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cs.AI, q-bio.NC updates on arXiv.org
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From Fixed Keys to Readable Schemas: Small Language Models for Vehicle Agent Function Calls
arXiv:2609.09476v1 Announce Type: cross Abstract: In-vehicle assistants must translate natural-language requests into accurate vehicle function calls under strict memory and latency constraints, making small language models (SLMs) attractive for on-device deployment. For such models, a key design choice is how the available function surface is presented. Two approaches are to represent each function with a dedicated Functional Token (FT) or provide function schemas directly in the prompt. FTs e
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cs.AI, q-bio.NC updates on arXiv.org
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SafeCtrl-RL: Inference-Time Adaptive Behaviour Control for LLM Dialogue via RL-Driven Prompt Optimisation
arXiv:2605.25984v1 Announce Type: cross Abstract: Ensuring safe and contextually appropriate behaviour in Large Language Models (LLMs) remains a critical challenge for real-world deployment. We present \textbf{SafeCtrl-RL}, an inference-time behavioural control framework that enables adaptive safety regulation without model retraining or parameter modification. The method formulates dialogue generation as a sequential decision process, where a reinforcement learning agent dynamically selects pr
SafeCtrl-RL: Inference-Time Adaptive Behaviour Control for LLM Dialogue via RL-Driven Prompt Optimisation
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(Multiomics OR Omics) AND (Pancreatic)
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Mendelian Randomization Analysis of the Relationship between Neurotransmitter-related Genes and Cancer: Insights from Multi-omics Data
Curr Top Med Chem. 2026 May 18. doi: 10.2174/0115680266436608260406113212. Online ahead of print.ABSTRACTINTRODUCTION: Epidemiological studies indicate a potential link between mental disorders and cancer; however, the role of neurotransmitter-related genes (NRGs) in carcinogenesis remains unclear. In this study, we employed Mendelian randomization utilizing multi-omics data to investigate the causal effects and mechanisms of NRGs in cancer.METHODS: We assessed the causal relationships between t
Mendelian Randomization Analysis of the Relationship between Neurotransmitter-related Genes and Cancer: Insights from Multi-omics Data
Curr Top Med Chem. 2026 May 18. doi: 10.2174/0115680266436608260406113212. Online ahead of print.
ABSTRACT
INTRODUCTION: Epidemiological studies indicate a potential link between mental disorders and cancer; however, the role of neurotransmitter-related genes (NRGs) in carcinogenesis remains unclear. In this study, we employed Mendelian randomization utilizing multi-omics data to investigate the causal effects and mechanisms of NRGs in cancer.
METHODS: We assessed the causal relationships between ten mental disorders and fourteen cancer types. NRGs were sourced from GeneCards, and transcriptome data for breast cancer (BC) were obtained from the Gene Expression Omnibus (GEO). Summary-data-based Mendelian Randomization (SMR) integrated genome-wide association study (GWAS) data with expression quantitative trait loci (eQTLs), DNA methylation QTLs (mQTLs), intestinal eQTLs, and fecal microbiota QTLs (mbQTLs). Colocalization analyses were conducted to explore the relationships between host genes and gut microbiota, with sensitivity assessments performed using two additional Mendelian randomization methods.
RESULTS: Mendelian randomization confirmed a causal association between mental disorders and BC. A meta-analysis of five BC datasets identified 821 differentially expressed genes (DEGs) among 829 non-redundant genes. SMR highlighted KRTCAP2 as a potential causal gene in blood, and cg24674445 as a significant methylation site. The expression of KRTCAP2 was found to be inversely correlated with BC, while methylation at cg24674445 downregulated KRTCAP2, suggesting that cg24674445 may promote BC progression.
DISCUSSION: This study advances beyond established epidemiological correlations by providing genetically validated evidence for a causal link between mental disorders and breast cancer. Its primary significance lies in delineating a plausible biological pathway-epigenetic regulation of neurotransmitter-related genes-that may mechanistically elucidate this connection. By integrating multi-omics data, we transition from mere association to a testable model of disease etiology, where genetic predispositions to mental illness and cancer converge upon shared regulatory mechanisms within the genome.
CONCLUSION: Multi-omics Mendelian randomization demonstrates that DNA methylation modulates the association between neurotransmitter-related genes and breast cancer.
