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cs.AI, q-bio.NC updates on arXiv.org
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LiteInception: A Lightweight and Interpretable Deep Learning Framework for General Aviation Fault Diagnosis
arXiv:2604.01725v1 Announce Type: new Abstract: General aviation fault diagnosis and efficient maintenance are critical to flight safety; however, deploying deep learning models on resource-constrained edge devices poses dual challenges in computational capacity and interpretability. This paper proposes LiteInception--a lightweight interpretable fault diagnosis framework designed for edge deployment. The framework adopts a two-stage cascaded architecture aligned with standard maintenance workfl
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cs.AI, q-bio.NC updates on arXiv.org
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UniMixer: A Unified Architecture for Scaling Laws in Recommendation Systems
arXiv:2604.00590v2 Announce Type: replace-cross Abstract: In recent years, the scaling laws of recommendation models have attracted increasing attention, which govern the relationship between performance and parameters/FLOPs of recommenders. Currently, there are three mainstream architectures for achieving scaling in recommendation models, namely attention-based, TokenMixer-based, and factorization-machine-based methods, which exhibit fundamental differences in both design philosophy and archit
UniMixer: A Unified Architecture for Scaling Laws in Recommendation Systems
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Omics In Lung
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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.ABSTRACTPulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and exp
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.
ABSTRACT
Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, we identify mechanosensitive Piezo1 upregulation in Endothelial cells as a hallmark of fibrotic progression. Endothelial-specific Piezo1 knockout significantly attenuates Bleomycin-induced fibrotic remodeling in male mice, establishing its pathogenic necessity. Mechanistically, PIEZO1 activation promotes pulmonary fibrosis development via CAPN2-mediated STAT3 phosphorylation, which may regulate the secretion of the pro-fibrotic molecule interleukin-33. These findings suggest that the endothelial PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for PF intervention.
PMID:41862476 | PMC:PMC13004862 | DOI:10.1038/s41467-026-70193-w
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Oncogene - Issue - nature.com science feeds
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METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation
Oncogene, Published online: 13 March 2026; doi:10.1038/s41388-026-03706-yMETTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation
METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation
Oncogene, Published online: 13 March 2026; doi:10.1038/s41388-026-03706-y
METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation-
cs.AI, q-bio.NC updates on arXiv.org
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Dialogue is Better Than Monologue: Instructing Medical LLMs via Strategical Conversations
arXiv:2501.17860v2 Announce Type: replace-cross Abstract: Current medical AI systems often fail to replicate real-world clinical reasoning, as they are predominantly trained and evaluated on static text and question-answer tasks. These tuning methods and benchmarks overlook critical aspects like evidence-based reasoning and handling distracting information. To bridge this gap, we introduce a novel benchmark that simulates real-world diagnostic scenarios, integrating noise and difficulty levels
Dialogue is Better Than Monologue: Instructing Medical LLMs via Strategical Conversations
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cs.AI, q-bio.NC updates on arXiv.org
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Deep Dense Exploration for LLM Reinforcement Learning via Pivot-Driven Resampling
arXiv:2602.14169v1 Announce Type: cross Abstract: Effective exploration is a key challenge in reinforcement learning for large language models: discovering high-quality trajectories within a limited sampling budget from the vast natural language sequence space. Existing methods face notable limitations: GRPO samples exclusively from the root, saturating high-probability trajectories while leaving deep, error-prone states under-explored. Tree-based methods blindly disperse budgets across trivial
Deep Dense Exploration for LLM Reinforcement Learning via Pivot-Driven Resampling
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cs.AI, q-bio.NC updates on arXiv.org
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Feature Recalibration Based Olfactory-Visual Multimodal Model for Fine-Grained Rice Deterioration Detection
arXiv:2602.14408v1 Announce Type: cross Abstract: Multimodal methods are widely used in rice deterioration detection, which exhibit limited capability in representing and extracting fine-grained abnormal features. Moreover, these methods rely on devices, such as hyperspectral cameras and mass spectrometers, increasing detection costs and prolonging data acquisition time. To address these issues, we propose a feature recalibration based olfactory-visual multimodal model for fine-grained rice det
Feature Recalibration Based Olfactory-Visual Multimodal Model for Fine-Grained Rice Deterioration Detection
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cs.AI, q-bio.NC updates on arXiv.org
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AECBench: A Hierarchical Benchmark for Knowledge Evaluation of Large Language Models in the AEC Field
arXiv:2509.18776v3 Announce Type: replace-cross Abstract: Large language models (LLMs), as a novel information technology, are seeing increasing adoption in the Architecture, Engineering, and Construction (AEC) field. They have shown their potential to streamline processes throughout the building lifecycle. However, the robustness and reliability of LLMs in such a specialized and safety-critical domain remain to be evaluated. To address this challenge, this paper establishes AECBench, a compreh
AECBench: A Hierarchical Benchmark for Knowledge Evaluation of Large Language Models in the AEC Field
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cs.AI, q-bio.NC updates on arXiv.org
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Prior-Guided Symbolic Regression: Towards Scientific Consistency in Equation Discovery
arXiv:2602.13021v2 Announce Type: replace-cross Abstract: Symbolic Regression (SR) aims to discover interpretable equations from observational data, with the potential to reveal underlying principles behind natural phenomena. However, existing approaches often fall into the Pseudo-Equation Trap: producing equations that fit observations well but remain inconsistent with fundamental scientific principles. A key reason is that these approaches are dominated by empirical risk minimization, lacking