Latent HIV reservoirs evade both antiviral therapy and immune surveillance. Luo and colleagues develop a multifunctional fusion protein that couples reservoir reactivation with targeted immune engagement and clearance, offering a coordinated strategy to expose and eliminate persistent HIV-infected cells.

Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02262-6

Charge-switching S-lipids generate S-lipid nanoparticles that are neutral or negative at physiological pH but become cationic in acidic endosomes, enabling nucleic acid delivery with reduced inflammation compared with conventional LNPs.

arXiv:2609.04867v2 Announce Type: replace-cross Abstract: Text-to-audio-video (T2AV) generation has advanced rapidly, but its evaluation still underestimates the audio modality. Existing benchmarks either treat audio as an auxiliary component of video quality or assess it in isolation from audiovisual grounding, making it difficult to diagnose where current systems truly succeed or fail in audio generation. We present PRISM-Bench, the first audio-centric diagnostic benchmark for T2AV generation. Built from a rigorously curated dataset of 900 human-verified samples, PRISM-Bench factorizes audio evaluation along two orthogonal axes: audio type (Speech, Music, and Sound) and sound-source visibility (On-screen vs. Off-screen). It evaluates generated content across four perceptual dimensions (Audio-Visual Coherence, Audio Quality, Audio Expressiveness, and Prompt Following) with 35 fine-grained criteria. To ensure reliable assessment, we adopt an enhanced MLLM-as-a-Judge protocol based on blind, side-by-side comparison against ground-truth references, demonstrating strong alignment (over 70% mean agreement) with human raters. Our evaluation of recent T2AV systems highlights a significant performance gap between frontier and open-source models. Furthermore, we demonstrate that current generation paradigms overfit to perceptual fidelity while struggling with complex grounding and control tasks, particularly in generating music and synchronized On-screen audio.

Oncogene, Published online: 03 September 2026; doi:10.1038/s41388-026-03959-7

The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation

Ancient DNA from 149 individuals at 11 sites in Gansu, China, dated to around 4,700–3,000 years ago, reveals human population history during early transcontinental exchanges of agriculture and technology, as well as contemporary social practices, at the large Mogou cemetery.