Zhang and colleagues reveal that GPX4 serves as a critical regulator of NRF2-mediated otoprotection against aminoglycoside-induced hair cell injury. Their findings identify a GPX4-dependent antioxidant mechanism that enables therapeutic activation of NRF2 and provides new insights into strategies for preventing drug-induced hearing loss.

arXiv:2603.29252v1 Announce Type: cross Abstract: Long video understanding is a key challenge that plagues the advancement of \emph{Multimodal Large language Models} (MLLMs). In this paper, we study this problem from the perspective of visual memory mechanism, and proposed a novel and training-free approach, termed \emph{Flexible Memory} (\textbf{FlexMem}). In principle, FlexMem aims to mimic human behavior of video watching, \emph{i.e.}, continually watching video content and recalling the most relevant memory fragments to answer the question. In this way, FlexMem can help MLLMs achieve video understanding of infinite lengths, unlike previous methods that process all video information at once and have input upper-limit. Concretely, FlexMem first consider the visual KV caches as the memory sources, and realize the effective memory transfer and writing via a dual-pathway compression design. Afterwards, FlexMem also explores different memory reading strategies for the diverse video understanding tasks, including the popular streaming one. To validate FlexMem, we apply it to two popular video-MLLMs, and conduct extensive experiments on five long video and one streaming video task. The experimental results show that on \textbf{a single 3090 GPU}, our FlexMem can achieve obvious improvements than existing efficient video understanding methods and process more than \textbf{1k frames}, which also helps the base MLLMs achieve comparable or even better performance than SOTA MLLMs on some benchmarks, \emph{e.g.} , GPT-4o and Gemini-1.5 Pro.

arXiv:2603.22911v1 Announce Type: cross Abstract: Due to the great saving of computation and memory overhead, token compression has become a research hot-spot for MLLMs and achieved remarkable progress in image-language tasks. However, for the video, existing methods still fall short of high-ratio token compression. We attribute this shortcoming to the insufficient modeling of temporal and continual video content, and propose a novel and training-free token pruning method for video MLLMs, termed ForestPrune, which achieves effective and high-ratio pruning via Spatial-temporal Forest Modeling. In practice, ForestPrune construct token forests across video frames based on the semantic, spatial and temporal constraints, making an overall comprehension of videos. Afterwards, ForestPrune evaluates the importance of token trees and nodes based on tree depth and node roles, thereby obtaining a globally optimal pruning decision. To validate ForestPrune, we apply it to two representative video MLLMs, namely LLaVA-Video and LLaVA-OneVision, and conduct extensive experiments on a bunch of video benchmarks. The experimental results not only show the great effectiveness for video MLLMs, e.g., retaining 95.8% average accuracy while reducing 90% tokens for LLaVA-OneVision, but also show its superior performance and efficiency than the compared token compression methods, e.g., +10.1% accuracy on MLVU and -81.4% pruning time than FrameFusion on LLaVA-Video.

arXiv:2503.23377v2 Announce Type: replace-cross Abstract: This paper introduces JavisDiT, a novel Joint Audio-Video Diffusion Transformer designed for synchronized audio-video generation (JAVG). Based on the powerful Diffusion Transformer (DiT) architecture, JavisDiT simultaneously generates high-quality audio and video content from open-ended user prompts in a unified framework. To ensure audio-video synchronization, we introduce a fine-grained spatio-temporal alignment mechanism through a Hierarchical Spatial-Temporal Synchronized Prior (HiST-Sypo) Estimator. This module extracts both global and fine-grained spatio-temporal priors, guiding the synchronization between the visual and auditory components. Furthermore, we propose a new benchmark, JavisBench, which consists of 10,140 high-quality text-captioned sounding videos and focuses on synchronization evaluation in diverse and complex real-world scenarios. Further, we specifically devise a robust metric for measuring the synchrony between generated audio-video pairs in real-world content. Experimental results demonstrate that JavisDiT significantly outperforms existing methods by ensuring both high-quality generation and precise synchronization, setting a new standard for JAVG tasks. Our code, model, and data are available at https://javisverse.github.io/JavisDiT-page/.