Normal view
-
Molecular Therapy
-
Inhaled nanosilica orchestrates a pulmonary macrophage-NK cell axis for memory-like NK programming toward synergistic cancer immunotherapy
Yuan and colleagues demonstrate that inhaled biodegradable nanosilica activates an alveolar macrophage–NK axis, triggering an IL-12/15/18 triad that programs memory-like NK cells. This non-fibrotic, cell-free strategy suppresses melanoma growth, prevents postsurgical recurrence, and synergizes with anti-PD-1, establishing a robust framework for in vivo NK cell immunotherapy.
-
Molecular Therapy
-
Viral gene replication enhances AAV vector quality and reduces manufacturing costs
Liu and colleagues developed a robust in cellulo plasmid DNA replication system in human cells for replicating plasmid-borne adeno-associated virus (AAV) Rep/Cap genes during recombinant AAV (rAAV) production. This new approach not only enables a 10- to 20-fold plasmid reduction to significantly lower manufacturing costs but also substantially enhances rAAV potency, titer, and purity.
Viral gene replication enhances AAV vector quality and reduces manufacturing costs
-
Nature - Issue - nature.com science feeds
-
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution-
Nature Biotechnology - Issue - nature.com science feeds
-
Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells
Nature Biotechnology, Published online: 02 September 2026; doi:10.1038/s41587-026-03294-yDNA recombination in rice is optimized by engineering genomic attachment sites.
Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells
Nature Biotechnology, Published online: 02 September 2026; doi:10.1038/s41587-026-03294-y
DNA recombination in rice is optimized by engineering genomic attachment sites.-
Oncogenesis - nature.com science feeds
-
CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11
Oncogenesis, Published online: 21 August 2026; doi:10.1038/s41389-026-00650-0CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11
CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11
Oncogenesis, Published online: 21 August 2026; doi:10.1038/s41389-026-00650-0
CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11-
cs.AI, q-bio.NC updates on arXiv.org
-
SAM: State-Adaptive Memory for Long-Horizon Reasoning Agent
arXiv:2605.24468v1 Announce Type: new Abstract: Long-horizon agentic reasoning requires large language models to act over long interaction histories containing thoughts, tool calls, observations, and partial conclusions. The challenge is not merely that these histories grow long, but that information needed for the current decision may be scattered across distant steps and only become relevant later. Existing approaches address this difficulty by truncating the interaction history, compressing
SAM: State-Adaptive Memory for Long-Horizon Reasoning Agent
-
cs.AI, q-bio.NC updates on arXiv.org
-
AgentFugue: Agent Scaling for Long-Horizon Tasks through Collective Reasoning
arXiv:2605.24486v1 Announce Type: new Abstract: Recent progress on long-horizon agentic tasks has been driven largely by scaling up individual agents through stronger models, better tools, and more effective scaffolding. In contrast, much less is understood about scaling out: whether multiple peer agents, all targeting the same task, can become an additional source of capability without relying on explicit role specialization or workflow orchestration. We study this question and propose AgentFu
AgentFugue: Agent Scaling for Long-Horizon Tasks through Collective Reasoning
-
cs.AI, q-bio.NC updates on arXiv.org
-
Reasoning as an Attack Surface: Adaptive Evolutionary CoT Jailbreaks for LLMs
arXiv:2605.24497v1 Announce Type: new Abstract: Large Reasoning Models (LRMs) have demonstrated remarkable capabilities in reasoning and generation tasks and are increasingly deployed in real-world applications. However, their explicit chain-of-thought (CoT) mechanism introduces new security risks, making them particularly vulnerable to jailbreak attacks. Existing approaches often rely on static CoT templates to elicit harmful outputs, but such fixed designs suffer from limited diversity, adapt
Reasoning as an Attack Surface: Adaptive Evolutionary CoT Jailbreaks for LLMs
-
cs.AI, q-bio.NC updates on arXiv.org
-
DarkForest: Less Talk, Higher Accuracy for Multi-Agent LLMs
