arXiv:2605.24219v2 Announce Type: new Abstract: Large Language Models (LLMs) are increasingly deployed as autonomous agents that reason, use tools, and act over multiple steps. Yet most hallucination benchmarks still evaluate only the final output, missing failures that originate in intermediate Thought-Action-Observation steps. We present Trajel, a dataset and evaluation framework for auditing trajectory-level hallucinations in multi-agent industrial workflows. Trajel introduces a five-type hallucination taxonomy (factual, referential, logical, procedural, and scope-based) over expert-annotated agent traces from AssetOpsBench. We benchmark supervised detection models at the subtask, trajectory, and long-context levels. Our results show that the most common failure modes are missed by existing benchmarks, that nearly half of hallucinated trajectories involve multiple types at once, and that automated detectors with high binary accuracy still misclassify the subtlest types. Trajectory-aware detection significantly outperforms standard post-hoc verification, making taxonomy-grounded evaluation necessary for safer agentic deployment.

arXiv:2605.24785v2 Announce Type: new Abstract: Recent advances in multimodal web agents often rely on increased inference-time computation, including rollout search, verifier passes, offline skill discovery, and specialist model stacks. This raises a central question: can a web agent become more efficient as it accumulates experience, rather than more expensive? We first analyze trajectories from VisualWebArena and identify three recurring sources of inefficiency: repeat-action loops, hidden discovery costs, and low prompt-cache reuse. We then introduce PANDO, a single-rollout online skill-distillation framework that maintains a structured Skill Library and combines progress reflection, confidence-based skill demotion, hierarchical routing, visual compression, and cache-aware prompting. On the full set of 910 VisualWebArena tasks, PANDO achieves a 58.3% success rate, outperforming SGV (54.0%) and our WALT reproduction (45.2%), while using 58% fewer tokens than SGV and 61% fewer tokens than WALT, without any pre-evaluation discovery budget. A 300-task ablation further shows that rules and routines provide most of the success gains, while routing, compression, and cache-aware prompting convert the larger skill library into lower marginal token cost. Finally, we introduce three trajectory-level efficiency metrics -- Action Repetition Rate, Step Overhead Ratio, and Prompt Cache Utilization -- to make efficiency visible beyond terminal success.

arXiv:2605.25160v1 Announce Type: new Abstract: Mobile GUI agents powered by large language models have progressed rapidly, creating urgent needs for realistic and comprehensive evaluation. Existing benchmarks prioritize reproducibility but are often limited to open-source apps or file-operation tasks for the difficulty of constructing rewards on real applications, leaving a gap between benchmark settings and real-world usage. Moreover, most benchmarks focus on basic grounding and navigation, with limited coverage of complex, long-horizon interactions. To address these limitations, we introduce SimuWoB, a fully synthetic benchmark for mobile GUI agents with 120 challenging tasks spanning diverse types and difficulty levels. We build a robust virtual environment generation framework that synthesizes high-fidelity tasks and environments, and automatically provides valid rewards for each task. Each environment is deployed as a backend-free webpage accessible via URL, enabling efficient and reproducible evaluation. We conduct comprehensive experiments on several state-of-the-art mobile GUI agents. The average success rate is only 27.92%, dropping to 17.82% on long-horizon tasks, which reveals substantial weaknesses in current agents under complex scenarios. Evaluation result comparison with real-world sample tasks demonstrate that agent assessments based on our synthetic environment generalize well. We further provide diagnostic insights across key capability dimensions and discuss implications for future mobile GUI agent development.

