Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Kernel-Complexity Edge Sanitization for Training-Free Defense against Structural Graph Attacks
arXiv:2609.09698v1 Announce Type: cross Abstract: Graph Neural Networks (GNNs) have achieved remarkable success across diverse applications, yet they remain highly vulnerable to adversarial attacks that maliciously perturb graph structure. Existing defenses often lack rigorous theoretical grounding, rely on attack-specific heuristics, or require costly retraining procedures such as adversarial training. To address these limitations, we propose Kernel-Complexity Edge Sanitization (KCES), a train
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Cell
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Skin-innervating glutamatergic neurons modulate aging
Within the skin, glutamatergic neurons expressing neurofilament heavy chain (Nefh) play a role in aging. Loss of Nefh during aging drives skin fibroblast senescence and collagen loss, whereas glutamate supplementation improves skin aging phenotypes.
Skin-innervating glutamatergic neurons modulate aging
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cs.AI, q-bio.NC updates on arXiv.org
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FrontierOR: Benchmarking LLMs' Capacity for Efficient Algorithm Design in Large-Scale Optimization
arXiv:2605.25246v2 Announce Type: new Abstract: Large language models (LLMs) are increasingly used for optimization modeling and solver-code generation, yet practical operations research and optimization problems often require a harder capability: designing scalable algorithms that exploit problem structure and outperform direct formulation-and-solve baselines. Existing benchmarks are limited to small or simplified examples far below real-world scale and complexity. We introduce FrontierOR, amo
FrontierOR: Benchmarking LLMs' Capacity for Efficient Algorithm Design in Large-Scale Optimization
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cs.AI, q-bio.NC updates on arXiv.org
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Iterative Refinement Neural Operators are Learned Fixed-Point Solvers: A Principled Approach to Spectral Bias Mitigation
arXiv:2605.24041v2 Announce Type: cross Abstract: Neural operators serve as fast, data-driven surrogates for scientific modeling but typically rely on a monolithic, single-pass inference procedure that struggles to resolve high-frequency details, a limitation known as spectral bias. We introduce the Iterative Refinement Neural Operator (IRNO), which augments pre-trained operators with a learned refinement module iteratively applied via fixed-point iteration. IRNO decomposes the prediction into
Iterative Refinement Neural Operators are Learned Fixed-Point Solvers: A Principled Approach to Spectral Bias Mitigation
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cs.AI, q-bio.NC updates on arXiv.org
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NSR-Boost: A Neuro-Symbolic Residual Boosting Framework for Industrial Legacy Models
arXiv:2601.10457v3 Announce Type: replace Abstract: Although the Gradient Boosted Decision Trees (GBDTs) dominate industrial tabular applications, upgrading legacy models in high-concurrency production environments still faces prohibitive retraining costs and systemic risks. To address this problem, we present NSR-Boost, a neuro-symbolic residual boosting framework designed specifically for industrial scenarios. Its core advantage lies in being ``non-intrusive''. It treats the legacy model as a
NSR-Boost: A Neuro-Symbolic Residual Boosting Framework for Industrial Legacy Models
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cs.AI, q-bio.NC updates on arXiv.org
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SkillOpt: Executive Strategy for Self-Evolving Agent Skills
arXiv:2605.23904v2 Announce Type: replace Abstract: Agent skills today are hand-crafted, generated one-shot, or evolved through loosely controlled self-revision, none of which behaves like a deep-learning optimizer for the skill, and none of which reliably improves over its starting point under feedback. We argue the skill should instead be trained as the external state of a frozen agent, with the same discipline that makes weight-space optimization reproducible. SkillOpt is, to our knowledge,
SkillOpt: Executive Strategy for Self-Evolving Agent Skills
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Nature - Issue - nature.com science feeds
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Forest carbon protocols underestimate climate-driven carbon loss risks
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10571-yThe buffer pool designed to compensate for unintended carbon losses from the largest forest climate mitigation programme in the United States is too small when considering the impact of future climate change scenarios.
Forest carbon protocols underestimate climate-driven carbon loss risks
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10571-y
The buffer pool designed to compensate for unintended carbon losses from the largest forest climate mitigation programme in the United States is too small when considering the impact of future climate change scenarios.-
Omics in Hepatocellular
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Stromal ACTA2 Counteracts TCDD-Induced Hepatocarcinogenesis via Suppression of the PI3K-AKT-mTOR Pathway
J Hepatocell Carcinoma. 2026 May 10;13:586916. doi: 10.2147/JHC.S586916. eCollection 2026.ABSTRACTPURPOSE: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that promotes hepatocellular carcinoma (HCC) through non-genotoxic mechanisms. However, stromal regulatory factors that counteract its tumor-promoting effects remain poorly defined. This study aimed to elucidate the role of actin alpha-2 (ACTA2) in TCDD-associated hepatocarcinogenesis.METHODS: An integrative
Stromal ACTA2 Counteracts TCDD-Induced Hepatocarcinogenesis via Suppression of the PI3K-AKT-mTOR Pathway
J Hepatocell Carcinoma. 2026 May 10;13:586916. doi: 10.2147/JHC.S586916. eCollection 2026.
