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Received — 15 September 2026 ⏭

Occamy-1.0: Open Pareto-frontier 35B Intelligence for Co-work

✇cs.AI, q-bio.NC updates on arXiv.org
By: Wenhui Chen · Shiwen Cheng · Hao Dong · Chenda Duan · Ruixiang Feng · Zhong Guan · Boqiang Guo · Xueyuan Han · Haojie Hao · Liangmeng Huang · Zhelong Huang · Xinke Kong · Hongyu Li · Jiazheng Li · Junbo Li · Qingchuan Li · Yukun Lian · Chang Liu · Tianyu Liu · Zicheng Liu · Shuyi Ouyang · Yijun Pan · Kunyu Shi · Xiaojun Tang · Bingquan Wang · Kesu Wang · Yuchen Wang · Sibo Wei · Sicong Xie · Xiaoying Xing · Yi Xu · Zhijun Xu · Hongwei Xue · Qingcheng Zeng · Di Zhang · Guannan Zhang · Haochen Zhang · Tianlong Zhang · Tianyu Zhao · Tianyu Zhao · Yanjun Zheng · Jialong Zhu · Zijian Zou
14 September 2026 at 12:00
arXiv:2609.11977v1 Announce Type: new Abstract: Co-work agents execute complex workflows that combine information gathering, tool use, coding, and file manipulation across many model invocations. Because cost and latency accumulate over the full episode, their practical value depends not only on peak capability but also on how efficiently that capability is delivered. Yet many steps in everyday work emphasize state tracking, coordination, recovery, and follow-through rather than frontier-scale reasoning. We present Occamy-1.0, a cost-efficient co-work model obtained by further training the post-trained Qwen3.6-35B-A3B checkpoint. We construct execution-grounded data and environments, capture replayable long-horizon trajectories across multiple harnesses, and use staged post-training to develop and consolidate complementary execution capabilities. Across a broad suite of co-work benchmarks, Occamy-1.0 is consistently among the strongest comparably sized models and remains competitive with substantially larger frontier systems on several tasks. Under our stated evaluation and pricing protocol, its aggregate performance across four representative benchmarks places it at the low-cost knee of the observed cost--performance Pareto frontier. Supporting evaluations in tool calling, coding, and instruction following further show that this specialization preserves broad agentic capability. We release the model weights and a subset of the training data to support research on practical co-work agents and agentic post-training.

Dynamic Expert Quantization for Scalable Mixture-of-Experts Inference

✇cs.AI, q-bio.NC updates on arXiv.org
By: Kexin Chu · Dawei Xiang · Zixu Shen · Yiwei Yang · Zecheng Liu · Wei Zhang
14 September 2026 at 12:00
arXiv:2511.15015v4 Announce Type: replace-cross Abstract: Mixture-of-Experts (MoE) has become a practical architecture for scaling LLM capacity while keeping per-token compute modest, but deploying MoE models on a single, memory-limited GPU remains difficult because expert weights dominate the HBM footprint. Existing expert offloading and prefetching systems reduce the resident set, yet they often pay expert-loading costs on the critical path when activation becomes dense. Post-training quantization (PTQ) lowers the footprint without transfers, but prevailing pipelines fix expert bit-widths offline and assume routing remains stable, even though MoE expert utilization is heavy-tailed and the hot set can shift across workloads. We present DynaExq, a runtime-aware mixed-precision serving system that treats single-GPU MoE inference under a hard HBM envelope as an online, budget-constrained precision allocation problem. The key insight is to keep the experts that dominate runtime traffic resident at higher precision, while maintaining a low-precision fallback for the remaining experts, so the system can reduce transfer volume and avoid the waiting latency that limits offloading and prefetching under dense activation. DynaExq estimates long-horizon expert hotness from router traces, selects a per-layer high-precision resident set via a budget-feasible top-$n$ rule, and applies promotions and demotions asynchronously through stable expert handles so the forward pass always executes on a fully materialized expert version. Across Qwen3-MoE-30B/80B and six benchmarks, DynaExq improves accuracy over static PTQ on Qwen3-80B (73.09% to 77.57%) under comparable device-memory budgets and achieves up to 2.73x higher throughput than offloading/prefetch baselines at batch size 32.
Received — 10 September 2026 ⏭

