Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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UnitBoost: Managing Compound LLM Systems with a Merge Operator, Not a Model
arXiv:2609.09815v1 Announce Type: new Abstract: Compound LLM systems often solve a coordination problem by adding a higher-level LLM. The resulting meta-agent reads workers' outputs, writes the final answer, allocates later calls, and decides when to stop. It is expressive, but it also concentrates three control decisions in an opaque, order-sensitive model call. We ask whether the manager needs to be generative at all. UnitBoost replaces that model with a defined meta-level operator: a task-gi
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Omics in Hepatocellular
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Stromal ACTA2 Counteracts TCDD-Induced Hepatocarcinogenesis via Suppression of the PI3K-AKT-mTOR Pathway
J Hepatocell Carcinoma. 2026 May 10;13:586916. doi: 10.2147/JHC.S586916. eCollection 2026.ABSTRACTPURPOSE: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that promotes hepatocellular carcinoma (HCC) through non-genotoxic mechanisms. However, stromal regulatory factors that counteract its tumor-promoting effects remain poorly defined. This study aimed to elucidate the role of actin alpha-2 (ACTA2) in TCDD-associated hepatocarcinogenesis.METHODS: An integrative
Stromal ACTA2 Counteracts TCDD-Induced Hepatocarcinogenesis via Suppression of the PI3K-AKT-mTOR Pathway
J Hepatocell Carcinoma. 2026 May 10;13:586916. doi: 10.2147/JHC.S586916. eCollection 2026.
ABSTRACT
PURPOSE: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that promotes hepatocellular carcinoma (HCC) through non-genotoxic mechanisms. However, stromal regulatory factors that counteract its tumor-promoting effects remain poorly defined. This study aimed to elucidate the role of actin alpha-2 (ACTA2) in TCDD-associated hepatocarcinogenesis.
METHODS: An integrative strategy combining network toxicology, Mendelian randomization, multi-omics and single-cell analyses, molecular docking and molecular dynamics simulations, along with in vitro experiments, was employed to investigate the functional role of ACTA2.
RESULTS: ACTA2 was identified as a stromal-associated factor linked to reduced HCC risk and improved patient survival. Single-cell and multi-omics analyses revealed that ACTA2 is predominantly expressed in hepatic stellate cells and fibroblast-like populations, reflecting tumor microenvironment composition rather than tumor cell-intrinsic expression. Functional enrichment analyses indicated that ACTA2 is associated with extracellular matrix remodeling and PI3K-AKT signaling. Molecular simulations demonstrated stable binding of TCDD to ACTA2 (ΔG_bind ≈ -7.05 kcal/mol), suggesting potential structural perturbation. In vitro experiments showed that TCDD downregulated ACTA2 expression, promoted proliferation of LX-2 and cancer-associated fibroblasts (CAFs), and activated PI3K-AKT-mTOR signaling, whereas ACTA2 overexpression attenuated these effects.
CONCLUSION: ACTA2 acts as a context-dependent stromal regulator that modulates PI3K-AKT-mTOR signaling in TCDD-induced hepatocarcinogenesis. These findings highlight the importance of stromal remodeling in environmental carcinogenesis and suggest ACTA2 as a potential biomarker and therapeutic target in dioxin-associated HCC.
PMID:42148320 | PMC:PMC13175077 | DOI:10.2147/JHC.S586916
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cs.AI, q-bio.NC updates on arXiv.org
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LiveMathematicianBench: A Live Benchmark for Mathematician-Level Reasoning with Proof Sketches
arXiv:2604.01754v1 Announce Type: cross Abstract: Mathematical reasoning is a hallmark of human intelligence, and whether large language models (LLMs) can meaningfully perform it remains a central question in artificial intelligence and cognitive science. As LLMs are increasingly integrated into scientific workflows, rigorous evaluation of their mathematical capabilities becomes a practical necessity. Existing benchmarks are limited by synthetic settings and data contamination. We present LiveM
LiveMathematicianBench: A Live Benchmark for Mathematician-Level Reasoning with Proof Sketches
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cs.AI, q-bio.NC updates on arXiv.org
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TTSR: Test-Time Self-Reflection for Continual Reasoning Improvement
arXiv:2603.03297v1 Announce Type: cross Abstract: Test-time Training enables model adaptation using only test questions and offers a promising paradigm for improving the reasoning ability of large language models (LLMs). However, it faces two major challenges: test questions are often highly difficult, making self-generated pseudo-labels unreliable, and existing methods lack effective mechanisms to adapt to a model's specific reasoning weaknesses, leading to inefficient learning. To address the
TTSR: Test-Time Self-Reflection for Continual Reasoning Improvement
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cs.AI, q-bio.NC updates on arXiv.org
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SpotIt+: Verification-based Text-to-SQL Evaluation with Database Constraints
arXiv:2603.04334v1 Announce Type: cross Abstract: We present SpotIt+, an open-source tool for evaluating Text-to-SQL systems via bounded equivalence verification. Given a generated SQL query and the ground truth, SpotIt+ actively searches for database instances that differentiate the two queries. To ensure that the generated counterexamples reflect practically relevant discrepancies, we introduce a constraint-mining pipeline that combines rule-based specification mining over example databases w
SpotIt+: Verification-based Text-to-SQL Evaluation with Database Constraints
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cs.AI, q-bio.NC updates on arXiv.org
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SpotIt: Evaluating Text-to-SQL Evaluation with Formal Verification
arXiv:2510.26840v2 Announce Type: replace-cross Abstract: Community-driven Text-to-SQL evaluation platforms play a pivotal role in tracking the state of the art of Text-to-SQL performance. The reliability of the evaluation process is critical for driving progress in the field. Current evaluation methods are largely test-based, which involves comparing the execution results of a generated SQL query and a human-labeled ground-truth on a static test database. Such an evaluation is optimistic, as t
SpotIt: Evaluating Text-to-SQL Evaluation with Formal Verification
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cs.AI, q-bio.NC updates on arXiv.org
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A Very Big Video Reasoning Suite
arXiv:2602.20159v1 Announce Type: cross Abstract: Rapid progress in video models has largely focused on visual quality, leaving their reasoning capabilities underexplored. Video reasoning grounds intelligence in spatiotemporally consistent visual environments that go beyond what text can naturally capture, enabling intuitive reasoning over spatiotemporal structure such as continuity, interaction, and causality. However, systematically studying video reasoning and its scaling behavior is hindere
A Very Big Video Reasoning Suite
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cs.AI, q-bio.NC updates on arXiv.org
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Reshaping MOFs text mining with a dynamic multi-agents framework of large language model
arXiv:2504.18880v4 Announce Type: replace Abstract: Accurately identifying the synthesis conditions of metal-organic frameworks (MOFs) is essential for guiding experimental design, yet remains challenging because relevant information in the literature is often scattered, inconsistent, and difficult to interpret. We present MOFh6, a large language model driven system that reads raw articles or crystal codes and converts them into standardized synthesis tables. It links related descriptions acros
Reshaping MOFs text mining with a dynamic multi-agents framework of large language model
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cs.AI, q-bio.NC updates on arXiv.org
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Anthropomorphism on Risk Perception: The Role of Trust and Domain Knowledge in Decision-Support AI
arXiv:2602.13625v1 Announce Type: cross Abstract: Anthropomorphic design is routinely used to make conversational agents more approachable and engaging. Yet its influence on users' perceptions remains poorly understood. Drawing on psychological theories, we propose that anthropomorphism influences risk perception via two complementary forms of trust, and that domain knowledge moderates these relationships. To test our model, we conducted a large-scale online experiment (N = 1,256) on a financia