Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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GA-GS: Generation-Assisted Gaussian Splatting for Static Scene Reconstruction
arXiv:2604.04331v1 Announce Type: cross Abstract: Reconstructing static 3D scene from monocular video with dynamic objects is important for numerous applications such as virtual reality and autonomous driving. Current approaches typically rely on background for static scene reconstruction, limiting the ability to recover regions occluded by dynamic objects. In this paper, we propose GA-GS, a Generation-Assisted Gaussian Splatting method for Static Scene Reconstruction. The key innovation of our
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Protective Effects of the Ethyl Acetate Fraction from Madeng'ai on Lipopolysaccharide-Induced Acute Lung Injury in Mice: Insights from Integrated Multi-Omics Analysis
J Ethnopharmacol. 2026 Apr 4:121650. doi: 10.1016/j.jep.2026.121650. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Madeng'ai (MDA) is a traditional medicinal plant of the Dong ethnic group. Its roots have been widely used in folk medicine for clearing heat and removing toxins, alleviating swelling and relieving pain, dispersing blood stasis and arresting bleeding, as well as promoting wound healing. It is taxonomically classified as a variety of Potentilla freyniana Bornm.AIM OF
Protective Effects of the Ethyl Acetate Fraction from Madeng'ai on Lipopolysaccharide-Induced Acute Lung Injury in Mice: Insights from Integrated Multi-Omics Analysis
J Ethnopharmacol. 2026 Apr 4:121650. doi: 10.1016/j.jep.2026.121650. Online ahead of print.
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE: Madeng'ai (MDA) is a traditional medicinal plant of the Dong ethnic group. Its roots have been widely used in folk medicine for clearing heat and removing toxins, alleviating swelling and relieving pain, dispersing blood stasis and arresting bleeding, as well as promoting wound healing. It is taxonomically classified as a variety of Potentilla freyniana Bornm.
AIM OF THE STUDY: Acute lung injury (ALI) is a life-threatening pulmonary disorder associated with high mortality, underscoring the urgent need to explore novel therapeutic strategies. This study aimed to evaluate the protective effects of the ethyl acetate fraction of MDA (MEA) against LPS-induced ALI in mice and to investigate its underlying mechanisms.
MATERIALS AND METHODS: LC-MS/MS was employed to tentatively identify the bioactive components of MEA. A mouse model of ALI was established by LPS induction. The protective effects of MEA were evaluated through assessments of lung histopathology, inflammatory cytokine levels, and oxidative stress markers. The underlying mechanisms were systematically investigated by integrating transcriptomics, metabolomics, network pharmacology, molecular docking, and Western blotting.
RESULTS: MEA significantly attenuated LPS-induced pulmonary pathological lesions, pulmonary edema, and excessive inflammatory responses in ALI mice. Comprehensive bioinformatics analyses predicted potential mechanisms involving oxidative stress and the regulation of metabolic pathways. Experimental validation via Western blotting confirmed that MEA inhibited TLR4-mediated inflammatory signaling and modulated the PI3K/AKT pathway, thereby exerting multi-pathway protective effects against ALI.
CONCLUSIONS: Collectively, this study confirms that MEA, as a traditional herbal extract, holds potential as an adjuvant therapeutic agent for ALI, providing experimental evidence for the modernization and development of ethnic medicines.
PMID:41941987 | DOI:10.1016/j.jep.2026.121650
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Omics In Lung
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Protective Effects of the Ethyl Acetate Fraction from Madeng'ai on Lipopolysaccharide-Induced Acute Lung Injury in Mice: Insights from Integrated Multi-Omics Analysis
J Ethnopharmacol. 2026 Apr 4:121650. doi: 10.1016/j.jep.2026.121650. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Madeng'ai (MDA) is a traditional medicinal plant of the Dong ethnic group. Its roots have been widely used in folk medicine for clearing heat and removing toxins, alleviating swelling and relieving pain, dispersing blood stasis and arresting bleeding, as well as promoting wound healing. It is taxonomically classified as a variety of Potentilla freyniana Bornm.AIM OF
Protective Effects of the Ethyl Acetate Fraction from Madeng'ai on Lipopolysaccharide-Induced Acute Lung Injury in Mice: Insights from Integrated Multi-Omics Analysis
J Ethnopharmacol. 2026 Apr 4:121650. doi: 10.1016/j.jep.2026.121650. Online ahead of print.
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE: Madeng'ai (MDA) is a traditional medicinal plant of the Dong ethnic group. Its roots have been widely used in folk medicine for clearing heat and removing toxins, alleviating swelling and relieving pain, dispersing blood stasis and arresting bleeding, as well as promoting wound healing. It is taxonomically classified as a variety of Potentilla freyniana Bornm.
AIM OF THE STUDY: Acute lung injury (ALI) is a life-threatening pulmonary disorder associated with high mortality, underscoring the urgent need to explore novel therapeutic strategies. This study aimed to evaluate the protective effects of the ethyl acetate fraction of MDA (MEA) against LPS-induced ALI in mice and to investigate its underlying mechanisms.
MATERIALS AND METHODS: LC-MS/MS was employed to tentatively identify the bioactive components of MEA. A mouse model of ALI was established by LPS induction. The protective effects of MEA were evaluated through assessments of lung histopathology, inflammatory cytokine levels, and oxidative stress markers. The underlying mechanisms were systematically investigated by integrating transcriptomics, metabolomics, network pharmacology, molecular docking, and Western blotting.
RESULTS: MEA significantly attenuated LPS-induced pulmonary pathological lesions, pulmonary edema, and excessive inflammatory responses in ALI mice. Comprehensive bioinformatics analyses predicted potential mechanisms involving oxidative stress and the regulation of metabolic pathways. Experimental validation via Western blotting confirmed that MEA inhibited TLR4-mediated inflammatory signaling and modulated the PI3K/AKT pathway, thereby exerting multi-pathway protective effects against ALI.
CONCLUSIONS: Collectively, this study confirms that MEA, as a traditional herbal extract, holds potential as an adjuvant therapeutic agent for ALI, providing experimental evidence for the modernization and development of ethnic medicines.
PMID:41941987 | DOI:10.1016/j.jep.2026.121650
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cs.AI, q-bio.NC updates on arXiv.org
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Captioning Daily Activity Images in Early Childhood Education: Benchmark and Algorithm
arXiv:2604.01941v1 Announce Type: cross Abstract: Image captioning for Early Childhood Education (ECE) is essential for automated activity understanding and educational assessment. However, existing methods face two key challenges. First, the lack of large-scale, domain-specific datasets limits the model's ability to capture fine-grained semantic concepts unique to ECE scenarios, resulting in generic and imprecise descriptions. Second, conventional training paradigms exhibit limitations in enha
Captioning Daily Activity Images in Early Childhood Education: Benchmark and Algorithm
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cs.AI, q-bio.NC updates on arXiv.org
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JFTA-Bench: Evaluate LLM's Ability of Tracking and Analyzing Malfunctions Using Fault Trees
arXiv:2603.22978v1 Announce Type: new Abstract: In the maintenance of complex systems, fault trees are used to locate problems and provide targeted solutions. To enable fault trees stored as images to be directly processed by large language models, which can assist in tracking and analyzing malfunctions, we propose a novel textual representation of fault trees. Building on it, we construct a benchmark for multi-turn dialogue systems that emphasizes robust interaction in complex environments, ev
JFTA-Bench: Evaluate LLM's Ability of Tracking and Analyzing Malfunctions Using Fault Trees
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cs.AI, q-bio.NC updates on arXiv.org
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SortedRL: Accelerating RL Training for LLMs through Online Length-Aware Scheduling
arXiv:2603.23414v1 Announce Type: cross Abstract: Scaling reinforcement learning (RL) has shown strong promise for enhancing the reasoning abilities of large language models (LLMs), particularly in tasks requiring long chain-of-thought generation. However, RL training efficiency is often bottlenecked by the rollout phase, which can account for up to 70% of total training time when generating long trajectories (e.g., 16k tokens), due to slow autoregressive generation and synchronization overhead
SortedRL: Accelerating RL Training for LLMs through Online Length-Aware Scheduling
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cs.AI, q-bio.NC updates on arXiv.org
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SARE: Sample-wise Adaptive Reasoning for Training-free Fine-grained Visual Recognition
arXiv:2603.17729v2 Announce Type: replace-cross Abstract: Recent advances in Large Vision-Language Models (LVLMs) have enabled training-free Fine-Grained Visual Recognition (FGVR). However, effectively exploiting LVLMs for FGVR remains challenging due to the inherent visual ambiguity of subordinate-level categories. Existing methods predominantly adopt either retrieval-oriented or reasoning-oriented paradigms to tackle this challenge, but both are constrained by two fundamental limitations:(1)
SARE: Sample-wise Adaptive Reasoning for Training-free Fine-grained Visual Recognition
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Nature - Issue - nature.com science feeds
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Precipitation observing network gaps limit climate change impact assessment
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.
Precipitation observing network gaps limit climate change impact assessment
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5
At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.-
Cell
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Human-specific features of the cerebellum and ZP2-regulated synapse development
Human-specific transcriptomic and regulatory features are present in the cerebellum, with ZP2 playing a key role in synapse regulation. ZP2 expression is induced by pontine mossy fibers, leading to decreased synaptic proteins and neuronal activity, which provides insights into the evolutionary development of the human cerebellum.
Human-specific features of the cerebellum and ZP2-regulated synapse development
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cs.AI, q-bio.NC updates on arXiv.org
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Evaluation Faking: Unveiling Observer Effects in Safety Evaluation of Frontier AI Systems
arXiv:2505.17815v2 Announce Type: replace Abstract: As foundation models grow increasingly more intelligent, reliable and trustworthy safety evaluation becomes more indispensable than ever. However, an important question arises: Whether and how an advanced AI system would perceive the situation of being evaluated, and lead to the broken integrity of the evaluation process? During standard safety tests on a mainstream large reasoning model, we unexpectedly observe that the model without any cont
Evaluation Faking: Unveiling Observer Effects in Safety Evaluation of Frontier AI Systems
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Journal of Medical Internet Research
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Effects of Digital Health Interventions on Functional and Psychological Outcomes in Older Patients With Hip Fractures: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Hip fractures in older adults increasingly challenge public health, making traditional rehabilitation very challenging. Digital health interventions (DHIs) have emerged as a promising solution for postoperative rehabilitation. However, evidence on DHIs’ effects on functional and psychological outcomes remains insufficient. Objective: This systematic review aimed to comprehensively examine the effects of DHIs on functional and psychological outcomes in older adults with hip fractures.
Effects of Digital Health Interventions on Functional and Psychological Outcomes in Older Patients With Hip Fractures: Systematic Review and Meta-Analysis of Randomized Controlled Trials
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cs.AI, q-bio.NC updates on arXiv.org
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Rel-MOSS: Towards Imbalanced Relational Deep Learning on Relational Databases
arXiv:2603.07916v1 Announce Type: new Abstract: In recent advances, to enable a fully data-driven learning paradigm on relational databases (RDB), relational deep learning (RDL) is proposed to structure the RDB as a heterogeneous entity graph and adopt the graph neural network (GNN) as the predictive model. However, existing RDL methods neglect the imbalance problem of relational data in RDBs and risk under-representing the minority entities, leading to an unusable model in practice. In this wo
Rel-MOSS: Towards Imbalanced Relational Deep Learning on Relational Databases
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Oncogene - Issue - nature.com science feeds
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Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor
Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03708-wDexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor
Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor
Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03708-w
Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor-
cs.AI, q-bio.NC updates on arXiv.org
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UniG2U-Bench: Do Unified Models Advance Multimodal Understanding?
arXiv:2603.03241v1 Announce Type: cross Abstract: Unified multimodal models have recently demonstrated strong generative capabilities, yet whether and when generation improves understanding remains unclear. Existing benchmarks lack a systematic exploration of the specific tasks where generation facilitates understanding. To this end, we introduce UniG2U-Bench, a comprehensive benchmark categorizing generation-to-understanding (G2U) evaluation into 7 regimes and 30 subtasks, requiring varying de
UniG2U-Bench: Do Unified Models Advance Multimodal Understanding?
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cs.AI, q-bio.NC updates on arXiv.org
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Revisiting Graph Neural Networks for Graph-level Tasks: Taxonomy, Empirical Study, and Future Directions
arXiv:2501.00773v2 Announce Type: replace-cross Abstract: Graphs are fundamental data structures for modeling complex interactions in domains such as social networks, molecular structures, and biological systems. Graph-level tasks, which involve predicting properties or labels for entire graphs, are crucial for applications like molecular property prediction and subgraph counting. While Graph Neural Networks (GNNs) have shown significant promise for these tasks, their evaluations are often limi
Revisiting Graph Neural Networks for Graph-level Tasks: Taxonomy, Empirical Study, and Future Directions
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cs.AI, q-bio.NC updates on arXiv.org
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ParaCook: On Time-Efficient Planning for Multi-Agent Systems
arXiv:2510.11608v2 Announce Type: replace Abstract: Large Language Models (LLMs) exhibit strong reasoning abilities for planning long-horizon, real-world tasks, yet existing agent benchmarks focus on task completion while neglecting time efficiency in parallel and asynchronous operations. To address this, we present ParaCook, a benchmark for time-efficient collaborative planning. Inspired by the Overcooked game, ParaCook provides an environment for various challenging interaction planning of mu