arXiv:2605.25338v1 Announce Type: cross Abstract: Large language model (LLM) agents frequently fail on multi-step tasks involving reasoning, tool use, and environment interaction. While such failures are typically logged or retried heuristically, they contain structured signals about where execution broke down. We introduce CausalFlow, an interventional framework that converts failed agent traces into minimal counterfactual repairs and reusable supervision. CausalFlow models execution traces as sequential chains of dependent steps and computes Causal Responsibility Scores(CRS) via step-level counterfactual intervention to identify failure-inducing steps. For these steps, we generate minimally edited repairs that flip the final outcome to success, producing validated contrastive pairs of the form (wrong step, corrected step). CausalFlow supports two complementary uses: targeted test-time repair that recovers from failures with minimal behavioral drift, and training-time supervision suitable for offline preference optimization or reward modeling. Across four benchmarks spanning mathematical reasoning, code generation, question answering, and medical browsing, CausalFlow converts failed executions into validated minimal repairs with high minimality and causal-consensus scores, and demonstrates that causal attribution is necessary for reliable improvement across diverse agent tasks, outperforming heuristic refinement in complex retrieval settings while producing more localized repairs throughout. These results demonstrate that interventional analysis over structured execution traces provides a principled and scalable mechanism for transforming agent failures into reliability gains and learning-ready supervision.

Nature Cancer, Published online: 25 May 2026; doi:10.1038/s43018-026-01165-8

In this phase 2 trial, Perez et al. reported the safety of the vitamin D receptor agonist paricalcitol with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma and the pharmacodynamic effects of paricalcitol in fibroblasts and immune cells.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0

Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.

Oncogene, Published online: 11 May 2026; doi:10.1038/s41388-026-03821-w

Editorial Expression of Concern: Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10319-8

During model distillation, large language models can subtly transmit traits unrelated to the training data.

Oncogene, Published online: 15 April 2026; doi:10.1038/s41388-026-03789-7

Correction to: Targeting Lyn regulates Snail family shuttling and inhibits metastasis

arXiv:2604.01594v1 Announce Type: new Abstract: How do LLMs decide what to teach next: by reasoning about a learner's knowledge, or by using simpler rules of thumb? We test this in a controlled task previously used to study human teaching strategies. On each trial, a teacher LLM sees a hypothetical learner's trajectory through a reward-annotated directed graph and must reveal a single edge so the learner would choose a better path if they replanned. We run a range of LLMs as simulated teachers and fit their trial-by-trial choices with the same cognitive models used for humans: a Bayes-Optimal teacher that infers which transitions the learner is missing (inverse planning), weaker Bayesian variants, heuristic baselines (e.g., reward based), and non-mentalizing utility models. In a baseline experiment matched to the stimuli presented to human subjects, most LLMs perform well, show little change in strategy over trials, and their graph-by-graph performance is similar to that of humans. Model comparison (BIC) shows that Bayes-Optimal teaching best explains most models' choices. When given a scaffolding intervention, models follow auxiliary inference- or reward-focused prompts, but these scaffolds do not reliably improve later teaching on heuristic-incongruent test graphs and can sometimes reduce performance. Overall, cognitive model fits provide insight into LLM tutoring policies and show that prompt compliance does not guarantee better teaching decisions.

arXiv:2604.01262v1 Announce Type: cross Abstract: Traditional Online Public Access Catalogues (OPACs) are becoming less effective due to the rapid growth of scholarly literature. Conventional search methods, such as keyword indexing and Boolean queries, often fail to support efficient knowledge discovery. This paper proposes a Smart OPAC framework that transforms traditional OPACs into intelligent discovery systems using artificial intelligence and knowledge graph techniques. The framework enables semantic search, thematic filtering, and knowledge graph-based visualization to enhance user interaction and exploration. It integrates multiple open scholarly data sources and applies semantic embeddings to improve relevance and contextual understanding. The system supports exploratory search, semantic navigation, and refined result filtering based on user-defined themes. Quantitative evaluation demonstrates improvements in retrieval efficiency, relevance, and reduction of information overload. The proposed approach offers practical implications for modernizing digital library services and supports next-generation research workflows. Future work includes user-centric evaluation, personalization, and dynamic knowledge graph updates.

