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Uncertainty Gating for Cost-Aware Explainable Artificial Intelligence

arXiv:2603.29915v1 Announce Type: new Abstract: Post-hoc explanation methods are widely used to interpret black-box predictions, but their generation is often computationally expensive and their reliability is not guaranteed. We propose epistemic uncertainty as a low-cost proxy for explanation reliability: high epistemic uncertainty identifies regions where the decision boundary is poorly defined and where explanations become unstable and unfaithful. This insight enables two complementary use cases: `improving worst-case explanations' (routing samples to cheap or expensive XAI methods based on expected explanation reliability), and `recalling high-quality explanations' (deferring explanation generation for uncertain samples under constrained budget). Across four tabular datasets, five diverse architectures, and four XAI methods, we observe a strong negative correlation between epistemic uncertainty and explanation stability. Further analysis shows that epistemic uncertainty distinguishes not only stable from unstable explanations, but also faithful from unfaithful ones. Experiments on image classification confirm that our findings generalize beyond tabular data.

Byzantine-Robust and Communication-Efficient Distributed Training: Compressive and Cyclic Gradient Coding

arXiv:2603.28780v1 Announce Type: cross Abstract: In this paper, we study the problem of distributed training (DT) under Byzantine attacks with communication constraints. While prior work has developed various robust aggregation rules at the server to enhance robustness to Byzantine attacks, the existing methods suffer from a critical limitation in that the solution error does not diminish when the local gradients sent by different devices vary considerably, as a result of data heterogeneity among the subsets held by different devices. To overcome this limitation, we propose a novel DT method, cyclic gradient coding-based DT (LAD). In LAD, the server allocates the entire training dataset to the devices before training begins. In each iteration, it assigns computational tasks redundantly to the devices using cyclic gradient coding. Each honest device then computes local gradients on a fixed number of data subsets and encodes the local gradients before transmitting to the server. The server aggregates the coded vectors from the honest devices and the potentially incorrect messages from Byzantine devices using a robust aggregation rule. Leveraging the redundancy of computation across devices, the convergence performance of LAD is analytically characterized, demonstrating improved robustness against Byzantine attacks and significantly lower solution error. Furthermore, we extend LAD to a communication-efficient variant, compressive and cyclic gradient coding-based DT (Com-LAD), which further reduces communication overhead under constrained settings. Numerical results validate the effectiveness of the proposed methods in enhancing both Byzantine resilience and communication efficiency.

Zero-Shot Coordination in Ad Hoc Teams with Generalized Policy Improvement and Difference Rewards

arXiv:2510.16187v2 Announce Type: replace-cross Abstract: Real-world multi-agent systems may require ad hoc teaming, where an agent must coordinate with other previously unseen teammates to solve a task in a zero-shot manner. Prior work often either selects a pretrained policy based on an inferred model of the new teammates or pretrains a single policy that is robust to potential teammates. Instead, we propose to leverage all pretrained policies in a zero-shot transfer setting. We formalize this problem as an ad hoc multi-agent Markov decision process and present a solution that uses two key ideas, generalized policy improvement and difference rewards, for efficient and effective knowledge transfer between different teams. We empirically demonstrate that our algorithm, Generalized Policy improvement for Ad hoc Teaming (GPAT), successfully enables zero-shot transfer to new teams in three simulated environments: cooperative foraging, predator-prey, and Overcooked. We also demonstrate our algorithm in a real-world multi-robot setting.

Sample-Efficient Hypergradient Estimation for Decentralized Bi-Level Reinforcement Learning

arXiv:2603.14867v3 Announce Type: replace-cross Abstract: Many strategic decision-making problems, such as environment design for warehouse robots, can be naturally formulated as bi-level reinforcement learning (RL), where a leader agent optimizes its objective while a follower solves a Markov decision process (MDP) conditioned on the leader's decisions. In many situations, a fundamental challenge arises when the leader cannot intervene in the follower's optimization process; it can only observe the optimization outcome. We address this decentralized setting by deriving the hypergradient of the leader's objective, i.e., the gradient of the leader's strategy that accounts for changes in the follower's optimal policy. Unlike prior hypergradient-based methods that require extensive data for repeated state visits or rely on gradient estimators whose complexity can increase substantially with the high-dimensional leader's decision space, we leverage the Boltzmann covariance trick to derive an alternative hypergradient formulation. This enables efficient hypergradient estimation solely from interaction samples, even when the leader's decision space is high-dimensional. Additionally, to our knowledge, this is the first method that enables hypergradient-based optimization for 2-player Markov games in decentralized settings. Experiments highlight the impact of hypergradient updates and demonstrate our method's effectiveness in both discrete and continuous state tasks.

Investigating the replicability of the social and behavioural sciences

Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-10078-y

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Reproducibility and robustness of economics and political science research

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10251-x

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Systems-Level Analysis of HPAI H5N1 Infection in Ducks: Integrating Transcriptomic, Proteomic, and Phosphoproteomic Data

Int J Mol Sci. 2026 Mar 23;27(6):2884. doi: 10.3390/ijms27062884.

ABSTRACT

Ducks, once considered mere reservoirs, now serve as both victims and amplifiers of persistent highly pathogenic avian influenza (HPAI) virus cycles in wild populations. The molecular pathogenesis of HPAI is shaped by complex, dysregulated molecular networks, necessitating a systems biology approach that integrates computational modeling of host-pathogen interactions. Despite recent advances, a comprehensive understanding of the signaling pathways, molecular mechanisms, and hub genes driving HPAI H5N1 pathogenesis in avian hosts remains incomplete. This study addresses this gap by employing an integrated multi-omics strategy-combining transcriptomic, proteomic, and phosphoproteomic analyses-to map the signaling networks and key host factors involved in HPAI H5N1 infection in duck lung tissue. Our network analysis revealed activation of RIG-I-like receptor, toll-like receptor, NOD-like receptor, NF-κB, and JAK/STAT signaling pathways. Phosphoproteomic profiling independently confirmed the activation of these pathways, supporting the integrated network findings. Key regulatory hub genes identified include STAT1, DDX58 (RIG-I), MYD88, NFKBIA, NFKB1, IRF7, SOCS3, ACTB, TLR4, TLR7, IL-6, CASP1, and CASP8, which form a central hub in duck antiviral immunity. Some of these genes may represent promising targets for therapeutic or vaccine development against avian influenza. Collectively, this work delineates the critical signaling pathways and hub genes underlying HPAI H5N1 pathogenesis in ducks through comprehensive multi-omics integration.

PMID:41898742 | PMC:PMC13026356 | DOI:10.3390/ijms27062884

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