Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
Uncertainty Gating for Cost-Aware Explainable Artificial Intelligence
arXiv:2603.29915v1 Announce Type: new Abstract: Post-hoc explanation methods are widely used to interpret black-box predictions, but their generation is often computationally expensive and their reliability is not guaranteed. We propose epistemic uncertainty as a low-cost proxy for explanation reliability: high epistemic uncertainty identifies regions where the decision boundary is poorly defined and where explanations become unstable and unfaithful. This insight enables two complementary use c
-
cs.AI, q-bio.NC updates on arXiv.org
-
Byzantine-Robust and Communication-Efficient Distributed Training: Compressive and Cyclic Gradient Coding
arXiv:2603.28780v1 Announce Type: cross Abstract: In this paper, we study the problem of distributed training (DT) under Byzantine attacks with communication constraints. While prior work has developed various robust aggregation rules at the server to enhance robustness to Byzantine attacks, the existing methods suffer from a critical limitation in that the solution error does not diminish when the local gradients sent by different devices vary considerably, as a result of data heterogeneity am
Byzantine-Robust and Communication-Efficient Distributed Training: Compressive and Cyclic Gradient Coding
-
cs.AI, q-bio.NC updates on arXiv.org
-
Zero-Shot Coordination in Ad Hoc Teams with Generalized Policy Improvement and Difference Rewards
arXiv:2510.16187v2 Announce Type: replace-cross Abstract: Real-world multi-agent systems may require ad hoc teaming, where an agent must coordinate with other previously unseen teammates to solve a task in a zero-shot manner. Prior work often either selects a pretrained policy based on an inferred model of the new teammates or pretrains a single policy that is robust to potential teammates. Instead, we propose to leverage all pretrained policies in a zero-shot transfer setting. We formalize thi
Zero-Shot Coordination in Ad Hoc Teams with Generalized Policy Improvement and Difference Rewards
-
cs.AI, q-bio.NC updates on arXiv.org
-
Sample-Efficient Hypergradient Estimation for Decentralized Bi-Level Reinforcement Learning
arXiv:2603.14867v3 Announce Type: replace-cross Abstract: Many strategic decision-making problems, such as environment design for warehouse robots, can be naturally formulated as bi-level reinforcement learning (RL), where a leader agent optimizes its objective while a follower solves a Markov decision process (MDP) conditioned on the leader's decisions. In many situations, a fundamental challenge arises when the leader cannot intervene in the follower's optimization process; it can only observ
Sample-Efficient Hypergradient Estimation for Decentralized Bi-Level Reinforcement Learning
-
Nature - Issue - nature.com science feeds
-
Investigating the replicability of the social and behavioural sciences
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-10078-yA large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.
Investigating the replicability of the social and behavioural sciences
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-10078-y
A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.-
Nature - Issue - nature.com science feeds
-
Reproducibility and robustness of economics and political science research
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10251-xRobustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.
Reproducibility and robustness of economics and political science research
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10251-x
Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.-
Omics In Lung
-
Systems-Level Analysis of HPAI H5N1 Infection in Ducks: Integrating Transcriptomic, Proteomic, and Phosphoproteomic Data
Int J Mol Sci. 2026 Mar 23;27(6):2884. doi: 10.3390/ijms27062884.ABSTRACTDucks, once considered mere reservoirs, now serve as both victims and amplifiers of persistent highly pathogenic avian influenza (HPAI) virus cycles in wild populations. The molecular pathogenesis of HPAI is shaped by complex, dysregulated molecular networks, necessitating a systems biology approach that integrates computational modeling of host-pathogen interactions. Despite recent advances, a comprehensive understanding o
Systems-Level Analysis of HPAI H5N1 Infection in Ducks: Integrating Transcriptomic, Proteomic, and Phosphoproteomic Data
Int J Mol Sci. 2026 Mar 23;27(6):2884. doi: 10.3390/ijms27062884.
ABSTRACT
Ducks, once considered mere reservoirs, now serve as both victims and amplifiers of persistent highly pathogenic avian influenza (HPAI) virus cycles in wild populations. The molecular pathogenesis of HPAI is shaped by complex, dysregulated molecular networks, necessitating a systems biology approach that integrates computational modeling of host-pathogen interactions. Despite recent advances, a comprehensive understanding of the signaling pathways, molecular mechanisms, and hub genes driving HPAI H5N1 pathogenesis in avian hosts remains incomplete. This study addresses this gap by employing an integrated multi-omics strategy-combining transcriptomic, proteomic, and phosphoproteomic analyses-to map the signaling networks and key host factors involved in HPAI H5N1 infection in duck lung tissue. Our network analysis revealed activation of RIG-I-like receptor, toll-like receptor, NOD-like receptor, NF-κB, and JAK/STAT signaling pathways. Phosphoproteomic profiling independently confirmed the activation of these pathways, supporting the integrated network findings. Key regulatory hub genes identified include STAT1, DDX58 (RIG-I), MYD88, NFKBIA, NFKB1, IRF7, SOCS3, ACTB, TLR4, TLR7, IL-6, CASP1, and CASP8, which form a central hub in duck antiviral immunity. Some of these genes may represent promising targets for therapeutic or vaccine development against avian influenza. Collectively, this work delineates the critical signaling pathways and hub genes underlying HPAI H5N1 pathogenesis in ducks through comprehensive multi-omics integration.
PMID:41898742 | PMC:PMC13026356 | DOI:10.3390/ijms27062884
-
Nature Biotechnology - Issue - nature.com science feeds
-
Unpaired data as a first-order challenge in single-cell and spatial proteomics
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8Unpaired data as a first-order challenge in single-cell and spatial proteomics
Unpaired data as a first-order challenge in single-cell and spatial proteomics
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8
Unpaired data as a first-order challenge in single-cell and spatial proteomics