Switchable single-atom catalysts for highly selective C–C coupling in direct methane oxidation

✇Nature Nanotechnology
By: Xiao Han · Peixin Cui · Geng Wu · Jinyan Cai · Chao Wang · Fanfei Sun · Panzhe Qiao · Xiaocheng Liu · Jiahao Zhuang · Huan Liu · Fabing Su · Gongming Wang · Wensheng Yan · Zeming Qi · Yue Lin · Xun Hong · Yadong Li
7 September 2026 at 08:00

Nature Nanotechnology, Published online: 07 September 2026; doi:10.1038/s41565-026-02271-5

Single copper atoms on boron nanosheets dynamically and reversibly switch to clusters, enabling the direct conversion of methane to acetic acid with 97% selectivity and high activity without the requirement for carbon monoxide.

EvolveScaler: Synthesizing Information-Evolution Contexts via Executable State Machines and Natural-Language Rendering

✇cs.AI, q-bio.NC updates on arXiv.org
By: Ziliang Zhao · Zenan Xu · Shuting Wang · Zhao Wang · Bowen Cao · Minda Hu · Lincheng Li · Pluto Zhou · Zhicheng Dou
10 September 2026 at 12:00
arXiv:2609.08435v2 Announce Type: replace Abstract: In persistent interactions, long contexts may encode an evolving process rather than a fixed record: later events can revise or revoke earlier information, changing what remains valid and what conclusions follow. We call this setting information evolution (IE). Solving IE requires identifying valid records, applying updates in order, and reconstructing the query-relevant state from the event history. Existing text-first synthesis pipelines make such data difficult to verify because state transitions and answer logic remain implicit. We introduce EvolveScaler, a code-driven framework that defines information evolution before rendering it as natural language. Human-authored operational specifications define state transitions, record validity, difficulty controls, and executable answer logic; a strong LLM then synthesizes a self-contained simulator from each specification. Executing validated simulators produces natural-language multi-turn event histories, while deterministic replay computes reference answers and atomic checklists. We instantiate EvolveScaler with 117 task prototypes and 159 final-question operators across five difficulty levels spanning approximately 7 to 1,200 events per instance, yielding about 35,100 training examples and 585 validated evaluation instances. On the very_long tier, the strongest model reaches 59.3% avg@5, while six models score below 10%. Training an internal A3B model on 6,000 EvolveScaler examples improves performance over its base checkpoint on all eight independently constructed out-of-distribution benchmarks, with a 5.25-point average gain. These results show that code-driven IE synthesis provides both challenging evaluation and transferable training supervision.
Received — 27 May 2026 ⏭

Accelerating Long-Tail Generation in Synchronous RLHF Training via Adaptive Tensor Parallelism

✇cs.AI, q-bio.NC updates on arXiv.org
By: Long Zhao · Qinghe Wang · Jiaan Zhu · Youhui Bai · Zewen Jin · Chaoyi Ruan · Shengnan Wang · Cheng Li
26 May 2026 at 12:00
arXiv:2605.23945v1 Announce Type: new Abstract: Reinforcement Learning from Human Feedback (RLHF) has become a key post-training paradigm for improving model quality. However, the synchronous three-stage RLHF pipeline is often bottlenecked by the generation stage, where response-length skew causes the effective batch size to shrink rapidly during decoding, leaving GPUs underutilized while a few long responses remain unfinished. Mainstream frameworks employ a static tensor parallelism (TP) configuration that cannot adapt to changing batch characteristics, leaving substantial performance headroom unexplored. We propose PAT, an adaptive TP method that dynamically reconfigures TP during the generation stage of each RLHF iteration. PAT introduces two key techniques. First, a predictor-guided online reconfiguration method decides both the reconfiguration point and the target TP configuration based on offline profiling, triggering reconfiguration only when the predicted latency benefit outweighs the reconfiguration overhead. Second, a lightweight online reconfiguration mechanism updates only the states and layouts affected by TP changes: it adapts unfinished decoding states through a cost-model-based choice between KV-cache migration and recomputation, performs in-place weight resharding, and reuses cached communication groups. We implement PAT on top of SGLang and integrate it with the VeRL framework. Evaluations on LLaMA3.1-8B and Qwen3-14B using DeepScaleR show that PAT reduces generation latency by up to 34.6% and end-to-end RLHF training iteration latency by up to 27.2% compared to the original VeRL setup.

