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cs.AI, q-bio.NC updates on arXiv.org
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Energy-Aware Reinforcement Learning for Robotic Manipulation of Articulated Components in Infrastructure Operation and Maintenance
arXiv:2602.12288v3 Announce Type: replace-cross Abstract: With the growth of intelligent civil infrastructure and smart cities, operation and maintenance (O&M) increasingly requires safe, efficient, and energy-conscious robotic manipulation of articulated components, including access doors, service drawers, and pipeline valves. However, existing robotic approaches either focus primarily on grasping or target object-specific articulated manipulation, and they rarely incorporate explicit actu
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Nature - Issue - nature.com science feeds
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Remembrance of inflammations past
Nature, Published online: 25 March 2026; doi:10.1038/d41586-026-00639-0Chronic inflammation increases the risk of colon cancer. This inflammation drives epigenetic changes in the nucleus of stem cells that promote tumour formation.
Remembrance of inflammations past
Nature, Published online: 25 March 2026; doi:10.1038/d41586-026-00639-0
Chronic inflammation increases the risk of colon cancer. This inflammation drives epigenetic changes in the nucleus of stem cells that promote tumour formation.-
Oncogene - Issue - nature.com science feeds
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PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8β+βT cells within the glioblastoma tumor microenvironment
Oncogene, Published online: 23 March 2026; doi:10.1038/s41388-026-03734-8PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8β+βT cells within the glioblastoma tumor microenvironment
PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8β+βT cells within the glioblastoma tumor microenvironment
Oncogene, Published online: 23 March 2026; doi:10.1038/s41388-026-03734-8
PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8β+βT cells within the glioblastoma tumor microenvironment-
Omics in Gastric
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Mechanisms of Xinwei Tang in stress-induced gastric dysmotility: evidence from rat and In Vitro models
In Vitro Cell Dev Biol Anim. 2026 Mar 18. doi: 10.1007/s11626-026-01151-5. Online ahead of print.ABSTRACTStress is a key trigger of gastric dysmotility, partly via mitochondrial dysfunction and disordered gut-brain hormonal signaling. Xinwei Tang (XWT) is a multi-herb formula used empirically for upper gastrointestinal symptoms, but its mechanisms remain unclear. This study aimed to determine whether XWT alleviates water-immersion restraint stress (WIRS)-induced gastric dysmotility and to deline
Mechanisms of Xinwei Tang in stress-induced gastric dysmotility: evidence from rat and In Vitro models
In Vitro Cell Dev Biol Anim. 2026 Mar 18. doi: 10.1007/s11626-026-01151-5. Online ahead of print.
ABSTRACT
Stress is a key trigger of gastric dysmotility, partly via mitochondrial dysfunction and disordered gut-brain hormonal signaling. Xinwei Tang (XWT) is a multi-herb formula used empirically for upper gastrointestinal symptoms, but its mechanisms remain unclear. This study aimed to determine whether XWT alleviates water-immersion restraint stress (WIRS)-induced gastric dysmotility and to delineate underlying mitochondrial and metabolic pathways using integrated in vivo, in vitro and multi-omics approaches. Male rats underwent 7-d WIRS and received vehicle, domperidone (3 mg/kg) or XWT (3, 6, 12 g/kg). Gastric emptying, serum motilin/gastrin, oxidative stress indices and PINK1/Parkin-LC3/p62 proteins were assessed, and HβOβ-injured GES-1 cells were treated with XWT-medicated serum. Gastric antra from MOD and XWT-H rats were analyzed by RNA-seq and DIA proteomics (n = 3/group). WIRS reduced gastric emptying by roughly half and lowered motilin/gastrin, increased ROS/MDA and disrupted PINK1/Parkin-LC3/p62 profiles; XWT dose-dependently reversed these changes, with XWT-H approximating domperidone. Omics revealed XWT-associated downregulation of inflammatory/protease and acute-phase genes/proteins and enrichment of oxidative phosphorylation, tricarboxylic-acid cycle and other metabolic pathways, without global activation of canonical autophagy/mitophagy gene sets. These preclinical data indicate that XWT ameliorates stress-induced gastric dysmotility via mitochondria- and metabolism-centred protection with selective tuning of mitophagy-related proteins.
PMID:41851413 | DOI:10.1007/s11626-026-01151-5