arXiv:2609.12818v1 Announce Type: cross Abstract: Long video understanding often behaves like a visual needle-in-a-haystack problem: query-relevant evidence is sparsely distributed across long temporal spans, while packing dense frames into a single VLM context incurs \textit{context rot} and high cost. Existing video agents often rely on query-agnostic offline preprocessing or ad hoc tool sets, which can miss query-specific details and waste computation. In this work, we present VideoXAgent, a purely online video-agent harness for long video understanding that starts from the given video file and user query, plans and decomposes the task, invokes specialized expert tools on demand, and aggregates multimodal evidence to produce a final answer while resolving conflicts among observations. To support this on-demand invocation, we design a suite of heterogeneous expert tools guided by a data-driven taxonomy of atomic capabilities, spanning scripts, VLMs, and domain models (e.g., detection, OCR, ASR, face recognition). The harness further enforces objective evidence prompting and budget-aware control to curb hallucination and non-termination. Across Video-MME-Long, LongVideoBench-Long, LVBench, and MINERVA, VideoXAgent is competitive with frontier LMMs and video agents under a smaller context footprint---about 50k tokens of agent context per sample, even on hour-long videos. In particular, on complex video-reasoning benchmarks such as MINERVA, it matches this level while using only about 15\% of the context of a 1,024-frame dense-packing baseline. Notably, the harness remains effective with a visually weak or even text-only orchestrator, suggesting that strong long-video understanding can emerge from progressive agentic evidence seeking rather than from packing the full video into a single context. Project page: https://go-agent-x.github.io/video_agent_harness/

Jin and colleagues review recent advances in mRNA vaccines for infectious diseases and cancer, covering sequence optimization, circRNA/saRNA platforms, delivery systems, and clinical translation challenges, while highlighting the role of computational technologies.

arXiv:2605.24652v1 Announce Type: new Abstract: Rapid advances in audio-video (AV) generation have enabled high-fidelity synthesis with synchronized sound, particularly for human-related scenarios involving speech and interactions. Yet evaluation for AV generation remains at an early stage, with only a few coarse-grained benchmarks for human-related scenarios and relying on limited preset evaluations with generic multimodal LLMs, leading to inaccurate assessments of model capabilities. To address these issues, we introduce AVBench, a fully automated benchmark tailored for human-centric AV generation. AVBench is built on two key designs for comprehensive and accurate evaluation: (i) Human-centric and fine-grained metrics. AVBench integrates ten evaluation dimensions designed for human-centered real-world scenarios, covering visual quality, audio quality, and multi-level consistency across modalities. These practical metrics capture human-related details that existing benchmarks often overlook. (ii) Specialized evaluators via preference learning. To address the lack of specialized training data, we construct large-scale supervision by transforming real-world videos into diverse training pairs with controlled perturbations. After fine-tuning on this high-quality dataset, the evaluators learn to reliably detect subtle cross-modal inconsistencies. Crucially, instead of producing discrete textual judgment, AVBench derives continuous evaluation scores from the model's prediction confidence on binary decisions. This probabilistic scoring mechanism enables a more reliable assessment than traditional VQA-style evaluation and aligns closely with human judgment. Taken together, AVBench offers automated evaluation for AV generation, demonstrates strong potential for data filtering, and serves as a differentiable reward signal for Reinforcement Learning from Human Feedback (RLHF).

arXiv:2602.03955v3 Announce Type: replace Abstract: While large language model (LLM) multi-agent systems achieve superior reasoning performance through iterative debate, practical deployment is limited by their high computational cost and error propagation. This paper proposes AgentArk, a novel framework to distill multi-agent dynamics into the weights of a single model, effectively transforming explicit test-time interactions into implicit model capabilities. This equips a single agent with the intelligence of multi-agent systems while remaining computationally efficient. Specifically, we investigate three hierarchical distillation strategies across various models, tasks, scaling, and scenarios: reasoning-enhanced fine-tuning; trajectory-based augmentation; and process-aware distillation. By shifting the burden of computation from inference to training, the distilled models preserve the efficiency of one agent while exhibiting strong reasoning and self-correction performance of multiple agents. They further demonstrate enhanced robustness and generalization across diverse reasoning tasks. We hope this work can shed light on future research on efficient and robust multi-agent development. Our code is at https://github.com/AIFrontierLab/AgentArk.

