Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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When Does Multi-Agent RL Improve LLM Workflows? Workflow, Scale, and Policy-Sharing Tradeoffs
arXiv:2605.24202v1 Announce Type: new Abstract: Multi-agent LLM workflows route inference through specialized roles to lift end-task accuracy, but jointly training those roles with reinforcement learning is unstable in ways that are poorly understood. We study when end-to-end RL training of multi-agent LLM workflows improves over their base models, comparing Shared-Policy training, where all roles update one policy, with Isolated-Policy training, where each role has its own parameters. Our expe
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cs.AI, q-bio.NC updates on arXiv.org
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STREAM: A Data-Centric Framework for Mining High-Value Task-Oriented Dialogues from Streaming Media
arXiv:2605.25162v1 Announce Type: cross Abstract: Large language models for vertical domains are bottlenecked by the scarcity of complex, domain-specific task-oriented dialogues. Existing data acquisition pipelines face a persistent trilemma: expert annotation is expensive, real-world service conversations are constrained by privacy and commercial restrictions, and static corpora quickly become temporally stale. We propose Stream, a data-centric framework that leverages publicly available strea
STREAM: A Data-Centric Framework for Mining High-Value Task-Oriented Dialogues from Streaming Media
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cs.AI, q-bio.NC updates on arXiv.org
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AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
arXiv:2605.20025v2 Announce Type: replace Abstract: Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across cycles. Existing autonomous research systems often model this process as a linear pipeline: they rely on single-agent reasoning, stop when execution fails, and do not carry experience across runs. We present
AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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BacktestBench: Benchmarking Large Language Models for Automated Quantitative Strategy Backtesting
arXiv:2605.17937v2 Announce Type: replace-cross Abstract: Quantitative backtesting is essential for evaluating trading strategies but remains hampered by high technical barriers and limited scalability. While Large Language Models (LLMs) offer a transformative path to automate this complex, interdisciplinary workflow through advanced code generation, tool usage, and agentic planning, the practical realization is significantly challenged by the current lack of a large-scale benchmark dedicated t
BacktestBench: Benchmarking Large Language Models for Automated Quantitative Strategy Backtesting
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AAAS: Table of Contents
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Nodeless superconducting gap and electron-boson coupling in (La,Pr,Sm)3Ni2O7 films
Science, Ahead of Print.
Nodeless superconducting gap and electron-boson coupling in (La,Pr,Sm)3Ni2O7 films
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Nature - Issue - nature.com science feeds
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A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-xA fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.
A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x
A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.-
Omics in Hepatocellular
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Spatial transcriptomic-metabolic features of tumor foci and tumor capsule in microvascular invasion with hepatocellular carcinoma: A spatial multi-omics study
PLoS Med. 2026 May 15;23(5):e1004703. doi: 10.1371/journal.pmed.1004703. eCollection 2026 May.ABSTRACTBACKGROUND: Microvascular invasion (MVI) is closely related to the recurrence and metastasis of hepatocellular carcinoma (HCC), but the underlying cellular mechanism remains largely elusive. This study aims to elucidate the regional cellular discrepancy between MVI-positive (MVI+) and MVI-negative (MVI-) HCC by integrating Spatial transcriptomics (ST) and spatial metabolomics (SM).METHODS AND FI
Spatial transcriptomic-metabolic features of tumor foci and tumor capsule in microvascular invasion with hepatocellular carcinoma: A spatial multi-omics study
PLoS Med. 2026 May 15;23(5):e1004703. doi: 10.1371/journal.pmed.1004703. eCollection 2026 May.
ABSTRACT
BACKGROUND: Microvascular invasion (MVI) is closely related to the recurrence and metastasis of hepatocellular carcinoma (HCC), but the underlying cellular mechanism remains largely elusive. This study aims to elucidate the regional cellular discrepancy between MVI-positive (MVI+) and MVI-negative (MVI-) HCC by integrating Spatial transcriptomics (ST) and spatial metabolomics (SM).
