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  • ✇cs.AI, q-bio.NC updates on arXiv.org
  • Fundamental Limitation in Explaining AI Atsushi Suzuki · Jing Wang
    arXiv:2605.24727v1 Announce Type: new Abstract: While large-scale models such as LLMs and diffusion models have achieved practical success, public institutions have emphasized the importance of explainability in AI. Existing methods for explaining AI, however, are not designed to provide completely faithful explanations of the behavior of large-scale AI systems. Although a completely faithful and interpretable explanation of the behavior of an AI system might be useful for AI governance, it has
     

Fundamental Limitation in Explaining AI

arXiv:2605.24727v1 Announce Type: new Abstract: While large-scale models such as LLMs and diffusion models have achieved practical success, public institutions have emphasized the importance of explainability in AI. Existing methods for explaining AI, however, are not designed to provide completely faithful explanations of the behavior of large-scale AI systems. Although a completely faithful and interpretable explanation of the behavior of an AI system might be useful for AI governance, it has not been known whether providing such an explanation is theoretically possible. In this paper, we mathematically prove a fundamental quadrilemma in explaining AI, stating that AI and its explanation cannot satisfy the following four conditions simultaneously: 1) the complexity of the operation environment, 2) the goodness of the AI's performance, 3) the interpretability of the AI's explanation, and 4) the complete faithfulness of the AI's explanation. This quadrilemma suggests that, in most applications where we cannot change the environment or sacrifice good AI performance and an interpretable explanation, we should give up complete faithfulness of explanations and should instead aim to explain only the parts that are important for applications. As a consequence, the quadrilemma implies that AI governance should be designed on the premise that the faithfulness of AI explanations is always incomplete.

D3S2: Diffusion-Guided Dataset Distillation for Semantic Segmentation

arXiv:2605.25022v1 Announce Type: cross Abstract: Dataset distillation (DD) aims to compress large-scale datasets into compact synthetic sets while preserving training efficacy. However, existing studies mainly focus on image classification, leaving dense prediction tasks such as semantic segmentation largely underexplored. In this work, we identify three key challenges for segmentation DD: (i) long-tailed class imbalance, (ii) the need for strict pixel-wise alignment between images and dense labels, and (iii) the high computational cost of optimizing high-resolution data with complex models. To address these challenges, we propose D3S2, a Diffusion-guided Dataset Distillation framework for Semantic Segmentation. Our method adopts a two-stage design. In Class-Balanced Mask Selection, we construct a representative mask set via a greedy strategy that prioritizes underrepresented classes. In Diffusion-Guided Image Synthesis, we employ a pretrained layout-to-image diffusion model to generate images conditioned on the selected masks, naturally ensuring spatial alignment. To further enhance the training utility of synthesized data, we introduce guided diffusion sampling with two complementary objectives: a segmentation-consistency loss for pixel-level alignment, and a class-wise feature matching loss for aligning per-class feature statistics across layers. Extensive experiments demonstrate the superiority of D3S2. Notably, at an extremely compression rate of 1%, our method achieves 24.99% and 35.49% mIoU on ADE20K and COCO-Stuff with Mask2Former (Swin-S), outperforming random selection by 9.34% and 5.70%, respectively.

A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

Neural representation of action symbols in primate frontal cortex

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10297-x

A drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.

Characterization of dysbiosis patterns in gut microbiota of digestive system cancers: an umbrella review

Front Microbiol. 2026 Apr 28;17:1782471. doi: 10.3389/fmicb.2026.1782471. eCollection 2026.

ABSTRACT

Digestive system cancers (DSCs) represent a substantial global health burden. In recent years, the role of gut microbiota in the DSCs has garnered considerable attention, but its change pattern during tumor progression and the specific mechanisms are still not fully understood. We conducted a comprehensive systematic review to characterize patterns of gut microbiota dysbiosis across different DSC types and assess their clinical significance. We systematically searched four English and three Chinese databases up to January 2025 to identify systematic reviews focused on the dynamic characteristics of the gut microbiota during gastrointestinal tumorigenesis. Microbiota biodiversity and taxonomic composition were extracted to identify specific signatures associated with DSCs. The ROBIS tool was used to evaluate the methodological quality of the included studies. Ultimately, 59 studies involving six distinct DSC types were included. Data synthesis and comparison revealed distinct microbiota profiles across DSCs. At the phylum level, Bacillota was decreased in esophageal cancer (EC) and pancreatic ductal adenocarcinoma (PDAC), Pseudomonadota was augmented in EC but exhibited divergent trajectories in colorectal cancer (CRC) and PDAC. Genus-level analyses revealed Veillonella enrichment in EC and PDAC, and Fusobacterium outgrowth in EC, gastric cancer (GC) and CRC. Parvimonas and Streptococcus showed a concordant ascending trend in GC and CRC. Prevotella was overrepresented in EC and GC. This synthesis delineates a qualitative landscape of gut microbiota imbalances associated with various DSCs, highlighting the potential for these microbial shifts to serve as markers for early detection and targeted therapy. Multiomics integration and prospective cohort studies should be prioritized to accelerate clinical translation.

PMID:42131199 | PMC:PMC13161176 | DOI:10.3389/fmicb.2026.1782471

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