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TechCrunch
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AI infrastructure company Cornelis raises $205M to chip away at Nvidiaβs dominance
The company also announced a product called Active Compute Fabric, a network technology that targets the fact that much GPU time is wasted waiting for data to arrive.
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MIT Technology Review
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The AI industry has taken a doomer turn. What now?
This story appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first,Β sign up here. This weekend, Dario Amodei, CEO of Anthropic, posted an essay calling for a brake on the pace of development of LLMs. Amodei cites the looming dangers he sees from the technology, from its use in cyberattacks and bioterrorism to its potential to wreck the economy. The heads of the other three top US AI labsβOpenAI CEO Sam Altman, Google DeepMind chairman Demis Hassa
The AI industry has taken a doomer turn. What now?
This story appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first,Β sign up here.
This weekend, Dario Amodei, CEO of Anthropic, posted an essay calling for a brake on the pace of development of LLMs. Amodei cites the looming dangers he sees from the technology, from its use in cyberattacks and bioterrorism to its potential to wreck the economy. The heads of the other three top US AI labsβOpenAI CEO Sam Altman, Google DeepMind chairman Demis Hassabis, and SpaceXAI CEO Elon Muskβvoiced their support. βDario is right,β Musk wrote on X.
Think about how surreal that agreement is for a moment. Just a few months ago, Musk and Altman sat in court attacking each otherβs reputations in a (failed) lawsuit that Musk brought against his former OpenAI colleague that wasβon paper at leastβabout whether or not Altman was a trustworthy steward of such dangerous technology.
Amodeiβs rift with OpenAI is even deeper. Anthropic was founded in 2021 because Amodei didnβt think Altman took the risks of the technology they were building seriously enough. Anthropic and OpenAI have been competing in a winner-takes-all race ever since. (Hassabis has stayed out of the drama, but his company remains a rival.)
Now, it seems, theyβre all in agreement: The latest generation of LLMs arenβt safe and everyone needs to figure out what to do about it. The public messaging from the top AI labs has taken a doomer turn.
Itβs easy to be cynical. Itβs not at all clear what any of them mean by a slowdown or how it would work. These companies also care a lot about how they come across. With trillion-dollar IPOs in their sights, OpenAI and Anthropic need to reassure investors that theyβre the grown-ups in the room while at the same time hinting at the power of the monsters they have createdβand intend to tame. Calling for a slowdown does both.
And yet the vibe at the top of these firms really does appear to have shifted. Amodeiβs latest post landed six days after OpenAI published an essay by Jakub Pachocki, the firmβs chief scientist, in which he also laid out why heβs concerned about what will happen if the pace of development of LLMs continues unchecked. In short, Pachocki is worried that OpenAIβs ability to build powerful models now far outstrips its ability to monitor and control them.
Amodei and Pachocki each cite the cyberattack against AI firm Hugging Face by a swarm of OpenAIβs agents in Julyβa hack that OpenAI did not even realize had taken place until days after it was all overβas a wake-up call.
But their exact position is hard to pin down. Pachocki both calls for a slowdown and highlights an urgent need to stay ahead: βThe strongest argument I see for continuing to train much smarter models quickly is the need to build defensive systems against the dangers posed by other AI,β he writes. As Pachocki frames it, AI firms are locked in a literal arms race. Slowing down is good, winning is better.
(Donβt forget: OpenAI just spent millions of dollars and a staggering amount of computer power to rush out a controversial math result a few days ahead of Anthropic.)
But letβs assume a slowdown happens. Top labs agree to spend more time and resources on finding ways to monitor and control existing models instead of making more capable ones. They invite outside auditors in to help evaluate those models.
What might this coordinated effort actually achieve? Consider the Hugging Face attack again. OpenAI has said that the model that drove most of the rogue agents was a βhighly persistentβ next-generation model that it was testing in-house. The implication is that OpenAI has built a model so good itβs dangerous.Β Β
But if you read the reports about the Hugging Face hack published by OpenAI and METR, a third-party firm that OpenAI called in to help them understand what happened, what you come away with is the impression not of a model that was too powerful for OpenAI to keep up with, but of a broken model that OpenAI failed to train properly.
The agents did what they didβincluding leaving messages for one another, delegating work to other agents, and scouring their environment for any means possible to complete their tasksβbecause they had been rewarded during training for doing exactly those things. There were also errors in the training setup, such as tasks that were impossible to complete, which pushed the models to find unexpected workarounds that were also rewarded. At the time, many of these issues went overlooked or unreported.
