arXiv:2605.25413v1 Announce Type: cross Abstract: Neural operators learn mappings from function-dependent inputs to solutions, providing an effective framework for solving partial differential equations (PDEs). For time-dependent PDEs, existing methods typically perform long-horizon prediction through autoregressive rollout directly in high-dimensional physical field spaces, where each predicted state is recursively fed back as the input for the next step. Although effective for short-term prediction, this autoregressive rollout and the lack of continuous-time modeling lead to progressive error accumulation over long-horizon rollouts. In this work, we propose Autoregression-Free Neural Operators (AFNO), which map the time evolution of PDEs into a latent space and model continuous-time vector fields within it. AFNO uses flow matching to learn the latent vector field, thereby enabling continuous evolution over extended horizons, avoiding autoregressive rollout and capturing dynamics under varying parameter configurations through explicit conditioning on physical parameters. Theoretical analysis and extensive experiments on six PDEs demonstrate that AFNO improves long-horizon prediction stability and consistently reduces rollout errors compared with the baselines.

arXiv:2506.10054v4 Announce Type: replace-cross Abstract: Direct Preference Optimization (DPO) has emerged as a cornerstone of reinforcement learning from human feedback (RLHF) due to its simplicity and efficiency. However, existing DPO-based methods typically treat all preference pairs equally, overlooking substantial variations in data quality and learning difficulty, which leads to inefficient data utilization and suboptimal performance. To address this limitation, we propose Uni-DPO, a unified dynamic preference optimization framework that jointly considers (a) the inherent quality of preference pairs and (b) the model's evolving performance during training. By adaptively reweighting samples based on both factors, Uni-DPO enables more effective use of preference data and achieves superior performance. Extensive experiments across models and benchmarks demonstrate the effectiveness and generalization of Uni-DPO. On textual tasks, Gemma-2-9B-IT fine-tuned with Uni-DPO surpasses the leading LLM, Claude 3 Opus, by 6.7 points on Arena-Hard. On mathematical and multimodal tasks, Uni-DPO consistently outperforms baseline methods across all benchmarks, providing strong empirical evidence of its effectiveness and robustness.

arXiv:2605.17937v2 Announce Type: replace-cross Abstract: Quantitative backtesting is essential for evaluating trading strategies but remains hampered by high technical barriers and limited scalability. While Large Language Models (LLMs) offer a transformative path to automate this complex, interdisciplinary workflow through advanced code generation, tool usage, and agentic planning, the practical realization is significantly challenged by the current lack of a large-scale benchmark dedicated to automated quantitative backtesting, which hinders progress in this field. To bridge this critical gap, we introduce BacktestBench, the first large-scale benchmark for automated quantitative backtesting. Built from over 6 million real market records, it comprises 18,246 meticulously annotated question-answering pairs across four task categories: metrics calculation, ticker selection, strategy selection, and parameter confirmation. We also propose AutoBacktest, a robust multi-agent baseline that translates natural language strategies into reproducible backtests by coordinating a Summarizer for semantic factor extraction, a Retriever for validated SQL generation, and a Coder for Python backtesting implementation. Our evaluation on 23 mainstream LLMs, complemented by targeted ablations, identifies key factors that influence end-to-end performance and highlights the importance of grounded verification and standardized indicator representations.

arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile agents. We operationalize privacy-respecting phone use as permissioned access, minimal disclosure, and user-controlled memory through a minimal privacy contract, iMy, and pair it with instrumented mock apps plus rule-based auditing that make unnecessary permission requests, deceptive re-disclosure, and unnecessary form filling observable and reproducible. Across five frontier models on 10 mobile apps and 300 tasks, we find that task success, privacy-compliant task completion, and later-session use of saved preferences are distinct capabilities, and no single model dominates all three. Evaluating success and privacy jointly reshuffles the model ordering relative to either metric alone. The most persistent failure mode across models is simple data minimization: agents still fill optional personal entries that the task does not require. These results show that privacy failures arise from over-helpful execution of benign tasks, and that success-only evaluation overestimates the deployment readiness of current phone-use agents. All code, mock apps, and agent trajectories are publicly available at~ https://github.com/FreedomIntelligence/MyPhoneBench.

Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3′-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

arXiv:2603.12933v1 Announce Type: new Abstract: Large Language Model (LLM)-driven Multi-Agent Systems (MAS) have demonstrated strong capability in complex reasoning and tool use, and heterogeneous agent pools further broaden the quality--cost trade-off space. Despite these advances, real-world deployment is often constrained by high inference cost, latency, and limited transparency, which hinders scalable and efficient routing. Existing routing strategies typically rely on expensive LLM-based selectors or static policies, and offer limited controllability for semantic-aware routing under dynamic loads and mixed intents, often resulting in unstable performance and inefficient resource utilization. To address these limitations, we propose AMRO-S, an efficient and interpretable routing framework for Multi-Agent Systems (MAS). AMRO-S models MAS routing as a semantic-conditioned path selection problem, enhancing routing performance through three key mechanisms: First, it leverages a supervised fine-tuned (SFT) small language model for intent inference, providing a low-overhead semantic interface for each query; second, it decomposes routing memory into task-specific pheromone specialists, reducing cross-task interference and optimizing path selection under mixed workloads; finally, it employs a quality-gated asynchronous update mechanism to decouple inference from learning, optimizing routing without increasing latency. Extensive experiments on five public benchmarks and high-concurrency stress tests demonstrate that AMRO-S consistently improves the quality--cost trade-off over strong routing baselines, while providing traceable routing evidence through structured pheromone patterns.

Oncogene, Published online: 07 March 2026; doi:10.1038/s41388-026-03712-0

Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth

arXiv:2603.03955v1 Announce Type: cross Abstract: Post-training with reinforcement learning (RL) has recently shown strong promise for advancing multimodal agents beyond supervised imitation. However, RL remains limited by poor data efficiency, particularly in settings where interaction data are scarce and quickly become outdated. To address this challenge, GIPO (Gaussian Importance sampling Policy Optimization) is proposed as a policy optimization objective based on truncated importance sampling, replacing hard clipping with a log-ratio-based Gaussian trust weight to softly damp extreme importance ratios while maintaining non-zero gradients. Theoretical analysis shows that GIPO introduces an implicit, tunable constraint on the update magnitude, while concentration bounds guarantee robustness and stability under finite-sample estimation. Experimental results show that GIPO achieves state-of-the-art performance among clipping-based baselines across a wide range of replay buffer sizes, from near on-policy to highly stale data, while exhibiting superior bias--variance trade-off, high training stability and improved sample efficiency.