IndexMem: Learned KV-Cache Eviction with Latent Memory for Long-Context LLM Inference

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xintong Yang · Hao Gu · Binxing Xu · Lujun Li · Bei Liu · Jiacheng Liu · Qiyuan Zhu · Sirui Han · Yike Guo
26 May 2026 at 12:00
arXiv:2605.25475v1 Announce Type: cross Abstract: Large Language Models (LLMs) are increasingly expected to operate over long contexts, yet standard softmax attention incurs a KV cache that grows linearly with sequence length, quickly becoming the bottleneck for long context inference. A practical remedy is to evict less important KV entries; however, existing eviction policies are largely heuristic and struggle to capture the rich, input-dependent distribution of token importance. In this work, we introduce a learnable indexer that predicts KV importance, enabling more accurate retention of critical tokens. Meanwhile, naively evicting tokens permanently discards their information, leading to irreversible forgetting and degraded retrieval over long ranges. To address this, we propose a lightweight latent memory module that compresses evicted tokens into a compact, online-updated state and provides residual readouts to compensate for the attention contributions lost through KV eviction. Collectively, our method enables accurate long-context inference under a bounded KV budget, delivering consistent improvements on RULER (4K/16K) across Qwen, Mistral, and Llama models (up to 25 points under aggressive eviction), markedly more stable Needle-in-a-Haystack retrieval, and superior LongBench scores and compression curves compared to existing eviction policies.

FG-CLIP 2: A Bilingual Fine-grained Vision-Language Alignment Model

✇cs.AI, q-bio.NC updates on arXiv.org
By: Chunyu Xie · Bin Wang · Fanjing Kong · Jincheng Li · Dawei Liang · Ji Ao · Dawei Leng · Yuhui Yin
26 May 2026 at 12:00
arXiv:2510.10921v3 Announce Type: replace-cross Abstract: Fine-grained vision-language understanding requires precise alignment between visual content and linguistic descriptions, a capability that remains limited in current models, particularly in non-English settings. While models like CLIP perform well on global alignment, they often struggle to capture fine-grained details in object attributes, spatial relations, and linguistic expressions, with limited support for bilingual comprehension. To address these challenges, we introduce FG-CLIP 2, a bilingual vision-language model designed to advance fine-grained alignment for both English and Chinese. Our approach leverages rich fine-grained supervision, including region-text matching and long-caption modeling, alongside multiple discriminative objectives. We further introduce the Textual Intra-modal Contrastive (TIC) loss to better distinguish semantically similar captions. Trained on a carefully curated mixture of large-scale English and Chinese data, including a newly released 12M Chinese region-text dataset, FG-CLIP 2 achieves powerful bilingual performance. To enable rigorous evaluation, we present a new benchmark for Chinese multimodal understanding, featuring long-caption retrieval and bounding box classification. Extensive experiments on 29 datasets across 8 tasks show that FG-CLIP 2 outperforms existing methods, achieving state-of-the-art results in both languages. We release the model, code, and benchmark to facilitate future research on bilingual fine-grained vision-language alignment.