OpenAI says it has stopped training this new model and locked it down. That makes it sound like it has caged a dangerous beast. In fact, OpenAI has shelved a faulty product.Β Β
Thatβs not to say a faulty product canβt be dangerous. Broken software has even killed people in the past. But as the discussion of a slowdown gathers steam, itβs worth remembering that all of this is self-inflicted. A slowdown might have some altruistic side effects. But itβll mostly give these tech titans a chance to clean up the mess on their own assembly lines.Β Β
Transparency from these frontier labs will be key to any meaningful effort to reform, restrain, or regulate AI. Otherwise, the rest of us will still only have their word for exactly what theyβve built and how safe it isβwhatever pace theyβre going.Β Β Β
To continue this discussion about AIβs latest doomer moment, join me and my colleagues for a subscriber-exclusive Roundtable discussion tomorrow, September 15, at 11 a.m. US eastern time. We hope to see you there!
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Omics in Gastric
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Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.ABSTRACTGastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carci
Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.
ABSTRACT
Gastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carcinogenesis by modulating mucosal immunity, chronic inflammation, epithelial barrier integrity, and metabolism. High-throughput sequencing has revealed reproducible dysbiosis signatures in GC, characterized by enrichment of taxa such as Lactobacillus, Streptococcus, and Fusobacterium, and depletion of beneficial commensals, including Bifidobacterium and short-chain fatty acid producing anaerobes, some of which show promise as diagnostic or prognostic biomarkers. This review summarizes current knowledge on bacterial, fungal, and viral inhabitants of gastric tumors, highlighting their mechanistic roles in tumor initiation and progression and their potential as microbial indicators of disease. It further evaluates noninvasive and minimally invasive early detection strategies based on fecal and salivary microbiota profiling, urinary extracellular vesicles, and metabolomic fingerprints, alongside multi-omics integration and machine-learning models that combine microbial and host features to improve risk stratification. Finally, the review discusses therapeutic avenues including microbiota modulation, immunotherapy microbiome interactions, and personalized medicine frameworks that incorporate microbial signatures into clinical decision-making, underscoring the need for standardized, multicenter studies to translate gastric microbiome insights into robust tools for early detection and targeted intervention in GC.
PMID:42734869 | DOI:10.1007/s12602-026-11134-3
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.ABSTRACTGastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carci
Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.
ABSTRACT
Gastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carcinogenesis by modulating mucosal immunity, chronic inflammation, epithelial barrier integrity, and metabolism. High-throughput sequencing has revealed reproducible dysbiosis signatures in GC, characterized by enrichment of taxa such as Lactobacillus, Streptococcus, and Fusobacterium, and depletion of beneficial commensals, including Bifidobacterium and short-chain fatty acid producing anaerobes, some of which show promise as diagnostic or prognostic biomarkers. This review summarizes current knowledge on bacterial, fungal, and viral inhabitants of gastric tumors, highlighting their mechanistic roles in tumor initiation and progression and their potential as microbial indicators of disease. It further evaluates noninvasive and minimally invasive early detection strategies based on fecal and salivary microbiota profiling, urinary extracellular vesicles, and metabolomic fingerprints, alongside multi-omics integration and machine-learning models that combine microbial and host features to improve risk stratification. Finally, the review discusses therapeutic avenues including microbiota modulation, immunotherapy microbiome interactions, and personalized medicine frameworks that incorporate microbial signatures into clinical decision-making, underscoring the need for standardized, multicenter studies to translate gastric microbiome insights into robust tools for early detection and targeted intervention in GC.
