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Integrating Transparent Models, LLMs, and Practitioner-in-the-Loop: A Case of Nonprofit Program Evaluation

arXiv:2510.19799v1 Announce Type: cross Abstract: Public and nonprofit organizations often hesitate to adopt AI tools because most models are opaque even though standard approaches typically analyze aggregate patterns rather than offering actionable, case-level guidance. This study tests a practitioner-in-the-loop workflow that pairs transparent decision-tree models with large language models (LLMs) to improve predictive accuracy, interpretability, and the generation of practical insights. Using data from an ongoing college-success program, we build interpretable decision trees to surface key predictors. We then provide each tree's structure to an LLM, enabling it to reproduce case-level predictions grounded in the transparent models. Practitioners participate throughout feature engineering, model design, explanation review, and usability assessment, ensuring that field expertise informs the analysis at every stage. Results show that integrating transparent models, LLMs, and practitioner input yields accurate, trustworthy, and actionable case-level evaluations, offering a viable pathway for responsible AI adoption in the public and nonprofit sectors.
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Beyond Biomarkers: Machine Learning-Driven Multiomics for Personalized Medicine in Gastric Cancer

J Pers Med. 2025 Apr 24;15(5):166. doi: 10.3390/jpm15050166.

ABSTRACT

Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with most cases diagnosed at advanced stages. Traditional biomarkers provide only partial insights into GC's heterogeneity. Recent advances in machine learning (ML)-driven multiomics technologies, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics, have facilitated a deeper understanding of GC by integrating molecular and imaging data. In this review, we summarize the current landscape of ML-based multiomics integration for GC, highlighting its role in precision diagnosis, prognosis prediction, and biomarker discovery for achieving personalized medicine.

PMID:40423038 | PMC:PMC12113022 | DOI:10.3390/jpm15050166

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Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway

Oncogene, Published online: 18 May 2023; doi:10.1038/s41388-023-02716-4

Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway
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