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cs.AI, q-bio.NC updates on arXiv.org
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Scale over Preference: The Impact of AI-Generated Content on Online Content Ecology
arXiv:2604.01690v1 Announce Type: new Abstract: The rapid proliferation of Artificial Intelligence-Generated Content (AIGC) is fundamentally restructuring online content ecologies, necessitating a rigorous examination of its behavioral and distributional implications. Leveraging a comprehensive longitudinal dataset comprising tens of millions of users from a leading Chinese video-sharing platform, this study elucidated the distinct creation and consumption behaviors characterizing AIGC versus H
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cs.AI, q-bio.NC updates on arXiv.org
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VectorGym: A Multitask Benchmark for SVG Code Generation, Sketching, and Editing
arXiv:2603.29852v1 Announce Type: cross Abstract: We introduce VectorGym, a comprehensive benchmark suite for Scalable Vector Graphics (SVG) that spans generation from text and sketches, complex editing, and visual understanding. VectorGym addresses the lack of realistic, challenging benchmarks aligned with professional design workflows. Our benchmark comprises four tasks with expert human-authored annotations: the novel Sketch2SVG task (VG-Sketch); a new SVG editing dataset (VG-Edit) featuring
VectorGym: A Multitask Benchmark for SVG Code Generation, Sketching, and Editing
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Oncogene - Issue - nature.com science feeds
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TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation
Oncogene, Published online: 24 March 2026; doi:10.1038/s41388-026-03728-6TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation
TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation
Oncogene, Published online: 24 March 2026; doi:10.1038/s41388-026-03728-6
TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation-
Omics in Hepatocellular
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Computational analysis of multi-omics data reveals CXCL10(+) DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma
Cell Mol Life Sci. 2026 Mar 19. doi: 10.1007/s00018-026-06167-4. Online ahead of print.NO ABSTRACTPMID:41854876 | DOI:10.1007/s00018-026-06167-4
Computational analysis of multi-omics data reveals CXCL10(+) DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma
Cell Mol Life Sci. 2026 Mar 19. doi: 10.1007/s00018-026-06167-4. Online ahead of print.
NO ABSTRACT
PMID:41854876 | DOI:10.1007/s00018-026-06167-4
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cs.AI, q-bio.NC updates on arXiv.org
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OpenSage: Self-programming Agent Generation Engine
arXiv:2602.16891v2 Announce Type: replace Abstract: Agent development kits (ADKs) provide effective platforms and tooling for constructing agents, and their designs are critical to the constructed agents' performance, especially the functionality for agent topology, tools, and memory. However, current ADKs either lack sufficient functional support or rely on humans to manually design these components, limiting agents' generalizability and overall performance. We propose OpenSage, the first ADK
OpenSage: Self-programming Agent Generation Engine
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Omics in Hepatocellular
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HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma
Clin Mol Hepatol. 2026 Mar 11. doi: 10.3350/cmh.2025.1269. Online ahead of print.ABSTRACTBACKGROUND/AIMS: Lenvatinib resistance and immune exclusion limit outcomes in HCC. We hypothesized that metabolic rewiring orchestrates resistance to lenvatinib and PD-1 blockade.METHODS: We established LS/LR HCC models and employed multi-omics (proteomics/RNA-seq), ChIP, luciferase, and RIP assays to map HKDC1 regulation. Tumor immunity was profiled by scRNA-seq, mIHC, and flow cytometry. SPD + lenvatinib e
HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma
Clin Mol Hepatol. 2026 Mar 11. doi: 10.3350/cmh.2025.1269. Online ahead of print.
ABSTRACT
BACKGROUND/AIMS: Lenvatinib resistance and immune exclusion limit outcomes in HCC. We hypothesized that metabolic rewiring orchestrates resistance to lenvatinib and PD-1 blockade.
METHODS: We established LS/LR HCC models and employed multi-omics (proteomics/RNA-seq), ChIP, luciferase, and RIP assays to map HKDC1 regulation. Tumor immunity was profiled by scRNA-seq, mIHC, and flow cytometry. SPD + lenvatinib efficacy was tested in cell lines, patient-derived organoids/xenografts. Tested therapy effect in an immunocompetent hydrodynamic HCC model with hepatocyte-specific Hkdc1 deletion; and analyzed a postoperative cohort (n = 40) treated with lenvatinib + PD-1.
RESULTS: HKDC1, upregulated in LR HCC, was transcriptionally activated by USF1 and promoted SMS-mediated polyamine rewiring. This impaired CD8⁺ T-cell metabolism, reversible by HKDC1 knockdown or spermidine (SPD). SPD synergized with lenvatinib, triggering autophagy and suppressing tumor growth in vitro and in vivo. High HKDC1 predicted poor response and survival in patients receiving lenvatinib + aPD-1.
CONCLUSIONS: A USF1/HKDC1/SMS axis couples polyamine metabolism to immune dysfunction and lenvatinib resistance. HKDC1 is a predictive biomarker and therapeutic node and support polyamine-axis modulation to sensitize HCC to lenvatinib plus PD-1 therapy.
