Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Claw-Anything: Benchmarking Always-On Personal Assistants with Broader Access to User's Digital World
arXiv:2605.26086v1 Announce Type: new Abstract: Large language model agents are increasingly envisioned as always-on personal assistants with access to anything relevant in the user's digital world. Yet current systems operate over only narrow slices of that world, limiting context-sensitive reasoning and effective assistance. Existing benchmarks similarly provide only partial user state and therefore fail to capture performance in such a broad, always-on setting. To address this gap, we introd
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Pulmonary nodule
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The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review
J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.ABSTRACTBACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidat
The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review
J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.
ABSTRACT
BACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidate the growth kinetics of solid nodular non-small cell lung cancer (NSCLC) as a critical determinant of early diagnosis, prognostic evaluation, and treatment strategy selection, and to address the challenge that significant heterogeneity in tumor growth poses to risk stratification and clinical decision-making.
METHODS: We conducted a retrospective search of PubMed, Embase, Web of Science, and Scopus databases, focusing on the current research status of solid nodular NSCLC, particularly in terms of molecular mechanisms, prognosis, modeling prediction, and management strategies related to its growth heterogeneity, with the aim of exploring future research directions.
KEY CONTENT AND FINDINGS: Volume doubling time (VDT) serves as a key metric for evaluating nodule dynamics. While earlier studies suggested a generally rapid growth pattern (VDT <400 days) in solid nodular NSCLC, recent evidence reveals considerable heterogeneity, with some tumors demonstrating indolent growth pattern (VDT >40-600 days). The prognosis of rapidly growing nodules is usually poor, so nodule management recommendations should be personalized based on growth dynamics and patient characteristics. Traditional radiological features, and deep learning models show promise for growth risk stratification but require large-scale external validation and refinement. Molecular and pathological studies suggest that the tumor microenvironment and immune cell infiltration may contribute to growth heterogeneity, though direct mechanistic evidence remains limited. Artificial intelligence (AI) based approaches exhibit significant potential in predicting individual tumor growth behavior.
CONCLUSIONS: Growth heterogeneity in solid nodular NSCLC carries substantial clinical significance but remains insufficiently studied. Future research should prioritize imaging based modeling to predict individualized growth dynamics. Integrating multi-omics analyses may help elucidate the molecular factors underlying growth heterogeneity. AI driven risk stratification based on large-scale multi center sequence data can achieve truly personalized and growth oriented management strategies.
PMID:42182806 | PMC:PMC13190150 | DOI:10.21037/jtd-2025-1-2697
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review
J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.ABSTRACTBACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidat
The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review
J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.
ABSTRACT
BACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidate the growth kinetics of solid nodular non-small cell lung cancer (NSCLC) as a critical determinant of early diagnosis, prognostic evaluation, and treatment strategy selection, and to address the challenge that significant heterogeneity in tumor growth poses to risk stratification and clinical decision-making.
METHODS: We conducted a retrospective search of PubMed, Embase, Web of Science, and Scopus databases, focusing on the current research status of solid nodular NSCLC, particularly in terms of molecular mechanisms, prognosis, modeling prediction, and management strategies related to its growth heterogeneity, with the aim of exploring future research directions.
KEY CONTENT AND FINDINGS: Volume doubling time (VDT) serves as a key metric for evaluating nodule dynamics. While earlier studies suggested a generally rapid growth pattern (VDT <400 days) in solid nodular NSCLC, recent evidence reveals considerable heterogeneity, with some tumors demonstrating indolent growth pattern (VDT >40-600 days). The prognosis of rapidly growing nodules is usually poor, so nodule management recommendations should be personalized based on growth dynamics and patient characteristics. Traditional radiological features, and deep learning models show promise for growth risk stratification but require large-scale external validation and refinement. Molecular and pathological studies suggest that the tumor microenvironment and immune cell infiltration may contribute to growth heterogeneity, though direct mechanistic evidence remains limited. Artificial intelligence (AI) based approaches exhibit significant potential in predicting individual tumor growth behavior.
CONCLUSIONS: Growth heterogeneity in solid nodular NSCLC carries substantial clinical significance but remains insufficiently studied. Future research should prioritize imaging based modeling to predict individualized growth dynamics. Integrating multi-omics analyses may help elucidate the molecular factors underlying growth heterogeneity. AI driven risk stratification based on large-scale multi center sequence data can achieve truly personalized and growth oriented management strategies.
PMID:42182806 | PMC:PMC13190150 | DOI:10.21037/jtd-2025-1-2697
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Omics In Lung
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The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review
J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.ABSTRACTBACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidat
The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review
J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.
