Synergistic Vision-Language Reinforcement Enables Scalable On-Demand Analysis across Diverse Clinical Tasks

By: Haonan Wang · Jiaji Mao · Lehan Wang · Qixiang Zhang · Marawan Elbatel · Yi Qin · Huijun Hu · Baoxun Li · Wenhui Deng · Weifeng Qin · Hongrui Li · Jialin Liang · Jun Shen · Xiaomeng Li

10 September 2026 at 12:00

arXiv:2505.03380v2 Announce Type: replace-cross Abstract: Accurate delineation of tumors and surrounding organs-at-risk is essential for radiotherapy, surgery and treatment response assessment, yet remains time-consuming and expertise-intensive. Existing artificial intelligence systems often require manual spatial prompts or task-specific retraining, while generic class labels provide limited semantic grounding for heterogeneous disease targets. Here we present SyRe, a promptable segmentation foundation model based on Synergistic vision-language Reinforcement. SyRe strengthens bidirectional interaction between visual and linguistic representations to improve semantically grounded spatial understanding. To support large-scale training, we introduce the Color Region Description strategy and construct SyReData, comprising 20 million image-mask-description triplets across 9 modalities and 229 segmentation tasks. Training with diversified prompt forms further enables open-ended prompting, invalid-prompt rejection and flexible switching between single- and multi-target analysis. SyRe achieves accurate text-prompted segmentation across diverse clinical scenarios, with particularly strong performance on disease-related targets. Across 28 unseen external datasets, including 20 cancer types and multinational in-house cohorts, SyRe generalizes robustly under real-world distribution shifts. SyRe-generated masks also preserve clinically relevant quantitative information in pathology and yield radiomics features that stratify survival and improve prognostic modeling across five retrospective CT and MRI tumor cohorts. Finally, clinician-in-the-loop refinement enables efficient case-level correction when greater precision is required. These results establish SyRe as a generalizable foundation for scalable quantitative oncology and clinician-guided segmentation refinement.

Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer

(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)

By: Xiaomeng Li · Xuejiao Li · Hongbo Wu · Rui Li

3 April 2026 at 18:00

Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.

ABSTRACT

Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and accelerated lipid synthesis (involving enzymes such as FASN). These metabolic alterations not only remodel the TME but also dampen antitumor immune responses by promoting immunosuppressive cell populations (e.g., Tregs and M2 macrophages) and inhibiting effector functions of CD8⁺ T cells and natural killer (NK) cells. Critically, a bidirectional crosstalk operates between tumor cell metabolism and the immunosuppressive TME: metabolic reprogramming drives immune suppression through metabolite accumulation, whereas the immunosuppressive TME, in turn, promotes tumor cell adaptability-thus forming a positive feedback loop that reinforces immune evasion and therapy resistance. This review elucidates key molecular pathways governing metabolic reprogramming in lung cancer-spanning glucose, amino acid, and lipid metabolism-and their dynamic crosstalk with immune regulation, including epigenetic modifications and non-coding RNA-mediated mechanisms. Additionally, it evaluates emerging therapeutic strategies targeting the metabolic-immune axis, such as inhibitors of HK2 or GLS1 combined with anti-PD-1/PD-L1 agents, which aim to reverse immunosuppression and improve clinical outcomes. By synthesizing recent advances, this work provides a theoretical framework for precision oncology interventions, highlighting the potential of metabolic immunotherapies and future directions integrating AI and multi-omics data to overcome resistance in lung cancer.

PMID:41930159 | PMC:PMC13040304 | DOI:10.32604/or.2026.076176

Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer

Omics In Lung

By: Xiaomeng Li · Xuejiao Li · Hongbo Wu · Rui Li

3 April 2026 at 18:00

Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.