METHODS AND FINDINGS: ST and SM were performed on six tissue samples from four patients (including 2 MVI+, 2 MVI-, and 2 paratumor tissues), with the integration of 79 public single-cell RNA sequencing datasets of HCC. Patient identity was used as a covariate in the linear equation for regional differentially expressed gene analysis with the ST data. Clinical validation was conducted through multiplex immunofluorescence staining in 79 patients, together with external validation in the cancer genome atlas (TCGA)-liver hepatocellular carcinoma (LIHC) cohort (n = 299) and an independent microarray dataset (n = 62). For cell-type-specific metabolic profiling, spatial transcriptomic-metabolic registration was performed. The functional roles of key metabolites were further validated in vitro using inflammatory cancer-associated fibroblasts (iCAFs) derived from hepatic stellate cells (HSCs) and primary CAFs through co-culture models and various functional assays assessing cell proliferation, migration, and invasion. In the tumor lesion, a malignant STMN1+HMGN2+GPC3+ cell subtype enriched in MVI+ HCC was identified, which exhibited enhanced proliferative activity and was associated with poor prognosis. This finding was further confirmed in a local cohort of 79 patients, where multiplex immunofluorescence staining for the three genes (STMN1, HMGN2, and GPC3) showed significantly higher expression in the MVI+ group than in the MVI- group (p = 0.046). Integrated SM analysis further revealed that this cell population underwent metabolic reprogramming characterized by suppressed glycerolipid metabolism. In the tumor capsule, iCAFs-related genes were downregulated in MVI+ cases, and iCAFs were located distally from the tumor boundary. Spatial metabolite mapping showed a strong correlation between taurine and iCAFs, and functional assays demonstrated that taurine promotes HCC proliferation and migration by suppressing iCAF activity. One limitation of this study is the small sample size of spatial omics data, which hinders a more complete molecular functional analysis of the STMN1+HMGN2+GPC3+ cell subtype and iCAFs in MVI+ HCC. Larger-scale ST cohorts are required to further validate and expand the findings of this study.
CONCLUSIONS: This integrative spatial atlas proposes a hypothesis that there exists a highly proliferative and metabolically reprogrammed malignant cell subtype in the tumor lesion of MVI+ HCC, and that taurine in the tumor capsule modulates iCAF activity to influence tumor progression. The exploratory results provide mechanistic insights into MVI-related HCC progression and offer potential avenues for targeted therapeutic intervention of MVI+ HCC.
PMID:42139279 | PMC:PMC13178920 | DOI:10.1371/journal.pmed.1004703
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Omics In Lung
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Integrated radiopathomics nomogram for predicting angiogenic microvascular patterns in NSCLC: a dual-center validation study
Ann Med. 2026 Dec;58(1):2654291. doi: 10.1080/07853890.2026.2654291. Epub 2026 Apr 17.ABSTRACTBACKGROUND: To develop and validate an integrated radiopathomics nomogram combining multiphase CT images, H&E-stained slides, and clinicopathological variables for predicting microvascular patterns (MVPs) in non-small cell lung cancer (NSCLC).METHODS: We retrospectively included consecutive surgically resected NSCLC patients from two centers (n = 258). Patients from center 1 were randomly divided in
Integrated radiopathomics nomogram for predicting angiogenic microvascular patterns in NSCLC: a dual-center validation study
Ann Med. 2026 Dec;58(1):2654291. doi: 10.1080/07853890.2026.2654291. Epub 2026 Apr 17.
ABSTRACT
BACKGROUND: To develop and validate an integrated radiopathomics nomogram combining multiphase CT images, H&E-stained slides, and clinicopathological variables for predicting microvascular patterns (MVPs) in non-small cell lung cancer (NSCLC).
METHODS: We retrospectively included consecutive surgically resected NSCLC patients from two centers (n = 258). Patients from center 1 were randomly divided into training and internal validation cohorts, while patients from center 2 formed external validation cohort. CD34-immunohistochemistry was used as the reference standard for MVPs to classify patients into non-angiogenic alveolar (NAA) and non-NAA groups. Radiomics and pathomics features were extracted to construct single-phase radiomics, combined radiomics, and pathomics models. Rad-score and Path-score were derived from combined radiomics and pathomics models, respectively. Rad-score, Path-score, and clinicopathological independent predictors were integrated to develop a nomogram. Model performance was assessed by area under the curve (AUC), calibration curve, decision curve analysis (DCA), and DeLong test.
RESULTS: On multivariable analysis, histological grade was an independent predictor of NAA MVP. Combined radiomics model for predicting MVPs achieved AUCs of 0.863, 0.856, and 0.849 in training, internal validation, and external validation cohorts, showing better performance than single-phase models. Pathomics model yielded AUCs of 0.878, 0.860, and 0.833, however, its specificity markedly decreased in validation cohorts. Nomogram model achieved the superior performance across all cohorts, with AUCs of 0.911, 0.903, and 0.901, outperforming single-modality models (DeLong test: all p < 0.05).
CONCLUSION: The nomogram demonstrated high accuracy and robustness in predicting MVPs in NSCLC, offering a promising tool for characterizing the tumor microenvironment and supporting individualized treatment.
PMID:41992828 | DOI:10.1080/07853890.2026.2654291
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Cell
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Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures
A pan-neurodegeneration atlas built from multilayer, deep proteomics of 2,279 brain samples across 6 major diseases integrates whole proteome, detergent-insoluble proteome, and posttranslational modifications to enable intra- and inter-disease comparisons to reveal disease-specific subtypes and dysregulated pathways, while identifying shared changes such as GPNMB upregulation and NPTX2 downregulation.
