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cs.AI, q-bio.NC updates on arXiv.org
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Grounded Continuation: A Linear-Time Runtime Verifier for LLM Conversations
arXiv:2605.14175v2 Announce Type: replace Abstract: In a long conversation, an LLM can produce a plausible continuation that rests on premises the conversation has already abandoned. No runtime check ties its output to what the conversation has established, a gap that context-manipulation attacks on deployed agents exploit. We close this gap with a runtime verifier: an LLM Interpreter classifies each utterance into one of eight epistemic operations, and a symbolic engine applies them to a depen
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Targeting KRAS reprograms a Treg-dominant immunosuppressive microenvironment and sensitizes KRAS-mutant gastric adenocarcinoma to CTLA-4 immunotherapy
Sci China Life Sci. 2026 Sep 3. doi: 10.1007/s11427-026-3438-4. Online ahead of print.ABSTRACTOncogenic KRAS mutations define a distinct molecular subset of gastric adenocarcinoma (GA), yet their impact on the tumor immune microenvironment remains incompletely understood. In this study, we established a genetically faithful and immunocompetent KRASG12D-driven mouse model of GA, together with matched organoids and cell lines, to investigate how oncogenic KRAS shapes tumor-immune interactions. KRA
Targeting KRAS reprograms a Treg-dominant immunosuppressive microenvironment and sensitizes KRAS-mutant gastric adenocarcinoma to CTLA-4 immunotherapy
Sci China Life Sci. 2026 Sep 3. doi: 10.1007/s11427-026-3438-4. Online ahead of print.
ABSTRACT
Oncogenic KRAS mutations define a distinct molecular subset of gastric adenocarcinoma (GA), yet their impact on the tumor immune microenvironment remains incompletely understood. In this study, we established a genetically faithful and immunocompetent KRASG12D-driven mouse model of GA, together with matched organoids and cell lines, to investigate how oncogenic KRAS shapes tumor-immune interactions. KRAS-mutant tumors consistently developed an immunosuppressive microenvironment characterized by enrichment of regulatory T cells (Tregs), accompanied by reduced cytotoxic lymphocyte infiltration and intrinsic resistance to PD-1 blockade. Although pharmacologic targeting of KRAS effectively suppressed tumor growth and increased immune cell infiltration, functional immune analyses revealed persistent Treg-mediated immunosuppression that limited effective antitumor immunity. Mechanistically, TGF-β signaling was required to maintain Treg dominance and suppress effector T cell function in KRAS-driven tumors. Importantly, disruption of this suppressive axis through combined KRAS inhibition and CTLA-4 blockade attenuated TGF-β activity, impaired Treg function, and enhanced antitumor immune responses in vivo. Collectively, these findings identify oncogenic KRAS as a key regulator of TGF-β-dependent immune suppression in GA and provide mechanistic insight into immune evasion within this molecular subtype.
PMID:42714795 | DOI:10.1007/s11427-026-3438-4
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cs.AI, q-bio.NC updates on arXiv.org
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CUA-Gym: Scaling Verifiable Training Environments and Tasks for Computer-Use Agents
arXiv:2605.25624v1 Announce Type: new Abstract: Reinforcement learning with verifiable rewards (RLVR) has driven breakthroughs in domains such as math, tool-use, and software engineering, yet its extension to computer-use agents (CUAs) has been bottlenecked by the scarcity of scalable training data with deterministic rewards. Constructing such data for CUAs requires consistent task instruction, executable environment, and verifiable reward. However, hand-curated benchmarks achieve high reward f
CUA-Gym: Scaling Verifiable Training Environments and Tasks for Computer-Use Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Nano World Models: A Minimalist Implementation of Future Video Prediction
arXiv:2605.23993v1 Announce Type: cross Abstract: World models have become a central paradigm for learning predictive simulators that support generation, planning, and decision-making. Yet, despite rapid progress in industry-scale interactive video generation, the broader research community still lacks compact, reproducible, and easily extensible implementations for studying the design choices underlying modern world models. We introduce Nano World Models, a minimalist codebase for future video
Nano World Models: A Minimalist Implementation of Future Video Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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Adversarial Error Correction for Visual Autoregressive Generation
arXiv:2605.24843v1 Announce Type: cross Abstract: Visual Autoregressive (VAR) models have emerged as a powerful paradigm for image synthesis by performing hierarchical next-scale prediction. However, VAR models are inherently prone to cascading error propagation, where subtle coarse-scale mispredictions are amplified across the hierarchy, ultimately distorting the final synthesis. To mitigate this, we propose AID-VAR, a plug-and-play framework that enhances pre-trained VARs through Adversariall
Adversarial Error Correction for Visual Autoregressive Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Hide to Guide: Learning via Semantic Masking
arXiv:2605.25198v1 Announce Type: cross Abstract: Reinforcement learning with verifiable rewards (RLVR) has become a powerful paradigm for improving language models on reasoning-intensive tasks, but its effectiveness is often limited by exploration. For example, models often fail on hard problems, leaving little useful reward signal. External expert traces offer a natural source of guidance, yet they may also expose reward-relevant content along the critical path to the verifier target, such as
Hide to Guide: Learning via Semantic Masking