E3AD: An Emotion-Aware Vision-Language-Action Model for Human-Centric End-to-End Autonomous Driving

✇cs.AI, q-bio.NC updates on arXiv.org
By: Yihong Tang · Haicheng Liao · Tong Nie · Junlin He · Ao Qu · Kehua Chen · Wei Ma · Zhenning Li · Lijun Sun · Chengzhong Xu
26 May 2026 at 12:00
arXiv:2512.04733v2 Announce Type: replace-cross Abstract: End-to-end autonomous driving (AD) systems increasingly adopt vision-language-action (VLA) models, yet they typically ignore the passenger's emotional state, which is central to comfort and AD acceptance. We introduce Open-Domain End-to-End (OD-E2E) autonomous driving, where an autonomous vehicle (AV) must interpret free-form natural-language commands, infer the emotion, and plan a physically feasible trajectory. We propose E3AD, an emotion-aware VLA framework that augments semantic understanding with two cognitively inspired components: a continuous Valenc-Arousal-Dominance (VAD) emotion model that captures tone and urgency from language, and a dual-pathway spatial reasoning module that fuses egocentric and allocentric views for human-like spatial cognition. A consistency-oriented training scheme, combining modality pretraining with preference-based alignment, further enforces coherence between emotional intent and driving actions. Across real-world datasets, E3AD improves visual grounding and waypoint planning and achieves state-of-the-art (SOTA) VAD correlation for emotion estimation. These evaluation results show that injecting emotion into VLA-style driving yields more human-aligned grounding, planning, and feedback.

RecGOAT: Graph Optimal Adaptive Transport for LLM-Enhanced Multimodal Recommendation with Dual Semantic Alignment

✇cs.AI, q-bio.NC updates on arXiv.org
By: Yuecheng Li · Hengwei Ju · Zeyu Song · Wei Yang · Chi Lu · Peng Jiang · Kun Gai
26 May 2026 at 12:00
arXiv:2602.00682v2 Announce Type: replace-cross Abstract: Integrating large language model (LLM) representations into multimodal recommendation has shown promise, yet a fundamental challenge remains largely overlooked: the semantic heterogeneity between generative LM representations and the ID-based collaborative signals that recommendation systems rely on. Naively injecting LM features without alignment degrades recommendation performance rather than improving it. To resolve this, we propose RecGOAT, a dual-granularity semantic alignment framework built on graph neural networks and optimal transport theory. RecGOAT first enriches collaborative semantics through multimodal attentive graphs that capture item-item, user-item, and user-user relationships, initializing user representations via LLM-inferred behavioral preferences. It then aligns LM-derived modality representations with recommendation IDs at two complementary granularities: (1) instance-level alignment via cross-modal contrastive learning (CMCL), which produces discriminative per-sample representations; and (2) distribution-level alignment via optimal adaptive transport (OAT), which minimizes the 1-Wasserstein distance between ID distributions and LLM semantics to produce a unified, consistently aligned feature space. Theoretically, we prove that the unified representation achieves strictly lower target error than any single-modality representation, with the gap bounded by the Wasserstein distance and the InfoNCE loss, providing rigorous guarantees for both alignment consistency and fusion comprehensiveness. Extensive experiments on three public benchmarks demonstrate state-of-the-art performance. Deployment on a large-scale online advertising platform further validates RecGOAT's industrial scalability. Our code is available at https://github.com/6lyc/RecGOAT-LLM4Rec.

A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence

✇Nature - Issue - nature.com science feeds
By: Min He · Jia Su · Xiaogang Zhou · Tuo Qi · Jiazheng Wang · Tianxin Zhang · Jinhua Chen · Mawsheng Chern · Youpin Xu · Xiang Lu · Qingqing Hou · Hongrui Liu · Wenfang Huang · Jiawei Liu · Shiying Li · Yunfei Zhu · Xue Chen · Senyu Ran · Han Li · Renju Liu · Mingliang Lei · Guosong Shu · Haicheng Liao · Junjie Yin · Xiaobo Zhu · Yongyan Tang · Li Song · Long Wang · Qing Xiong · Jiali Liu · Yu Bi · Yihua Yang · Hai Qing · Bingtian Ma · Yan Li · Jing Fan · Peng Qin · Yuping Wang · Jianming Wu · Wenming Wang · Shigui Li · Weitao Li · Jing Wang · Xuewei Chen
20 May 2026 at 08:00

