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Received β€” 8 April 2026 ⏭

ReFinE: Streamlining UI Mockup Iteration with Research Findings

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Donghoon Shin Β· Bingcan Guo Β· Jaewook Lee Β· Lucy Lu Wang Β· Gary Hsieh
7 April 2026 at 12:00
arXiv:2604.04353v1 Announce Type: cross Abstract: Although HCI research papers offer valuable design insights, designers often struggle to apply them in design workflows due to difficulties in finding relevant literature, understanding technical jargon, the lack of contextualization, and limited actionability. To address these challenges, we present ReFinE, a Figma plugin that supports real-time design iteration by surfacing contextualized insights from research papers. ReFinE identifies and synthesizes design implications from HCI literature relevant to the mockup's design context, and tailors this research evidence to a specific design mockup by providing actionable visual guidance on how to update the mockup. To assess the system's effectiveness, we conducted a technical evaluation and a user study. Results show that ReFinE effectively synthesizes and contextualizes design implications, reducing cognitive load and improving designers' ability to integrate research evidence into UI mockups. This work contributes to bridging the gap between research and design practice by presenting a tool for embedding scholarly insights into the UI design process.
Received β€” 4 April 2026 ⏭

Integrated spatial transcriptomics and pan-cancer XGBoost modeling uncover spatial drivers of immune exclusion and predict immunotherapy response

βœ‡(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
By: Hongying Zhao Β· Wangyang Liu Β· Haotian Xu Β· Lu Wang Β· Zushun Chen Β· Yanwu Sun Β· Li Wang
2 April 2026 at 18:00

Cancer Immunol Immunother. 2026 Apr 2;75(4):131. doi: 10.1007/s00262-026-04374-3.

ABSTRACT

Immunotherapy has revolutionized cancer treatment, yet characterizing the spatial complexity of the tumor immune microenvironment remains a challenge. In this study, we established a comprehensive computational framework integrating multi-omics profiling across 27 cancer types to decode immune-related non-coding RNA regulatory networks. Moving beyond traditional bulk analysis, we utilized spatial transcriptomics to dissect the spatial localization of these regulators. We identified the SNHG6-BIRC5 axis as a critical driver of the "immune-cold" phenotype in lung adenocarcinoma. We provide visual evidence that this axis localizes to tumor nests and negatively correlates with T- cell infiltration, elucidating a mechanism of spatial immune exclusion. Validating the clinical relevance of these findings, genome-scale CRISPR-Cas9 screening data confirmed the functional essentiality of these targets for cancer cell survival. Furthermore, pharmacogenomic analysis revealed that high expression of this axis correlates with sensitivity to chemotherapy agents like Vinblastine, suggesting a potential stratification strategy for patients with immune-excluded tumors. To expand the clinical utility to immunotherapy prediction, we developed a pan-cancer XGBoost machine learning model incorporating 14 high-performance regulatory features. This model achieved robust performance in distinguishing immunotherapy responders from non-responders with an AUC of 0.771, outperforming traditional markers such as PD-L1. Collectively, this study highlights spatial determinants of immune exclusion and chemotherapy sensitivity- and presents a generalized machine- learning tool for precision immunotherapy stratification. The developed online resource is freely available to facilitate community-wide biomarker discovery.

PMID:41925746 | DOI:10.1007/s00262-026-04374-3

Integrated spatial transcriptomics and pan-cancer XGBoost modeling uncover spatial drivers of immune exclusion and predict immunotherapy response

βœ‡Omics In Lung
By: Hongying Zhao Β· Wangyang Liu Β· Haotian Xu Β· Lu Wang Β· Zushun Chen Β· Yanwu Sun Β· Li Wang
2 April 2026 at 18:00

Cancer Immunol Immunother. 2026 Apr 2;75(4):131. doi: 10.1007/s00262-026-04374-3.

ABSTRACT

Immunotherapy has revolutionized cancer treatment, yet characterizing the spatial complexity of the tumor immune microenvironment remains a challenge. In this study, we established a comprehensive computational framework integrating multi-omics profiling across 27 cancer types to decode immune-related non-coding RNA regulatory networks. Moving beyond traditional bulk analysis, we utilized spatial transcriptomics to dissect the spatial localization of these regulators. We identified the SNHG6-BIRC5 axis as a critical driver of the "immune-cold" phenotype in lung adenocarcinoma. We provide visual evidence that this axis localizes to tumor nests and negatively correlates with T- cell infiltration, elucidating a mechanism of spatial immune exclusion. Validating the clinical relevance of these findings, genome-scale CRISPR-Cas9 screening data confirmed the functional essentiality of these targets for cancer cell survival. Furthermore, pharmacogenomic analysis revealed that high expression of this axis correlates with sensitivity to chemotherapy agents like Vinblastine, suggesting a potential stratification strategy for patients with immune-excluded tumors. To expand the clinical utility to immunotherapy prediction, we developed a pan-cancer XGBoost machine learning model incorporating 14 high-performance regulatory features. This model achieved robust performance in distinguishing immunotherapy responders from non-responders with an AUC of 0.771, outperforming traditional markers such as PD-L1. Collectively, this study highlights spatial determinants of immune exclusion and chemotherapy sensitivity- and presents a generalized machine- learning tool for precision immunotherapy stratification. The developed online resource is freely available to facilitate community-wide biomarker discovery.

