❌

Normal view

Let the Agent Steer: Closed-Loop Ranking Optimization via Influence Exchange

arXiv:2603.27765v2 Announce Type: replace Abstract: Recommendation ranking is fundamentally an influence allocation problem: a sorting formula distributes ranking influence among competing factors, and the business outcome depends on finding the optimal "exchange rates" among them. However, offline proxy metrics systematically misjudge how influence reallocation translates to online impact, with asymmetric bias across metrics that a single calibration factor cannot correct. We present Sortify, the first fully autonomous LLM-driven ranking optimization agent deployed in a large-scale production recommendation system. The agent reframes ranking optimization as continuous influence exchange, closing the full loop from diagnosis to parameter deployment without human intervention. It addresses structural problems through three mechanisms: (1) a dual-channel framework grounded in Savage's Subjective Expected Utility (SEU) that decouples offline-online transfer correction (Belief channel) from constraint penalty adjustment (Preference channel); (2) an LLM meta-controller operating on framework-level parameters rather than low-level search variables; (3) a persistent Memory DB with 7 relational tables for cross-round learning. Its core metric, Influence Share, provides a decomposable measure where all factor contributions sum to exactly 100%. Sortify has been deployed across two markets. In Country A, the agent pushed GMV from -3.6% to +9.2% within 7 rounds with peak orders reaching +12.5%. In Country B, a cold-start deployment achieved +4.15% GMV/UU and +3.58% Ads Revenue in a 7-day A/B test, leading to full production rollout.

InCoder-32B: Code Foundation Model for Industrial Scenarios

arXiv:2603.16790v3 Announce Type: replace-cross Abstract: Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligence across chip design, GPU kernel optimization, embedded systems, compiler optimization, and 3D modeling. By adopting an efficient architecture, we train InCoder-32B from scratch with general code pre-training, curated industrial code annealing, mid-training that progressively extends context from 8K to 128K tokens with synthetic industrial reasoning data, and post-training with execution-grounded verification. We conduct extensive evaluation on 14 mainstream general code benchmarks and 9 industrial benchmarks spanning 4 specialized domains. Results show InCoder-32B achieves highly competitive performance on general tasks while establishing strong open-source baselines across industrial domains.

A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease

npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0

A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease

Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35

Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.

ABSTRACT

Glycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the energy derived from glucose metabolism and the cellular proteins by its intermediate products influence gastric cancer development. However, as an important branch of glucose metabolism, sialic acid metabolism and its mediated sialylation modifications remain insufficiently studied in gastric cancer, and their specific relationship with malignant tumor progression requires further exploration. This study employed a multi‑omics approach, integrating metabolomics, single‑cell RNA sequencing, and bulk RNA sequencing analyses, to investigate the metabolic landscape of gastric cancer and its associated alterations. The results indicated that sialic acid is a characteristic metabolite in malignant gastric cancer tissues. It modulates biological functions such as immune response, proliferative activity, and metabolic remodeling within gastric cancer tissues by influencing sialylation modifications. Furthermore, we identified the drug WZ35, which can inhibit the malignant proliferation of gastric cancer by targeting both sialic acid metabolism and sialylated protein modifications. We put forward a conjecture that the metabolism and modification of sialic acid promote the malignant development of gastric cancer, and we discovered that the drug WZ35 has an inhibitory effect on the sialic acid metabolism of gastric cancer.

GRAPHICAL ABSTRACT:

PMID:41870836 | PMC:PMC13009457 | DOI:10.1007/s13402-026-01194-6

❌