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

A SAUR gene enhances maize drought resilience by promoting silk elongation

✇Nature - Issue - nature.com science feeds
By: Chaohui Zhu · Zhirui Yang · Shiping Yang · Xueyan Zhou · Boxin Liu · Tian Tian · Bochen Zhao · Yingying Xie · Yujun Liu · Jinkui Cheng · Huaijun Tang · Yanjun Zhang · Xiaoqing Xie · Lei Zhang · Cheng Liu · Xingrong Wang · Shengxue Liu · Feng Qin
20 May 2026 at 08:00

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10566-9

The Small Auxin Up RNA (SAUR) protein ZmSAUR72 in maize (Zea mays) promotes silk growth via regulation of H+-ATPase activity, and is a key determinant of the anthesis-silking interval and thus resilience to drought.

Multi-omics integration identifies ribosome biogenesis-active macrophage subpopulation and its key gene GNL2 in driving liver hepatocellular carcinoma progression and mechanisms

✇Omics in Hepatocellular
By: Yajie Qi · Kun Li · Pincheng Li · Jianyu Yan · Shuyue Feng · Dan Wan · Ke Du · Xiao Liang · Fan Yang · Erzheng Zhou · Na Huang · Qian Wang · Nanbin Liu
14 May 2026 at 18:00

Cancer Cell Int. 2026 May 14. doi: 10.1186/s12935-026-04330-2. Online ahead of print.

ABSTRACT

BACKGROUND: Liver hepatocellular carcinoma (LIHC) is a common malignancy, yet the core genes driving its progression and potential therapeutic targets remain insufficiently explored. Ribosome biogenesis (RB) is a critical biological process linked to various cancers; however, its systematic role in LIHC remains unclear.

METHODS: This study integrated LIHC single-cell RNA-Seq, bulk RNA-Seq, and spatial transcriptomic data with ribosome biogenesis-related gene sets to construct a single-cell atlas of LIHC. Weighted Gene Co-expression Network Analysis (WGCNA) was employed to characterize myeloid cell subsets. Furthermore, an LIHC prognostic risk model based on RB-related genes was developed using 117 machine-learning algorithm combinations. Key findings were subsequently corroborated through experimental validation and clinical sample analysis.

RESULTS: We identified a distinct macrophage subpopulation with high ribosome biogenesis activity, termed ribosome biogenesis-active macrophages (RAMs). These cells exhibited strong communication with inflammatory macrophages, potentially mediated by MIF-related receptor-ligand interactions. We further constructed an 8-gene prognostic model (PA2G4, GNL2, PWP1, DDX49, NOC4L, GDI2, CST7, and RCL1), which showed good predictive performance. Drug sensitivity analysis suggested that the high-risk group may be more responsive to several agents, including docetaxel. Among these genes, GNL2 was selected for further investigation. Elevated GNL2 expression was associated with increased stemness features in myeloid cells. Molecular docking analysis identified several candidate compounds with potential binding affinity to GNL2. Functionally, GNL2 knockdown in macrophages reduced TGF-β and TNF-α expression and was associated with decreased proliferation, migration, and invasion of LIHC cells.

CONCLUSION: We identified a highly active ribosome biogenesis-macrophage subpopulation (RAM), and constructed a robust risk model to aid in the diagnosis, prognosis, and treatment of LIHC. GNL2 is associated with increased expression of TGF-β and TNF-α and may contribute to LIHC progression.