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Characterization and regulatory mechanism evaluation of C8orf33 in hepatocellular carcinoma through multiomics profiling
Discov Oncol. 2026 Apr 11. doi: 10.1007/s12672-026-04951-z. Online ahead of print.ABSTRACTBACKGROUND: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Chromosome 8 open reading frame 33 (C8orf33) has been noted as a potential oncogenic factor in several cancers, but its biological roles and regulatory mechanism in HCC microenvironment remain unknown.METHODS: We integrated bulk RNA sequencing, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST) to
Characterization and regulatory mechanism evaluation of C8orf33 in hepatocellular carcinoma through multiomics profiling
Discov Oncol. 2026 Apr 11. doi: 10.1007/s12672-026-04951-z. Online ahead of print.
ABSTRACT
BACKGROUND: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Chromosome 8 open reading frame 33 (C8orf33) has been noted as a potential oncogenic factor in several cancers, but its biological roles and regulatory mechanism in HCC microenvironment remain unknown.
METHODS: We integrated bulk RNA sequencing, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST) to characterize the expression landscape of C8orf33. We then performed C8orf33 loss-of-function studies in HCC cell lines, including in vitro phenotypic assays and subcutaneous xenografts.
RESULTS: C8orf33 was broadly overexpressed and associated with unfavorable prognosis across multiple Cancers. In HCC, higher C8orf33 aligned with advanced stage and shorter overall survival. C8orf33 knockdown reduced proliferation and migration, impaired tumorigenic capacity, and increased apoptosis. ScRNA-seq analyses identified a malignant population of Epi3 with high C8orf33 expression. Cell-cell communication analysis suggested that C8orf33-high Epi3 state was associated with an enriched MIF-CD74/CXCR4/CD44 signaling program toward macrophage populations with M2-like features. ST analyses further confirmed the colocalization of C8orf33 with malignant features in tumor cores. In Huh7 cells, C8orf33 knockdown was accompanied by reduced mRNA and protein levels of MIF and its receptor components. Consistently, xenografts derived from C8orf33-silenced cells showed lower expression of these MIF-axis components and reduced infiltration of CD163 and CD206-positive macrophages.
CONCLUSION: These results support a tumor-promoting association of C8orf33 in HCC and suggest a potential link to macrophage-associated immunomodulatory features, nominating C8orf33 as a candidate biomarker and therapeutic target.
PMID:41965457 | DOI:10.1007/s12672-026-04951-z
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Omics in Hepatocellular
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Characterization and regulatory mechanism evaluation of C8orf33 in hepatocellular carcinoma through multiomics profiling
Discov Oncol. 2026 Apr 11. doi: 10.1007/s12672-026-04951-z. Online ahead of print.ABSTRACTBACKGROUND: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Chromosome 8 open reading frame 33 (C8orf33) has been noted as a potential oncogenic factor in several cancers, but its biological roles and regulatory mechanism in HCC microenvironment remain unknown.METHODS: We integrated bulk RNA sequencing, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST) to
Characterization and regulatory mechanism evaluation of C8orf33 in hepatocellular carcinoma through multiomics profiling
Discov Oncol. 2026 Apr 11. doi: 10.1007/s12672-026-04951-z. Online ahead of print.
ABSTRACT
BACKGROUND: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Chromosome 8 open reading frame 33 (C8orf33) has been noted as a potential oncogenic factor in several cancers, but its biological roles and regulatory mechanism in HCC microenvironment remain unknown.
METHODS: We integrated bulk RNA sequencing, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST) to characterize the expression landscape of C8orf33. We then performed C8orf33 loss-of-function studies in HCC cell lines, including in vitro phenotypic assays and subcutaneous xenografts.
RESULTS: C8orf33 was broadly overexpressed and associated with unfavorable prognosis across multiple Cancers. In HCC, higher C8orf33 aligned with advanced stage and shorter overall survival. C8orf33 knockdown reduced proliferation and migration, impaired tumorigenic capacity, and increased apoptosis. ScRNA-seq analyses identified a malignant population of Epi3 with high C8orf33 expression. Cell-cell communication analysis suggested that C8orf33-high Epi3 state was associated with an enriched MIF-CD74/CXCR4/CD44 signaling program toward macrophage populations with M2-like features. ST analyses further confirmed the colocalization of C8orf33 with malignant features in tumor cores. In Huh7 cells, C8orf33 knockdown was accompanied by reduced mRNA and protein levels of MIF and its receptor components. Consistently, xenografts derived from C8orf33-silenced cells showed lower expression of these MIF-axis components and reduced infiltration of CD163 and CD206-positive macrophages.