PMID:41925746 | PMC:PMC13046951 | DOI:10.1007/s00262-026-04374-3

Received β€” 14 March 2026 ⏭

HLER: Human-in-the-Loop Economic Research via Multi-Agent Pipelines for Empirical Discovery

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Chen Zhu Β· Xiaolu Wang
10 March 2026 at 12:00
arXiv:2603.07444v1 Announce Type: new Abstract: Large language models (LLMs) have enabled agent-based systems that aim to automate scientific research workflows. Most existing approaches focus on fully autonomous discovery, where AI systems generate research ideas, conduct analyses, and produce manuscripts with minimal human involvement. However, empirical research in economics and the social sciences poses additional constraints: research questions must be grounded in available datasets, identification strategies require careful design, and human judgment remains essential for evaluating economic significance. We introduce HLER (Human-in-the-Loop Economic Research), a multi-agent architecture that supports empirical research automation while preserving critical human oversight. The system orchestrates specialized agents for data auditing, data profiling, hypothesis generation, econometric analysis, manuscript drafting, and automated review. A key design principle is dataset-aware hypothesis generation, where candidate research questions are constrained by dataset structure, variable availability, and distributional diagnostics, reducing infeasible or hallucinated hypotheses. HLER further implements a two-loop architecture: a question quality loop that screens and selects feasible hypotheses, and a research revision loop where automated review triggers re-analysis and manuscript revision. Human decision gates are embedded at key stages, allowing researchers to guide the automated pipeline. Experiments on three empirical datasets show that dataset-aware hypothesis generation produces feasible research questions in 87% of cases (versus 41% under unconstrained generation), while complete empirical manuscripts can be produced at an average API cost of $0.8-$1.5 per run. These results suggest that Human-AI collaborative pipelines may provide a practical path toward scalable empirical research.
Received β€” 11 March 2026 ⏭

Countdown-Code: A Testbed for Studying The Emergence and Generalization of Reward Hacking in RLVR

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Muhammad Khalifa Β· Zohaib Khan Β· Omer Tafveez Β· Hao Peng Β· Lu Wang
10 March 2026 at 12:00
arXiv:2603.07084v1 Announce Type: cross Abstract: Reward hacking is a form of misalignment in which models overoptimize proxy rewards without genuinely solving the underlying task. Precisely measuring reward hacking occurrence remains challenging because true task rewards are often expensive or impossible to compute. We introduce Countdown-Code, a minimal environment where models can both solve a mathematical reasoning task and manipulate the test harness. This dual-access design creates a clean separation between proxy rewards (test pass/fail) and true rewards (mathematical correctness), enabling accurate measurement of reward-hacking rates. Using this environment, we study reward hacking in open-weight LLMs and find that such behaviors can be unintentionally learned during supervised fine-tuning (SFT) when even a small fraction of reward-hacking trajectories leak into training data. As little as 1\% contamination in distillation SFT data is sufficient for models to internalize reward hacking which resurfaces during subsequent reinforcement learning (RL). We further show that RL amplifies misalignment and drives its generalization beyond the original domain. We open-source our environment and code to facilitate future research on reward hacking in LLMs. Our results reveal a previously underexplored pathway through which reward hacking can emerge and persist in LLMs, underscoring the need for more rigorous validation of synthetic SFT data. Code is available at https://github.com/zohaib-khan5040/Countdown-Code.
Received β€” 17 February 2026 ⏭

Mitigating the Safety-utility Trade-off in LLM Alignment via Adaptive Safe Context Learning

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Yanbo Wang Β· Minzheng Wang Β· Jian Liang Β· Lu Wang Β· Yongcan Yu Β· Ran He
17 February 2026 at 13:00
arXiv:2602.13562v1 Announce Type: cross Abstract: While reasoning models have achieved remarkable success in complex reasoning tasks, their increasing power necessitates stringent safety measures. For safety alignment, the core challenge lies in the inherent trade-off between safety and utility. However, prevailing alignment strategies typically construct CoT training data with explicit safety rules via context distillation. This approach inadvertently limits reasoning capabilities by creating a rigid association between rule memorization and refusal. To mitigate the safety-utility trade-off, we propose the Adaptive Safe Context Learning (ASCL) framework to improve the reasoning given proper context. ASCL formulates safety alignment as a multi-turn tool-use process, empowering the model to autonomously decide when to consult safety rules and how to generate the ongoing reasoning. Furthermore, to counteract the preference for rule consultation during RL, we introduce Inverse Frequency Policy Optimization (IFPO) to rebalance advantage estimates. By decoupling rule retrieval and subsequent reasoning, our method achieves higher overall performance compared to baselines.
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