PMID:42135716 | DOI:10.1186/s12935-026-04330-2

Received — 8 April 2026 ⏭

Safety-Aligned 3D Object Detection: Single-Vehicle, Cooperative, and End-to-End Perspectives

✇cs.AI, q-bio.NC updates on arXiv.org
By: Brian Hsuan-Cheng Liao · Chih-Hong Cheng · Hasan Esen · Alois Knoll
7 April 2026 at 12:00
arXiv:2604.03325v1 Announce Type: cross Abstract: Perception plays a central role in connected and autonomous vehicles (CAVs), underpinning not only conventional modular driving stacks, but also cooperative perception systems and recent end-to-end driving models. While deep learning has greatly improved perception performance, its statistical nature makes perfect predictions difficult to attain. Meanwhile, standard training objectives and evaluation benchmarks treat all perception errors equally, even though only a subset is safety-critical. In this paper, we investigate safety-aligned evaluation and optimization for 3D object detection that explicitly characterize high-impact errors. Building on our previously proposed safety-oriented metric, NDS-USC, and safety-aware loss function, EC-IoU, we make three contributions. First, we present an expanded study of single-vehicle 3D object detection models across diverse neural network architectures and sensing modalities, showing that gains under standard metrics such as mAP and NDS may not translate to safety-oriented criteria represented by NDS-USC. With EC-IoU, we reaffirm the benefit of safety-aware fine-tuning for improving safety-critical detection performance. Second, we conduct an ego-centric, safety-oriented evaluation of AV-infrastructure cooperative object detection models, underscoring its superiority over vehicle-only models and demonstrating a safety impact analysis that illustrates the potential contribution of cooperative models to "Vision Zero." Third, we integrate EC-IoU into SparseDrive and show that safety-aware perception hardening can reduce collision rate by nearly 30% and improve system-level safety directly in an end-to-end perception-to-planning framework. Overall, our results indicate that safety-aligned perception evaluation and optimization offer a practical path toward enhancing CAV safety across single-vehicle, cooperative, and end-to-end autonomy settings.

RDEx-CMOP: Feasibility-Aware Indicator-Guided Differential Evolution for Fixed-Budget Constrained Multiobjective Optimization

✇cs.AI, q-bio.NC updates on arXiv.org
By: Sichen Tao · Yifei Yang · Ruihan Zhao · Kaiyu Wang · Sicheng Liu · Shangce Gao
7 April 2026 at 12:00
arXiv:2604.03708v1 Announce Type: cross Abstract: Constrained multiobjective optimisation requires fast feasibility attainment together with stable convergence and diversity preservation under strict evaluation budgets. This report documents RDEx-CMOP, the differential evolution variant used in the IEEE CEC 2025 numerical optimisation competition (C06 special session) constrained multiobjective track. RDEx-CMOP integrates an {\epsilon}-level feasibility schedule, a SPEA2-style indicator-driven fitness assignment, and a fitness-oriented current-to-pbest/1 mutation operator. We evaluate RDEx-CMOP on the official CEC 2025 CMOP benchmark using the median-target U-score framework and the released trace data. Experimental results show that RDEx-CMOP achieves the highest total score and the best overall average rank among all released comparison algorithms, with strong target-attainment behaviour and near-zero final violation on most problems.

XModBench: Benchmarking Cross-Modal Capabilities and Consistency in Omni-Language Models

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xingrui Wang · Jiang Liu · Chao Huang · Xiaodong Yu · Ze Wang · Ximeng Sun · Jialian Wu · Alan Yuille · Emad Barsoum · Zicheng Liu
7 April 2026 at 12:00
arXiv:2510.15148v2 Announce Type: replace-cross Abstract: Omni-modal large language models (OLLMs) aim to unify audio, vision, and text understanding within a single framework. While existing benchmarks primarily evaluate general cross-modal question-answering ability, it remains unclear whether OLLMs achieve modality-invariant reasoning or exhibit modality-specific biases. We introduce XModBench, a large-scale tri-modal benchmark explicitly designed to measure cross-modal consistency. XModBench comprises 60,828 multiple-choice questions spanning five task families and systematically covers all six modality compositions in question-answer pairs, enabling fine-grained diagnosis of an OLLM's modality-invariant reasoning, modality disparity, and directional imbalance. Experiments show that even the strongest model, Gemini 2.5 Pro, (i) struggles with spatial and temporal reasoning, achieving less than 60% accuracy, (ii) reveals persistent modality disparities, with performance dropping substantially when the same semantic content is conveyed through audio rather than text, and (iii) shows systematic directional imbalance, exhibiting lower consistency when vision serves as context compared to text. These findings indicate that current OLLMs remain far from truly modality-invariant reasoning and position XModBench as a fundamental diagnostic tool for evaluating and improving cross-modal competence. All data and evaluation tools will be available at https://xingruiwang.github.io/projects/XModBench/.

