Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Let the Agent Steer: Closed-Loop Ranking Optimization via Influence Exchange
arXiv:2603.27765v2 Announce Type: replace Abstract: Recommendation ranking is fundamentally an influence allocation problem: a sorting formula distributes ranking influence among competing factors, and the business outcome depends on finding the optimal "exchange rates" among them. However, offline proxy metrics systematically misjudge how influence reallocation translates to online impact, with asymmetric bias across metrics that a single calibration factor cannot correct. We present Sortify
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cs.AI, q-bio.NC updates on arXiv.org
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InCoder-32B: Code Foundation Model for Industrial Scenarios
arXiv:2603.16790v3 Announce Type: replace-cross Abstract: Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligenc
InCoder-32B: Code Foundation Model for Industrial Scenarios
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Oncogene - Issue - nature.com science feeds
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LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03737-5LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer
LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03737-5
LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer-
npj Digital Medicine
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A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease-
Omics in Gastric
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Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.ABSTRACTGlycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the energy derived from glucose metabolism and the cellular proteins by its intermediate products influence gastric cancer development. However, as an important branch of glucose metabolism, sialic acid metabolism and its mediated sialylation modifications remain insufficiently studied in gastric canc
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.
ABSTRACT
Glycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the energy derived from glucose metabolism and the cellular proteins by its intermediate products influence gastric cancer development. However, as an important branch of glucose metabolism, sialic acid metabolism and its mediated sialylation modifications remain insufficiently studied in gastric cancer, and their specific relationship with malignant tumor progression requires further exploration. This study employed a multi‑omics approach, integrating metabolomics, single‑cell RNA sequencing, and bulk RNA sequencing analyses, to investigate the metabolic landscape of gastric cancer and its associated alterations. The results indicated that sialic acid is a characteristic metabolite in malignant gastric cancer tissues. It modulates biological functions such as immune response, proliferative activity, and metabolic remodeling within gastric cancer tissues by influencing sialylation modifications. Furthermore, we identified the drug WZ35, which can inhibit the malignant proliferation of gastric cancer by targeting both sialic acid metabolism and sialylated protein modifications. We put forward a conjecture that the metabolism and modification of sialic acid promote the malignant development of gastric cancer, and we discovered that the drug WZ35 has an inhibitory effect on the sialic acid metabolism of gastric cancer.
GRAPHICAL ABSTRACT:
PMID:41870836 | PMC:PMC13009457 | DOI:10.1007/s13402-026-01194-6