ABSTRACT

Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and accelerated lipid synthesis (involving enzymes such as FASN). These metabolic alterations not only remodel the TME but also dampen antitumor immune responses by promoting immunosuppressive cell populations (e.g., Tregs and M2 macrophages) and inhibiting effector functions of CD8⁺ T cells and natural killer (NK) cells. Critically, a bidirectional crosstalk operates between tumor cell metabolism and the immunosuppressive TME: metabolic reprogramming drives immune suppression through metabolite accumulation, whereas the immunosuppressive TME, in turn, promotes tumor cell adaptability-thus forming a positive feedback loop that reinforces immune evasion and therapy resistance. This review elucidates key molecular pathways governing metabolic reprogramming in lung cancer-spanning glucose, amino acid, and lipid metabolism-and their dynamic crosstalk with immune regulation, including epigenetic modifications and non-coding RNA-mediated mechanisms. Additionally, it evaluates emerging therapeutic strategies targeting the metabolic-immune axis, such as inhibitors of HK2 or GLS1 combined with anti-PD-1/PD-L1 agents, which aim to reverse immunosuppression and improve clinical outcomes. By synthesizing recent advances, this work provides a theoretical framework for precision oncology interventions, highlighting the potential of metabolic immunotherapies and future directions integrating AI and multi-omics data to overcome resistance in lung cancer.

PMID:41930159 | PMC:PMC13040304 | DOI:10.32604/or.2026.076176

PRET is a few-shot system for pan-cancer recognition without example training

Nature Cancer

By: Yi Li · Ziyu Ning · Tianqi Xiang · Qixiang Zhang · Zhihao Lin · Min Yi · Feiyan Feng · Baozhen Zeng · Xuexia Qian · Lu Sun · Jiace Qin · Ling Xiang · Chao Fan · Tian Qin · Qian Wang · Xiu-Wu Bian · Kun-Hsing Yu · Kang Zhang · Qingling Zhang · Xiaomeng Li

3 April 2026 at 08:00

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01141-2

Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks and pathologists in lymph node metastasis detection.

Escaping the BLEU Trap: A Signal-Grounded Framework with Decoupled Semantic Guidance for EEG-to-Text Decoding

cs.AI, q-bio.NC updates on arXiv.org

By: Yuchen Wang · Haonan Wang · Yu Guo · Honglong Yang · Xiaomeng Li

5 March 2026 at 13:00

arXiv:2603.03312v1 Announce Type: cross Abstract: Decoding natural language from non-invasive EEG signals is a promising yet challenging task. However, current state-of-the-art models remain constrained by three fundamental limitations: Semantic Bias (mode collapse into generic templates), Signal Neglect (hallucination based on linguistic priors rather than neural inputs), and the BLEU Trap, where evaluation metrics are artificially inflated by high-frequency stopwords, masking a lack of true semantic fidelity. To address these challenges, we propose SemKey, a novel multi-stage framework that enforces signal-grounded generation through four decoupled semantic objectives: sentiment, topic, length, and surprisal. We redesign the interaction between the neural encoder and the Large Language Model (LLM) by injecting semantic prompts as Queries and EEG embeddings as Key-Value pairs, strictly forcing the model to attend to neural inputs. Furthermore, we move beyond standard translation metrics by adopting N-way Retrieval Accuracy and Fr\'echet Distance to rigorously assess diversity and alignment. Extensive experiments demonstrate that our approach effectively eliminates hallucinations on noise inputs and achieves SOTA performance on these robust protocols. Code will be released upon acceptance at https://github.com/xmed-lab/SemKey.

DenseMLLM: Standard Multimodal LLMs are Intrinsic Dense Predictors

cs.AI, q-bio.NC updates on arXiv.org

By: Yi Li · Hongze Shen · Lexiang Tang · Xin Li · Xinpeng Ding · Yinsong Liu · Deqiang Jiang · Xing Sun · Xiaomeng Li

17 February 2026 at 13:00

arXiv:2602.14134v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) have demonstrated exceptional capabilities in high-level visual understanding. However, extending these models to fine-grained dense prediction tasks, such as semantic segmentation and depth estimation, typically necessitates the incorporation of complex, task-specific decoders and other customizations. This architectural fragmentation increases model complexity and deviates from the generalist design of MLLMs, ultimately limiting their practicality. In this work, we challenge this paradigm by accommodating standard MLLMs to perform dense predictions without requiring additional task-specific decoders. The proposed model is called DenseMLLM, grounded in the standard architecture with a novel vision token supervision strategy for multiple labels and tasks. Despite its minimalist design, our model achieves highly competitive performance across a wide range of dense prediction and vision-language benchmarks, demonstrating that a standard, general-purpose MLLM can effectively support dense perception without architectural specialization.

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