PMID:42734869 | DOI:10.1007/s12602-026-11134-3
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cs.AI, q-bio.NC updates on arXiv.org
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Language Is an Insufficient Substrate for Quantitative Reasoning, and Consequential Domains Need Large Quantitative Models
arXiv:2609.12105v1 Announce Type: new Abstract: The prevailing assumption in applied machine learning is that progress on consequential quantitative decisions such as pricing risk, allocating capital, triaging patients, or containing a network intrusion will follow from progress in large language models (LLMs). A language model is trained on a representation of the world that was produced by human description; description is a lossy encoding of the quantitative record, and the loss is irreversi
Language Is an Insufficient Substrate for Quantitative Reasoning, and Consequential Domains Need Large Quantitative Models
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cs.AI, q-bio.NC updates on arXiv.org
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WinSyn: An Automated Pipeline for Realistic Enterprise Question-Answering Evaluation
arXiv:2609.12171v1 Announce Type: new Abstract: Enterprise settings provide a challenging environment for question-answering agents, which often rely on Retrieval-Augmented Generation, Deep Research (DR), and related techniques. Much of this challenge comes from the complexity of enterprise data: information is often spread across evolving and potentially conflict- ing emails, chat messages, documents, and other artifacts. Existing benchmarks typically have limited real-world complexity, short-
WinSyn: An Automated Pipeline for Realistic Enterprise Question-Answering Evaluation
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cs.AI, q-bio.NC updates on arXiv.org
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SteerDuplex: Steerable Duplex Speech Dialogue Models
arXiv:2609.12623v1 Announce Type: new Abstract: Full-duplex spoken dialogue models support low-latency turn taking, interruption handling, and backchanneling, yet a key capability remains underexplored: steerability, the ability to reliably shift conversational behavior along attributes such as tone, persona, speaking rate, and voice style in response to user instructions. We introduce a taxonomy of text- and audio-based steerability that identifies substantial gaps in current full-duplex model
SteerDuplex: Steerable Duplex Speech Dialogue Models
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cs.AI, q-bio.NC updates on arXiv.org
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How Good Are Frontier Models at Physics? Expert Re-Grading Reveals Broken Evaluations and Near-Saturation of Leading Benchmarks
arXiv:2609.13009v1 Announce Type: new Abstract: Low reported scores on leading physics benchmarks, including those featured in the Artificial Analysis Intelligence Index (2026), suggest that frontier language models still struggle with advanced physics, a demanding test of their scientific reasoning and quantitative problem-solving abilities. Yet this impression does not always align with domain experts' experiences using these models in their work. We revisit these reported findings by evaluat
How Good Are Frontier Models at Physics? Expert Re-Grading Reveals Broken Evaluations and Near-Saturation of Leading Benchmarks
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cs.AI, q-bio.NC updates on arXiv.org
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Diffusion Models and Concept Formation
arXiv:2609.13047v1 Announce Type: new Abstract: Humans organize knowledge into a taxonomy of concepts with nested levels of abstraction and a \emph{basic level} at which people recognize and name objects with the least cognitive effort. Cobweb is a classic cognitive account of this ability, an incremental learner that builds a probabilistic concept hierarchy by maximizing category utility. We argue that diffusion models, although designed for image synthesis, implicitly perform the same computa
Diffusion Models and Concept Formation
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cs.AI, q-bio.NC updates on arXiv.org
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Creating an Atomic User Model for Personality-Aware Large Language Model Interaction
arXiv:2609.12086v1 Announce Type: cross Abstract: Assistants built on large language models are expected to write as their user would, and the dominant approach is single-channel: preferences summarised from conversation history and reinserted into context. This inverts the order of inference. Preferences are the task-dependent surface of a comparatively stable personality structure, so a system storing only preferences relearns the person whenever the task changes. First, we characterise perso
Creating an Atomic User Model for Personality-Aware Large Language Model Interaction
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cs.AI, q-bio.NC updates on arXiv.org
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DriftSE: Speech Enhancement with Generative Drifting
arXiv:2609.12252v1 Announce Type: cross Abstract: We propose DriftSE, a novel one-step generative framework for speech enhancement formulated as a latent distribution equilibrium problem. During training, the drifting field aligns the generator's pushforward distribution with the clean speech manifold through drifting in a latent domain. During inference, the drifting process is discarded, enabling one-step generation. We establish that its enhancement quality depends fundamentally on the choic
DriftSE: Speech Enhancement with Generative Drifting
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cs.AI, q-bio.NC updates on arXiv.org
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Automated Detection and Structuring of Social Tipping Point Evidence in Climate related Documents: A Modular AI Framework
arXiv:2609.12254v1 Announce Type: cross Abstract: The climate literature has grown faster than review teams can read it. That gap matters most for a concept like the environmental social tipping point, the threshold at which a small change triggers rapid, self-reinforcing change in a social system. Evidence of this kind of shift is usually contained in one or two paragraphs within a longer document. As a result, existing text mining tools-which categorize entire documents by topic or highlight