ABSTRACT
BACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidate the growth kinetics of solid nodular non-small cell lung cancer (NSCLC) as a critical determinant of early diagnosis, prognostic evaluation, and treatment strategy selection, and to address the challenge that significant heterogeneity in tumor growth poses to risk stratification and clinical decision-making.
METHODS: We conducted a retrospective search of PubMed, Embase, Web of Science, and Scopus databases, focusing on the current research status of solid nodular NSCLC, particularly in terms of molecular mechanisms, prognosis, modeling prediction, and management strategies related to its growth heterogeneity, with the aim of exploring future research directions.
KEY CONTENT AND FINDINGS: Volume doubling time (VDT) serves as a key metric for evaluating nodule dynamics. While earlier studies suggested a generally rapid growth pattern (VDT <400 days) in solid nodular NSCLC, recent evidence reveals considerable heterogeneity, with some tumors demonstrating indolent growth pattern (VDT >40-600 days). The prognosis of rapidly growing nodules is usually poor, so nodule management recommendations should be personalized based on growth dynamics and patient characteristics. Traditional radiological features, and deep learning models show promise for growth risk stratification but require large-scale external validation and refinement. Molecular and pathological studies suggest that the tumor microenvironment and immune cell infiltration may contribute to growth heterogeneity, though direct mechanistic evidence remains limited. Artificial intelligence (AI) based approaches exhibit significant potential in predicting individual tumor growth behavior.
CONCLUSIONS: Growth heterogeneity in solid nodular NSCLC carries substantial clinical significance but remains insufficiently studied. Future research should prioritize imaging based modeling to predict individualized growth dynamics. Integrating multi-omics analyses may help elucidate the molecular factors underlying growth heterogeneity. AI driven risk stratification based on large-scale multi center sequence data can achieve truly personalized and growth oriented management strategies.
PMID:42182806 | PMC:PMC13190150 | DOI:10.21037/jtd-2025-1-2697
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AAAS: Table of Contents
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Nodeless superconducting gap and electron-boson coupling in (La,Pr,Sm)3Ni2O7 films
Science, Ahead of Print.
Nodeless superconducting gap and electron-boson coupling in (La,Pr,Sm)3Ni2O7 films
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Nature - Issue - nature.com science feeds
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Nonlinear atomic tunnelling boosted by bright squeezed vacuum
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10485-9Bright squeezed vacuum light boosts nonlinear atomic tunnelling ionization more than 20-fold compared with coherent light, enabling quantum control of strong-field processes without increasing classical intensity.
Nonlinear atomic tunnelling boosted by bright squeezed vacuum
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10485-9
Bright squeezed vacuum light boosts nonlinear atomic tunnelling ionization more than 20-fold compared with coherent light, enabling quantum control of strong-field processes without increasing classical intensity.-
Nature Cancer
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Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance
Nature Cancer, Published online: 19 May 2026; doi:10.1038/s43018-026-01174-7Tang et al. identify cysteinyl leukotriene receptor 1 (CysLTR1) as a critical regulator of tumor-induced myelopoiesis, suggesting CysLTR1 targeting to sensitize tumors to immune checkpoint blockade.
Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance
Nature Cancer, Published online: 19 May 2026; doi:10.1038/s43018-026-01174-7
Tang et al. identify cysteinyl leukotriene receptor 1 (CysLTR1) as a critical regulator of tumor-induced myelopoiesis, suggesting CysLTR1 targeting to sensitize tumors to immune checkpoint blockade.-
Nature - Issue - nature.com science feeds
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Engineered immunosuppressive dendritic cells protect against cardiac remodelling
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.
Engineered immunosuppressive dendritic cells protect against cardiac remodelling
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5
Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.-
Nature - Issue - nature.com science feeds
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Superconductivity and electronic structures of nickelate thin film superstructures
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .
Superconductivity and electronic structures of nickelate thin film superstructures
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7
Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .-
Nature Biotechnology - Issue - nature.com science feeds
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Sequence Display enables large-scale sequence–activity datasets for rapid protein evolution
Nature Biotechnology, Published online: 08 April 2026; doi:10.1038/s41587-026-03087-3Sequence Display maps protein variant activities to a sequencing-based readout.