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cs.AI, q-bio.NC updates on arXiv.org
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Multi-Objective Learning for Diffusion Models: A Statistical Theory under Semi-Supervised Learning
arXiv:2605.25210v1 Announce Type: cross Abstract: Diffusion models are increasingly used as powerful conditional generators, yet real deployments often involve multiple target distributions arising from different tasks, e.g., diverse prompt domains in text-to-image generation, or multiple environments in robotics with diffusion policies. This naturally leads to a multi-objective learning (MOL) problem. A key challenge is that achieving good Pareto trade-offs can require a generalist model class
Multi-Objective Learning for Diffusion Models: A Statistical Theory under Semi-Supervised Learning
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cs.AI, q-bio.NC updates on arXiv.org
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SAMark: A Self-Anchored Text Watermarking with Paragraph-Level Paraphrase Robustness
arXiv:2605.25796v1 Announce Type: cross Abstract: Semantic-level watermarking (SWM) improves robustness against text modifications by treating sentences as the basic unit. However, robustness to paragraph-level paraphrasing remains difficult because such attacks globally disrupt watermark signals by changing sentence order. In this work, we propose SAMark, a self-anchored watermarking framework that removes the dependency on sentence order by establishing a step-independent green region in sema
SAMark: A Self-Anchored Text Watermarking with Paragraph-Level Paraphrase Robustness
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cs.AI, q-bio.NC updates on arXiv.org
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Why Your Deep Research Agent Fails? On Hallucination Evaluation in Full Research Trajectory
arXiv:2601.22984v2 Announce Type: replace Abstract: Diagnosing failure patterns in Deep Research Agents (DRAs) remains a critical challenge. Existing benchmarks predominantly rely on end-to-end evaluation, obscuring intermediate hallucinations that accumulate throughout the research trajectory. To bridge this gap, we propose a shift from outcome-based to processaware evaluation by auditing hallucinations in the full plan-search-summarize trajectory. We introduce the PING Taxonomy, which categor
Why Your Deep Research Agent Fails? On Hallucination Evaluation in Full Research Trajectory
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cs.AI, q-bio.NC updates on arXiv.org
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OASES: Outcome-Aligned Search-Evaluation Co-Training for Agentic Search
arXiv:2604.03675v3 Announce Type: replace Abstract: Agentic search enables language models to solve knowledge-intensive tasks by adaptively acquiring external evidence over multiple steps. Reinforcement learning with verifiable rewards (RLVR) has emerged as a widely adopted training paradigm for search agents, yet outcome-only rewards are sparse and provide limited credit assignment for intermediate search actions. Existing process-reward methods therefore seek to densify supervision through pr
OASES: Outcome-Aligned Search-Evaluation Co-Training for Agentic Search
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cs.AI, q-bio.NC updates on arXiv.org
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EditCaption: Human-Refined SFT and HAE-DPO for Image Editing Instruction Synthesis
arXiv:2604.08213v2 Announce Type: replace-cross Abstract: High-quality source-target image pairs with precise editing instructions are essential for instruction-guided image editing, yet constructing such training triplets at scale remains costly. Recent pipelines often rely on vision-language models to synthesize editing instructions automatically, but we find that strong VLMs still struggle to describe visual transformations between image pairs. In particular, they exhibit three recurring fai
EditCaption: Human-Refined SFT and HAE-DPO for Image Editing Instruction Synthesis
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cs.AI, q-bio.NC updates on arXiv.org
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From Muscle Bursts to Motor Intent: Self-Supervised Token Modeling for Heterogeneous EMG
arXiv:2605.03462v3 Announce Type: replace-cross Abstract: Surface electromyography provides a practical way to infer human movement intention from wearable muscle recordings, but models trained under a single acquisition setting often lose reliability when the user, session, electrode layout, or gesture protocol changes. This paper proposes AEMG, a self-supervised learning approach designed to extract reusable neuromuscular representations from diverse EMG sources. Eight public gesture datasets
From Muscle Bursts to Motor Intent: Self-Supervised Token Modeling for Heterogeneous EMG
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cs.AI, q-bio.NC updates on arXiv.org
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Action with Visual Primitives
arXiv:2605.22183v2 Announce Type: replace-cross Abstract: Vision-Language-Action (VLA) models have emerged as a promising paradigm for generalist robotic manipulation. A common design in current architectures maps language instructions and visual observations to actions in a single forward pass. While conceptually simple, this formulation entangles instruction comprehension, spatial scene understanding, and motor control within a single learning objective. As a result, the action expert must im
Action with Visual Primitives
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Nature Biotechnology - Issue - nature.com science feeds
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Fetal monitoring for high-risk pregnancies using a wearable ultrasound patch
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03140-1A wearable ultrasound device is optimized for continuous monitoring of pregnancies.