Oncogenesis, Published online: 01 April 2026; doi:10.1038/s41389-026-00611-7

Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation

arXiv:2603.28925v1 Announce Type: cross Abstract: Safety fine-tuning in Large Language Models (LLMs) seeks to suppress potentially harmful forms of mind-attribution such as models asserting their own consciousness or claiming to experience emotions. We investigate whether suppressing mind-attribution tendencies degrades intimately related socio-cognitive abilities such as Theory of Mind (ToM). Through safety ablation and mechanistic analyses of representational similarity, we demonstrate that LLM attributions of mind to themselves and to technological artefacts are behaviorally and mechanistically dissociable from ToM capabilities. Nevertheless, safety fine-tuned models under-attribute mind to non-human animals relative to human baselines and are less likely to exhibit spiritual belief, suppressing widely shared perspectives regarding the distribution and nature of non-human minds.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

Nature, Published online: 30 March 2026; doi:10.1038/d41586-026-00973-3

Anne Poelina gives first authorship to a source with deep knowledge about water — the river itself.

Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y

Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.

arXiv:2603.23308v1 Announce Type: cross Abstract: Automated radiology report generation from 3D computed tomography (CT) volumes is challenging due to extreme sequence lengths, severe class imbalance, and the tendency of large language models (LLMs) to ignore visual tokens in favor of linguistic priors. We present Ker-VLJEPA-3B, a four-phase curriculum learning framework for free-text report generation from thoracic CT volumes. A phased training curriculum progressively adapts a Llama 3.2 3B decoder to ground its output in visual features from a frozen, self-supervised encoder. Our visual backbone (LeJEPA ViT-Large) is trained via self-supervised joint-embedding prediction on unlabeled CTs, without text supervision. Unlike contrastive models (CLIP, BiomedCLIP), this language-free backbone yields modality-pure representations. Vision-language alignment is deferred to the curriculum's bridge and generation phases. This modality-agnostic design can integrate any self-supervised encoder into an LLM without paired text during foundation training. Methodological innovations include: (1) zone-constrained cross-attention compressing slice embeddings into 32 spatially-grounded visual tokens; (2) PCA whitening of anisotropic LLM embeddings; (3) a positive-findings-only strategy eliminating posterior collapse; (4) warm bridge initialization transferring projection weights; and (5) selective cross-attention freezing with elastic weight consolidation to prevent catastrophic forgetting. Evaluated on the CT-RATE benchmark (2,984 validation volumes, 18 classes), Ker-VLJEPA-3B achieves a macro F1 of 0.429, surpassing the state-of-the-art (U-VLM, macro F1 = 0.414) by 3.6%, and reaching 0.448 (+8.2%) with threshold optimization. Ablation studies confirm 56.6% of generation quality derives from patient-specific visual content. Code and weights are available.

arXiv:2506.09276v3 Announce Type: replace-cross Abstract: This paper presents a state representation framework for Markov decision processes (MDPs) that can be learned solely from state trajectories, requiring neither reward signals nor the actions executed by the agent. We propose learning the minimum action distance (MAD), defined as the minimum number of actions required to transition between states, as a fundamental metric that captures the underlying structure of an environment. MAD naturally enables critical downstream tasks such as goal-conditioned reinforcement learning and reward shaping by providing a dense, geometrically meaningful measure of progress. Our self-supervised learning approach constructs an embedding space where the distances between embedded state pairs correspond to their MAD, accommodating both symmetric and asymmetric approximations. We evaluate the framework on a comprehensive suite of environments with known MAD values, encompassing both deterministic and stochastic dynamics, as well as discrete and continuous state spaces, and environments with noisy observations. Empirical results demonstrate that the proposed approach not only efficiently learns accurate MAD representations across these diverse settings but also significantly outperforms existing state representation methods in terms of representation quality.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03045-z

Base editor precision is increased by reverting established mutations.

arXiv:2601.21866v2 Announce Type: replace-cross Abstract: Real-world multivariate time series can exhibit intricate multi-scale structures, including global trends, local periodicities, and non-stationary regimes, which makes long-horizon forecasting challenging. Although sparse Mixture-of-Experts (MoE) approaches improve scalability and specialization, they typically rely on homogeneous MLP experts that poorly capture the diverse temporal dynamics of time series data. We address these limitations with MoHETS, an encoder-only Transformer that integrates sparse Mixture-of-Heterogeneous-Experts (MoHE) layers. MoHE routes temporal patches to a small subset of expert networks, combining a shared depthwise-convolution expert for sequence-level continuity with routed Fourier-based experts for patch-level periodic structures. MoHETS further improves robustness to non-stationary dynamics by incorporating exogenous information via cross-attention over covariate patch embeddings. Finally, we replace parameter-heavy linear projection heads with a lightweight convolutional patch decoder, improving parameter efficiency, reducing training instability, and allowing a single model to generalize across arbitrary forecast horizons. We validate across seven multivariate benchmarks and multiple horizons, with MoHETS consistently achieving state-of-the-art performance, reducing the average MSE by $12\%$ compared to strong recent baselines, demonstrating effective heterogeneous specialization for long-term forecasting.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1

In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03022-6

Endosomal escape of lipid nanoparticles is quantified and optimized in vivo.