arXiv:2605.25188v1 Announce Type: new Abstract: Multi-agent LLM systems improve reasoning by combining outputs from multiple agents, but interaction-heavy methods can introduce error propagation and high communication overhead. When agents exchange raw responses or reasoning traces, incorrect intermediate reasoning may be adopted and amplified, leading to confident but wrong consensus; multi-round communication also increases token consumption, latency, and inference cost. In this paper, we pro
DarkForest: Less Talk, Higher Accuracy for Multi-Agent LLMs
-
cs.AI, q-bio.NC updates on arXiv.org
-
Distributionally Robust Transfer Learning with Structurally Missing Covariates, with Application to Cross-National Cardiac Arrest Prediction
arXiv:2605.24212v1 Announce Type: cross Abstract: Deploying clinical prediction models across healthcare systems often fails when key training covariates are unavailable at deployment and labeled outcomes are limited in the target domain. For example, high-performing models for out-of-hospital cardiac arrest (OHCA) rely on detailed prehospital measurements routinely collected in high-resource settings but unavailable in many international registries. Existing methods either discard missing cova
Distributionally Robust Transfer Learning with Structurally Missing Covariates, with Application to Cross-National Cardiac Arrest Prediction
-
Nature Medicine
-
AI-induced never-skilling in medical education
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-yWill medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.
AI-induced never-skilling in medical education
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-y
Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.-
Omics in Gastric
-
Characterization of dysbiosis patterns in gut microbiota of digestive system cancers: an umbrella review
Front Microbiol. 2026 Apr 28;17:1782471. doi: 10.3389/fmicb.2026.1782471. eCollection 2026.ABSTRACTDigestive system cancers (DSCs) represent a substantial global health burden. In recent years, the role of gut microbiota in the DSCs has garnered considerable attention, but its change pattern during tumor progression and the specific mechanisms are still not fully understood. We conducted a comprehensive systematic review to characterize patterns of gut microbiota dysbiosis across different DSC t
Characterization of dysbiosis patterns in gut microbiota of digestive system cancers: an umbrella review
Front Microbiol. 2026 Apr 28;17:1782471. doi: 10.3389/fmicb.2026.1782471. eCollection 2026.
ABSTRACT
Digestive system cancers (DSCs) represent a substantial global health burden. In recent years, the role of gut microbiota in the DSCs has garnered considerable attention, but its change pattern during tumor progression and the specific mechanisms are still not fully understood. We conducted a comprehensive systematic review to characterize patterns of gut microbiota dysbiosis across different DSC types and assess their clinical significance. We systematically searched four English and three Chinese databases up to January 2025 to identify systematic reviews focused on the dynamic characteristics of the gut microbiota during gastrointestinal tumorigenesis. Microbiota biodiversity and taxonomic composition were extracted to identify specific signatures associated with DSCs. The ROBIS tool was used to evaluate the methodological quality of the included studies. Ultimately, 59 studies involving six distinct DSC types were included. Data synthesis and comparison revealed distinct microbiota profiles across DSCs. At the phylum level, Bacillota was decreased in esophageal cancer (EC) and pancreatic ductal adenocarcinoma (PDAC), Pseudomonadota was augmented in EC but exhibited divergent trajectories in colorectal cancer (CRC) and PDAC. Genus-level analyses revealed Veillonella enrichment in EC and PDAC, and Fusobacterium outgrowth in EC, gastric cancer (GC) and CRC. Parvimonas and Streptococcus showed a concordant ascending trend in GC and CRC. Prevotella was overrepresented in EC and GC. This synthesis delineates a qualitative landscape of gut microbiota imbalances associated with various DSCs, highlighting the potential for these microbial shifts to serve as markers for early detection and targeted therapy. Multiomics integration and prospective cohort studies should be prioritized to accelerate clinical translation.