CONCLUSION: These results support a tumor-promoting association of C8orf33 in HCC and suggest a potential link to macrophage-associated immunomodulatory features, nominating C8orf33 as a candidate biomarker and therapeutic target.
PMID:41965457 | DOI:10.1007/s12672-026-04951-z
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Nature - Issue - nature.com science feeds
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Single-cell spatiotemporal dissection of the human maternal–fetal interface
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10316-xA single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.
Single-cell spatiotemporal dissection of the human maternal–fetal interface
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10316-x
A single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.-
Nature - Issue - nature.com science feeds
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Superconductivity and electronic structures of nickelate thin film superstructures
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .
Superconductivity and electronic structures of nickelate thin film superstructures
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7
Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .-
Nature Cancer
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Harnessing foundation models for digital pathology without re-training
Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-025-01108-9Applications of digital pathology in clinical oncology have largely depended on the requirement for labeled data and model re-training. A study now presents PRET, a training-free framework with robust performance for pan-cancer diagnosis that adapts pathology foundation models to diverse tasks at inference stage, from screening and subtyping tasks to segmentation and metastasis detection tasks.
Harnessing foundation models for digital pathology without re-training
Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-025-01108-9
Applications of digital pathology in clinical oncology have largely depended on the requirement for labeled data and model re-training. A study now presents PRET, a training-free framework with robust performance for pan-cancer diagnosis that adapts pathology foundation models to diverse tasks at inference stage, from screening and subtyping tasks to segmentation and metastasis detection tasks.-
cs.AI, q-bio.NC updates on arXiv.org
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Beyond Matching to Tiles: Bridging Unaligned Aerial and Satellite Views for Vision-Only UAV Navigation
arXiv:2603.22153v2 Announce Type: replace-cross Abstract: Recent advances in cross-view geo-localization (CVGL) methods have shown strong potential for supporting unmanned aerial vehicle (UAV) navigation in GNSS-denied environments. However, existing work predominantly focuses on matching UAV views to onboard map tiles, which introduces an inherent trade-off between accuracy and storage overhead, and overlooks the importance of the UAV's heading during navigation. Moreover, the substantial disc
Beyond Matching to Tiles: Bridging Unaligned Aerial and Satellite Views for Vision-Only UAV Navigation
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cs.AI, q-bio.NC updates on arXiv.org
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Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
arXiv:2512.16301v3 Announce Type: replace Abstract: Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool use, and OpenClaw highlights a newer direction in which agents accumulate persistent memory and reusable skills. Yet the research landscape remains fragmented across post-training, retrieval, memory, and skill
Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
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cs.AI, q-bio.NC updates on arXiv.org
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Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
arXiv:2602.13810v2 Announce Type: replace-cross Abstract: Learning expressive and efficient policy functions is a promising direction in reinforcement learning (RL). While flow-based policies have recently proven effective in modeling complex action distributions with a fast deterministic sampling process, they still face a trade-off between expressiveness and computational burden, which is typically controlled by the number of flow steps. In this work, we propose mean velocity policy (MVP), a
Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Condition-Gated Reasoning for Context-Dependent Biomedical Question Answering
arXiv:2602.17911v2 Announce Type: replace-cross Abstract: Current biomedical question answering (QA) systems often assume that medical knowledge applies uniformly, yet real-world clinical reasoning is inherently conditional: nearly every decision depends on patient-specific factors such as comorbidities and contraindications. Existing benchmarks do not evaluate such conditional reasoning, and retrieval-augmented or graph-based methods lack explicit mechanisms to ensure that retrieved knowledge
Condition-Gated Reasoning for Context-Dependent Biomedical Question Answering
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cs.AI, q-bio.NC updates on arXiv.org
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GreenPhase: A Green Learning Approach for Earthquake Phase Picking
arXiv:2603.03344v1 Announce Type: cross Abstract: Earthquake detection and seismic phase picking are fundamental yet challenging tasks in seismology due to low signal-to-noise ratios, waveform variability, and overlapping events. Recent deep-learning models achieve strong results but rely on large datasets and heavy backpropagation training, raising concerns over efficiency, interpretability, and sustainability. We propose GreenPhase, a multi-resolution, feed-forward, and mathematically inter
GreenPhase: A Green Learning Approach for Earthquake Phase Picking
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cs.AI, q-bio.NC updates on arXiv.org
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Kaleido: Open-Sourced Multi-Subject Reference Video Generation Model
arXiv:2510.18573v2 Announce Type: replace-cross Abstract: We present Kaleido, a subject-to-video~(S2V) generation framework, which aims to synthesize subject-consistent videos conditioned on multiple reference images of target subjects. Despite recent progress in S2V generation models, existing approaches remain inadequate at maintaining multi-subject consistency and at handling background disentanglement, often resulting in lower reference fidelity and semantic drift under multi-image conditio