arXiv:2605.24180v1 Announce Type: cross Abstract: Collaboration is the defining mode of modern science, yet its core mechanism -- feedback -- remains hard to observe, difficult to scale, and unequally distributed. Here we test whether large language models (LLMs) can contribute to this hidden but vital practice and reallocate scientific feedback, an essential yet scarce resource for knowledge production. In a global large-scale randomized field experiment, we delivered customized LLM-generated feedback for over 31,000 arXiv preprints across 150 fields and more than 45,000 researchers from 133 geographic regions. Relative to controls, authors who received feedback had a significantly higher likelihood of revising their manuscripts, corresponding to a 12.55% relative increase over the baseline revision rate. Exposure to AI feedback also increased authors' subsequent use of LLM tools in their future papers, suggesting longer-run shifts in scientific practice. These effects were strongest among authors from non-English-dominant research regions, manuscripts less embedded in the scholarly literature, and teams with lower h-indexes and earlier career stages, consistent with the idea that AI feedback may provide the greatest benefit where access to timely critique is otherwise limited. Together, these findings provide causal evidence that structured AI-based interventions can transform access to scientific feedback from a largely private advantage into a more widely distributed resource, with broader implications for productivity, equity, and capacity across the global research system.

arXiv:2605.25396v1 Announce Type: cross Abstract: Reliable quality control (QC) of ultrasound images is essential for both real-time acquisition guidance and retrospective clinical audit, yet existing approaches rely heavily on per-plane annotations, or employ pseudo-labeling prone to systematic bias under spatial deformations inherent in clinical acquisition. We present STRIQ, a registration-driven framework that recasts annotation-free US plane quality control as a subspace-guided consistency measurement problem. Specifically, STRIQ introduces a Latent Registration Aligner (LRA) to establish hierarchical feature space correspondences between query images and variance-driven anchors, which are autonomously distilled from unlabeled data via a variance spectrum criterion to serve as structurally stable prototypes. To further disambiguate anatomical planes and mitigate negative knowledge transfer, we propose an Orthogonal Knowledge Subspace (OKS) module. The OKS decomposes plane-specific representations into mutually orthogonal subspaces, enabling fine-grained expert collaboration while preventing inter-plane interference, ensuring that the quality metric is grounded in principled subspace proximity. Extensive experiments on the in-house US4QA and public CAMUS datasets demonstrate that STRIQ achieves state-of-the-art correlation with clinical quality scores, establishing a new paradigm for annotation-free, real-time reliable ultrasound quality control. Our code is available at https://github.com/zhcz328/STRIQ.

arXiv:2605.25402v1 Announce Type: cross Abstract: Self-supervised pre-training paradigm has gained increasing prominence for learning transferable representations in medical imaging, yet existing methods for ultrasound (US) images operate at the image or frame level, overlooking the anatomical context for clinical-aligned representation learning. In this work, we propose an anatomy-anchored ultrasound self-supervision framework ANAUS that shifts representation learning from generic visual regions to clinically meaningful anatomical structures. Utilizing a learnable latent prompt engine alongside a one-time domain adaptation on existing public image--mask pairs, we empower the LP-SAM module to achieve annotation-free anatomy delineation at scale. Building upon this anatomical grounding, we propose a dual-policy self-supervised learning paradigm consisting of inter-view semantics-aware anatomy-separating alignment and contextual core-region prediction to enhance representation learning. Specifically, the former enforces feature invariance within identical anatomical regions while promoting discriminability across distinct structures; the latter compels the model to reconstruct corrupted regions, thereby capturing fine-grained structural details. Extensive evaluations on six public datasets demonstrate that \ours{} consistently outstrips current state-of-the-art methods while maintaining the computational efficiency essential for clinical deployment. Code is available at https://github.com/zhcz328/ANAUS.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10566-9

The Small Auxin Up RNA (SAUR) protein ZmSAUR72 in maize (Zea mays) promotes silk growth via regulation of H+-ATPase activity, and is a key determinant of the anthesis-silking interval and thus resilience to drought.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5

Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based diffusional primary Igk into one-loop-based linear scanning secondary mechanisms.

Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01215-2

Deep-sea mining mustn’t go ahead until there are baseline data

A pan-neurodegeneration atlas built from multilayer, deep proteomics of 2,279 brain samples across 6 major diseases integrates whole proteome, detergent-insoluble proteome, and posttranslational modifications to enable intra- and inter-disease comparisons to reveal disease-specific subtypes and dysregulated pathways, while identifying shared changes such as GPNMB upregulation and NPTX2 downregulation.

arXiv:2601.01162v2 Announce Type: replace-cross Abstract: Categorical data are prevalent in domains such as healthcare, marketing, and bioinformatics, where clustering serves as a fundamental tool for pattern discovery. A core challenge in categorical data clustering lies in measuring similarity among attribute values that lack inherent ordering or distance. Without appropriate similarity measures, values are often treated as equidistant, creating a semantic gap that obscures latent structures and degrades clustering quality. Although existing methods infer value relationships from within-dataset co-occurrence patterns, such inference becomes unreliable when samples are limited, leaving the semantic context of the data underexplored. To bridge this gap, we present ARISE (Attention-weighted Representation with Integrated Semantic Embeddings), which draws on external semantic knowledge from Large Language Models (LLMs) to construct semantic-aware representations that complement the metric space of categorical data for accurate clustering. That is, LLM is adopted to describe attribute values for representation enhancement, and the LLM-enhanced embeddings are combined with the original data to explore semantically prominent clusters. Experiments on eight benchmark datasets demonstrate consistent improvements over seven representative counterparts, with gains of 19-27%. Code is available at https://github.com/develop-yang/ARISE

arXiv:2604.01674v1 Announce Type: new Abstract: Model merging aims to integrate multiple expert models into a single model that inherits their complementary strengths without incurring the inference-time cost of ensembling. Recent progress has shown that merging can be highly effective when all source models are \emph{homogeneous}, i.e., derived from the same pretrained backbone and therefore share aligned parameter coordinates or compatible task vectors. Yet this assumption is increasingly unrealistic in open model ecosystems, where useful experts are often built on different families such as Llama, Qwen, and Mistral. In such \emph{heterogeneous} settings, direct weight-space fusion becomes ill-posed due to architectural mismatch, latent basis misalignment, and amplified cross-source conflict. We address this problem with \texttt{HeteroFusion} for heterogeneous language model fusion, which consists of two key components: topology-based alignment that transfers knowledge across heterogeneous backbones by matching functional module structures instead of raw tensor coordinates, and conflict-aware denoising that suppresses incompatible or noisy transfer signals during fusion. We further provide analytical justification showing that preserving the target adapter basis while predicting structured updates leads to a stable and well-conditioned transfer process. Across heterogeneous transfer, multi-source fusion, noisy-source robustness, and cross-family generalization settings, \texttt{HeteroFusion} consistently outperforms strong merging, fusion, and ensemble baselines.

arXiv:2506.03828v3 Announce Type: replace Abstract: AI for Industrial Asset Lifecycle Management aims to automate complex operational workflows, such as condition monitoring and maintenance scheduling, to minimize system downtime. While traditional AI/ML approaches solve narrow tasks in isolation, Large Language Model (LLM) agents offer a next-generation opportunity for end-to-end automation. In this paper, we introduce AssetOpsBench, a unified framework for orchestrating and evaluating domain-specific agents for Industry 4.0. AssetOpsBench provides a multimodal ecosystem comprising a catalog of four domain-specific agents, a curated dataset of 140+ human-authored natural-language queries grounded in real industrial scenarios, and a simulated, CouchDB-backed IoT environment. We introduce an automated evaluation framework that uses three key metrics to analyze architectural trade-offs between the Tool-As-Agent and Plan-Executor paradigms, along with a systematic procedure for the automated discovery of emerging failure modes. The practical relevance of AssetOpsBench is demonstrated by its broad community adoption, with 250+ users and over 500 agents submitted to our public benchmarking platform, supporting reproducible and scalable research for real-world industrial operations. The code is accesible at https://github.com/IBM/AssetOpsBench .