PMID:42131199 | PMC:PMC13161176 | DOI:10.3389/fmicb.2026.1782471
-
Oncogene - Issue - nature.com science feeds
-
Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis
Oncogene, Published online: 18 April 2026; doi:10.1038/s41388-026-03797-7Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis
Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis
Oncogene, Published online: 18 April 2026; doi:10.1038/s41388-026-03797-7
Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis-
Nature - Issue - nature.com science feeds
-
Autonomous closed-loop framework for reproducible perovskite solar cells
Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10482-yAutonomous closed-loop framework for reproducible perovskite solar cells
Autonomous closed-loop framework for reproducible perovskite solar cells
Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10482-y
Autonomous closed-loop framework for reproducible perovskite solar cells-
cs.AI, q-bio.NC updates on arXiv.org
-
ART: Adaptive Relational Transformer for Pedestrian Trajectory Prediction with Temporal-Aware Relations
arXiv:2604.03649v1 Announce Type: cross Abstract: Accurate prediction of real-world pedestrian trajectories is crucial for a wide range of robot-related applications. Recent approaches typically adopt graph-based or transformer-based frameworks to model interactions. Despite their effectiveness, these methods either introduce unnecessary computational overhead or struggle to represent the diverse and time-varying characteristics of human interactions. In this work, we present an Adaptive Relati
ART: Adaptive Relational Transformer for Pedestrian Trajectory Prediction with Temporal-Aware Relations
-
cs.AI, q-bio.NC updates on arXiv.org
-
FAST-CAD: A Fairness-Aware Framework for Non-Contact Stroke Diagnosis
arXiv:2511.08887v4 Announce Type: replace-cross Abstract: Stroke is an acute cerebrovascular disease, and timely diagnosis significantly improves patient survival. However, existing automated diagnosis methods suffer from fairness issues across demographic groups, potentially exacerbating healthcare disparities. In this work we propose FAST-CAD, a theoretically grounded framework that combines domain-adversarial training (DAT) with group distributionally robust optimization (Group-DRO) for fair
FAST-CAD: A Fairness-Aware Framework for Non-Contact Stroke Diagnosis
-
cs.AI, q-bio.NC updates on arXiv.org
-
GPA: Learning GUI Process Automation from Demonstrations
arXiv:2604.01676v2 Announce Type: replace-cross Abstract: GUI Process Automation (GPA) is a lightweight but general vision-based Robotic Process Automation (RPA), which enables fast and stable process replay with only a single demo. Addressing the fragility of traditional RPA and the non-deterministic risks of current vision language model-based GUI agents, GPA introduces three core benefits: (1) Robustness via Sequential Monte Carlo-based localization to handle rescaling and detection uncertai
GPA: Learning GUI Process Automation from Demonstrations
-
Cell Death Discovery nature.com science feeds
-
FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactylation and metabolic reprogramming
Cell Death Discovery, Published online: 07 April 2026; doi:10.1038/s41420-026-03054-6FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactylation and metabolic reprogramming
FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactylation and metabolic reprogramming
Cell Death Discovery, Published online: 07 April 2026; doi:10.1038/s41420-026-03054-6
FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactylation and metabolic reprogramming-
cs.AI, q-bio.NC updates on arXiv.org
-
GPA: Learning GUI Process Automation from Demonstrations
arXiv:2604.01676v1 Announce Type: cross Abstract: GUI Process Automation (GPA) is a lightweight but general vision-based Robotic Process Automation (RPA), which enables fast and stable process replay with only a single demo. Addressing the fragility of traditional RPA and the non-deterministic risks of current vision language model-based GUI agents, GPA introduces three core benefits: (1) Robustness via Sequential Monte Carlo-based localization to handle rescaling and detection uncertainty; (2)
GPA: Learning GUI Process Automation from Demonstrations
-
npj Digital Medicine
-
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02527-3Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02527-3
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma