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Received — 10 September 2026 ⏭
  • ✇cs.AI, q-bio.NC updates on arXiv.org
  • Kernel-Managed Shared Memory for System-Wide Personalization Ryan Lum · Yongfeng Zhang
    arXiv:2609.10144v1 Announce Type: new Abstract: AI systems become more useful when they can adapt to the people using them, but in multi-agent systems, useful context learned by one agent often remains unavailable to others. We present kernel-managed shared memory, a system-level abstraction in which specialized agents write structured, tagged memories while the agent-system kernel, not individual agents, governs retrieval, privacy enforcement, and prompt injection. We implement and evaluate th
     
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Kernel-Managed Shared Memory for System-Wide Personalization

✇cs.AI, q-bio.NC updates on arXiv.org
By: Ryan Lum · Yongfeng Zhang
10 September 2026 at 12:00
arXiv:2609.10144v1 Announce Type: new Abstract: AI systems become more useful when they can adapt to the people using them, but in multi-agent systems, useful context learned by one agent often remains unavailable to others. We present kernel-managed shared memory, a system-level abstraction in which specialized agents write structured, tagged memories while the agent-system kernel, not individual agents, governs retrieval, privacy enforcement, and prompt injection. We implement and evaluate this design on AIOS and compare it against three alternatives across three assistant models (GPT-4o, Llama-3.1:8B, Qwen-2.5:7B) and 1,800 total trials. Against an unmanaged external memory backend (Mem0) using identical underlying storage, kernel-managed retrieval and injection improve personalization scores by 2.4-4.0 points on a 5-point scale (e.g., 1.05 to 4.69 profile usage on GPT-4o), with every comparison significant at p

From Monolithic Blending to Agentic Orchestration: Dynamic Response for Conversational Assistants at Scale

✇cs.AI, q-bio.NC updates on arXiv.org
By: Cen Mia Zhao · Peng Wang · Chuan Shi · Yufeng Zhang · Ying Lyu · Wanmeng Ren · Robert Xue · Claire Na Cheng · Yashar Mehdad
10 September 2026 at 12:00
arXiv:2609.05758v2 Announce Type: replace Abstract: Conversational assistants can blend retrieval, action selection, escalation, and wording in a single model path, or separate those roles. We report a production migration of a customer-support assistant at a large accommodation marketplace (millions of conversations per month, 11 languages, 10-second P90). Dynamic Response (DR) replaces a single Qwen3-235B-A22B blended responder with a bounded ReAct orchestrator over typed tools plus a smaller generator that writes from a backend-validated context contract. Because the migration also changed prompts, alignment, and serving, we attribute each effect to its cause and claim as architecture effects only those measured on identical replayed turns: typed entity selection moves the reservation selector to a precision-first operating point (precision 8.3% to 89.1%, recall 75.2% to 67.3%), and typed action IDs with a membership check remove observed structured-action hallucination (2.14% to 0.0%). A low-ramp A/B test reproduces the replay escalation reductions: hard-escalation responses fall from 5.60% to 3.08% and soft-escalation responses from 9.56% to 2.49%, while production handoff volume holds roughly steady; self-solve is directional (+5.1 points, 95% CI [-2, +12]). Serving optimizations cut orchestrator P90 latency from 3.87s to 2.24s on a GPU footprint reduced by roughly one-third, and self-hosting reduces estimated annual model-serving cost by more than an order of magnitude.

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

✇Omics in Hepatocellular
By: Jun Ma · Tong Wu · Diyu Chen · Can Zhu · Shanhe Huang · Keyi Du · Chuanhui Peng · Junru Chen · Yunhao Chen · Haiyang Xie · Feng Zhang · Jianzhong Chen · Shusen Zheng · Jian Wu
7 September 2026 at 18:00

Gut. 2026 Sep 7:gutjnl-2025-337414. doi: 10.1136/gutjnl-2025-337414. Online ahead of print.

ABSTRACT

BACKGROUND: Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood.

OBJECTIVE: To elucidate the metabolic and molecular programmes that enable tumour-associated neutrophils (TANs) to resist ferroptosis and sustain immunosuppression in HCC.

DESIGN: We employed human HCC samples, multiple murine HCC models, transcriptomic and lipidomic profiling, genetic loss-of-function systems and therapeutic interventions. Ferroptosis sensitivity, lipid metabolic rewiring and immunological consequences of TANs were systematically evaluated across models and validated in patient datasets and biospecimens.

RESULTS: TANs in human HCC and mouse models exhibit pronounced lipid accumulation and oxidative stress compared with peripheral neutrophils. Multi-omic profiling revealed that TANs are enriched for lipid-binding gene programmes and undergo rewiring towards sphingolipid and unsaturated fatty acid metabolism. We identified triggering receptor expressed on myeloid cells 2 (TREM2) as a key lipid-sensing receptor selectively expressed in TANs. Functional deletion of TREM2 reprogrammed the tumour immune microenvironment, restoring CD8+ T cell activity and suppressing HCC progression. Mechanistically, tumour-derived sphingosine-1-phosphate (S1P) activates TREM2, triggering nuclear factor erythroid 2-related factor 2 (NRF2)-mediated transcription of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11), thereby promoting ferroptosis resistance. TREM2 expression is transcriptionally induced by granulocyte-macrophage colony-stimulating factor-signal transducer and activator of transcription 3 (GM-CSF-STAT3) signalling. Genetic deletion of TREM2, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9)-mediated knockout of sphingosine kinase 1/2 (SPHK1/2) in tumour cells, or pharmacological inhibition of S1P synthesis disrupts this protective lipid-immune circuit, sensitises TANs to ferroptosis and restricts tumour growth. Therapeutically, a peptide-based TREM2 inhibitor reprogrammes TANs, restores CD8+ T cell function and enhances anti-programmed cell death protein 1 (PD-1) immunotherapy efficacy. Clinically, TREM2+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are enriched in HCC tumours, correlate with SPHK1/2 expression and T cell dysfunction and associate with poor patient prognosis.

CONCLUSION: Our study uncovers the S1P-TREM2-NRF2 axis as a critical metabolic-immune circuit that preserves neutrophil survival and immunosuppressive function in HCC. Targeting this lipid-dependent ferroptosis resistance pathway offers a promising therapeutic strategy to overcome immunotherapy resistance in liver cancer.

PMID:42705697 | DOI:10.1136/gutjnl-2025-337414

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

✇(Multiomics OR Omics) AND (Pancreatic)
By: Jun Ma · Tong Wu · Diyu Chen · Can Zhu · Shanhe Huang · Keyi Du · Chuanhui Peng · Junru Chen · Yunhao Chen · Haiyang Xie · Feng Zhang · Jianzhong Chen · Shusen Zheng · Jian Wu
7 September 2026 at 18:00

Gut. 2026 Sep 7:gutjnl-2025-337414. doi: 10.1136/gutjnl-2025-337414. Online ahead of print.

ABSTRACT

BACKGROUND: Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood.

OBJECTIVE: To elucidate the metabolic and molecular programmes that enable tumour-associated neutrophils (TANs) to resist ferroptosis and sustain immunosuppression in HCC.

DESIGN: We employed human HCC samples, multiple murine HCC models, transcriptomic and lipidomic profiling, genetic loss-of-function systems and therapeutic interventions. Ferroptosis sensitivity, lipid metabolic rewiring and immunological consequences of TANs were systematically evaluated across models and validated in patient datasets and biospecimens.

RESULTS: TANs in human HCC and mouse models exhibit pronounced lipid accumulation and oxidative stress compared with peripheral neutrophils. Multi-omic profiling revealed that TANs are enriched for lipid-binding gene programmes and undergo rewiring towards sphingolipid and unsaturated fatty acid metabolism. We identified triggering receptor expressed on myeloid cells 2 (TREM2) as a key lipid-sensing receptor selectively expressed in TANs. Functional deletion of TREM2 reprogrammed the tumour immune microenvironment, restoring CD8+ T cell activity and suppressing HCC progression. Mechanistically, tumour-derived sphingosine-1-phosphate (S1P) activates TREM2, triggering nuclear factor erythroid 2-related factor 2 (NRF2)-mediated transcription of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11), thereby promoting ferroptosis resistance. TREM2 expression is transcriptionally induced by granulocyte-macrophage colony-stimulating factor-signal transducer and activator of transcription 3 (GM-CSF-STAT3) signalling. Genetic deletion of TREM2, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9)-mediated knockout of sphingosine kinase 1/2 (SPHK1/2) in tumour cells, or pharmacological inhibition of S1P synthesis disrupts this protective lipid-immune circuit, sensitises TANs to ferroptosis and restricts tumour growth. Therapeutically, a peptide-based TREM2 inhibitor reprogrammes TANs, restores CD8+ T cell function and enhances anti-programmed cell death protein 1 (PD-1) immunotherapy efficacy. Clinically, TREM2+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are enriched in HCC tumours, correlate with SPHK1/2 expression and T cell dysfunction and associate with poor patient prognosis.

CONCLUSION: Our study uncovers the S1P-TREM2-NRF2 axis as a critical metabolic-immune circuit that preserves neutrophil survival and immunosuppressive function in HCC. Targeting this lipid-dependent ferroptosis resistance pathway offers a promising therapeutic strategy to overcome immunotherapy resistance in liver cancer.

PMID:42705697 | DOI:10.1136/gutjnl-2025-337414

Itaconate and its derivatives in human health and diseases

✇(Multiomics OR Omics) AND (Pancreatic)
By: Jianyou Gu · Wenying Zhang · Junfeng Zhang · Silue Zeng · Renpei Xia · Lei Cai · Xiaosheng Zhong · Shixiang Guo · Huaizhi Wang · Zhe-Sheng Chen
3 September 2026 at 18:00

Signal Transduct Target Ther. 2026 Sep 4;11(1):363. doi: 10.1038/s41392-026-02936-6.

ABSTRACT

Metabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting the tricarboxylic acid cycle to immune signaling, the IRG1/ACOD1 and itaconate axes play a central role in coordinating inflammatory tone and redox balance. Itaconate, generated through the decarboxylation of cis aconitate, acts as an immunometabolic brake that engages multiple regulatory pathways to sustain the dynamic equilibrium between inflammation and tissue homeostasis. Across a broad spectrum of pathological conditions, including infectious diseases, metabolic disorders, ischemia‒reperfusion injury, neurodegenerative diseases, autoimmune disorders, and cancers, itaconate and its derivatives generally exert anti-inflammatory and cytoprotective effects. However, within specific microenvironments, these molecules may also be exploited by pathogens to evade immune clearance or promote immunosuppressive and protumorigenic responses. Future studies should further elucidate tissue- and lineage-specific functions, define bidirectional regulatory mechanisms, and optimize the pharmacokinetic properties of itaconate derivatives. With the advancement of multiomics integration, systems immunology, rational drug design, and engineered itaconate delivery technologies, the IRG1/ACOD1-itaconate axis and derivative-based therapeutic strategies are poised to emerge as key metabolic checkpoints and therapeutic targets in inflammatory-, metabolic-, immune-, and cancer-related diseases.

PMID:42693110 | PMC:PMC13542262 | DOI:10.1038/s41392-026-02936-6

Nitrogen dioxide exposure promotes CD8(+)T cell infiltration and contributes to increased susceptibility to ulcerative colitis: An integrative multi-omics, artificial intelligence, and mouse model study

✇(Multiomics OR Omics) AND (Pancreatic)
By: Zhijie Wang · Xin Chang · Tian Fu · Dan Xu · Yuanhong Ma · Hao Zhang · Hubin Xia · Xiaofeng Zhang · Yingdong Hou
1 September 2026 at 18:00

J Hazard Mater. 2026 Sep 15;516:143449. doi: 10.1016/j.jhazmat.2026.143449. Epub 2026 Aug 30.

ABSTRACT

The global incidence of ulcerative colitis (UC) has significantly increased in rapidly industrializing nations, with numerous studies highlighting environmental exposures, particularly nitrogen dioxide (NO2), as potential contributors to disease susceptibility. However, the clinical implications and molecular mechanisms linking NO2 exposure to UC susceptibility remain poorly understood. This study investigated the associations between NO2 and UC by integrating multi-omics data. We identified a CD8+ T cell subpopulation with a distinct phenotype characterized by perforin production, which potentially exacerbated colonic inflammation related to NO2 exposure. To validate this hypothesis, we established mouse models exposed to NO2, confirming increased CD8+ T cell infiltration and elevated perforin secretion through immunofluorescent (IF) staining. Employing artificial intelligence techniques, we identified Cell Division Cycle 25B (CDC25B) as a gene of interest correlated with putative NO2-related UC signatures. Finally, through molecular docking (MD) and molecular dynamics simulations (MDS), we identified ozanimod as one of several computationally nominated compounds associated with the CDC25B‑related network; however, none of these computational predictions were experimentally validated in the present study. Collectively, these findings suggest a correlative link between perforin or CD8+ T cell-associated colonic inflammation and NO2-associated UC susceptibility, and nominate CDC25B as a candidate gene for further investigation.

PMID:42679583 | DOI:10.1016/j.jhazmat.2026.143449

Received — 27 May 2026 ⏭

SEP-Attack: A Simple and Effective Paradigm for Transfer-Based Textual Adversarial Attack

✇cs.AI, q-bio.NC updates on arXiv.org
By: Han Liu · Zhi Xu · Xiaotong Zhang · Feng Zhang · Xiaoming Xu · Wei Wang · Fenglong Ma · Hong Yu
26 May 2026 at 12:00
arXiv:2605.24958v1 Announce Type: cross Abstract: Despite the strong performance of deep neural networks in modern Web and language applications, they remain vulnerable to adversarial attacks, especially transferable attacks that generate adversarial examples using surrogate models without accessing the victim model. Transferable attacks in the text domain are still under-explored, with only a few studies addressing this challenging issue, often with suboptimal results due to equal treatment of submodels or inaccurate estimation of importance scores. To address these challenges, we propose a simple yet effective paradigm for transfer-based textual adversarial attack, named SEP-Attack. Specifically, we employ the Determinantal Point Process (DPP) to generate diverse surrogate ensemble weights, representing the transferability of submodels. Using these weights, we introduce a new metric to evaluate prediction confidence scores, which in turn are used to calculate word importance scores and generate adversarial candidates. Finally, we quantify the transferability score for each candidate and select the top ones as the final transferable adversarial examples. Experiments conducted on four datasets and two real-world APIs validate the efficacy of SEP-Attack, significantly outperforming state-of-the-art baselines.

Action with Visual Primitives

✇cs.AI, q-bio.NC updates on arXiv.org
By: Weilong Guo · Yuchen Wang · Renping Zhou · Yunfeng Zhang · Rui Fang · Yuyang Pang · Wenda Xu · Gao Huang
26 May 2026 at 12:00
arXiv:2605.22183v2 Announce Type: replace-cross Abstract: Vision-Language-Action (VLA) models have emerged as a promising paradigm for generalist robotic manipulation. A common design in current architectures maps language instructions and visual observations to actions in a single forward pass. While conceptually simple, this formulation entangles instruction comprehension, spatial scene understanding, and motor control within a single learning objective. As a result, the action expert must implicitly relearn cognitive and perceptual capabilities already present in the pretrained VLM, which can limit both learning efficiency and generalization. We introduce AVP (Action with Visual Primitives), an end-to-end architecture that implements this visual-primitive-centric interface: the VLM infers the next-stage target and emits visual-primitive tokens that condition a flow-matching action expert, with supervision derived from end-effector kinematics. Real-robot experiments on general pick-and-place tasks show that AVP improves the success rate by 27.61% over pi_0.5 and outperforms other recent methods, with consistent gains in data efficiency, spatial-compositional generalization, and object-level transfer.
Received — 13 April 2026 ⏭
Received — 4 April 2026 ⏭

Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema

✇Cell
By: Wenqin Xiao · Yan Zhu · Xinjie Tang · Kongkai Zhu · Weifeng Zhang · Mengting Chen · Kui Cai · San Xu · Zheng Wu · Mei Wang · Jiayi Liu · Linglong Long · Zixin Tan · Aike Wu · Songqi Zhou · Zhixiang Zhao · Yan Tang · Yingxue Huang · Ben Wang · Fangfen Liu · Qian Wang · Fan Yang · Dan Jian · Wei Shi · Hongfu Xie · Xiang Chen · Lulu Guo · Zhili Deng · Jinpeng Sun · Ji Li
5 March 2026 at 08:00
Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation underlying erythema. Cryo-EM reveals a bipartite-acid pocket of OXGR1 that enables structure-guided development of A-1, a selective agonist that alleviates erythema in rosacea-like models.
Received — 2 April 2026 ⏭

Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles

✇cs.AI, q-bio.NC updates on arXiv.org
By: Qingyan Wei · Yaojie Zhang · Zhiyuan Liu · Puyu Zeng · Yuxuan Wang · Biqing Qi · Dongrui Liu · Linfeng Zhang
1 April 2026 at 12:00
arXiv:2506.10848v3 Announce Type: replace-cross Abstract: Diffusion-based language models (dLLMs) have emerged as a promising alternative to traditional autoregressive LLMs by enabling parallel token generation and significantly reducing inference latency. However, existing sampling strategies for dLLMs, such as confidence-based or semi-autoregressive decoding, often suffer from static behavior, leading to suboptimal efficiency and limited flexibility. In this paper, we propose SlowFast Sampling, a novel dynamic sampling strategy that adaptively alternates between exploratory and accelerated decoding stages. Our method is guided by three golden principles: certainty principle, convergence principle, and positional principle, which govern when and where tokens can be confidently and efficiently decoded. We further integrate our strategy with dLLM-Cache to reduce redundant computation. Extensive experiments across benchmarks and models show that SlowFast Sampling achieves up to 15.63$\times$ speedup on LLaDA with minimal accuracy drop, and up to 34.22$\times$ when combined with caching. Notably, our approach outperforms strong autoregressive baselines like LLaMA3 8B in throughput, demonstrating that well-designed sampling can unlock the full potential of dLLMs for fast and high-quality generation.
Received — 26 March 2026 ⏭

Suicidal Thoughts and Behaviors Among Chinese Adolescents in Relation to Negative Life Events, Internet Addiction, and Sexual Abuse: Cross-Sectional Study

✇Journal of Medical Internet Research
By: Juanfang Zhu · Qinqin Jiang · Feng Zhang · Hao Liu · Shaojie Yu · Jinhai Sun · Zhe Zhao · Lijuan Liu · Lei Yuan
26 March 2026 at 04:30
Background: Increasing suicidal thoughts and behaviors (STB) among adolescents raise social concerns and have a well-recognized association with sexual abuse (SA). However, research regarding the mechanisms explaining the association between SA and STB remains limited. Objective: This study aims to examine the chained mediating effects of negative life events (NLE) and internet addiction (IA) between SA and STB among adolescents in China. Methods: This cross-sectional study used data from the Science Database of the People Mental Health survey conducted between March 2013 and December 2022 by the National Population Health Data Center of the National Research Institute for Family Planning. Through stratified sampling, 20,893 adolescents were recruited from 16 Chinese provinces. After excluding samples with missing relevant variables, 10,664 (55.89%; aged 16-17.9 y; n=5826, 54.63% women) adolescents were included in the final analysis. STB was the outcome variable, with NLE and IA as mediators, all assessed via a questionnaire that was uniformly administered by trained investigators in school settings. The Pearson χ test was used to analyze the association between SA and STB. Using a combination of multiple linear regression and bootstrap testing, the study constructed a chain mediation model to explore how SA influences STB in adolescents through NLE and IA. Results: The scores for SA, NLE, IA, and STB were 1.330 (SD 1.714), 51.960 (SD 23.822), 34.88 (SD 13.852), and 0.690 (SD 1.396), respectively. Multiple linear regression analysis indicated SA was associated with NLE (β=2.382, 95% CI 2.112‐2.653;

Towards Self-Evolving Benchmarks: Synthesizing Agent Trajectories via Test-Time Exploration under Validate-by-Reproduce Paradigm

✇cs.AI, q-bio.NC updates on arXiv.org
By: Dadi Guo · Tianyi Zhou · Dongrui Liu · Chen Qian · Qihan Ren · Shuai Shao · Zhiyuan Fan · Yi R. Fung · Kun Wang · Linfeng Zhang · Jing Shao
25 March 2026 at 12:00
arXiv:2510.00415v3 Announce Type: replace Abstract: Recent advances in large language models (LLMs) and agent system designs have empowered agents with unprecedented levels of capability. However, existing agent benchmarks are showing a trend of rapid ceiling-hitting by newly developed agents, making it difficult to meet the demands for evaluating agent abilities. To address this problem, we propose the Trajectory-based Validated-by-Reproducing Agent-benchmark Complexity Evolution (TRACE) framework. This framework takes an original task from an existing benchmark and encourages agents to freely explore and evolve it into a new task with higher difficulty while recording validatable agent trajectories. The framework proceeds in three stages: (1) evolutionary proposal mining, which provides task evolution proposals through preliminary exploration and divergent thinking; (2) problem formation and free exploration, where proposals are conceptualized into feasible problem candidates and the agents then explore them freely while recording their execution trajectories; and (3) multi-level validation, which ensures that the evolved tasks are accompanied by validatable and reproducible trajectories. Experiments on the GAIA benchmark demonstrate that the TRACE framework consistently enhances task complexity while improving the reliability of correctness through validatable execution trajectories. In addition, our framework can successfully adapt to and improve reasoning datasets represented by AIME-2024. This work marks a paradigm shift from static, manually curated benchmarks to dynamic, self-evolving evaluation systems, providing a sustainable and challenging runway for agent development
Received — 14 March 2026 ⏭
Received — 11 March 2026 ⏭

Your Agent May Misevolve: Emergent Risks in Self-evolving LLM Agents

✇cs.AI, q-bio.NC updates on arXiv.org
By: Shuai Shao · Qihan Ren · Chen Qian · Boyi Wei · Dadi Guo · Jingyi Yang · Xinhao Song · Linfeng Zhang · Weinan Zhang · Dongrui Liu · Jing Shao
10 March 2026 at 12:00
arXiv:2509.26354v2 Announce Type: replace Abstract: Advances in Large Language Models (LLMs) have enabled a new class of self-evolving agents that autonomously improve through interaction with the environment, demonstrating strong capabilities. However, self-evolution also introduces novel risks overlooked by current safety research. In this work, we study the case where an agent's self-evolution deviates in unintended ways, leading to undesirable or even harmful outcomes. We refer to this as Misevolution. To provide a systematic investigation, we evaluate misevolution along four key evolutionary pathways: model, memory, tool, and workflow. Our empirical findings reveal that misevolution is a widespread risk, affecting agents built even on top-tier LLMs (e.g., Gemini-2.5-Pro). Different emergent risks are observed in the self-evolutionary process, such as the degradation of safety alignment after memory accumulation, or the unintended introduction of vulnerabilities in tool creation and reuse. To our knowledge, this is the first study to systematically conceptualize misevolution and provide empirical evidence of its occurrence, highlighting an urgent need for new safety paradigms for self-evolving agents. Finally, we discuss potential mitigation strategies to inspire further research on building safer and more trustworthy self-evolving agents. Our code and data are available at https://github.com/ShaoShuai0605/Misevolution . Warning: this paper includes examples that may be offensive or harmful in nature.

Think, Speak, Decide: Language-Augmented Multi-Agent Reinforcement Learning for Economic Decision-Making

✇cs.AI, q-bio.NC updates on arXiv.org
By: Heyang Ma · Qirui Mi · Qipeng Yang · Zijun Fan · Bo Li · Haifeng Zhang
10 March 2026 at 12:00
arXiv:2511.12876v3 Announce Type: replace Abstract: Economic decision-making depends not only on structured signals such as prices and taxes, but also on unstructured language, including peer dialogue and media narratives. While multi-agent reinforcement learning (MARL) has shown promise in optimizing economic decisions, it struggles with the semantic ambiguity and contextual richness of language. We propose LAMP (Language-Augmented Multi-Agent Policy), a framework that integrates language into economic decision-making and narrows the gap to real-world settings. LAMP follows a Think-Speak-Decide pipeline: (1) Think interprets numerical observations to extract short-term shocks and long-term trends, caching high-value reasoning trajectories; (2) Speak crafts and exchanges strategic messages based on reasoning, updating beliefs by parsing peer communications; and (3) Decide fuses numerical data, reasoning, and reflections into a MARL policy to optimize language-augmented decision-making. Experiments in economic simulation show that LAMP outperforms both MARL and LLM-only baselines in cumulative return (+63.5%, +34.0%), robustness (+18.8%, +59.4%), and interpretability. These results demonstrate the potential of language-augmented policies to deliver more effective and robust economic strategies.

