arXiv:2605.25281v2 Announce Type: cross Abstract: Recent advances in large language models (LLMs) have made it increasingly difficult to distinguish human-written text from AI-generated content. Many existing detectors train supervised neural classifiers that achieve strong in-distribution performance but are often opaque and can degrade substantially under distribution shift. We present READER, a reasoning-enhanced AI text detector that outputs both a human/AI label and a structured rationale describing the evidence for its decision. A key component of our approach is READ, a curated supervision set of rationales and verdicts. We fine-tune an LLM on READ to build READER, which reasons before detecting at inference time. Despite having only 1.5B parameters, READER consistently outperforms existing detectors as well as prompted, high-capacity LLM baselines (GPT-5.2, Gemini-3-Pro, and DeepSeek-V3.2), which are 100 to 1000 times larger in scale.

Oncogene, Published online: 24 May 2026; doi:10.1038/s41388-026-03826-5

Liver-specific SIRT1 knockout-induced hyperglycemia promotes spontaneous lung adenocarcinomas through HSF1-MDM2

Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10644-y

Accelerating scientific discovery with Co-Scientist

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0

PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10349-2

Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the equator and declined towards higher latitudes, partly linked to temperature, legumes, mycorrhizal associations and canopy nursing effect.

arXiv:2501.11782v2 Announce Type: replace-cross Abstract: As modern video games become increasingly complex, traditional manual testing methods are proving costly and inefficient, limiting the ability to ensure high-quality game experiences. While advancements in Artificial Intelligence (AI) offer the potential to assist human testers, the effectiveness of AI in truly enhancing real-world human performance remains underexplored. This study investigates how AI can improve game testing by developing and experimenting with an AI-assisted workflow that leverages state-of-the-art machine learning models for defect detection. Through an experiment involving 800 test cases and 276 participants of varying backgrounds, we evaluate the effectiveness of AI assistance under four conditions: with or without AI support, and with or without detailed knowledge of defects and design documentation. The results indicate that AI assistance significantly improves defect identification performance, particularly when paired with detailed knowledge. However, challenges arise when AI errors occur, negatively impacting human decision-making. Our findings show the importance of optimizing human-AI collaboration and implementing strategies to mitigate the effects of AI inaccuracies. By this research, we demonstrate AI's potential and problems in enhancing efficiency and accuracy in game testing workflows and offers practical insights for integrating AI into the testing process.

arXiv:2510.05318v3 Announce Type: replace Abstract: Large language models (LLMs) have demonstrated remarkable performance on single-turn text-to-SQL tasks, but real-world database applications predominantly require multi-turn interactions to handle ambiguous queries, execution errors, and evolving user requirements. Existing multi-turn benchmarks fall short by treating conversation histories as static context or limiting evaluation to read-only operations, failing to reflect production-grade database assistant challenges. We introduce BIRD-INTERACT, a benchmark that restores this realism through: (1) a comprehensive interaction environment coupling each database with a hierarchical knowledge base, metadata files, and a function-driven user simulator, enabling models to solicit clarifications, retrieve knowledge, and recover from errors without human supervision; (2) two evaluation settings consisting of a pre-defined conversational protocol (c-Interact) and an open-ended agentic setting (a-Interact) where models autonomously decide when to query the user simulator or explore the environment; (3) a challenging task suite covering the full CRUD spectrum for business-intelligence and operational use cases, guarded by executable test cases. Each task features ambiguous and follow-up sub-tasks requiring dynamic interaction. The suite comprises BIRD-INTERACT-FULL (600 tasks, up to 11,796 interactions) for comprehensive performance assessment, and BIRD-INTERACT-LITE (300 tasks with simplified databases) for detailed behavioral analysis and rapid method development. Our empirical results highlight BIRD-INTERACT's difficulty: GPT-5 completes only 8.67% of tasks in c-Interact and 17.00% in a-Interact. Analysis via memory grafting and Interaction Test-time Scaling validates the importance of effective interaction for complex, dynamic text-to-SQL tasks.

Nature Cancer, Published online: 13 March 2026; doi:10.1038/s43018-026-01137-y

RNA N6-methyladenosine (m6A) is the most abundant internal RNA modification, yet its functional landscape in cancer remains poorly defined. A study now introduces a METTL3-based RNA base-editing screen that maps functional m6A sites and reveals m6A-dependent translational activation of the tumor suppressor CHD9 in prostate cancer and beyond.

arXiv:2602.10016v2 Announce Type: replace-cross Abstract: Deriving predictable scaling laws that govern the relationship between model performance and computational investment is crucial for designing and allocating resources in massive-scale recommendation systems. While such laws are established for large language models, they remain challenging for recommendation systems, especially those processing both user history and context features. We identify poor scaling efficiency as the main barrier to predictable power-law scaling, stemming from inefficient modules with low Model FLOPs Utilization (MFU) and suboptimal resource allocation. We introduce Kunlun, a scalable architecture that systematically improves model efficiency and resource allocation. Our low-level optimizations include Generalized Dot-Product Attention (GDPA), Hierarchical Seed Pooling (HSP), and Sliding Window Attention. Our high-level innovations feature Computation Skip (CompSkip) and Event-level Personalization. These advances increase MFU from 17% to 37% on NVIDIA B200 GPUs and double scaling efficiency over state-of-the-art methods. Kunlun is now deployed in major Meta Ads models, delivering significant production impact.