PMID:42163732 | DOI:10.2174/0115680266436608260406113212
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Oncogene - Issue - nature.com science feeds
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XPO1 inhibitor KPT-330 disrupts the core transcriptional regulatory circuitry of dedifferentiated liposarcoma by modulating the translation process
Oncogene, Published online: 16 April 2026; doi:10.1038/s41388-026-03794-wXPO1 inhibitor KPT-330 disrupts the core transcriptional regulatory circuitry of dedifferentiated liposarcoma by modulating the translation process
XPO1 inhibitor KPT-330 disrupts the core transcriptional regulatory circuitry of dedifferentiated liposarcoma by modulating the translation process
Oncogene, Published online: 16 April 2026; doi:10.1038/s41388-026-03794-w
XPO1 inhibitor KPT-330 disrupts the core transcriptional regulatory circuitry of dedifferentiated liposarcoma by modulating the translation process-
Omics In Lung
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GPNMB Drives Brain Metastasis by Sculpting a Pathological Endothelial-Immune Interactome
Cancer Discov. 2026 Apr 15. doi: 10.1158/2159-8290.CD-25-1663. Online ahead of print.ABSTRACTBrain metastases (BM) remain a devastating disease with dismal prognosis. How circulating tumor cells (CTCs) penetrate the blood brain barrier (BBB) and reprogram the brain microenvironment remain unclear. Using spatially resolved multi-omic profiling of CTCs and brain metastases, integrated with experimental and clinical analyses, we identified Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) as a
GPNMB Drives Brain Metastasis by Sculpting a Pathological Endothelial-Immune Interactome
Cancer Discov. 2026 Apr 15. doi: 10.1158/2159-8290.CD-25-1663. Online ahead of print.
ABSTRACT
Brain metastases (BM) remain a devastating disease with dismal prognosis. How circulating tumor cells (CTCs) penetrate the blood brain barrier (BBB) and reprogram the brain microenvironment remain unclear. Using spatially resolved multi-omic profiling of CTCs and brain metastases, integrated with experimental and clinical analyses, we identified Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) as a CTC-secreted driver of vascular disruption and brain colonization. CBX3 upregulation induced GPNMB expression, which bound endothelial EGFR, triggering CBL-mediated ubiquitination and degradation. Attenuated EGFR signaling suppressed FTO and disrupted endothelial junctions via YTHDF2-dependent TJP1 m6A methylation. Remarkably, GPNMB-induced BBB remodeling promoted immune infiltration via CXCL12-CXCR4 axis, and induced time course-dependent T cell exhaustion within the brain microenvironment. Clinically, elevated CBX3⁺GPNMB⁺ CTCs and plasma CXCL12 were significantly associated with BM progression in lung cancer and melanoma. Therapeutically, dual blockade of GPNMB and PD1 enhanced anti-BM efficacy in mice, unveiling GPNMB as a promising target for precision immunotherapy.
PMID:41973996 | DOI:10.1158/2159-8290.CD-25-1663
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cs.AI, q-bio.NC updates on arXiv.org
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GA-GS: Generation-Assisted Gaussian Splatting for Static Scene Reconstruction
arXiv:2604.04331v1 Announce Type: cross Abstract: Reconstructing static 3D scene from monocular video with dynamic objects is important for numerous applications such as virtual reality and autonomous driving. Current approaches typically rely on background for static scene reconstruction, limiting the ability to recover regions occluded by dynamic objects. In this paper, we propose GA-GS, a Generation-Assisted Gaussian Splatting method for Static Scene Reconstruction. The key innovation of our
GA-GS: Generation-Assisted Gaussian Splatting for Static Scene Reconstruction
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npj Digital Medicine
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Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes
npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02593-7Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes
Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes
npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02593-7
Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes-
cs.AI, q-bio.NC updates on arXiv.org
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AffordTissue: Dense Affordance Prediction for Tool-Action Specific Tissue Interaction
arXiv:2604.01371v1 Announce Type: cross Abstract: Surgical action automation has progressed rapidly toward achieving surgeon-like dexterous control, driven primarily by advances in learning from demonstration and vision-language-action models. While these have demonstrated success in table-top experiments, translating them to clinical deployment remains challenging: current methods offer limited predictability on where instruments will interact on tissue surfaces and lack explicit conditioning
AffordTissue: Dense Affordance Prediction for Tool-Action Specific Tissue Interaction
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cs.AI, q-bio.NC updates on arXiv.org
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Tex3D: Objects as Attack Surfaces via Adversarial 3D Textures for Vision-Language-Action Models
arXiv:2604.01618v1 Announce Type: cross Abstract: Vision-language-action (VLA) models have shown strong performance in robotic manipulation, yet their robustness to physically realizable adversarial attacks remains underexplored. Existing studies reveal vulnerabilities through language perturbations and 2D visual attacks, but these attack surfaces are either less representative of real deployment or limited in physical realism. In contrast, adversarial 3D textures pose a more physically plausib
Tex3D: Objects as Attack Surfaces via Adversarial 3D Textures for Vision-Language-Action Models
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cs.AI, q-bio.NC updates on arXiv.org
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GISTBench: Evaluating LLM User Understanding via Evidence-Based Interest Verification
arXiv:2603.29112v1 Announce Type: new Abstract: We introduce GISTBench, a benchmark for evaluating Large Language Models' (LLMs) ability to understand users from their interaction histories in recommendation systems. Unlike traditional RecSys benchmarks that focus on item prediction accuracy, our benchmark evaluates how well LLMs can extract and verify user interests from engagement data. We propose two novel metric families: Interest Groundedness (IG), decomposed into precision and recall comp
GISTBench: Evaluating LLM User Understanding via Evidence-Based Interest Verification
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cs.AI, q-bio.NC updates on arXiv.org
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SAW: Toward a Surgical Action World Model via Controllable and Scalable Video Generation
arXiv:2603.13024v1 Announce Type: cross Abstract: A surgical world model capable of generating realistic surgical action videos with precise control over tool-tissue interactions can address fundamental challenges in surgical AI and simulation -- from data scarcity and rare event synthesis to bridging the sim-to-real gap for surgical automation. However, current video generation methods, the very core of such surgical world models, require expensive annotations or complex structured intermediat
SAW: Toward a Surgical Action World Model via Controllable and Scalable Video Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Accelerating Video Generation Inference with Sequential-Parallel 3D Positional Encoding Using a Global Time Index
arXiv:2603.06664v1 Announce Type: cross Abstract: Diffusion Transformer (DiT)-based video generation models inherently suffer from bottlenecks in long video synthesis and real-time inference, which can be attributed to the use of full spatiotemporal attention. Specifically, this mechanism leads to explosive O(N^2) memory consumption and high first-frame latency. To address these issues, we implement system-level inference optimizations for a causal autoregressive video generation pipeline. We a
Accelerating Video Generation Inference with Sequential-Parallel 3D Positional Encoding Using a Global Time Index
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cs.AI, q-bio.NC updates on arXiv.org
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Survey of Computerized Adaptive Testing: A Machine Learning Perspective
arXiv:2404.00712v3 Announce Type: replace-cross Abstract: Computerized Adaptive Testing (CAT) offers an efficient and personalized method for assessing examinee proficiency by dynamically adjusting test questions based on individual performance. Compared to traditional, non-personalized testing methods, CAT requires fewer questions and provides more accurate assessments. As a result, CAT has been widely adopted across various fields, including education, healthcare, sports, sociology, and the e
Survey of Computerized Adaptive Testing: A Machine Learning Perspective
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cs.AI, q-bio.NC updates on arXiv.org
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Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
arXiv:2510.24702v2 Announce Type: replace-cross Abstract: Public research results on large-scale supervised finetuning of AI agents remain relatively rare, since the collection of agent training data presents unique challenges. In this work, we argue that the bottleneck is not a lack of underlying data sources, but that a large variety of data is fragmented across heterogeneous formats, tools, and interfaces. To this end, we introduce the agent data protocol (ADP), a light-weight representation
Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Boolean Satisfiability via Imitation Learning
arXiv:2509.25411v2 Announce Type: replace Abstract: We propose ImitSAT, a branching policy for conflict-driven clause learning (CDCL) solvers based on imitation learning for the Boolean satisfiability problem (SAT). Unlike previous methods that predict instance-level signals to improve CDCL branching indirectly, or rely on reinforcement learning and insufficient CDCL information to enhance branching, ImitSAT learns from expert KeyTrace that collapses a full run into the sequence of surviving de
Boolean Satisfiability via Imitation Learning
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cs.AI, q-bio.NC updates on arXiv.org
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WoVR: World Models as Reliable Simulators for Post-Training VLA Policies with RL
arXiv:2602.13977v1 Announce Type: cross Abstract: Reinforcement learning (RL) promises to unlock capabilities beyond imitation learning for Vision-Language-Action (VLA) models, but its requirement for massive real-world interaction prevents direct deployment on physical robots. Recent work attempts to use learned world models as simulators for policy optimization, yet closed-loop imagined rollouts inevitably suffer from hallucination and long-horizon error accumulation. Such errors do not merel
WoVR: World Models as Reliable Simulators for Post-Training VLA Policies with RL
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cs.AI, q-bio.NC updates on arXiv.org
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Automated Proof Generation for Rust Code via Self-Evolution
arXiv:2410.15756v3 Announce Type: replace-cross Abstract: Ensuring correctness is crucial for code generation. Formal verification offers a definitive assurance of correctness, but demands substantial human effort in proof construction and hence raises a pressing need for automation. The primary obstacle lies in the severe lack of data-there is much fewer proofs than code snippets for Large Language Models (LLMs) to train upon. In this paper, we introduce SAFE, a framework that overcomes the la
Automated Proof Generation for Rust Code via Self-Evolution
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cs.AI, q-bio.NC updates on arXiv.org
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C^2ROPE: Causal Continuous Rotary Positional Encoding for 3D Large Multimodal-Models Reasoning
arXiv:2602.10551v2 Announce Type: replace-cross Abstract: Recent advances in 3D Large Multimodal Models (LMMs) built on Large Language Models (LLMs) have established the alignment of 3D visual features with LLM representations as the dominant paradigm. However, the inherited Rotary Position Embedding (RoPE) introduces limitations for multimodal processing. Specifically, applying 1D temporal positional indices disrupts the continuity of visual features along the column dimension, resulting in sp