Sequence Display enables large-scale sequence–activity datasets for rapid protein evolution
Nature Biotechnology, Published online: 08 April 2026; doi:10.1038/s41587-026-03087-3
Sequence Display maps protein variant activities to a sequencing-based readout.-
cs.AI, q-bio.NC updates on arXiv.org
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Can LLMs Learn to Reason Robustly under Noisy Supervision?
arXiv:2604.03993v1 Announce Type: cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) effectively trains reasoning models that rely on abundant perfect labels, but its vulnerability to unavoidable noisy labels due to expert scarcity remains critically underexplored. In this work, we take the first step toward a systematic analysis of noisy label mechanisms in RLVR. In contrast to supervised classification, most RLVR algorithms incorporate a rollout-based condition: a label's i
Can LLMs Learn to Reason Robustly under Noisy Supervision?
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cs.AI, q-bio.NC updates on arXiv.org
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Vero: An Open RL Recipe for General Visual Reasoning
arXiv:2604.04917v2 Announce Type: cross Abstract: What does it take to build a visual reasoner that works across charts, science, spatial understanding, and open-ended tasks? The strongest vision-language models (VLMs) show such broad visual reasoning is within reach, but the recipe behind them remains unclear, locked behind proprietary reinforcement learning (RL) pipelines with non-public data. We introduce Vero, a family of fully open VLMs that matches or exceeds existing open-weight models a
Vero: An Open RL Recipe for General Visual Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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RaPA: Enhancing Transferable Targeted Attacks via Random Parameter Pruning
arXiv:2504.18594v3 Announce Type: replace-cross Abstract: Compared to untargeted attacks, targeted transfer-based attack is still suffering from much lower Attack Success Rates (ASRs), although significant improvements have been achieved by kinds of methods, such as diversifying input, stabilizing the gradient, and re-training surrogate models. In this paper, we find that adversarial examples generated by existing methods rely heavily on a small subset of surrogate model parameters, which in tu
RaPA: Enhancing Transferable Targeted Attacks via Random Parameter Pruning
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Oncogene - Issue - nature.com science feeds
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NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy
Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03762-4NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy
NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy
Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03762-4
NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy-
Cell
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Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain
The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.
Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain
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cs.AI, q-bio.NC updates on arXiv.org
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LLM-Meta-SR: In-Context Learning for Evolving Selection Operators in Symbolic Regression
arXiv:2505.18602v3 Announce Type: replace-cross Abstract: Large language models (LLMs) have revolutionized algorithm development, yet their application in symbolic regression, where algorithms automatically discover symbolic expressions from data, remains limited. In this paper, we propose a meta-learning framework that enables LLMs to automatically design selection operators for evolutionary symbolic regression algorithms. We first identify two key limitations in existing LLM-based algorithm e
LLM-Meta-SR: In-Context Learning for Evolving Selection Operators in Symbolic Regression
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Cell Death Discovery nature.com science feeds
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p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials
Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03060-8p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials
p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials
Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03060-8
p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials-
cs.AI, q-bio.NC updates on arXiv.org
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OpenSage: Self-programming Agent Generation Engine
arXiv:2602.16891v2 Announce Type: replace Abstract: Agent development kits (ADKs) provide effective platforms and tooling for constructing agents, and their designs are critical to the constructed agents' performance, especially the functionality for agent topology, tools, and memory. However, current ADKs either lack sufficient functional support or rely on humans to manually design these components, limiting agents' generalizability and overall performance. We propose OpenSage, the first ADK
OpenSage: Self-programming Agent Generation Engine
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cs.AI, q-bio.NC updates on arXiv.org
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OTESGN: Optimal Transport-Enhanced Syntactic-Semantic Graph Networks for Aspect-Based Sentiment Analysis
arXiv:2509.08612v3 Announce Type: replace-cross Abstract: Aspect-based sentiment analysis (ABSA) aims to identify aspect terms and determine their sentiment polarity. While dependency trees combined with contextual semantics provide structural cues, existing approaches often rely on dot-product similarity and fixed graphs, which limit their ability to capture nonlinear associations and adapt to noisy contexts. To address these limitations, we propose the Optimal Transport-Enhanced Syntactic-Sem
OTESGN: Optimal Transport-Enhanced Syntactic-Semantic Graph Networks for Aspect-Based Sentiment Analysis
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cs.AI, q-bio.NC updates on arXiv.org
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MapReduce LoRA: Advancing the Pareto Front in Multi-Preference Optimization for Generative Models
arXiv:2511.20629v4 Announce Type: replace-cross Abstract: Reinforcement learning from human feedback (RLHF) with reward models has advanced alignment of generative models to human aesthetic and perceptual preferences. However, jointly optimizing multiple rewards often incurs an alignment tax, improving one dimension while degrading others. To address this, we introduce two complementary methods: MapReduce LoRA and Reward-aware Token Embedding (RaTE). MapReduce LoRA trains preference-specific Lo