ABSTRACT
PURPOSE: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that promotes hepatocellular carcinoma (HCC) through non-genotoxic mechanisms. However, stromal regulatory factors that counteract its tumor-promoting effects remain poorly defined. This study aimed to elucidate the role of actin alpha-2 (ACTA2) in TCDD-associated hepatocarcinogenesis.
METHODS: An integrative strategy combining network toxicology, Mendelian randomization, multi-omics and single-cell analyses, molecular docking and molecular dynamics simulations, along with in vitro experiments, was employed to investigate the functional role of ACTA2.
RESULTS: ACTA2 was identified as a stromal-associated factor linked to reduced HCC risk and improved patient survival. Single-cell and multi-omics analyses revealed that ACTA2 is predominantly expressed in hepatic stellate cells and fibroblast-like populations, reflecting tumor microenvironment composition rather than tumor cell-intrinsic expression. Functional enrichment analyses indicated that ACTA2 is associated with extracellular matrix remodeling and PI3K-AKT signaling. Molecular simulations demonstrated stable binding of TCDD to ACTA2 (ΔG_bind ≈ -7.05 kcal/mol), suggesting potential structural perturbation. In vitro experiments showed that TCDD downregulated ACTA2 expression, promoted proliferation of LX-2 and cancer-associated fibroblasts (CAFs), and activated PI3K-AKT-mTOR signaling, whereas ACTA2 overexpression attenuated these effects.
CONCLUSION: ACTA2 acts as a context-dependent stromal regulator that modulates PI3K-AKT-mTOR signaling in TCDD-induced hepatocarcinogenesis. These findings highlight the importance of stromal remodeling in environmental carcinogenesis and suggest ACTA2 as a potential biomarker and therapeutic target in dioxin-associated HCC.
PMID:42148320 | PMC:PMC13175077 | DOI:10.2147/JHC.S586916
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Omics in Gastric
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Refined immune-based molecular subtypes of gastric cancer: Integrating mismatch repair status and tumor microenvironment for enhanced immunotherapy prediction
Chin J Cancer Res. 2026 Apr 30;38(2):234-251. doi: 10.21147/j.issn.1000-9604.2026.02.09.ABSTRACTOBJECTIVE: Gastric cancer (GC) is heterogeneous, and current mismatch repair (MMR)-based classifications incompletely predict response to immune checkpoint inhibitors (ICIs).METHODS: RNA sequencing (RNA-seq) and immune infiltration profiles from 189 resected GC were used to derive four refined immune-MMR subtypes (R1-R4) by integrating MMR status, survival, and tumor microenvironment (TME) features. M
Refined immune-based molecular subtypes of gastric cancer: Integrating mismatch repair status and tumor microenvironment for enhanced immunotherapy prediction
Chin J Cancer Res. 2026 Apr 30;38(2):234-251. doi: 10.21147/j.issn.1000-9604.2026.02.09.
ABSTRACT
OBJECTIVE: Gastric cancer (GC) is heterogeneous, and current mismatch repair (MMR)-based classifications incompletely predict response to immune checkpoint inhibitors (ICIs).
METHODS: RNA sequencing (RNA-seq) and immune infiltration profiles from 189 resected GC were used to derive four refined immune-MMR subtypes (R1-R4) by integrating MMR status, survival, and tumor microenvironment (TME) features. Multi-omics profiling and pathway analysis defined subtype biology. External transcriptomic cohorts and an ICI-treated cohort were classified with Nearest Template Prediction (NTP). Immune response-associated genes were identified from responder vs. non-responder comparisons within the ICI-sensitive subtype and validated by multiplex immunohistochemistry (mIHC).
RESULTS: R1 showed the best prognosis and highest immunotherapy response with objective response rate (ORR) 54.5%, while R4 had the worst prognosis. R2 represented an immune-unresponsive deficient mismatch repair (dMMR) subset, and R3 captured an immune-active proficient mismatch repair (pMMR) subgroup with moderate therapy sensitivity. Multi-omics integration revealed subtype-specific pathways (e.g., ECM remodeling in R1, metabolic reprogramming in R2). Reclassification of pMMR tumors based on transcriptional similarity to R1 identified a New R3 subset with enhanced immune features and higher ICI response. Eight immune response-associated genes (e.g., CXCL10, CXCL11, ELN, GAD1, IL32, MT1E, OR2I1P, SLC3A1) were identified and validated by mIHC for predictive relevance.