arXiv:2604.00931v2 Announce Type: replace Abstract: Existing methods for AI psychological counselors predominantly rely on supervised fine-tuning using static dialogue datasets. However, this contrasts with human experts, who continuously refine their proficiency through clinical practice and accumulated experience. To bridge this gap, we propose an Experience-Driven Lifelong Learning Agent (\texttt{PsychAgent}) for psychological counseling. First, we establish a Memory-Augmented Planning Engine tailored for longitudinal multi-session interactions, which ensures therapeutic continuity through persistent memory and strategic planning. Second, to support self-evolution, we design a Skill Evolution Engine that extracts new practice-grounded skills from historical counseling trajectories. Finally, we introduce a Reinforced Internalization Engine that integrates the evolved skills into the model via rejection fine-tuning, aiming to improve performance across diverse scenarios. Comparative analysis shows that our approach achieves higher scores than strong general LLMs (e.g., GPT-5.4, Gemini-3) and domain-specific baselines across all reported evaluation dimensions. These results suggest that lifelong learning can improve the consistency and overall quality of multi-session counseling responses.

arXiv:2510.08640v3 Announce Type: replace-cross Abstract: Android is the largest mobile platform, yet automatically building applications remains a practical challenge. While Large Language Models (LLMs) show promise for code repair, their use for fixing Android build errors remains underexplored. To address this gap, we first introduce AndroidBuildBench, a benchmark of 1,019 build failures curated from the commit histories of 43 open-source Android projects. Each problem is paired with a verified solution from a subsequent commit, ensuring that fixes are feasible. Second, we propose GradleFixer, an LLM agent with domain-specific tools for inspecting and manipulating the Gradle build environment. GradleFixer achieves a resolve rate of 81.4% (pass@1), significantly outperforming a state-of-the-art coding agent that relies on a general-purpose shell. GradleFixer's success suggests that while LLMs possess the high-level knowledge to solve these failures, they struggle to translate this knowledge into effective low-level actions using a general-purpose shell. We demonstrate the effectiveness of a strategy we term Tool Bridging, which replaces general-purpose shell commands with domain-aware abstractions. We hypothesize this approach works through two mechanisms: 1) it provides tools in an API-like format that LLMs use more reliably, and 2) it constrains the action space to relevant operations. This approach bridges the gap between the model's high-level reasoning and effective low-level execution.

arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile agents. We operationalize privacy-respecting phone use as permissioned access, minimal disclosure, and user-controlled memory through a minimal privacy contract, iMy, and pair it with instrumented mock apps plus rule-based auditing that make unnecessary permission requests, deceptive re-disclosure, and unnecessary form filling observable and reproducible. Across five frontier models on 10 mobile apps and 300 tasks, we find that task success, privacy-compliant task completion, and later-session use of saved preferences are distinct capabilities, and no single model dominates all three. Evaluating success and privacy jointly reshuffles the model ordering relative to either metric alone. The most persistent failure mode across models is simple data minimization: agents still fill optional personal entries that the task does not require. These results show that privacy failures arise from over-helpful execution of benign tasks, and that success-only evaluation overestimates the deployment readiness of current phone-use agents. All code, mock apps, and agent trajectories are publicly available at~ https://github.com/FreedomIntelligence/MyPhoneBench.

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-y

Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.

npj Digital Medicine, Published online: 01 April 2026; doi:10.1038/s41746-026-02589-3

Multidimensional evaluation of large language models in radiology report readability

arXiv:2603.29895v1 Announce Type: new Abstract: We present a new theory of categorization based on an information-theoretic rational analysis. To evaluate this theory, we investigate how well it can account for key findings from classic categorization experiments conducted by Hayes-Roth and Hayes-Roth (1977), Medin and Schaffer (1978), and Smith and Minda (1998). We find that it explains the human categorization behavior at least as well (or better) than the independent cue and context models (Medin & Schaffer, 1978), the rational model of categorization (Anderson, 1991), and a hierarchical Dirichlet process model (Griffiths et al., 2007).

Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7

Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.