CauKer: Classification Time Series Foundation Models Can Be Pretrained on Synthetic Data

✇cs.AI, q-bio.NC updates on arXiv.org
By: Shifeng Xie · Vasilii Feofanov · Ambroise Odonnat · Lei Zan · Marius Alonso · Jianfeng Zhang · Themis Palpanas · Lujia Pan · Keli Zhang · Ievgen Redko
10 March 2026 at 12:00
arXiv:2508.02879v3 Announce Type: replace-cross Abstract: Time series foundation models (TSFMs) have recently gained significant attention due to their strong zero-shot capabilities and widespread real-world applications. Such models typically require a computationally costly pre-training on large-scale, carefully curated collections of real-world sequences. To allow for a sample-efficient pre-training of TSFMs, we propose \textsc{CauKer}, a novel algorithm designed to generate diverse, causally coherent synthetic time series with realistic trends, seasonality, and nonlinear interactions. \textsc{CauKer} combines Gaussian Process (GP) kernel composition with Structural Causal Models (SCM) to produce data for sample-efficient pre-training of state-of-the-art classification TSFMs having different architectures and following different pre-training approaches. Additionally, our experiments reveal that \textsc{CauKer}-generated datasets exhibit clear scaling laws for both dataset size (10K to 10M samples) and model capacity (1M to 783M parameters), unlike real-world datasets, which display irregular scaling behavior. The source code is publicly available at https://github.com/ShifengXIE/CauKer.
Received — 5 March 2026 ⏭

Sim2Sea: Sim-to-Real Policy Transfer for Maritime Vessel Navigation in Congested Waters

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xinyu Cui · Xuanfa Jin · Xue Yan · Yongcheng Zeng · Luoyang Sun · Siying Wei · Ruizhi Zhang · Jian Zhao · Haifeng Zhang · Jun Wang
5 March 2026 at 13:00
arXiv:2603.04057v1 Announce Type: cross Abstract: Autonomous navigation in congested maritime environments is a critical capability for a wide range of real-world applications. However, it remains an unresolved challenge due to complex vessel interactions and significant environmental uncertainties. Existing methods often fail in practical deployment due to a substantial sim-to-real gap, which stems from imprecise simulation, inadequate situational awareness, and unsafe exploration strategies. To address these, we propose \textbf{Sim2Sea}, a comprehensive framework designed to bridge simulation and real-world execution. Sim2Sea advances in three key aspects. First, we develop a GPU-accelerated parallel simulator for scalable and accurate maritime scenario simulation. Second, we design a dual-stream spatiotemporal policy that handles complex dynamics and multi-modal perception, augmented with a velocity-obstacle-guided action masking mechanism to ensure safe and efficient exploration. Finally, a targeted domain randomization scheme helps bridge the sim-to-real gap. Simulation results demonstrate that our method achieves faster convergence and safer trajectories than established baselines. In addition, our policy trained purely in simulation successfully transfers zero-shot to a 17-ton unmanned vessel operating in real-world congested waters. These results validate the effectiveness of Sim2Sea in achieving reliable sim-to-real transfer for practical autonomous maritime navigation.
Received — 25 February 2026 ⏭

MolReasoner: Toward Effective and Interpretable Reasoning for Molecular LLMs

✇cs.AI, q-bio.NC updates on arXiv.org
By: Guojiang Zhao · Zixiang Lu · Yutang Ge · Sihang Li · Zheng Cheng · Haitao Lin · Lirong Wu · Hanchen Xia · Hengxing Cai · Wentao Guo · Hongshuai Wang · Mingjun Xu · Siyu Zhu · Guolin Ke · Linfeng Zhang · Zhifeng Gao
24 February 2026 at 13:00
arXiv:2508.02066v2 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have shown impressive performance across various domains, but their ability to perform molecular reasoning remains underexplored. Existing methods mostly rely on general-purpose prompting, which lacks domain-specific molecular semantics, or fine-tuning, which faces challenges in interpretability and reasoning depth, often leading to structural and textual hallucinations. To address these issues, we introduce MolReasoner, a two-stage framework that transitions LLMs from memorization to high-fidelity chemical reasoning. In the Mol-SFT stage, knowledge-enhanced Chain-of-Thought (CoT) data provides a strong foundation, while the Mol-RL stage refines reasoning using a novel, task-adaptive reward system to mitigate hallucinations. Extensive evaluations demonstrate that MolReasoner significantly outperforms a wide range of strong baselines in both molecule generation and captioning tasks. Further analyses highlight the framework's synergistic design and its ability to produce more interpretable outputs. Our work presents a principled and effective new approach for advancing high-fidelity molecular reasoning.
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