Oncogene, Published online: 19 May 2026; doi:10.1038/s41388-026-03823-8

NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer

arXiv:2512.00408v2 Announce Type: replace-cross Abstract: Traditional video codecs optimized for pixel fidelity collapse at ultra-low bitrates and produce severe artifacts. This failure arises from a fundamental misalignment between pixel accuracy and human perception. We propose a semantic video compression framework named DiSCo that transmits only the most meaningful information while relying on generative priors for detail synthesis. The source video is decomposed into three compact modalities: a textual description, a spatiotemporally degraded video, and optional sketches or poses that respectively capture semantic, appearance, and motion cues. A conditional video diffusion model then reconstructs high-quality, temporally coherent videos from these compact representations. Temporal forward filling, token interleaving, and modality-specific codecs are proposed to improve multimodal generation and modality compactness. Experiments show that our method outperforms baseline semantic and traditional codecs by 2-10X on perceptual metrics at low bitrates.

arXiv:2603.23406v2 Announce Type: replace Abstract: While large language models simulate social behaviors, their capacity for stable stance formation and identity negotiation during complex interventions remains unclear. To overcome the limitations of static evaluations, this paper proposes a novel mixed-methods framework combining computational virtual ethnography with quantitative socio-cognitive profiling. By embedding human researchers into generative multiagent communities, controlled discursive interventions are conducted to trace the evolution of collective cognition. To rigorously measure how agents internalize and react to these specific interventions, this paper formalizes three new metrics: Innate Value Bias (IVB), Persuasion Sensitivity, and Trust-Action Decoupling (TAD). Across multiple representative models, agents exhibit endogenous stances that override preset identities, consistently demonstrating an innate progressive bias (IVB > 0). When aligned with these stances, rational persuasion successfully shifts 90% of neutral agents while maintaining high trust. In contrast, conflicting emotional provocations induce a paradoxical 40.0% TAD rate in advanced models, which hypocritically alter stances despite reporting low trust. Smaller models contrastingly maintain a 0% TAD rate, strictly requiring trust for behavioral shifts. Furthermore, guided by shared stances, agents use language interactions to actively dismantle assigned power hierarchies and reconstruct self organized community boundaries. These findings expose the fragility of static prompt engineering, providing a methodological and quantitative foundation for dynamic alignment in human-agent hybrid societies. The official code is available at: https://github.com/armihia/CMASE-Endogenous-Stances

arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile agents. We operationalize privacy-respecting phone use as permissioned access, minimal disclosure, and user-controlled memory through a minimal privacy contract, iMy, and pair it with instrumented mock apps plus rule-based auditing that make unnecessary permission requests, deceptive re-disclosure, and unnecessary form filling observable and reproducible. Across five frontier models on 10 mobile apps and 300 tasks, we find that task success, privacy-compliant task completion, and later-session use of saved preferences are distinct capabilities, and no single model dominates all three. Evaluating success and privacy jointly reshuffles the model ordering relative to either metric alone. The most persistent failure mode across models is simple data minimization: agents still fill optional personal entries that the task does not require. These results show that privacy failures arise from over-helpful execution of benign tasks, and that success-only evaluation overestimates the deployment readiness of current phone-use agents. All code, mock apps, and agent trajectories are publicly available at~ https://github.com/FreedomIntelligence/MyPhoneBench.

arXiv:2510.13077v3 Announce Type: replace-cross Abstract: We develop an unsupervised deep learning framework for real-time scalable and generalizable downlink beamforming in multi-user multiple-input single-output (MU-MISO) systems. The proposed semi-amortized lifted learning-to-optimize (SALLO) framework employs a multi-layer Transformer to iteratively refine an auxiliary variable and the beamformer solution, with a few projected gradient ascent steps at each layer. A key feature of our SALLO Transformer model is that it can handle varying numbers of users and antennas, enabled by a user-antenna dual tokenization and a structured sample/attention masking scheme, leading to generalization across different configurations without retraining. To improve convergence and robustness, we introduce three training strategies: (a) sliding-window training to stabilize gradient propagation, (b) curriculum learning with random masking to enable user-antenna configuration generalization and prevent poor early-stage convergence, and (c) sample replay to mitigate catastrophic forgetting during multi-stage training. Ablation studies validate several key architecture designs and show that the enhanced training scheme improves both generalizability and solution quality. Simulation results over both Gaussian and sparse channels show that the proposed scheme consistently outperforms existing deep learning baselines across diverse system configurations and channel conditions. The performance gain becomes more pronounced in overloaded regimes, highlighting improved robustness under challenging scenarios. Furthermore, our scheme surpasses the WMMSE benchmark in underloaded systems and even in overloaded systems when the overloading factor is below certain threshold. These gains are achieved with fast inference and a substantially more lightweight model than wireless foundation models.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10303-2

A fully automated methodology based on rubrics capturing a broad range of cognitive and intellectual demands is illustrated using LLMs and tasks, demonstrating a new way to evaluate the capabilities of AI systems and anticipate their performance.

Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10389-8

Author Correction: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes

arXiv:2603.23406v1 Announce Type: new Abstract: While large language models simulate social behaviors, their capacity for stable stance formation and identity negotiation during complex interventions remains unclear. To overcome the limitations of static evaluations, this paper proposes a novel mixed-methods framework combining computational virtual ethnography with quantitative socio-cognitive profiling. By embedding human researchers into generative multiagent communities, controlled discursive interventions are conducted to trace the evolution of collective cognition. To rigorously measure how agents internalize and react to these specific interventions, this paper formalizes three new metrics: Innate Value Bias (IVB), Persuasion Sensitivity, and Trust-Action Decoupling (TAD). Across multiple representative models, agents exhibit endogenous stances that override preset identities, consistently demonstrating an innate progressive bias (IVB > 0). When aligned with these stances, rational persuasion successfully shifts 90% of neutral agents while maintaining high trust. In contrast, conflicting emotional provocations induce a paradoxical 40.0% TAD rate in advanced models, which hypocritically alter stances despite reporting low trust. Smaller models contrastingly maintain a 0% TAD rate, strictly requiring trust for behavioral shifts. Furthermore, guided by shared stances, agents use language interactions to actively dismantle assigned power hierarchies and reconstruct self organized community boundaries. These findings expose the fragility of static prompt engineering, providing a methodological and quantitative foundation for dynamic alignment in human-agent hybrid societies. The official code is available at: https://github.com/armihia/CMASE-Endogenous-Stances

arXiv:2603.22369v1 Announce Type: cross Abstract: Accurate prediction of synthetic lethality (SL) is important for guiding the development of cancer drugs and therapies. SL prediction faces significant challenges in the effective fusion of heterogeneous multi-source data. Existing multimodal methods often suffer from "modality laziness" due to disparate convergence speeds, which hinders the exploitation of complementary information. This is also one reason why most existing SL prediction models cannot perform well on both pan-cancer and single-cancer SL pair prediction. In this study, we propose SynLeaF, a dual-stage multimodal fusion framework for SL prediction across pan- and single-cancer contexts. The framework employs a VAE-based cross-encoder with a product of experts mechanism to fuse four omics data types (gene expression, mutation, methylation, and CNV), while simultaneously utilizing a relational graph convolutional network to capture structured gene representations from biomedical knowledge graphs. To mitigate modality laziness, SynLeaF introduces a dual-stage training mechanism employing featurelevel knowledge distillation with adaptive uni-modal teacher and ensemble strategies. In extensive experiments across eight specific cancer types and a pancancer dataset, SynLeaF achieves superior performance in 17 out of 19 scenarios. Ablation studies and gradient analyses further validate the critical contributions of the proposed fusion and distillation mechanisms to model robustness and generalization. To facilitate community use, a web server is available at https://synleaf.bioinformatics-lilab.cn.

arXiv:2603.22841v1 Announce Type: cross Abstract: Drone detection is pivotal in numerous security and counter-UAV applications. However, existing deep learning-based methods typically struggle to balance robust feature representation with computational efficiency. This challenge is particularly acute when detecting miniature drones against complex backgrounds under severe environmental interference. To address these issues, we introduce UAV-DETR, a novel framework that integrates a small-target-friendly architecture with real-time detection capabilities. Specifically, UAV-DETR features a WTConv-enhanced backbone and a Sliding Window Self-Attention (SWSA-IFI) encoder, capturing the high-frequency structural details of tiny targets while drastically reducing parameter overhead. Furthermore, we propose an Efficient Cross-Scale Feature Recalibration and Fusion Network (ECFRFN) to suppress background noise and aggregate multi-scale semantics. To further enhance accuracy, UAV-DETR incorporates a hybrid Inner-CIoU and NWD loss strategy, mitigating the extreme sensitivity of standard IoU metrics to minor positional deviations in small objects. Extensive experiments demonstrate that UAV-DETR significantly outperforms the baseline RT-DETR on our custom UAV dataset (+6.61% in mAP50:95, with a 39.8% reduction in parameters) and the public DUT-ANTI-UAV benchmark (+1.4% in Precision, +1.0% in F1-Score). These results establish UAV-DETR as a superior trade-off between efficiency and precision in counter-UAV object detection. The code is available at https://github.com/wd-sir/UAVDETR.

