Oncogenesis, Published online: 19 April 2026; doi:10.1038/s41389-026-00619-z

PRMT6-mediated EZH2 arginine methylation is critical for breast cancer development

arXiv:2603.28532v2 Announce Type: replace-cross Abstract: Low left ventricular ejection fraction (LEF) frequently remains undetected until progression to symptomatic heart failure, underscoring the need for scalable screening strategies. Although artificial intelligence-enabled electrocardiography (AI-ECG) has shown promise, existing approaches rely solely on end-to-end black-box models with limited interpretability or on tabular systems dependent on commercial ECG measurement algorithms with suboptimal performance. We introduced ECG-based Predictor-Driven LEF (ECGPD-LEF), a structured framework that integrates foundation model-derived diagnostic probabilities with interpretable modeling for detecting LEF from ECG. Trained on the benchmark EchoNext dataset comprising 72,475 ECG-echocardiogram pairs and evaluated in predefined independent internal (n=5,442) and external (n=16,017) cohorts, our framework achieved robust discrimination for moderate LEF (internal AUROC 88.4%, F1 64.5%; external AUROC 86.8%, F1 53.6%), consistently outperforming the official end-to-end baseline provided with the benchmark across demographic and clinical subgroups. Interpretability analyses identified high-impact predictors, including normal ECG, incomplete left bundle branch block, and subendocardial injury in anterolateral leads, driving LEF risk estimation. Notably, these predictors independently enabled zero-shot-like inference without task-specific retraining (internal AUROC 75.3-81.0%; external AUROC 71.6-78.6%), indicating that ventricular dysfunction is intrinsically encoded within structured diagnostic probability representations. This framework reconciles predictive performance with mechanistic transparency, supporting scalable enhancement through additional predictors and seamless integration with existing AI-ECG systems.

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03742-8

Deciphering functional intra-tumoral heterogeneity in BRAF^V600E-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling

Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7

Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.

arXiv:2603.12298v1 Announce Type: cross Abstract: Activation engineering enables precise control over Large Language Models (LLMs) without the computational cost of fine-tuning. However, existing methods deriving vectors from static activation differences are susceptible to high-dimensional noise and layer-wise semantic drift, often capturing spurious correlations rather than the target intent. To address this, we propose Global Evolutionary Refined Steering (GER-steer), a training-free framework that grounded in the geometric stability of the network's representation evolution. GER-steer exploits this global signal to rectify raw steering vectors, effectively decoupling robust semantic intent from orthogonal artifacts. Extensive evaluations confirm that GER-steer consistently outperforms baselines, delivering superior efficacy and generalization without layer-specific tuning, establishing a universal solution for reliable model alignment.