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cs.AI, q-bio.NC updates on arXiv.org
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AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
arXiv:2605.20025v2 Announce Type: replace Abstract: Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across cycles. Existing autonomous research systems often model this process as a linear pipeline: they rely on single-agent reasoning, stop when execution fails, and do not carry experience across runs. We present
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cs.AI, q-bio.NC updates on arXiv.org
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M$^\star$: Every Task Deserves Its Own Memory Harness
arXiv:2604.11811v2 Announce Type: replace-cross Abstract: Large language model agents rely on specialized memory systems to accumulate and reuse knowledge during extended interactions. Recent architectures typically adopt a fixed memory design tailored to specific domains, such as semantic retrieval for conversations or skills reused for coding. However, a memory system optimized for one purpose frequently fails to transfer to others. To address this limitation, we introduce M$^\star$, a method
M$^\star$: Every Task Deserves Its Own Memory Harness
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Oncogene - Issue - nature.com science feeds
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Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion
Oncogene, Published online: 23 May 2026; doi:10.1038/s41388-026-03825-6Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion
Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion
Oncogene, Published online: 23 May 2026; doi:10.1038/s41388-026-03825-6
Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion-
Oncogene - Issue - nature.com science feeds
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GPX8<sup>+</sup> cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
Oncogene, Published online: 22 May 2026; doi:10.1038/s41388-026-03711-1GPX8+ cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
GPX8<sup>+</sup> cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
Oncogene, Published online: 22 May 2026; doi:10.1038/s41388-026-03711-1
GPX8+ cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma-
Omics in Gastric
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Exploring the prognostic role of senescence-related genes in gastric cancer through multi-omics integration and machine learning
Hum Genomics. 2026 May 9. doi: 10.1186/s40246-026-00979-y. Online ahead of print.ABSTRACTCellular senescence plays a context-dependent role in gastric cancer (GC), functioning both through tumor-suppressive arrest and the tumor-promoting senescence-associated secretory phenotype. However, its systematic integration into prognostic models remains limited. Here, we develop a novel interpretable framework to identify and validate a robust senescence-related gene signature for GC prognosis. We first
Exploring the prognostic role of senescence-related genes in gastric cancer through multi-omics integration and machine learning
Hum Genomics. 2026 May 9. doi: 10.1186/s40246-026-00979-y. Online ahead of print.
ABSTRACT
Cellular senescence plays a context-dependent role in gastric cancer (GC), functioning both through tumor-suppressive arrest and the tumor-promoting senescence-associated secretory phenotype. However, its systematic integration into prognostic models remains limited. Here, we develop a novel interpretable framework to identify and validate a robust senescence-related gene signature for GC prognosis. We first introduce a dual-model interpretable feature selection strategy that integrates a biologically informed Kolmogorov-Arnold Network with a tabular foundation model to identify cancer-associated senescence genes. From the initial candidates, an ensemble of ten machine learning algorithms distills a core 4-gene signature to construct a Senescence Risk Score (SRS). The SRS proves to be a powerful and independent prognostic indicator, effectively stratifies patients into high- and low-risk groups with distinct overall survival across multiple cohorts. High-risk patients exhibit an "immune-hot" but potentially dysfunctional tumor microenvironment, characterized by enriched immune cell infiltration, elevated checkpoint expression, and distinct metabolic reprogramming favoring pathways such as angiogenesis and epithelial-mesenchymal transition (EMT). Furthermore, the SRS correlates with differential somatic mutation profiles and suggests potential sensitivity to specific chemotherapeutic agents. In vitro functional assays confirmed the oncogenic role of SERPINE1, a top-ranked core gene, in promoting GC cell proliferation. Regulatory network analysis revealed potential upstream transcription factors and miRNAs governing the signature. Collectively, we present a validated senescence-related prognostic signature that enables effective risk stratification of patients with gastric cancer.
PMID:42106891 | DOI:10.1186/s40246-026-00979-y