Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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SAM: State-Adaptive Memory for Long-Horizon Reasoning Agent
arXiv:2605.24468v1 Announce Type: new Abstract: Long-horizon agentic reasoning requires large language models to act over long interaction histories containing thoughts, tool calls, observations, and partial conclusions. The challenge is not merely that these histories grow long, but that information needed for the current decision may be scattered across distant steps and only become relevant later. Existing approaches address this difficulty by truncating the interaction history, compressing
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cs.AI, q-bio.NC updates on arXiv.org
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AgentFugue: Agent Scaling for Long-Horizon Tasks through Collective Reasoning
arXiv:2605.24486v1 Announce Type: new Abstract: Recent progress on long-horizon agentic tasks has been driven largely by scaling up individual agents through stronger models, better tools, and more effective scaffolding. In contrast, much less is understood about scaling out: whether multiple peer agents, all targeting the same task, can become an additional source of capability without relying on explicit role specialization or workflow orchestration. We study this question and propose AgentFu
AgentFugue: Agent Scaling for Long-Horizon Tasks through Collective Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Distributionally Robust Transfer Learning with Structurally Missing Covariates, with Application to Cross-National Cardiac Arrest Prediction
arXiv:2605.24212v1 Announce Type: cross Abstract: Deploying clinical prediction models across healthcare systems often fails when key training covariates are unavailable at deployment and labeled outcomes are limited in the target domain. For example, high-performing models for out-of-hospital cardiac arrest (OHCA) rely on detailed prehospital measurements routinely collected in high-resource settings but unavailable in many international registries. Existing methods either discard missing cova
Distributionally Robust Transfer Learning with Structurally Missing Covariates, with Application to Cross-National Cardiac Arrest Prediction
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Nature Medicine
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AI-induced never-skilling in medical education
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-yWill medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.
AI-induced never-skilling in medical education
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-y
Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.-
Omics in Gastric
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Characterization of dysbiosis patterns in gut microbiota of digestive system cancers: an umbrella review
Front Microbiol. 2026 Apr 28;17:1782471. doi: 10.3389/fmicb.2026.1782471. eCollection 2026.ABSTRACTDigestive system cancers (DSCs) represent a substantial global health burden. In recent years, the role of gut microbiota in the DSCs has garnered considerable attention, but its change pattern during tumor progression and the specific mechanisms are still not fully understood. We conducted a comprehensive systematic review to characterize patterns of gut microbiota dysbiosis across different DSC t
Characterization of dysbiosis patterns in gut microbiota of digestive system cancers: an umbrella review
Front Microbiol. 2026 Apr 28;17:1782471. doi: 10.3389/fmicb.2026.1782471. eCollection 2026.
ABSTRACT
Digestive system cancers (DSCs) represent a substantial global health burden. In recent years, the role of gut microbiota in the DSCs has garnered considerable attention, but its change pattern during tumor progression and the specific mechanisms are still not fully understood. We conducted a comprehensive systematic review to characterize patterns of gut microbiota dysbiosis across different DSC types and assess their clinical significance. We systematically searched four English and three Chinese databases up to January 2025 to identify systematic reviews focused on the dynamic characteristics of the gut microbiota during gastrointestinal tumorigenesis. Microbiota biodiversity and taxonomic composition were extracted to identify specific signatures associated with DSCs. The ROBIS tool was used to evaluate the methodological quality of the included studies. Ultimately, 59 studies involving six distinct DSC types were included. Data synthesis and comparison revealed distinct microbiota profiles across DSCs. At the phylum level, Bacillota was decreased in esophageal cancer (EC) and pancreatic ductal adenocarcinoma (PDAC), Pseudomonadota was augmented in EC but exhibited divergent trajectories in colorectal cancer (CRC) and PDAC. Genus-level analyses revealed Veillonella enrichment in EC and PDAC, and Fusobacterium outgrowth in EC, gastric cancer (GC) and CRC. Parvimonas and Streptococcus showed a concordant ascending trend in GC and CRC. Prevotella was overrepresented in EC and GC. This synthesis delineates a qualitative landscape of gut microbiota imbalances associated with various DSCs, highlighting the potential for these microbial shifts to serve as markers for early detection and targeted therapy. Multiomics integration and prospective cohort studies should be prioritized to accelerate clinical translation.
PMID:42131199 | PMC:PMC13161176 | DOI:10.3389/fmicb.2026.1782471
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Oncogene - Issue - nature.com science feeds
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Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis
Oncogene, Published online: 18 April 2026; doi:10.1038/s41388-026-03797-7Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis
Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis
Oncogene, Published online: 18 April 2026; doi:10.1038/s41388-026-03797-7
Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis-
npj Digital Medicine
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Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02527-3Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02527-3
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma-
cs.AI, q-bio.NC updates on arXiv.org
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MCP Security Bench (MSB): Benchmarking Attacks Against Model Context Protocol in LLM Agents
arXiv:2510.15994v2 Announce Type: replace-cross Abstract: The Model Context Protocol (MCP) standardizes how large language model (LLM) agents discover, describe, and call external tools. While MCP unlocks broad interoperability, it also enlarges the attack surface by making tools first-class, composable objects with natural-language metadata, and standardized I/O. We present MSB (MCP Security Benchmark), the first end-to-end evaluation suite that systematically measures how well LLM agents resi