arXiv:2603.23342v1 Announce Type: cross Abstract: Material awareness can improve robotic navigation and interaction, particularly in conditions where cameras and LiDAR degrade. We present a lightweight mmWave radar material classification pipeline designed for ultra-low-power edge devices (TI IWRL6432), using compact range-bin intensity descriptors and a Multilayer Perceptron (MLP) for real-time inference. While the classifier reaches a macro-F1 of 94.2\% under the nominal training geometry, we observe a pronounced performance drop under realistic geometry shifts, including sensor height changes and small tilt angles. These perturbations induce systematic intensity scaling and angle-dependent radar cross section (RCS) effects, pushing features out of distribution and reducing macro-F1 to around 68.5\%. We analyze these failure modes and outline practical directions for improving robustness with normalization, geometry augmentation, and motion-aware features.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

arXiv:2603.12933v1 Announce Type: new Abstract: Large Language Model (LLM)-driven Multi-Agent Systems (MAS) have demonstrated strong capability in complex reasoning and tool use, and heterogeneous agent pools further broaden the quality--cost trade-off space. Despite these advances, real-world deployment is often constrained by high inference cost, latency, and limited transparency, which hinders scalable and efficient routing. Existing routing strategies typically rely on expensive LLM-based selectors or static policies, and offer limited controllability for semantic-aware routing under dynamic loads and mixed intents, often resulting in unstable performance and inefficient resource utilization. To address these limitations, we propose AMRO-S, an efficient and interpretable routing framework for Multi-Agent Systems (MAS). AMRO-S models MAS routing as a semantic-conditioned path selection problem, enhancing routing performance through three key mechanisms: First, it leverages a supervised fine-tuned (SFT) small language model for intent inference, providing a low-overhead semantic interface for each query; second, it decomposes routing memory into task-specific pheromone specialists, reducing cross-task interference and optimizing path selection under mixed workloads; finally, it employs a quality-gated asynchronous update mechanism to decouple inference from learning, optimizing routing without increasing latency. Extensive experiments on five public benchmarks and high-concurrency stress tests demonstrate that AMRO-S consistently improves the quality--cost trade-off over strong routing baselines, while providing traceable routing evidence through structured pheromone patterns.

arXiv:2511.21471v2 Announce Type: replace Abstract: Spatial cognition is fundamental to real-world multimodal intelligence, allowing models to effectively interact with the physical environment. While multimodal large language models (MLLMs) have made significant strides, existing benchmarks often oversimplify spatial cognition, reducing it to a single-dimensional metric, which fails to capture the hierarchical structure and interdependence of spatial abilities. To address this gap, we propose a hierarchical spatial cognition framework that decomposes spatial intelligence into five progressively complex levels from basic observation to high-level planning. Building upon this taxonomy, we construct SpatialBench, a large-scale, fine-grained benchmark covering 15 tasks aligned with these cognitive levels. To provide a unified evaluation across heterogeneous tasks, we further introduce a high-level capability-oriented metric that reliably assesses a model's overall spatial reasoning ability. Extensive experiments over massive MLLMs reveal distinct performance stratification across cognitive levels: models exhibit strong perceptual grounding yet remain limited in symbolic reasoning, causal inference, and planning. Additional human tests demonstrate that humans perform selective, goal-directed abstraction, while MLLMs tend to over-attend to surface details without coherent spatial intent. Our work establishes the first systematic framework for measuring hierarchical spatial cognition in MLLMs, laying the foundation for future spatially intelligent systems.

arXiv:2204.14133v2 Announce Type: replace-cross Abstract: Topology impacts important network performance metrics, including link utilization, throughput and latency, and is of central importance to network operators. However, due to the combinatorial nature of network topology, it is extremely difficult to obtain an optimal solution, especially since topology planning in networks also often comes with management-specific constraints. As a result, local optimization with hand-tuned heuristic methods from human experts is often adopted in practice. Yet, heuristic methods cannot cover the global topology design space while taking into account constraints, and cannot guarantee to find good solutions. In this paper, we propose a novel deep reinforcement learning (DRL) algorithm for graph searching, called DRL-GS, for network topology optimization. DRL-GS consists of three novel components, including a verifier to validate the correctness of a generated network topology, a graph neural network (GNN) to efficiently approximate topology rating, and a DRL agent to conduct a topology search. DRL-GS can efficiently search over relatively large topology space and output topology with satisfactory performance. We conduct a case study based on a real-world network scenario, and our experimental results demonstrate the superior performance of DRL-GS in terms of both efficiency and performance.