PMID:41812646 | DOI:10.3350/cmh.2025.1269
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cs.AI, q-bio.NC updates on arXiv.org
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Towards Efficient Federated Learning of Networked Mixture-of-Experts for Mobile Edge Computing
arXiv:2511.01743v2 Announce Type: replace-cross Abstract: Recent advancements in large artificial intelligence models (LAMs) are driving significant innovations in mobile edge computing within next-generation wireless networks. However, the substantial demands for computational resources and larges-cale training data required to train LAMs conflict with the limited storage and computational capacity of edge devices, posing significant challenges to training and deploying LAMs at the edge. In th
Towards Efficient Federated Learning of Networked Mixture-of-Experts for Mobile Edge Computing
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cs.AI, q-bio.NC updates on arXiv.org
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CrystaL: Spontaneous Emergence of Visual Latents in MLLMs
arXiv:2602.20980v2 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) have achieved remarkable performance by integrating powerful language backbones with large-scale visual encoders. Among these, latent Chain-of-Thought (CoT) methods enable implicit reasoning in continuous hidden states, facilitating seamless vision-language integration and faster inference. However, existing heuristically predefined supervision signals in latent CoT provide limited guidance for pr
CrystaL: Spontaneous Emergence of Visual Latents in MLLMs
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cs.AI, q-bio.NC updates on arXiv.org
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CubeComposer: Spatio-Temporal Autoregressive 4K 360{\deg} Video Generation from Perspective Video
arXiv:2603.04291v1 Announce Type: cross Abstract: Generating high-quality 360{\deg} panoramic videos from perspective input is one of the crucial applications for virtual reality (VR), whereby high-resolution videos are especially important for immersive experience. Existing methods are constrained by computational limitations of vanilla diffusion models, only supporting $\leq$ 1K resolution native generation and relying on suboptimal post super-resolution to increase resolution. We introduce C
CubeComposer: Spatio-Temporal Autoregressive 4K 360{\deg} Video Generation from Perspective Video
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cs.AI, q-bio.NC updates on arXiv.org
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R1-Code-Interpreter: LLMs Reason with Code via Supervised and Multi-stage Reinforcement Learning
arXiv:2505.21668v3 Announce Type: replace Abstract: Practical guidance on training Large Language Models (LLMs) to leverage Code Interpreter across diverse tasks remains lacking. We present R1-Code-Interpreter, an extension of a text-only LLM trained via multi-turn supervised fine-tuning (SFT) and reinforcement learning (RL) to autonomously generate multiple code queries during step-by-step reasoning. Unlike prior RL + tool-use efforts focused on narrow domains such as math or retrieval, we cur
R1-Code-Interpreter: LLMs Reason with Code via Supervised and Multi-stage Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
arXiv:2510.24702v2 Announce Type: replace-cross Abstract: Public research results on large-scale supervised finetuning of AI agents remain relatively rare, since the collection of agent training data presents unique challenges. In this work, we argue that the bottleneck is not a lack of underlying data sources, but that a large variety of data is fragmented across heterogeneous formats, tools, and interfaces. To this end, we introduce the agent data protocol (ADP), a light-weight representation
Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Test-Time Learning of Causal Structure from Interventional Data
arXiv:2602.19131v1 Announce Type: cross Abstract: Supervised causal learning has shown promise in causal discovery, yet it often struggles with generalization across diverse interventional settings, particularly when intervention targets are unknown. To address this, we propose TICL (Test-time Interventional Causal Learning), a novel method that synergizes Test-Time Training with Joint Causal Inference. Specifically, we design a self-augmentation strategy to generate instance-specific training
Test-Time Learning of Causal Structure from Interventional Data
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cs.AI, q-bio.NC updates on arXiv.org
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A Very Big Video Reasoning Suite
arXiv:2602.20159v1 Announce Type: cross Abstract: Rapid progress in video models has largely focused on visual quality, leaving their reasoning capabilities underexplored. Video reasoning grounds intelligence in spatiotemporally consistent visual environments that go beyond what text can naturally capture, enabling intuitive reasoning over spatiotemporal structure such as continuity, interaction, and causality. However, systematically studying video reasoning and its scaling behavior is hindere
A Very Big Video Reasoning Suite
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cs.AI, q-bio.NC updates on arXiv.org
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Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction
Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
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cs.AI, q-bio.NC updates on arXiv.org
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VividFace: Real-Time and Realistic Facial Expression Shadowing for Humanoid Robots
arXiv:2602.07506v2 Announce Type: replace-cross Abstract: Humanoid facial expression shadowing enables robots to realistically imitate human facial expressions in real time, which is critical for lifelike, facially expressive humanoid robots and affective human-robot interaction. Existing progress in humanoid facial expression imitation remains limited, often failing to achieve either real-time performance or realistic expressiveness due to offline video-based inference designs and insufficient