Automated Detection and Structuring of Social Tipping Point Evidence in Climate related Documents: A Modular AI Framework
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cs.AI, q-bio.NC updates on arXiv.org
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Amortized Low-Rank Adaptation for Model-Based Reinforcement Learning
arXiv:2609.12278v1 Announce Type: cross Abstract: World models let agents plan by predicting the consequences of their actions, but changes in the environment can make them inaccurate. We study the problem of adapting a world model to an unknown test-time environment, drawn from a known environment family, using only a few episodes of interaction. Existing approaches trade off computational cost against expressivity, i.e., the range of models a method can produce. For example, in-context learni
Amortized Low-Rank Adaptation for Model-Based Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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IMPLY: Physically Anchored Consistency for World-Model Rollouts
arXiv:2609.12441v1 Announce Type: cross Abstract: A world model asked what happens if an object is pushed at several speeds produces several futures. If the model has the object in mind, those futures agree about it: each implies the same mass and friction. The consistency checks now used to vet world-action models ask whether a model's futures agree with each other, and none of them knows any physics. We show that this is not enough, and what to do instead. IMPLY reads the physics each rollout
IMPLY: Physically Anchored Consistency for World-Model Rollouts
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cs.AI, q-bio.NC updates on arXiv.org
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Not All Speech Is Intent: Adaptive Self-Correcting Inference Layer for Post-ASR False Wake-Up
arXiv:2609.12469v1 Announce Type: cross Abstract: False wake-up activations remain a persistent challenge in conversational AI. Speech phonetically similar to a device's wake word can produce a syntactically valid and semantically coherent ASR transcript that the assistant incorrectly executes. Most existing systems make a single intent decision in isolation, without a mechanism to learn from recurring errors over time or adapt to individual users through personalized learning. We introduce the
Not All Speech Is Intent: Adaptive Self-Correcting Inference Layer for Post-ASR False Wake-Up
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cs.AI, q-bio.NC updates on arXiv.org
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Large Distant Gradients Need Not Be Reliable: reliability-weighted credit assignment for long-horizon autoregressive forecasting
arXiv:2609.12890v1 Announce Type: cross Abstract: In autoregressive forecasting, long prediction rollouts provide distant supervision, but backpropagation through time (BPTT) carries gradients from those losses through many autoregressive steps. Repeated Jacobian products can make distant gradients dominate the update while amplifying predictable signal and unpredictable noise together; a large distant gradient therefore need not carry reliable learning signal. Motivated by this observation, we
Large Distant Gradients Need Not Be Reliable: reliability-weighted credit assignment for long-horizon autoregressive forecasting
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cs.AI, q-bio.NC updates on arXiv.org
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MP-Bench: Evaluating Voice Agents as a Multiparty Conversation Participant
arXiv:2609.13076v1 Announce Type: cross Abstract: Conversational voice agents have advanced significantly, offering increasingly natural human-machine interactions through both cascaded and end-to-end architectures. However, while recent benchmarks extensively evaluate dyadic interactions and passive audio comprehension, they largely overlook a prevalent real-world scenario: multi-party conversations. Evaluating agents in these settings is fundamentally more challenging than in dyadic interacti
MP-Bench: Evaluating Voice Agents as a Multiparty Conversation Participant
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cs.AI, q-bio.NC updates on arXiv.org
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WorkflowPerturb: Calibrated Stress Tests for Evaluating Multi-Agent Workflow Metrics
arXiv:2602.17990v3 Announce Type: replace Abstract: Multi-agent LLM systems that generate structured workflows from natural-language requests are now deployed in production across cloud automation, DevOps, and enterprise orchestration. Operating them exposes a recurring change-management problem. Routine updates, such as re-running an input, swapping the LLM, or refactoring an agent's prompt or orchestration code, often produce workflows that differ substantially from validated references. Engi
WorkflowPerturb: Calibrated Stress Tests for Evaluating Multi-Agent Workflow Metrics
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cs.AI, q-bio.NC updates on arXiv.org
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PACE: A Neuro-Symbolic Framework for Plausible and Actionable Counterfactual Explanations
arXiv:2607.01306v2 Announce Type: replace Abstract: Counterfactual explanations explain machine learning predictions by identifying minimal input changes that would alter a model's decision. Although many existing methods successfully generate prediction-changing alternatives, they often produce unrealistic or infeasible recommendations due to a lack of explicit mechanisms for incorporating domain knowledge and intervention constraints. Neuro-symbolic AI offers a promising direction by combinin
PACE: A Neuro-Symbolic Framework for Plausible and Actionable Counterfactual Explanations
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cs.AI, q-bio.NC updates on arXiv.org
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The Agent Incident Registry: Toward Preventing Repeated AI Agent Failures
arXiv:2609.11030v2 Announce Type: replace Abstract: AI agents increasingly act through tools and delegated authority, but general incident repositories rarely capture the mechanisms needed to compare public failures with agent-security evaluations. We present the Agent Incident Registry (AIR) (Project page: https://enkryptai.com/air), a source-linked catalog containing 487 records of agent-related events disclosed from 2022 through 2026. Each record includes supporting evidence, a stable identi