RASA: Routing-Aware Safety Alignment for Mixture-of-Experts Models

✇cs.AI, q-bio.NC updates on arXiv.org
By: Jiacheng Liang · Yuhui Wang · Tanqiu Jiang · Ting Wang
7 April 2026 at 12:00
arXiv:2602.04448v2 Announce Type: replace-cross Abstract: Mixture-of-Experts (MoE) language models introduce unique challenges for safety alignment due to their sparse routing mechanisms, which can enable degenerate optimization behaviors under standard full-parameter fine-tuning. In our preliminary experiments, we observe that naively applying full-parameter safety fine-tuning to MoE models can reduce attack success rates through routing or expert dominance effects, rather than by directly repairing Safety-Critical Experts. To address this challenge, we propose RASA, a routing-aware expert-level alignment framework that explicitly repairs Safety-Critical Experts while preventing routing-based bypasses. RASA identifies experts disproportionately activated by successful jailbreaks, selectively fine-tunes only these experts under fixed routing, and subsequently enforces routing consistency with safety-aligned contexts. Across two representative MoE architectures and a diverse set of jailbreak attacks, RASA achieves near-perfect robustness, strong cross-attack generalization, and substantially reduced over-refusal, while preserving general capabilities on benchmarks such as MMLU, GSM8K, and TruthfulQA. Our results suggest that robust MoE safety alignment benefits from targeted expert repair rather than global parameter updates, offering a practical and architecture-preserving alternative to prior approaches.
Received — 4 April 2026 ⏭

Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling

✇Nature Cancer
By: Yang Huang · Yifan Hou · Jiahui Yang · Wanqi Yang · Hanxin Liu · Haibao Peng · Xiaohui Li · Jiaxu Zhao · Ye Zhang · Rui Zeng · Youming Zeng · Cheng Li · Qiangqiang Zhang · Yudan Chi
3 April 2026 at 08:00

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-y

Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.
Received — 2 April 2026 ⏭

InfiniteVL: Synergizing Linear and Sparse Attention for Highly-Efficient, Unlimited-Input Vision-Language Models

✇cs.AI, q-bio.NC updates on arXiv.org
By: Hongyuan Tao · Bencheng Liao · Shaoyu Chen · Haoran Yin · Qian Zhang · Wenyu Liu · Xinggang Wang
1 April 2026 at 12:00
arXiv:2512.08829v2 Announce Type: replace-cross Abstract: Vision-Language Models (VLMs) are increasingly tasked with ultra-long multimodal understanding. While linear architectures offer constant computation and memory footprints, they often struggle with high-frequency visual perception compared to standard Transformers. To bridge this gap, we introduce \textbf{InfiniteVL}. We first develop a hybrid base model called \textbf{InfiniteVL-Base} that interleaves a small fraction of Full Attention layers with Gated DeltaNet. Empowered by a tailored distillation and fine-tuning strategy, InfiniteVL-Base matches the fundamental multimodal performance of equivalent Transformers while achieving a \textbf{1.7$\times$} decoding speedup. However, the quadratic complexity of the retained Full Attention inevitably becomes an efficiency bottleneck when scaling to ultra long context. To break this barrier, we propose a novel Long-Sequence Architectural Fine-Tuning strategy that seamlessly transforms the dense attention into vision-specific sparse mechanisms. This yields two specialized variants: \textbf{InfiniteVL-Offline} for offline retrieval and \textbf{InfiniteVL-Online} for online streaming. By eliminating the computation explosion of global attention without sacrificing high-frequency visual recall, InfiniteVL-Offline achieves Transformer-level length generalization with a \textbf{5x} prefill acceleration at 256K context. Concurrently, InfiniteVL-Online delivers robust streaming perception with a constant memory footprint and a real-time throughput of \textbf{25} FPS. Code and models are available at https://github.com/hustvl/InfiniteVL.

