues. Our findings reveal monocyte-related parameters as clinically accessible indicators that link systemic immunity with the tumor microenvironment and hold promise for predicting IC responsiveness in patients with LUSC.
PMID:41912871 | DOI:10.1038/s44321-026-00410-y
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cs.AI, q-bio.NC updates on arXiv.org
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From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents
arXiv:2603.22386v1 Announce Type: new Abstract: Large language model (LLM)-based systems are becoming increasingly popular for solving tasks by constructing executable workflows that interleave LLM calls, information retrieval, tool use, code execution, memory updates, and verification. This survey reviews recent methods for designing and optimizing such workflows, which we treat as agentic computation graphs (ACGs). We organize the literature based on when workflow structure is determined, whe
From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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MedCausalX: Adaptive Causal Reasoning with Self-Reflection for Trustworthy Medical Vision-Language Models
arXiv:2603.23085v1 Announce Type: new Abstract: Vision-Language Models (VLMs) have enabled interpretable medical diagnosis by integrating visual perception with linguistic reasoning. Yet, existing medical chain-of-thought (CoT) models lack explicit mechanisms to represent and enforce causal reasoning, leaving them vulnerable to spurious correlations and limiting their clinical reliability. We pinpoint three core challenges in medical CoT reasoning: how to adaptively trigger causal correction, c
MedCausalX: Adaptive Causal Reasoning with Self-Reflection for Trustworthy Medical Vision-Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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MetaKE: Meta-learning Aligned Knowledge Editing via Bi-level Optimization
arXiv:2603.12677v1 Announce Type: cross Abstract: Knowledge editing (KE) aims to precisely rectify specific knowledge in Large Language Models (LLMs) without disrupting general capabilities. State-of-the-art methods suffer from an open-loop control mismatch. We identify a critical "Semantic-Execution Disconnect": the semantic target is derived independently without feedback from the downstream's feasible region. This misalignment often causes valid semantic targets to fall within the prohibited
MetaKE: Meta-learning Aligned Knowledge Editing via Bi-level Optimization
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Nature - Issue - nature.com science feeds
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Insulin resistance prediction from wearables and routine blood biomarkers
Nature, Published online: 16 March 2026; doi:10.1038/s41586-026-10179-2A machine-learning model that integrates data from wearable devices (such as smartwatches) with blood biomarkers and demographic data can predict whether someone has insulin resistance, enabling timely lifestyle interventions to prevent progression to type 2 diabetes.
Insulin resistance prediction from wearables and routine blood biomarkers
Nature, Published online: 16 March 2026; doi:10.1038/s41586-026-10179-2
A machine-learning model that integrates data from wearable devices (such as smartwatches) with blood biomarkers and demographic data can predict whether someone has insulin resistance, enabling timely lifestyle interventions to prevent progression to type 2 diabetes.-
cs.AI, q-bio.NC updates on arXiv.org
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Property-driven Protein Inverse Folding With Multi-Objective Preference Alignment
arXiv:2603.06748v1 Announce Type: cross Abstract: Protein sequence design must balance designability, defined as the ability to recover a target backbone, with multiple, often competing, developability properties such as solubility, thermostability, and expression. Existing approaches address these properties through post hoc mutation, inference-time biasing, or retraining on property-specific subsets, yet they are target dependent and demand substantial domain expertise or careful hyperparamet
Property-driven Protein Inverse Folding With Multi-Objective Preference Alignment
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cs.AI, q-bio.NC updates on arXiv.org
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Real-Time Aligned Reward Model beyond Semantics
arXiv:2601.22664v3 Announce Type: replace Abstract: Reinforcement Learning from Human Feedback (RLHF) is a pivotal technique for aligning large language models (LLMs) with human preferences, yet it is susceptible to reward overoptimization, in which policy models overfit to the reward model, exploit spurious reward patterns instead of faithfully capturing human intent. Prior mitigations primarily relies on surface semantic information and fails to efficiently address the misalignment between th
Real-Time Aligned Reward Model beyond Semantics
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cs.AI, q-bio.NC updates on arXiv.org
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How Well Do Multimodal Models Reason on ECG Signals?
arXiv:2603.00312v2 Announce Type: replace Abstract: While multimodal large language models offer a promising solution to the "black box" nature of health AI by generating interpretable reasoning traces, verifying the validity of these traces remains a critical challenge. Existing evaluation methods are either unscalable, relying on manual clinician review, or superficial, utilizing proxy metrics (e.g. QA) that fail to capture the semantic correctness of clinical logic. In this work, we introduc
How Well Do Multimodal Models Reason on ECG Signals?
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cs.AI, q-bio.NC updates on arXiv.org
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Adaptive Batch-Wise Sample Scheduling for Direct Preference Optimization
arXiv:2506.17252v4 Announce Type: replace-cross Abstract: Direct Preference Optimization (DPO) has emerged as an effective approach for aligning large language models (LLMs) with human preferences. However, its performance is highly dependent on the quality of the underlying human preference data. To address this bottleneck, prior work has explored various data selection strategies, but these methods often overlook the impact of the evolving states of the language model during the optimization
Adaptive Batch-Wise Sample Scheduling for Direct Preference Optimization
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cs.AI, q-bio.NC updates on arXiv.org
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Metric-Topology Factorization: A Computational Framework for Hippocampal-Neocortical Intelligence
arXiv:2603.03362v1 Announce Type: new Abstract: The brain achieves stability and plasticity in a topologically complex, shifting world through Metric-Topology Factorization (MTF), separating discrete topological indexing for context selection from continuous metric condensation for local inference. Semantically rich environments defy single globally contractive geometries, causing obstructions under shifts, so intelligence factorizes these: the hippocampus provides sparse signatures indexing ma