Fetal monitoring for high-risk pregnancies using a wearable ultrasound patch
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03140-1
A wearable ultrasound device is optimized for continuous monitoring of pregnancies.-
Oncogene - Issue - nature.com science feeds
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GPX8<sup>+</sup> cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
Oncogene, Published online: 22 May 2026; doi:10.1038/s41388-026-03711-1GPX8+ cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
GPX8<sup>+</sup> cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
Oncogene, Published online: 22 May 2026; doi:10.1038/s41388-026-03711-1
GPX8+ cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma-
Nature - Issue - nature.com science feeds
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EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.
EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8
A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.-
Nature - Issue - nature.com science feeds
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Composable neural emulators accelerate thermoelectric generator design
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10223-1A composable neural network emulator is described for speeding up thermoelectric generator design, demonstrating the ability to predict generator performance with >99% accuracy while taking only 0.01% of the time compared with commercial finite-element solvers.
Composable neural emulators accelerate thermoelectric generator design
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10223-1
A composable neural network emulator is described for speeding up thermoelectric generator design, demonstrating the ability to predict generator performance with >99% accuracy while taking only 0.01% of the time compared with commercial finite-element solvers.-
cs.AI, q-bio.NC updates on arXiv.org
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PRAISE: Prefix-Based Rollout Reuse in Agentic Search Training
arXiv:2604.03675v1 Announce Type: new Abstract: In agentic search, large language models (LLMs) are trained to perform multi-turn retrieval and reasoning for complex tasks such as multi-hop question answering (QA). However, current search-based Reinforcement Learning (RL) methods suffer from two core limitations: expensive long-horizon rollouts are under-utilized during training, and supervision is typically available only at the final answer, resulting in severe reward sparsity. We present Pre
PRAISE: Prefix-Based Rollout Reuse in Agentic Search Training
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cs.AI, q-bio.NC updates on arXiv.org
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SoLA: Leveraging Soft Activation Sparsity and Low-Rank Decomposition for Large Language Model Compression
arXiv:2604.03258v1 Announce Type: cross Abstract: Large language models (LLMs) have demonstrated impressive capabilities across various tasks, but the billion-scale parameters pose deployment challenges. Although existing methods attempt to reduce the scale of LLMs, they require either special hardware support or expensive post-training to maintain model quality. To facilitate efficient and affordable model slimming, we propose a novel training-free compression method for LLMs, named "SoLA", wh
SoLA: Leveraging Soft Activation Sparsity and Low-Rank Decomposition for Large Language Model Compression
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cs.AI, q-bio.NC updates on arXiv.org
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Safe Decentralized Operation of EV Virtual Power Plant with Limited Network Visibility via Multi-Agent Reinforcement Learning
arXiv:2604.03278v1 Announce Type: cross Abstract: As power systems advance toward net-zero targets, behind-the-meter renewables are driving rapid growth in distributed energy resources (DERs). Virtual power plants (VPPs) increasingly coordinate these resources to support power distribution network (PDN) operation, with EV charging stations (EVCSs) emerging as a key asset due to their strong impact on local voltages. However, in practice, VPPs must make operational decisions with only partial vi