CONCLUSIONS: This immune-based molecular framework refines risk stratification beyond conventional MMR categories, identifies ICI-sensitive subsets among both dMMR and pMMR tumors, and proposes candidate biomarkers for patient selection.
PMID:42147371 | PMC:PMC13171420 | DOI:10.21147/j.issn.1000-9604.2026.02.09
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cs.AI, q-bio.NC updates on arXiv.org
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SortedRL: Accelerating RL Training for LLMs through Online Length-Aware Scheduling
arXiv:2603.23414v1 Announce Type: cross Abstract: Scaling reinforcement learning (RL) has shown strong promise for enhancing the reasoning abilities of large language models (LLMs), particularly in tasks requiring long chain-of-thought generation. However, RL training efficiency is often bottlenecked by the rollout phase, which can account for up to 70% of total training time when generating long trajectories (e.g., 16k tokens), due to slow autoregressive generation and synchronization overhead
SortedRL: Accelerating RL Training for LLMs through Online Length-Aware Scheduling
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cs.AI, q-bio.NC updates on arXiv.org
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FCMBench: The First Large-scale Financial Credit Multimodal Benchmark for Real-world Applications
arXiv:2601.00150v3 Announce Type: replace-cross Abstract: FCMBench is the first large-scale and privacy-compliant multimodal benchmark for real-world financial credit applications, covering tasks and robustness challenges from domain specific workflows and constraints. The current version of FCMBench covers 26 certificate types, with 5198 privacy-compliant images and 13806 paired VQA samples. It evaluates models on Perception and Reasoning tasks under real-world Robustness interferences, includ
FCMBench: The First Large-scale Financial Credit Multimodal Benchmark for Real-world Applications
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Cell Death Discovery nature.com science feeds
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Ferroptosis of smooth muscle cells in vascular diseases: from basic principles to clinical translation
Cell Death Discovery, Published online: 09 March 2026; doi:10.1038/s41420-026-02950-1Ferroptosis of smooth muscle cells in vascular diseases: from basic principles to clinical translation
Ferroptosis of smooth muscle cells in vascular diseases: from basic principles to clinical translation
Cell Death Discovery, Published online: 09 March 2026; doi:10.1038/s41420-026-02950-1
Ferroptosis of smooth muscle cells in vascular diseases: from basic principles to clinical translation-
cs.AI, q-bio.NC updates on arXiv.org
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When Scaling Fails: Mitigating Audio Perception Decay of LALMs via Multi-Step Perception-Aware Reasoning
arXiv:2603.02266v1 Announce Type: cross Abstract: Test-Time Scaling has shown notable efficacy in addressing complex problems through scaling inference compute. However, within Large Audio-Language Models (LALMs), an unintuitive phenomenon exists: post-training models for structured reasoning trajectories results in marginal or even negative gains compared to post-training for direct answering. To investigate it, we introduce CAFE, an evaluation framework designed to precisely quantify audio re
When Scaling Fails: Mitigating Audio Perception Decay of LALMs via Multi-Step Perception-Aware Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Advancing Mobile GUI Agents: A Verifier-Driven Approach to Practical Deployment
arXiv:2503.15937v5 Announce Type: replace Abstract: We propose V-Droid, a mobile GUI task automation agent. Unlike previous mobile agents that utilize Large Language Models (LLMs) as generators to directly generate actions at each step, V-Droid employs LLMs as verifiers to evaluate candidate actions before making final decisions. To realize this novel paradigm, we introduce a comprehensive framework for constructing verifier-driven mobile agents: the discretized action space construction couple
Advancing Mobile GUI Agents: A Verifier-Driven Approach to Practical Deployment
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cs.AI, q-bio.NC updates on arXiv.org
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Landscaper: Understanding Loss Landscapes Through Multi-Dimensional Topological Analysis
arXiv:2602.07135v3 Announce Type: replace-cross Abstract: Loss landscapes are a powerful tool for understanding neural network optimization and generalization, yet traditional low-dimensional analyses often miss complex topological features. We present Landscaper, an open-source Python package for arbitrary-dimensional loss landscape analysis. Landscaper combines Hessian-based subspace construction with topological data analysis to reveal geometric structures such as basin hierarchy and connect