Proposed Role of Circadian Clock Genes in Pathogenesis of HCC: Molecular Subtyping and Characterization

✇Omics in Hepatocellular
By: Zhikui Lu · Yi Zhou · Jian Luo · Zhicheng Liu · Zhenyu Xiao
28 March 2026 at 18:00

Biomedicines. 2026 Mar 12;14(3):645. doi: 10.3390/biomedicines14030645.

ABSTRACT

Background: Hepatocellular carcinoma (HCC) stands as a prevalent global health issue with increasing incidence and mortality rates. Hepatocellular carcinoma (HCC) exhibits profound molecular and clinical heterogeneity, which limits the effectiveness of current therapeutic strategies. Circadian rhythm disruption has been implicated in metabolic reprogramming, proliferation, and immune modulation in cancer, but its role in shaping HCC heterogeneity remains poorly defined. Methods: Four public HCC transcriptomic cohorts (TCGA-LIHC, CHCC, LIRI, LICA) were integrated using RMA normalization and ComBat for batch correction. Consensus clustering based on 31 core circadian clock genes (CCGs) identified robust molecular subtypes. Multi-omics characterization-including genomic alterations, pathway activity (GSEA/GSVA), immune microenvironment profiling (CIBERSORT, EPIC, MCP-counter, xCell), and drug-sensitivity prediction (pRRophetic/oncoPredict)-was performed to delineate subtype-specific biological properties. A nine-gene CCG-based RiskScore model was constructed using LASSO Cox regression to internally validate subtype robustness and intra-subtype risk stratification. Results: Using consensus clustering of 31 core CCGs in TCGA-LIHC and three independent validation cohorts (CHCC, LIRI, LICA), we identified three reproducible subtypes-Cluster-1 (metabolic-quiescent), Cluster-2 (transition-intermediate), and Cluster-3 (proliferation-inflammatory)-which were recapitulated across cohorts and showed distinct overall survival (Cluster-3 worst; log-rank p values significant across datasets). Multi-omic characterization revealed that Cluster-3 exhibits the highest tumor mutational burden and CNV burden with enrichment of TP53/AXIN1/TERT alterations, strong activation of cell-cycle, E2F, and G2M programs, and an immune-hot yet immunosuppressed microenvironment enriched for TAMs, Tregs and MDSCs. By contrast, Cluster-1 shows relative genomic stability, dominant hepatic metabolic signatures (fatty-acid oxidation, bile-acid and xenobiotic metabolism) and an immune-cold phenotype. Single-cell mapping linked ALAS1 expression to malignant hepatocytes predominating in Cluster-1, whereas NONO and CSNK1D localized to stromal (CAFs/TECs) and both malignant/immune compartments respectively in Cluster-3, providing a cellular mechanism for subtype-specific metabolism, angiogenesis and immune modulation. Finally, a nine-gene CCG-based RiskScore validated prognostic stratification and drug-sensitivity predictions indicated subtype-specific therapeutic vulnerabilities (notably increased predicted TKI sensitivity in Cluster-3). Conclusion: In conclusion, this study proposes a robust circadian rhythm-based molecular classification of hepatocellular carcinoma, revealing three biologically and clinically distinct subtypes characterized by divergent genomic alterations, metabolic programs, immune microenvironment states, and prognostic patterns. By integrating bulk and single-cell transcriptomic data, we identify subtype-specific roles of key circadian regulators-including ALAS1, NONO, and CSNK1D-in shaping tumor metabolism, proliferation, stromal remodeling, and immune suppression. These findings highlight circadian dysregulation as a potential upstream factor associated with HCC heterogeneity and provide a conceptual framework for developing subtype-tailored mechanistic studies and circadian-informed therapeutic strategies.

PMID:41898292 | PMC:PMC13024568 | DOI:10.3390/biomedicines14030645

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